个体智力与人格的差异:进化遗传学的视角

进化遗传学是现代遗传学的主要研究领域之一。文章首先对进化遗传学研究的理论基础及早期重要的研究进行回顾及简要介绍。进而着重阐述了当前该领域的三种主要进化遗传机制模型,选择中立机制、突变——选择平衡机制以及平衡选择机制,对个体智力差异和人格差异的解释,并列举一系列实证研究证据。最后本文探讨了进化遗传学研究对于解释个体心理差异的贡献与不足。     

遗传与环境的相关及交互作用分析--兼评行为遗传学研究方法的新进展

遗传与环境的“相关”与“交互作用”这两个既有联系又相区别的概念的提出,使人们对传统的行为遗传学研究有了新的认识。该文在此分析的基础上,提出利用精巧的实验设计及分子遗传分析对两者进行考察的新方法,并对已有行为遗传学研究方法存在的局限与发展前景予以简要评述。     

发展行为遗传学简介

发展行为遗传学是发展心理学与行为遗传学的交叉学科, 旨在探明遗传与环境对人类心理与行为发展是否存在影响, 如何产生影响, 以及该影响及其作用机制是否随年龄增长而发展变化的问题。该学科与行为遗传学在研究对象、设计和内容等方面存在不同; 开展发展行为遗传学研究需要综合运用心理测量法和行为遗传学研究方法; 未来研究应拓宽和深化候选基因与行为关联性的考察, 并着力探析基因与环境的相互作用机制。     

人格行为遗传学研究的两类取向

随着行为主义衰落和生物学技术发展,长期遭受“冷遇”的人格行为遗传学研究近些年成为颇受关注的领域,并由数量遗传学取向发展到分子遗传学取向.数量遗传学取向主张运用双生子研究、收养研究等设计来估计群体中遗传因素对人格表现型方差的贡献率,在人格特质、人格障碍、态度与偏好等人格方面做了大量研究.分子遗传学取向主张在DNA水平上用基因测定方法研究特定基因对人格表现型的影响效应,着重从多巴胺、5-羟色胺和去甲肾上腺素三种神经递质路径考察了基因与人格的关系.未来研究要强调在数量遗传设计中加入对特定基因型的直接测量,注重多学科和多范式的有效整合,扩大对健康人群积极人格品质的研究,加强基因对人格的深层作用机制研究和分子医学层面的人格干预研究.     

青少年焦虑、抑郁与偏差行为的行为遗传学研究

焦虑、抑郁和偏差行为等问题的行为遗传学研究有助于了解人类情绪与行为受遗传和环境交互影响的内在机制。近年来,行为遗传学研究方法的迅速发展使科学家们能够更深入地探讨了基因与环境的作用和影响。文章了分析了焦虑、抑郁和偏差行为的行为遗传学研究进展,介绍了国内外双生子研究的发展情况,提出在我国建立双生子数据库,开展有关青少年焦虑、抑郁和偏差行为的行为遗传学研究     

医学遗传服务与遗传学研究的伦理问题

遗传工程的分子技术于本世纪７０年代问世。这一技术的创新使人类与医学遗传学突飞猛进,由此导致遗传医学的飞速发展。与此同步,医学伦理学兴起,临床医学遗传服务与遗传学研究的伦理问题日益成为人文科学关注的核心。世界卫生组织（ＷＨＯ）于１９９７年发布的《医学遗传学与遗传服务伦理问题的建议国际准则》。探讨我国医学伦理学发展的策略和面临的挑战,祈盼适合我国国情的中华医学遗传服务与遗传学研究的伦理准则早日问世。     

人类行为遗传学的伦理问题

行为遗传学是试图定位与行为特性有关的特殊基因或基因组及了解基因与环境之间复杂关系的一种研究.行为遗传学是研究正常范围内的非病理变化,与人类疾病遗传学存在差异.行为遗传学研究面临许多伦理学问题,诸如,智力的遗传性,基因能否决定一切,生物社会学与人类文化评估,生命伦理学与行为遗传学的关系等,因此,对行为遗传学研究结果的阐述必须十分谨慎.     

