应激神经成像的研究述评

HPA轴(hypothalamic-pituitary-adrenal cortex axis)是人体的重要内分泌应激系统, 大脑通过控制HPA轴活动影响机体在应激情境中皮质醇(cortisol)的分泌, 同时皮质醇分泌对大脑也具有负反馈作用, 影响着大脑边缘系统的重塑; 海马、杏仁核、前额叶皮层和脑干都参与了应激反应中的皮质醇调节; 未来研究要进一步对应激源细化分类, 并且试图找到适合事件相关电位技术的社会心理性应激实验范式。     

高校教师生活压力的研究

本研究采用因素分析法研究了广东高校教师的生活压力。结果表明 ,高校教师的生活压力来自家庭生活、发展提高、人际关系、工作性质、工作冲突以及兴趣和满意感等 6个方面     

The effects of threatened social evaluation of the physique on cortisol activity

Social self preservation theory asserts that situations high in social-evaluative threat elicit increases in cortisol, a hormone released by the hypothalamic-pituitary-adrenal axis. Most tests of the theory have examined threats associated with social evaluation of a performance. Two experiments examined the effects of threatened social evaluation of one's physique. In Experiments 1 (n?=?50) and 2 (n?=?40), participants allocated to an experimental (threat) condition had significantly higher post-manipulation cortisol than participants in a control (no threat) condition. In Experiment 1, perceptions of social-evaluative threat were significantly correlated with post-manipulation cortisol levels. These results suggest that the threatened social evaluation of one's body can activate the cortisol response. Women who frequently experience such threats may be at increased risk for a variety of health conditions associated with chronic cortisol exposure.     

大学生自我和谐与生活应激、生活满意度的相关

本研究探讨大学生生活应激、生活满意度与自我和谐之间的关系。采用SCCS,SLSI和CSLSS对420名大学生进行调查,对数据进行相关分析、多元逐步回归等,得出不同自我和谐程度的大学生在生活应激和生活满意度上差异显著;应激源、应激反应、主、客观生活满意度进入自我和谐的回归方程。因此,大学生生活应激、生活满意度能较好地预测自我和谐。     

早期经历影响个体成年后行为的表观遗传学机制

既往研究已证实早期经历与个体成年后的行为密切相关,然而早期经历对个体成年后的行为产生长期影响的分子生物机制并不清楚。近年来越来越多的研究表明表观遗传因素在早期经历调控成年个体行为中发挥了重要功能。表观遗传是研究没有DNA序列变化,但是可遗传和可逆转的基因组功能的调控。本文试图从早期经历参与调控个体成年后行为表现以及基因表达的相关表观遗传学修饰进行综述。     

大学生宽恕行为抑制机制的个体差异多因素系统模型的初步建构

为探讨神经质特质、大学生宽恕行为、焦虑型依恋及攻击型幽默风格之间的关系,选取550名大学生为被试,采用大五人格问卷、情景宽恕问卷、成人依恋问卷及幽默风格量表进行测试。结果表明：（1）神经质对大学生宽恕行为有显著的正向影响,并间接地通过焦虑型依恋对大学生宽恕行为产生作用;（2）攻击型幽默风格在神经质对大学生宽恕行为的影响中起显著的调节作用,具体而言,在高攻击型幽默风格水平下,神经质对大学生宽恕行为的预测更强。     

童年期创伤对大学生抑郁的影响:早期适应不良图式和负性生活事件的作用

目的:考察早期适应不良图式、负性生活事件在童年期创伤与大学生抑郁间的影响机制。方法:采用童年期创伤问卷、Young图式问卷短版中文修订版、青少年生活事件量表及90项症状自评量表对1423名大学生进行调查,结果表明:(1)童年期创伤既可以直接正向预测大学生抑郁,也可以通过早期适应不良图式中的分离和拒绝、自主性及能力受损两大图式类别间接地正向预测大学生抑郁;(2)负性生活事件调节了早期适应不良图式在童年期创伤与抑郁间的中介作用     

Early trauma,negative affect,and anxious attachment: the role of metacognition

Background and Objectives: Metacognition is linked to the etiology and maintenance of negative emotions and psychological disorder in the Self-Regulatory Executive Function Model. Although there is significant evidence supporting the model, little is currently known about the situational factors for developing dysfunctional metacognitions. The current study explored the hypothesis that early aversive experiences might be important and also tested if metacognitions could mediate the relationship between such experiences and psychological symptoms. Design and Methods: Three hundred and fifty non-clinical adults completed a retrospective early trauma measure, as well as measures of current metacognitive beliefs, negative affect, and anxious attachment. Results: Early emotional abuse positively and significantly correlated with several metacognitive belief dimensions but other forms of early trauma did not. Metacognition fully mediated the relationship between emotional abuse and negative affect. Anxious attachment was also positively and significantly associated with metacognitive beliefs and specific relationships remained after controlling for early emotional abuse and current negative affect. Conclusions: Findings are consistent with the ideas that: (i) early negative experiences, and emotional abuse in particular, could be a factor in the formation of problematic metacognitions and (ii) these metacognitions may be important in determining the effects of abuse on subsequent psychological symptoms.     

