Charting the progression in semantic dementia: Implications for the organisation of semantic memory

Abstract

A patient, JL, with the syndrome of semantic dementia was assessed longitudinally over a two-year period. The data presented here address the controversy concerning the hierarchical organisation of semantic memory. On a range of category fluency tests, when first tested JL was just within the normal range on the broadest categories of animals and household items, but was virtually unable to produce any instances of specific categories such as breeds of dog or musical instruments. Longitudinal fluency data for the animal category demonstrate that while JL continued to produce the most prototypical responses (cat, dog, horse), other animal labels dropped out early from his vocabulary. On the picture-sorting tests from our semantic memory test battery, JL's discrimination between living things and man-made objects was preserved for a substantial time in conjunction with a marked decline in his sorting ability for more specific categories, particularly features or attributes (e.g. size, foreign-ness, or ferocity of animals).

An analysis of naming responses to the 260 Snodgrass and Vanderwart pictures on four occasions suggests a progressive loss of the features of semantic representations that enable discrimination between specific category instances. There was a progressive decline in circumlocutory and category co-ordinate responses with a rise in broad superordinate and cross-category errors. The latter are of particular theoretical interest; on session I, all cross-category errors respected the living/man-made distinction, but by session IV almost half of such errors failed to respect this distinction. The emergence of category prototypes was another notable feature, particularly in the living domain: at one stage, land (or four-legged) animals were all named either cat, dog, or horse. By contrast, within the man-made domain, items were frequently described in terms of their broad use or function, until eventually no defining features were produced. These findings are discussed in the context of competing theories of semantic organisation.     

Free recall and retrieval speed of categorized items by kindergarten children

Kindergarten Ss were presented with 16 pictorial items in four category sets or a partially random ordem with one item from each category composing the four presentation sets. The pictures were presented either on conceptually related background pictures or on white backgrounds. The categorically grouped presentation facilitated free recall performance, both in terms of number of items recalled and the speed with which the items were recalled, and increased the amount of clustering in recall. Categorical clustering in recall was associated with shorter within- than between-category intervals and for those Ss who recalled items from each of four categories successively, the over-all temporal pattern in recall closely approximated that found with adults. No background effects were found.     

Associative and categorical hypotheses of organization in the free recall of adults and children

Associative and categorical explanations for the organization children and adults display in free recall were tested. It was expected that young children would show output clustering as a function of associations between individual items within categories rather than relationship to the taxonomy itself. Kindergarten, fourth-grade, and tenth-grade subjects were presented with pictures representing the four factorial combinations of high and low interitem association and high and low category relatedness. Each set of pictures could be divided into four taxonomic categories of six items each. Kindergarteners displayed greater category clustering of highly associated items than weak associates. Older subjects showed sensitivity to both organizational dimensions. These data support a hypothesis that young children cluster in recall as a function of associations while older individuals show organizational flexibility which serves to facilitate greater recall.     

Classifying pictures and words: Implications for the dual-coding hypothesis

In deciding that two items come from the same category, subjects were delayed if the items were presented as a word and a picture, as compared with two words or two pictures. Subjects were not delayed if the items were not to be compared. Hence, the delay appears to occur during the retrieval and comparison of know ledge about the items, not during their perceptual analysis. The results suggest that there are two distinct codes involved in the categorization of words and pictures, rather than a single code.     

Action and object processing in aphasia: from nouns and verbs to the effect of manipulability

The processing of words and pictures representing actions and objects was tested in 21 aphasic patients and 20 healthy controls across three word production tasks: picture-naming (PN), single word reading (WR) and word repetition (WRP). Analysis 1 targeted task and lexical category (noun-verb), revealing worse performance on PN and verb items for both patients and control participants. For Analysis 2 we used data collected in a concurrent gesture norming study to re-categorize the noun-verb items along hand imagery parameters (i.e., objects that can/cannot be manipulated and actions which do/do not involve fine hand movements). Here, patients displayed relative difficulty with the 'manipulable' items, while controls displayed the opposite pattern. Therefore, whereas the noun-verb distinction resulted simply in lower verb accuracy across groups, the 'manipulability' distinction revealed a 'double-dissociation' between patients and control participants. These results carry implications for theories of embodiment, lexico-semantic dissociations, and the organization of meaning in the brain.     