学习能力与学习障碍的遗传学： 英国的近期发展和中国的研究的可能方向

中国的行为遗传学诞生在遗传学突飞猛进的时代,令人振奋。作为一个新兴学科,中国的行为遗传学研究可以避免走前人的弯路,而成为领先而不是滞后的领域。以学习能力的研究为例,计量行为遗传学可以避免“性与养”（nature vs. nurture）的争论而直接研究一些遗传学与心理学里有意义的问题,包括正常与异常、稳定与变动、同质与异质的关系等问题。尤为重要的是超越“性与养”的争论而直接研究遗传对行为的影响。本文也扼要介绍了英国“双生子早期发展”项目的计量行为遗传学和“全基因组关联”对学习能力研究的结果。可以预计,飞速发展的遗传学发现将会持续一些时日,其发展将会对中国和世界的心理学产生更大的影响     

主动性攻击和反应性攻击的遗传基础研究述评

根据攻击行为的意图可以将攻击分为主动性攻击和反应性攻击。近年来, 研究者对遗传和环境在主动性攻击和反应性攻击发展中的作用进行了探讨, 并获得了两类攻击具有不同遗传和环境基础的重要发现。既有研究主要采用定量行为遗传学研究的范式考察两类攻击的遗传基础, 未来研究应从确定与两类攻击相关的候选基因、遗传基因与环境的交互作用机制、遗传基因作用于两类攻击的神经生物机制等方面展开。     

发展性阅读困难的行为遗传学研究

发展性阅读困难是学龄儿童常见的学习障碍,其病源学问题极其复杂,很多行为遗传学家针对遗传和环境对阅读困难的影响进行了大量的研究。该文对阅读困难的行为遗传学研究进行了回顾,特别是综合介绍了分子遗传学研究所取得的重要成果及不足。最后指出了研究所面临的困难和将来的方向,并对与教育的关系进行了总结与评价。     

Intelligence: genetics, genes, and genomics

More is known about the genetics of intelligence than about any other trait, behavioral or biological, which is selectively reviewed in this article. Two of the most interesting genetic findings are that heritability of intelligence increases throughout the life span and that the same genes affect diverse cognitive abilities. The most exciting direction for genetic research on intelligence is to harness the power of the Human Genome Project to identify some of the specific genes responsible for the heritability of intelligence. The next research direction will be functional genomics--for example, understanding the brain pathways between genes and intelligence. Deoxyribonucleic acid (DNA) will integrate life sciences research on intelligence; bottom-up molecular biological research will meet top-down psychological research in the brain.     

The future of genetics in public health

During the 1980s, we have witnessed an erosion in federal and state funding for the coordination of genetic services in state health departments. As this decade begins, the federal budget for the support of the national genetics program is less than half of the total available in 1980. In addition, priorities in state maternal and child health programs have changed, and genetic services have often received lower rankings aside of programs to improve prenatal care and to address problems such as teenage pregnancy. Clearly we are at a critical point for the future of genetics programs in the public health arena. Fortunately, despite the problems with funding and priority setting, important coalitions have been built during the past decade and continued advances in medical genetics have made it difficult for public health officials to ignore the potential impact of genetic services. Council of Regional Networks for Genetic Services (CORN) and the regional genetic services networks have provided opportunities for interaction and coordination between genetic services providers and public health officials that had not been available to any significant extent. The full potential of these coalitions has yet to be realized, but efforts in data collection, development of national guidelines and standards, and information sharing and networking have already had an influence on state genetic services programs. Continuing research on the genetics of chronic diseases and the influence of discoveries in molecular genetics will undoubtedly broaden the current scope of state public health programs in genetics, which all too often have been limited to newborn screening and administration of grants for genetic services. The regional and national genetic services programs should be strengthened and appropriate training programs should be developed in Schools of Public Health to provide the expertise and leadership that will be needed to guide the future of genetics in public health.     

Genes, race, and psychology in the genome era: an introduction

The mapping of the human genome has reawakened interest in the topic of race and genetics, especially the use of genetic technology to examine racial differences in complex outcomes such as health and intelligence. Advances in genomic research challenge psychology to address the myriad conceptual, methodological, and analytical issues associated with research on genetics and race. In addition, the field needs to understand the numerous social, ethical, legal, clinical, and policy implications of research in this arena. Addressing these issues should not only benefit psychology but could also serve to guide such thought in other fields, including molecular biology. The purpose of this special issue is to begin a discussion of this issue of race and genetics within the field of psychology. Several scholars who work in the fields of genetics, race, or related areas were invited to write (or had previously submitted) articles sharing their perspectives.     