早期应激对情绪调节的影响及其神经机制

在个体生命早期遭遇的长期或重大的应激经历会显著增加个体罹患抑郁、焦虑等心理疾患的风险, 而情绪调节能力的损伤是引发这些心理疾患的重要因素之一。以人类为对象的行为实验和调查研究表明, 早期应激不仅会影响日常生活中情绪调节策略的使用, 还会对情绪调节能力造成影响, 其影响方向可能与早期应激的严重程度有关。目前, 大部分研究表明严重的早期应激会损伤情绪调节能力, 但中度的早期应激也可能提高情绪调节能力。更为整合性的研究表明情绪调节能力中介了早期应激和各类疾患之间的关系。进一步, 我们从神经层面上阐述了早期应激对情绪调节相关脑区和神经环路的影响。未来研究应当注意控制无关变量, 进一步探究不同早期应激对于情绪调节的影响。     

Emotional Constriction and Risk for Posttraumatic Stress: The Roles of Trauma History and Gender

Research suggests there are qualitative differences in emotionality across gender, with men being more emotionally constrictive than women. Constrictive emotionality has consistently been linked to posttraumatic stress disorder (PTSD) and because men are generally more emotionally constrictive, one could infer they are at increased risk for PTSD. However, research demonstrates that twice as many women are diagnosed with PTSD than men. In an undergraduate sample, men reported significantly greater emotional constriction, but significantly less posttraumatic stress severity in comparison to women. The gender differences in emotional constriction disappeared in a subsample of students who endorsed experiencing an upsetting event. Emotional constriction mediated the relationship between trauma and posttraumatic stress severity, although it was a stronger mediator for women than men.     

Early life adversity potentiates the effects of later life stress on cumulative physiological dysregulation

Background and Objectives: Previous research indicates that early life adversity may heighten stress reactivity and impair mechanisms for adaptive coping, suggesting that experience of stress in early life may also potentiate adults' physiological vulnerability to stress in later life. The study tested this hypothesis by investigating whether the experience of stressful events and circumstances (SEC) in childhood or adolescence amplified the effect of adulthood SEC on physiological dysregulation (allostatic load, AL) in later midlife. Design: Observational data were used in the present study. Physiological functioning was measured in later midlife (participants' age ranged from 49 to 63 years). Both childhood/adolescence and adulthood SEC were reported retrospectively on the same occasion. Methods: Participants were 5309 Danish men and women from Copenhagen Aging and Midlife Biobank (CAMB). SEC included socioeconomic and family factors. The AL index was based on nine cardiovascular, metabolic, and immune biomarkers. Results: Experience of SEC in both early life and adulthood independently predicted higher AL. In men, experience of SEC in early life also potentiated the effect of SEC in adulthood on AL. Conclusions: The results provide further insight into the mechanisms behind the “biological embedding” of childhood stress.     

内-外倾人格对情绪调节的影响及神经机制

内—外倾人格(即外倾性)是与情绪活动密切相关的人格特质：该特质不但影响人类的适应能力与主观幸福感,还与焦虑、冲动等情绪—行为障碍的产生有密切关联。在以往研究中,外倾性与情绪健康的关系集中体现为内—外倾人格对情绪事件易感性的影响,如外倾人格得分的增高伴随着对奖赏刺激更强的积极情绪反应水平。然而,上述联系也有可能是由于外倾性不同的人群具有不同的情绪调节特点导致。因此,可通过系统操纵外倾性人格因素与情绪调节方式,从外倾性人格特质对情绪调节方式及调节效果影响的角度,深入探讨外倾性和人类情绪与健康的关系。拟综合使用行为调查与生理测量、EEG/ERP 与 fMRI 手段,开展如下三个层面的研究工作：1)情绪调节问卷的编制及内、外倾人群情绪调节策略的比较研究;2)外倾性对情绪调节的影响及其脑机制研究,探讨认知情绪调节的生理变化、时间进程及神经基础与内—外倾人格的关系;3)情绪稳定性不同的内、外倾人群其情绪调节的特点及其脑机制研究。通过上述系列研究,深化对情绪与人格关系的认识,从而为心理健康的维护,情绪障碍的治疗及相关疗法的开发应用奠定理论基础。     

创伤后应激障碍的动物模型及其神经生物学机制

创伤后应激障碍是指个体由于经历对生命具有威胁的事件或严重的创伤,导致症状长期持续的精神障碍。研究创伤后应激障碍的主要动物模型为条件性恐惧和应激敏感化模型。研究表明,创伤后应激障碍中长时程留存的恐惧性记忆、高唤醒等症状与大脑杏仁核、内侧前额叶皮层和海马三个脑区及下丘脑-垂体-肾上腺轴负反馈功能增强密切相关。其中杏仁核活动增强是条件性恐惧记忆获得、保持和表达的关键神经基础。内侧前额叶皮层对杏仁核的去抑制及海马向杏仁核传递的威胁性环境信息,促进创伤后应激障碍症状的出现。在经历创伤应激后糖皮质激素受体的上调及多巴胺活动的增强是创伤后应激障碍产生的主要神经基础。对创伤后应激障碍的药物治疗研究证明多巴胺D2受体在改善患者症状中的作用比较重要,但仍需作更深入的探索     