Discrimination and categorization of photographs of natural objects by chimpanzees (Pan troglodytes)

Two experiments assessed the ability of four adult female chimpanzees to categorize natural objects. Chimpanzees were initially trained to match different color photographs of familiar objects from four possible categories. In training, all the comparison stimuli were from the same category in one condition, and from different categories in another condition. For all subjects, training performance was consistently better for the "different category" than for the "same category" trials. Probe trials were shown after training. In probe trials, the sample and positive comparison stimuli were different items from the same category, and the foils were selected from among the three other test categories. Individual performance was above chance in probe trials, suggesting that categorization by chimpanzees may transcend perceptual resemblance. These results were later replicated with novel stimulus items from the same four categories (experiment 2). Altogether, this research demonstrates that chimpanzees grouped perceptually different exemplars within the same category, and further suggests that these animals formed conceptual representations of the categories. Accepted after revision: 10 August 2001 Electronic Publication     

Predicting the Completion of an Integrative and Intensive Outpatient Chronic Pain Treatment With the Personality Assessment Inventory

The X-zero distinction has been used as the operational definition of MMPI item subtlety in previous research. A consistent finding has been that the X items, which are obvious in terms of pathological content, can be faked whereas the more subtle zero items cannot be faked. The present study examined the relationship between instructional sets and endorsement patterns, using a more refined, comprehensive measure of item subtlety. Sixty (30 male, 30 female) subjects completed two MMPI protocols, one under a standard instructional set and the other under either a fake-good or fake-bad response set. Order of administration and sex were counterbalanced. In general, the findings for the subtle-obvious dimension paralleled the previous findings with the X-zero distinction. Endorsement of obvious items was a direct function of instructional set, whereas endorsement of subtle items was inversely related to instructional set. Because subtle items did not appear to measure the constructs for which they had been originally intended, other uses for subtle items were discussed.     

SCALING THE EPISODIC FAMILIARITIES OF PICTURES AND WORDS

Abstract— Most current memory theories assume that judgments of past occurrence are based on a unidimensional familiarity signal In a test of this hypothesis, subjects studied mixed lists of pictures and words that occurred up to three times each They then were given two tests a forced-choice frequency discrimination test including all pairs of conditions (e g., picture seen twice vs word never seen) and a numerical frequency judgment test on individual items Forced-choice proportions for all pairings (picture-picture, word-word, and picture-word) were well fit by a one-dimensional scaling solution, suggesting a common basis of recognition and frequency judgments for both pictures and words Both forced-choice and numerical judgment data indicated that familiarities of pictures started lower than those of words but increased more rapidly with repetition Results are discussed in connection with the distinction between familiarity and recall, and the possible role of rescaling in the mirror effect.     

Drawing deficits in brain-damaged patients' freehand pictures

This study examines errors in brain-damaged patients' attempts to produce freehand drawings of common objects in response to a linguistic target (e.g., "fruit"). The pictures were carefully analyzed according to the features which dictionaries claim should vary necessarily from item to item, including color, shape, relative size, and special features which help distinguish between similar items. A "recognizability score" was created to quantify patients' overall drawing capacity. The findings revealed that subjects with right hemispheric insult are significantly more impaired overall than left hemisphere-damaged patients in producing freehand pictures. However, freehand drawing skills do not break down in an undifferentiated fashion after right hemispheric insult: Group and individual data reveal that patients with right central (primarily parietal) insult are most impaired at expressing shape attributes in their pictures, right posterior patients with primarily temporoparietal insult experience the greatest difficulty attributing color to their pictures, but patients with right anterior insult are impaired at expressing color, shape, and relative size in their pictures. All patients with right hemisphere insult often attribute specific features indiscriminantly to any member of the same category, resulting in anomalous pictures like a "potato bush." One patient with left posterior insult seemed to encounter difficulty generating the mental images necessary to serve as the basis for his pictures. These findings are discussed with reference to an image-based model for freehand drawing.     

Refractory semantics in global aphasia: On semantic organisation and the Access–Storage distinction in neuropsychology

Abstract

A single case study is reported of a global aphasic patient, JM, with impaired access to semantic information which was particularly severe for the class of proper names. JM's ability to perform matching tasks with printed words and pictures to auditory words deteriorated when items were repeated, especially when the response–stimulus interval was short. Performance was also inconsistent across items. The effect of repeated testing on items generalised to other, previously untested members of the same category. Despite this, JM was able to access general semantic information about stimuli from the affected categories (e.g. to categorise boys' and girls' names), and showed good ability to access an input lexicon concerning these stimuli. There was also a close relationship between the categories affected when he was tested with pictures and printed words. We propose that JM's deficit can be attributed to his semantic system entering an abnormal refractory state once semantic access for a particular item has been achieved, and with this stage being isolated from the procedures providing access to stored lexical knowledge. Furthermore, the representations affected seem common to pictures and printed words. We discuss the implications of the results for understanding the nature of semantic representations in general and for proper names in particular, and for the distinction between access and storage deficits in neuropsychology.     