人格研究中的行为遗传学取向的发展

人格的行为遗传学研究,是以研究遗传和环境的差异来解释人格的个体差异的程度为目的,为探讨遗传和环境在个体发展中的作用提供了新的研究途径。该文以天性和教养为突破口,紧紧围绕行为遗传学在人格研究领域的发展脉络:遗传力、环境、特定基因的研究,进一步探讨在个体人格发展过程中遗传和环境的交互作用的关系。     

抑郁遗传效应的发展动态性

抑郁的遗传效应存在发展动态性。一方面,在发展过程中,抑郁的遗传率会发生改变,抑郁的风险基因及其与环境的交互作用模式也存在动态变化。另一方面,遗传因素会影响抑郁的发展变化模式。通过梳理既有相关研究,本文从生理成熟因素、表观遗传和发展级联效应三方面分析抑郁遗传效应发展动态性的原因。未来研究应区分重要发展阶段,增加脑功能、性激素、神经生物蛋白以及表观遗传等指标考察抑郁遗传效应的变化模式及其发生机制。     

Attitudes toward genetic counseling and prenatal diagnosis among a group of individuals with physical disabilities

Few studies have been published on the attitudes of people with physical disabilities toward genetic counseling and prenatal diagnosis. Articles in the lay press and social science literature on this topic, mainly written by disability rights activists and advocates, imply opposition to prenatal diagnosis and the field of clinical genetics by the physically disabled population. In this study, 15 adults with physical disabilities were interviewed regarding their attitudes toward genetic counseling and prenatal diagnosis. Genetic counseling and prenatal diagnosis were generally viewed favorably by this sample of the disability community. Only a small percentage of the sample perceived genetics to be eugenic. Implications for genetic counseling and future research are discussed.     

Nursing and genetic health care

Advances in DNA technology are leading to major developments in nursing practice in clinical genetics, including the creation of new roles for nurses who care for people with genetic conditions. Application of genetic information and testing is moving genetics into the mainstream of health care. Therefore, it is anticipated that nurses in all areas of practice will become involved in the provision of information about genetic testing and assisting individuals and families in decision making and adjustment to new genetic information. This article provides an overview of the profession of nursing which may be useful to genetic counselors in the development of collaborative relationships between the two professions.     

Online health communication about human genetics: perceptions and preferences of internet users.

Unprecedented advancements in human genetics research necessitate keeping the public abreast of new information, applications, and implications and the Internet represents an important method of communicating with the public. Our research used cross-sectional self-report survey data collected from a diverse convenience sample of 780 Internet users in two states. Multivariate regression analysis explored the relationships between experiences, perceptions, and preferences for online health and genetics communication. Online health information seeking was associated with previous genetic information seeking, comfort with online genetic communication, perceived risk for genetic abnormality, being female, and having more education. Comfort with online genetics communication was associated with a preference for online genetic information, previous online health and off-line genetics information seeking, having a healthy lifestyle, believing in the positive impact of human genetics research, and being female. Perceiving online health information to be accurate was associated with preferring the Internet for genetics communication, being older, less educated, and perceiving Internet use as anonymous. Preferring online genetics communication to other communication channels was associated with perceiving online health information as accurate, being comfortable receiving online genetics information, having lower intrinsic religiosity, and being male. The implications of findings for Web-based health message design are discussed.     

人类基因组研究与遗传学的历史教训

第１８届国际遗传学大会达成的八点共识对于人类基因组的研究及其应用具有重要意义,也指明了在遗传学及其应用问题上不同文化之间如何解决它们之间分歧的最佳途径。纳粹德国的优生实践和前苏联李森科学派的兴衰都给我们留下了不可忘记的教训。围绕中国母婴保健法的争论反映了科学、伦理和政策的交叉。我们的基因组研究和遗传服务是为了增进个人的健康和促进家庭的幸福,而不能也不应以减少残疾人口为目标。在基因组研究和遗传服务中