Child Maltreatment,Emotion Regulation,and Posttraumatic Stress: The Impact of Emotional Abuse

This study examined the relationship of emotion regulation to multiple forms of child abuse and subsequent posttraumatic stress. Particular consideration was given to emotional abuse, which has received less attention in the literature. Results from a survey of 912 female college students revealed that women who reported a history of sexual, physical, or emotional abuse endorsed greater emotion regulation difficulties compared to women without abuse histories. Notably, emotional abuse was the strongest predictor of emotion deregulation. Mediation analyses indicated that emotion dysregulation partially explained the relationship between physical and emotional abuse and symptoms of posttraumatic stress, suggesting that intervention efforts aimed at improving emotion regulation strategies might be beneficial in decreasing posttraumatic stress among women with child maltreatment histories.     

Parent Perspectives on the Use of Group Well-Child Care to Address Toxic Stress in Early Childhood

We sought to understand the experiences of parents who participated in Group Well-Child Care (GWCC) and Trauma-Informed GWCC (TI-GWCC). Three focus groups and design sessions with parents from either standard GWCC or TI-GWCC (N = 17) were conducted and synthesized into common themes using thematic analysis. Focus group themes included: (1) GWCC can empower parents to recognize toxic stress; (2) Parents identify ways that they role model behaviors for their child(ren); (3) Activities that facilitate reflection on attachment and anger management encourage intentional parenting practices. Our qualitative findings suggest that TI-GWCC supports the prevention of childhood adversity by creating connections between parents, helping families understand and identify toxic stress, and teaching parenting practices that mitigate stressors.     

The Impact of Life Design Counselling on Adolescents

This study records a process of heightening self-awareness within a semi-structured ‘life design counselling’ process. The research was conducted on the basis of a case study designed to facilitate co-constructive conversation with a purposefully selected youth. The participant was enabled to reconstruct a preferred and meaningful future that could change as different experiences, challenges and needs arose. The study suggested that the postmodern techniques that were implemented enhanced the involvement of the participant in the study. The participant revealed heightened self-insight into his personal experiences, a ‘changed’ attitude to certain aspects of his life context and pro-active behaviour with regard to the challenges he was facing. We (the researchers) concluded that life design counselling could be a promising strategy that could have a lasting effect on adolescents.     

乳腺癌患者经济负担对情绪健康及生活质量的影响研究进展

通过文献综述的方式,对乳腺癌患者疾病经济负担、情绪健康、生活质量及三者相关关系的实证研究成果进行系统梳理。研究证实,乳腺癌患者疾病经济负担的主观感知严重程度对患者治疗依从性、情绪健康和生活质量产生重要负面影响。长期的治疗以及靶向药物、免疫药物使用的增加,加重了患者及其家庭经济负担,进而增加抑郁、焦虑的患病风险,导致患者总体生活质量下降。并在探讨当前研究局限性的基础上,提出对未来研究方向的建议与展望。

     

震前生活事件、创伤程度对中学生震后心理应激状况的影响

采用青少年生活事件量表（ASLEC）、自编震后创伤程度调查表和PTSD自评量表对汶川地震区413名中学生进行问卷调查,探讨震前生活事件、创伤程度对震后心理应激反应的影响。结果表明：中学生PTSD症状有显著的性别差异,女生高于男生;震前生活事件、创伤程度的各维度与PTSD症状反应总分相关显著;学习压力、暴露和丧失程度均对再体验有显著的正向影响;学习压力、受惩罚、其他、暴露和丧失程度对逃避及麻木有显著影响;学习压力、其他、暴露和丧失程度对过度觉醒有显著的正向影响;震前生活事件对PTSD症状反应有重要的影响     

急性应激障碍（ASD）研究述评

急性应激障碍是个体在亲历、目击或面临一个对自己或他人具有死亡威胁、严重伤害的创伤事件后的2天至4周内所表现的应激反应。急性应激障碍的症状主要表现为分离、再历、回避和过度警觉。文章回顾了以往的相关研究,从急性应激障碍的测评方法、发生率、与创伤后应激障碍和创伤记忆的关系、心理治疗和干预等方面进行了综述。最后对未来可能的研究方向提出了展望     

Joseph and His Brothers: A Biblical Paradigm for the Optimal Handling of Traumatic Stress

The long-lasting effects of emotional trauma and the important role of unconscious emotional defenses have become increasingly recognized only in the past century. Yet their role is actually manifest, although still overlooked, in one of the most well-known of biblical stories. This paper presents the story of Joseph and his brothers, and the important lessons it teaches about unconscious defenses and the optimal handling of emotional trauma.