Depressive symptoms and lymphocyte proliferation in older adults

In an 18-month prospective study, community-dwelling older adults, including both spousal caregivers of dementia patients and noncaregiving controls, were examined. Participants were selected on the basis of the presence or absence of chronic depressive symptoms that exceeded a cutoff score for clinically relevant depressive symptoms on a self-report symptom measure. Compared with nondepressed older adults, those with chronic, mild depressive symptoms had poorer T cell responses to 2 mitogens from baseline to follow-up. Additionally, among individuals with depressive symptoms, older age was associated with the poorest blastogenic response to the mitogens at follow-up. These findings extend the association between depression and immune function to community-dwelling older adults with chronic, mild depressive symptoms.     

Age differences in the effect of physical activity on depressive symptoms

This study examined associations between physical activity and depressive symptoms in 1,151 community-dwelling adults in Japan. Physical activity was measured using a pedometer, whereas depressive symptoms were assessed with the Center for Epidemiological Studies-Depression Scale. A structural equation modeling with a cross-lagged panel design revealed that for the older adults (65-79 years of age), daily walking at baseline predicted fewer depressive symptoms at the 2-year follow-up, even after adjusting for confounders. In contrast, the association was not confirmed for the middle-aged adults (40-64 years of age). Findings suggest that age should be considered when estimating the effect of physical activity on psychological well-being.     

The effects of behavioral activation therapy with inpatient geriatric psychiatry patients

This study examined the effects of Behavioral Activation (BA) treatment on depressive symptoms and quality of life among older adult patients in a geriatric psychiatry facility. There were 50 participants with mild to moderate cognitive impairment, each being 65 years of age or older. A 2 (between) × 3 (time of measurement) design was used in this study comparing control (treatment-as-usual) and experimental (BA) conditions at pre-, mid-, and posttreatment. BA consisted of eight 30- to 60-minute sessions across 4 weeks. Intent-to-treat analyses indicated a significant Group × Time interaction on depressive symptoms, with this effect remaining when only completer data were included. Further analyses indicated that this effect was due to significant change early in treatment in both the full and completer samples. There was no evidence of a significant effect on the quality-of-life measure. Cognitive status was not related to change in depressive symptoms, suggesting that BA may be useful across a range of older adults.     

Processing of Ambiguous Facial Affect in Adolescents with Depressive Symptoms Prior to and Following Social Exclusion: The Role of Perceptual Sensitivity and Response Bias

Depressive symptoms in adolescents are an important mental health issue and are associated with adverse developmental outcomes. Impairments in facial affect processing are considered an important factor in the etiology of depression. However, studies on facial affect processing in youth with depressive symptoms are lacking. This study investigated alterations in facial affect processing and the underlying mechanisms (perceptual sensitivity vs. response bias) related to adolescent depression, as well as the potential impact of negative social experiences. Sixty adolescents (M age?=?13.24, SD?=?1.03, 66.7 % female) with high (HD) and low (LD) depressive symptoms rated the predominant affective expression in ambiguous stimuli with varying intensity (happy-sad, happy-angry, sad-angry) prior to and following a negative (social rejection), positive (social inclusion), or no social experience with the depicted model identities. There were no baseline differences between groups. The LD group exhibited an increased perceptual sensitivity to happy expressions depicted by benevolent and stranger models, whereas the HD exhibited a higher sensitivity toward happy expressions depicted by rejecting social partners. The results suggest that depressive symptoms in adolescents may be associated with an altered processing of facial affect for partners who had previously rejected them. Implications of these findings for development and maintenance of adolescent depression are discussed.     

Passive coping response to depressive symptoms among low-income homebound older adults: Does it affect depression severity and treatment outcome?

Due to their homebound state, lack of financial resources, and/or other life demands, a significant proportion of depressed, low-income homebound older adults experience depression. Because of their limited access to psychotherapy, most of these older adults self-manage their depressive symptoms. The purposes of this study were to examine (1) the relationship between homebound older adults' coping responses to depressed mood and the severity of their depressive symptoms at baseline (n = 121), and (2) the moderating effect of passive coping responses on the relationship between participation in problem-solving therapy (PST: in-person or telehealth delivery) and depressive symptoms at 12- and 24-week follow-ups. Controlling for the effects of demographic and disability characteristics, cognitive passive coping was significantly associated with baseline depressive symptoms, while behavioral passive coping was not. The main effect of baseline cognitive passive coping response was also significant in mixed-effects regression analysis, but the interaction between coping pattern and group was not significant. The results point to a possibility that cognitive passive copers may have benefited as much from PST as the rest of the PST participants. Further research needs to examine the moderating effect of coping responses to depressive symptoms on treatment efficacy of PST and other psychosocial interventions for late-life depression.     