Semantic and formational clustering in deaf and hearing subjects’ free recall of signs

To investigate whether formational properties of sign language are used spontaneously to organize long-term memory, 16 deaf college students were given a free recall task with items that could be categorized either by shared semantic category or by shared sign language hand shape. Both presentation and response modes (signed or written) were varied between subjects. Analyses revealed no effects of mode on trials to criterion or number of items recalled at 1 week. The clustering that occurred was exclusively semantic, with significantly higher clustering scores during acquisition trials in subjects required to sign their responses. In Experiment 2, formational clustering was encouraged by including formational similarity as the only experimenter-defined basis of categorization, by increasing formational similarity within categories, and by testing only subjects with high signing skills. Input and output modes were again varied between subjects. Subjects were deaf college students with deaf parents (n = 10) or hearing parents (n = 16), and hearing adults with deaf parents (n = 8). Again, spontaneous clustering by formational similarity was extremely low. In only one case— deaf subjects with hearing parents given signed input—did formational clustering increase significantly across the eight acquisition trials. After the categorical nature of the list was explained to subjects at a 1-week retention session, all groups clustered output by formational categories. Apparently, fluent signers do have knowledge of the formational structure of signs, but do not spontaneously use this knowledge as a basis of mnemonic organization in long-term memory.     

Sex categorization of conspecific pictures in Japanese monkeys (Macaca fuscata)

We investigated whether monkeys discriminate the sex of individuals from their pictures. Whole-body pictures of adult and nonadult monkeys were used as stimuli. Two male Japanese monkeys were trained for a two-choice sex categorization task in which each of two choice pictures were assigned to male and female, respectively. Following the training, the monkeys were presented with novel monkey pictures, and whether they had acquired the categorization task was tested. The results suggested that while monkeys discriminate between the pictures of adult males and females, discrimination of nonadult pictures was difficult. Partial presentations of the pictures showed that conspicuous and sexually characteristic parts (i.e., underbellies including male scrotums or breasts including female nipples) played an important role in the sex categorization.     

Long-term memory for pictures and sentences

Two experiments were conducted to examine the fan effect in recognition memory for pictures and sentences. Subjects in the first experiment memorized sets of pictures (N= 13) or sentences (N=13) in which the study items comprised concept combinations (e.g., the clock is on the television) that could be unambiguously depicted in each modality. The fan effect, contrasting study items involving unique- and shared-concepts combinations, was observed in the recognition reaction time data for sentences but not for pictures. Subjects in the second experiment (N= 17) memorized sets of pictures and sentences in which, in addition to the unique and shared intramodality conditions used in Experiment 1, subjects memorized items in each modality that shared concepts with items in the alternative modality. Although the fan effect was reduced for sentences in the second experiment, the intramodality results were qualitatively comparable to those obtained in Experiment 1. The results in the intermodality conditions indicated that, although pictorial study items influenced reaction time to sentences with which they shared a concept, the reverse was not the case. The results were thought to be inconsistent with the view that pictures and sentences enjoy a common representational format in long-term memory.     

The measurement of cyberbullying: dimensional structure and relative item severity and discrimination

In relation to a sample of 1,092 Italian adolescents (50.9% females), the present study aims to: (a) analyze the most parsimonious structure of the cyberbullying and cybervictimization construct in male and female Italian adolescents through confirmatory factor analysis; and (b) analyze the severity and the discrimination parameters of each act using the item response theory. Results showed that the structure of the cyberbullying scale for perpetrated and received behaviors in both genders could best be represented by a monodimensional model where each item lies on a continuum of severity of aggressive acts. For both genders, the less severe acts are silent/prank calls and insults on instant messaging, and the most severe acts are unpleasant pictures/photos on Web sites, phone pictures/photos/videos of intimate scenes, and phone pictures/photos/videos of violent scenes. The items nasty text messages, nasty or rude e-mails, insults on Web sites, insults in chatrooms, and insults on blogs range from moderate to high levels of severity. Regarding the discrimination level of the acts, several items emerged as good indicators at various levels of cyberbullying and cybervictimization severity, with the exception of silent/prank calls. Furthermore, gender specificities underlined that the visual items can be considered good indicators of severe cyberbullies and cybervictims only in males. This information can help in understanding better the nature of the phenomenon, its severity in a given population, and to plan more specific prevention and intervention strategies.     