Genetic Mediation of the Associations Among Motor and Perceptual Speed and Adult Cognitive Abilities

Quantitative genetic analyses were conducted to determine the genetic mediation of the associations among motor speed, perceptual speed, and cognitive abilities in normal aging. Measures of motor performance, perceptual speed, and cognitive functioning in four domains (crystallized, fluid, spatial, and memory) were available from the Swedish Adoption/Twin Study of Aging. The sample included 206 twin pairs ranging in age from 44 to 82 years. A Motor Speed factor was constructed from 17 timed measures of motor performance. Heritability of Motor Speed was .26 in middle-aged twins and .00 in older twins. Results indicated that genetic variance in cognitive functioning in the middle-aged cohort may be defined by working memory, whereas genetic variance in the older cohort was defined by perceptual speed. Indications of a nonshared environmental component in the association among motor speed, perceptual speed, and spatial abilities suggest possible frontal lobe involvement.     

Depressive Symptoms and Suicide Risk in Older Adults: Value Placed on Autonomy as a Moderator for Men but Not Women

Risk for suicide is elevated among older men. We examined whether value placed on autonomy amplifies the relation between depressive symptoms and suicide risk differently for older men and women. Participants were 98 community‐dwelling older adults, M age 73.6 (SD = 8.6), 65.1% female, 93.1% White. Questionnaires measured suicide risk (SBQ‐R), depressive symptoms (CESD), and value placed on autonomy (PSI‐II autonomy). Among men, depressive symptoms were associated with suicide risk only when PSI‐II autonomy was elevated. Among women, greater depressive symptoms were associated with suicide risk at all levels of PSI‐II autonomy. Further research on attitudes toward autonomy is warranted.     

Age differences and similarities in the correlates of depressive symptoms

The authors investigated whether several life events or concerns were differentially related to depressive symptoms across 3 adult age groups (young adults, middle-aged adults, and older adults). They examined the relationships of 2 measures of depressive symptoms to work status and satisfaction, relationship status and satisfaction, loneliness, recent losses, parenting strain, and caregiving. Some differences between age groups in these relationships were found. Yet, most results suggested that, although the frequency with which people experience specific life events or concerns varies across the adult life span, the relationships between these events or concerns and depressive symptoms are similar across age groups.     

Experience-based attenuation of age-related differences in music cognition tasks

Pianists of a wide experience and age range were tested on measures of musical memory and musical perceptual speed to better understand the effects of experience on age-cognition relations. Experience-related attenuation might be in the form of an Age x Experience interaction or in the form of a "confounding" of age and experience such that positive age-experience relations offset negative age-cognition relations. It was predicted that the former, considered evidence for disuse interpretations of aging, would be likely to emerge in tasks with strong experience effects and strong age-related declines among inexperienced individuals. However, in no case were the interactions of age and experience on the memory or perceptual speed variables significant. There was, however, evidence that high levels of experience in the older participants partially attenuated the negative effects of age on the memory and perceptual speed tasks.     

Cognition and survival in a biracial urban population of old people

We examined the relation of level of cognition to survival in a biracial community population of more than 10,000 older persons. At baseline, participants completed 4 cognitive tests from which a composite global cognitive measure was derived. During up to 14 years of follow-up (mean = 6.9 years), 4201 people died (41.6%). Higher level of cognitive function was associated with increased survival even after controlling for health related and lifestyle variables. The association did not differ between African Americans and whites; it was stronger in older than younger persons; and it was especially pronounced for perceptual speed. The results underscore the importance of cognition to survival in old age.     