Natural categories: Well defined or fuzzy sets?

Thirty college students made category membership decisions for each of 540 candidate exemplar-category name pairs (e.g.,apple-fruit) in each of two separate sessions. For highly typical category members (e.g., chair for thefurniture category), and for items unrelated to a category (e.g.,cucumber-furniture), subjects agreed with each other and were consistent in their decisions. However, for intermediate-typicality items (e.g.,bookends-furniture), subjects disagreed with each other and were frequently inconsistent from one session to the next. These data suggest that natural categories are fuzzy sets, with no clear boundaries separating category members from nonmembers.     

An associative account of the development of word learning

Word learning is a notoriously difficult induction problem because meaning is underdetermined by positive examples. How do children solve this problem? Some have argued that word learning is achieved by means of inference: young word learners rely on a number of assumptions that reduce the overall hypothesis space by favoring some meanings over others. However, these approaches have difficulty explaining how words are learned from conversations or text, without pointing or explicit instruction. In this research, we propose an associative mechanism that can account for such learning. In a series of experiments, 4-year-olds and adults were presented with sets of words that included a single nonsense word (e.g. dax). Some lists were taxonomic (i.,e., all items were members of a given category), some were associative (i.e., all items were associates of a given category, but not members), and some were mixed. Participants were asked to indicate whether the nonsense word was an animal or an artifact. Adults exhibited evidence of learning when lists consisted of either associatively or taxonomically related items. In contrast, children exhibited evidence of word learning only when lists consisted of associatively related items. These results present challenges to several extant models of word learning, and a new model based on the distinction between syntagmatic and paradigmatic associations is proposed.     

Part-list cuing in amnesic patients: evidence for a retrieval deficit

Part-list cuing--the detrimental effect of the presentation of a subset of learned items on recall of the remaining items--was examined in amnesic patients and healthy control subjects. Subjects studied two types of categorized item lists: lists in which each category consisted of strong and moderate items and lists in which each category consisted of weak and moderate items. The subjects recalled a category's strong and weak items in either the presence of or absence of the moderate items serving as retrieval cues. In healthy subjects, part-list cuing impaired recall of the strong items but not of the weak items; in amnesics, part-list cuing impaired recall of both types of items. Part-list cuing is often attributed to a change in the retrieval process from a more effective one when cues are absent to a less effective one when they are present. On the basis of this view, our results indicate that part-list cuing causes a stronger retrieval inefficiency in amnesic patients than in healthy people.     

Effect of depth of processing on recognition memory for normal and inverted photographs of faces

40 undergraduates categorized photographs of faces on the basis of sex or liking and then attempted to recognize them in normal or inverted orientations. For photographs which were normally oriented, accuracy and confidence were greater for pictures initially categorized for liking than for pictures initially categorized for sex. However, for inverted photographs, accuracy and confidence scores did not differ as a function of initial judgement, although they were generally poorer for the inverted than normal faces. Finally, subjects more often correctly recalled the initial category for normal than for inverted photographs, although both levels were close to chance. These findings are interpreted as being more consistent with a semantic than a feature model of facial representation.     

Processing emotional pictures and words: Effects of valence and arousal

There is considerable debate regarding the extent to which limbic regions respond differentially to items with different valences (positive or negative) or to different stimulus types (pictures or words). In the present event-related fMRI study, 21 participants viewed words and pictures that were neutral, negative, or positive. Negative and positive items were equated on arousal. The participants rated each item for whether it depicted or described something animate or inanimate or something common or uncommon. For both pictures and words, the amygdala, dorsomedial prefrontal cortex (PFC), and ventromedial PFC responded equally to all high-arousal items, regardless of valence. Laterality effects in the amygdala were based on the stimulus type (word 5 left, picture 5 bilateral). Valence effects were most apparent when the individuals processed pictures, and the results revealed a lateral/medial distinction within the PFC: The lateral PFC responded differentially to negative items, whereas the medial PFC was more engaged during the processing of positive pictures.