Gender and age differences in emotion regulation strategies and their relationship to depressive symptoms

We examined differences between men and women, and between young, middle and older age adults in emotion regulation strategies (rumination, suppression, reappraisal, problem-solving, acceptance, social support) and the relationships between these strategies and depressive symptoms. Women were more likely than men to report using several different emotion regulation strategies, and these gender differences were significant even after statistically controlling for gender differences in depressive symptoms. Use of most strategies decreased with age, with two exceptions: (1) use of suppression increased with age for women but not for men and (2) use of acceptance did not decrease with age for women. Use of maladaptive strategies was associated with more depressive symptoms in all age groups and both genders, yet, the use of adaptive strategies generally was not related to lower levels depressive symptoms across groups.     

Activity engagement is related to level, but not change in cognitive ability across adulthood

It is unclear whether the longitudinal relation between activity participation and cognitive ability is due to preserved differentiation (active individuals have higher initial levels of cognitive ability), or differential preservation (active individuals show less negative change across time). This distinction has never been evaluated after dividing time-varying activity into its two sources of variation: between-person and within-person variability. Further, few studies have investigated how the association between activity participation and cognitive ability may differ from early to older adulthood. Using the PATH Through Life Project, we evaluated whether between- and within-person variation in activity participation was associated with cognitive ability and change within cohorts aged 20-24 years, 40-44 years, and 60-64 years at baseline (n = 7,152) assessed on three occasions over an 8-year interval. Multilevel models indicated that between-person differences in activity significantly predicted baseline cognitive ability for all age cohorts and for each assessed cognitive domain (perceptual speed, short-term memory, working memory, episodic memory, and vocabulary), even after accounting for sex, education, occupational status, and physical and mental health. In each case, greater average participation was associated with higher baseline cognitive ability. However, the size of the relationship involving average activity participation and baseline cognitive ability did not differ across adulthood. Between-person activity and within-person variation in activity level were both not significantly associated with change in cognitive test performance. Results suggest that activity participation is indeed related to cognitive ability across adulthood, but only in relation to the starting value of cognitive ability, and not change over time.     

Is episodic memory performance more vulnerable to depressive affect in older adulthood?

This study examined how age, depressive symptoms, demographic variables, frailty, and health factors jointly influence episodic memory across the lifespan in two large, diverse samples. Hierarchical regression analyses from both samples showed that depressive symptoms negatively impacted episodic memory performance with the effect being more pronounced for older adults. Health and frailty tended not to be associated with episodic memory. However, the main effect of depressive symptoms tended to remain significant over and above other predictors, while the interaction with age was weakened with the addition of demographic variables. The unique contribution of this study is demonstrating that the relationship between depressive symptoms and episodic memory is moderated by age across relatively large non-clinical lifespan samples of adults. The findings indicate the importance of measuring and studying depressive symptoms during the course of aging in order to better understand the complex relationship between age, affect, physical functioning, and memory.     

Developmental Pathways to Depressive Symptoms in Adolescence: A Multi-Wave Prospective Study of Negative Emotionality,Stressors, and Anxiety

This study examined two potential developmental pathways through which the temperament risk factor of negative emotionality (NE) leads to prospective increases in depressive symptoms through the mediating role of stressors and anxious symptoms in a sample of early to middle adolescents (N = 350, 6th–10th graders). The primary hypothesized model was that baseline NE leads to increased stressors, which results in increases in anxious arousal, which culminates with elevated depressive symptoms. An alternate model hypothesized that baseline NE leads to increased anxious arousal, which results in increases in stressors, and this culminates in elevated depressive symptoms. Youth completed self-report measures of NE, stressors, anxious arousal, and depressive symptoms at four time-points. Path analysis supported the primary model and showed that the mediating influence of stressors and anxious arousal explained 78% of the association between NE and prospective elevations in depressive symptoms. The alternate model was not supported. Neither gender nor age were moderators.     

The role of parent depressive symptoms in positive and negative parenting in a preventive intervention

This study examined the role of parent depressive symptoms as a mediator of change in behaviorally observed positive and negative parenting in a preventive intervention program. The purpose of the program was to prevent child problem behaviors in families with a parent who has current or a history of major depressive disorder. One hundred eighty parents and one of their 9- to 15-year-old children served as participants and were randomly assigned to a family group cognitive-behavioral (FGCB) intervention or a written information (WI) comparison condition. At two months after baseline, parents in the FGCB condition had fewer depressive symptoms than those in the WI condition, and these symptoms served as a mediator for changes in negative, but not positive, parenting at 6 months after baseline. The findings indicate that parent depressive symptoms are important to consider in family interventions with a parent who has current or a history of depression. (PsycINFO Database Record (c) 2012 APA, all rights reserved).     

Do the Emotional Benefits of Optimism Vary Across Older Adulthood? A Life Span Perspective

This study examined whether the emotional benefits of dispositional optimism for managing stressful encounters decrease across older adulthood. Such an effect might emerge because age‐related declines in opportunities for overcoming stressors could reduce the effectiveness of optimism. This hypothesis was tested in a 6‐year longitudinal study of 171 community‐dwelling older adults (age range = 64–90 years). Hierarchical linear models showed that dispositional optimism protected relatively young participants from exhibiting elevations in depressive symptoms over time, but that these benefits became increasingly reduced among their older counterparts. Moreover, the findings showed that an age‐related association between optimism and depressive symptoms was observed particularly during periods of enhanced, as compared to reduced, stress. These results suggest that dispositional optimism protects emotional well‐being during the early phases of older adulthood, but that its effects are reduced in advanced old age.     

The role of rumination in depressive disorders and mixed anxiety/depressive symptoms

Several studies have shown that people who engage in ruminative responses to depressive symptoms have higher levels of depressive symptoms over time, after accounting for baseline levels of depressive symptoms. The analyses reported here showed that rumination also predicted depressive disorders, including new onsets of depressive episodes. Rumination predicted chronicity of depressive disorders before accounting for the effects of baseline depressive symptoms but not after accounting for the effects of baseline depressive symptoms. Rumination also predicted anxiety symptoms and may be particularly characteristic of people with mixed anxiety/depressive symptoms.     

Excessive Reassurance Seeking, Hassles, and Depressive Symptoms in Children of Affectively Ill Parents: A Multiwave Longitudinal Study

The current study examined whether excessive reassurance seeking serves as a vulnerability factor to depression in a sample of high-risk youth using a multiwave longitudinal design. At Time 1, 140 children (aged 6-14) of affectively disordered parents completed measures assessing reassurance seeking and depressive symptoms. In addition, every 6 weeks during the following year, children and parents completed measures assessing depressive symptoms and the occurrence of hassles. In line with hypotheses, the results of contemporaneous analyses indicated that children with high levels of reassurance seeking reported greater elevations in depressive symptoms following elevations in either hassles or parental depressive symptoms than children with low levels. At the same time, the results of time-lagged analyses indicated that both these relationships were moderated by age with excessive reassurance seeking being associated with greater elevations in depressive symptoms following elevations in either hassles or parental depressive symptoms in older but not younger children.     

Self-concealment and suicidal behaviors

Understanding self-concealment, the tendency to actively conceal distressing personal information from others, may be important in developing effective ways to help individuals with suicidal ideation. No published study has yet assessed the relation between self-concealment and suicidal behaviors. Additionally, most self-concealment research has been conducted solely with younger adults. The relation between self-concealment and depressive symptoms among older adults (age 65 and older), and between self-concealment and suicidal behaviors among both younger (college student) and older adults, was investigated in this study. As predicted, self-concealment was significantly related to suicidal behaviors in younger adults. Furthermore, self-concealment was significantly related to depressive symptoms in older adults. Interestingly, the association between self-concealment and suicidal behaviors in this age group was not significant.     

Social participation attenuates decline in perceptual speed in old and very old age

Does an engaged and active lifestyle in old age alleviate cognitive decline, does high cognitive functioning in old age increase the possibility of maintaining an engaged and active lifestyle, or both? The authors approach this conundrum by applying a structural equation model for testing dynamic hypotheses, the dual change score model (J. J. McArdle & F. Hamagami, 2001), to 3-occasion longitudinal data from the Berlin Aging Study (Time 1: n=516, age range=70-103 years). Results reveal that within a bivariate system of perceptual speed and social participation, with age and sociobiographical status as covariates, prior scores of social participation influence subsequent changes in perceptual speed, while the opposite does not hold. Results support the hypothesis that an engaged and active lifestyle in old and very old age may alleviate decline in perceptual speed.