BDNF serum levels in subjects developing or not post-traumatic stress disorder after trauma exposure

Post-traumatic stress disorder (PTSD) is a syndrome resulting from exposure to a severe traumatic event that poses threatened death or injury and produces intense fear and helplessness. The neural structures implicated in PTSD development belong to the limbic system, an important region for emotional processing. Brain-derived neurotrophic factor (BDNF) is a neurotrophin that serves as survival factor for selected populations of central nervous system (CNS) neurons and plays a role in the limbic system by regulating synaptic plasticity, memory processes and behavior. Impaired BDNF production in the brain can lead to a variety of CNS dysfunctions including symptoms associated with PTSD. However, so far fewer studies have investigated this neurotrophin in patients with PTSD. Furthermore, given the multiple role of BDNF in various CNS disorders, it cannot be excluded that traumatic events per se may influence neurotrophin levels, without a direct association to the PTSD syndrome.     

A behavior-analytic conceptualization of the side effects of psychotropic medication

A range of behavior-much deemed problematic by society-is treated with behavioral methods or psychotropic medications. Although the processes associated with behavioral interventions have been investigated using conceptual, experimental, and applied analyses, less is known about the behavioral processes associated with the use of psychotropic medication. Psychotropic drugs produce at least two types of effects of behavioral interest: (a) primary effects of drug action on target behaviors and (b) side effects that change the target or other behavior. Although an empirical literature exists regarding the former effects, little attention has been given to the latter topic. In this paper we offer a conceptual analysis of the side effects of psychotropic medication. We propose that the side effects of various drugs can influence behavior by functioning as motivating operations, conditional or discriminative stimuli, or by establishing new response-reinforcer relations. This conceptualization may facilitate the empirical analysis of how psychotropic drugs change behavior.     

The nature of categorical and coordinate spatial relation processing: An interference study

Spatial relation information can be encoded in two different ways: categorically, which is abstract, and coordinately, which is metric. Although categorical and coordinate spatial relation processing is commonly conceived as relying on spatial representations and spatial cognitive processes, some suggest that representations and cognitive processes involved in categorical spatial relation processing can be verbal as well as spatial. We assessed the extent to which categorical and coordinate spatial relation processing engages verbal and spatial representations and processes using a dual-task paradigm. Participants performed the classical dot-bar paradigm and simultaneously performed either a spatial tapping task, or an articulatory suppression task. When participants were requested to tap blocks in a given pattern (spatial tapping), their performance decreased in both the categorical and coordinate tasks compared to a control condition without interference. In contrast, articulatory suppression did not affect performance in either spatial relation task. A follow-up experiment indicated that this outcome could not be attributed to different levels of difficulty of the two interference tasks. These results provide strong evidence that both coordinate and categorical spatial relation processing relies mainly on spatial mechanisms. These findings have implications for theories on why categorical and coordinate spatial relations processing are lateralised in the brain.     

Processing reduced word forms: the suffix restoration effect

Listeners cannot recognize highly reduced word forms in isolation, but they can do so when these forms are presented in context (Ernestus, Baayen, & Schreuder, 2002). This suggests that not all possible surface forms of words have equal status in the mental lexicon. The present study shows that the reduced forms are linked to the canonical representations in the mental lexicon, and that these latter representations induce reconstruction processes. Listeners restore suffixes that are partly or completely missing in reduced word forms. A series of phoneme-monitoring experiments reveals the nature of this restoration: the basis for suffix restoration is mainly phonological in nature, but orthography has an influence as well.     

The effects of stimulus structure and familiarity on same-different comparison

It was hypothesized that performance in the same-different comparison task is based on two modes of processing: (1) structural processes that organize the detailed parts of a stimulus into a well-formed whole, and (2)analytic processes that decompose the stimulus into features. This hypothesis was supported, but with the unexpected finding of individual differences in the mode of processing underlying “same” responses. Those Ss in the “same” condition whose reaction times were faster for symmetrical than for asymmetrical patterns supported the hypothesis for structural processes. The remaining Ss in the “same” condition, as well as all the Ss in the “different” condition, were unaffected by symmetry. These Ss supported the hypothesis for analytic processes. Although familiarity effects were obtained for both structural and analytic Ss, the rotation of the familiar patterns into an unfamiliar orientation virtually eliminated familiarity effects for the structural Ss, but left them intact for analytic Ss.     

Epinephrine administration increases neural impulses propagated along the vagus nerve: Role of peripheral beta-adrenergic receptors

A significant number of animal and human studies demonstrate that memories for new experiences are encoded more effectively under environmental or laboratory conditions which elevate peripheral concentrations of the hormone epinephrine and in turn, induce emotional arousal. Although this phenomenon has been replicated across several learning paradigms, understanding of how this arousal related hormone affects memory processing remains obscure because epinephrine does not freely enter into the central circulation to produce any direct effects on the brain. This study examined whether epinephrine's actions on the CNS may be mediated by the initial activation of peripheral vagal fibers that project to the brain. The vagus was selected as a candidate for this role since it is densely embedded with beta-adrenergic receptors and the peripheral endings of this nerve innervate a broad spectrum of sensory organs that are directly affected by epinephrine release. Electrophysiological recordings of cervical vagal activity was measured over 110 min in urethane-anesthetized Sprague-Dawley rats given saline, epinephrine (0.3 mg/kg), the peripherally acting beta-adrenergic antagonist sotalol (2.0 mg/kg), or a combination of sotalol followed 15 min later by an injection of epinephrine. Epinephrine produced a significant increase in vagal nerve firing 10 min post-injection (p < .05) relative to controls and neural impulses recorded from the vagus remained significantly elevated for the remaining 55 min collection period. The excitatory actions of epinephrine were not observed in groups given an identical dose of the hormone after peripheral beta-adrenergic receptor blockade with sotalol. These findings demonstrate that neural discharge in vagal afferent fibers is increased by elevations in peripheral concentrations of epinephrine and the significance of these findings in understanding how epinephrine modulates brain limbic structures to encode and store new information into memory is discussed.     

ADHD and DCD: a relationship in need of research

Although the connection between attention deficit hyperactivity disorder (ADHD) and developmental coordination disorder (DCD) has been recognized for several decades, little research has examined the relationship between these two disorders. This paper draws attention to the contribution the cognitive-energetic model (CEM) can make in determining the specific nature of these two disorders. An information processing approach such as the CEM is a useful model to identify specific and overlapping mechanisms that are disrupted in these two disorders. This paper describes the CEM and reviews the research so-far in relation to the model. The CEM has several advantages over other models: First, it predicts which task variables will be independent or may interact, thus enabling the investigator to determine the success/failure of the task manipulation(s) and identify spurious findings. Second, the CEM links energetic factors to task variables and predicts both additive and interactive effects. Third, the CEM enables executive processes such as selective attention, working memory and inhibition to be related to both energetic and lower level processes. Fourth, by employing the CEM in clinical research, taxonomy of deficits can be derived enabling further insight into the nature of the disorders and their specific neuropsychological dysfunction. Suggestions are made for future research into the neuropsychological deficits associated with ADHD and DCD.     

A neural network approach to movement pattern analysis

Movements are time-dependent processes and so can be modelled by time-series of coordinates: E.g., each articulation has geometric coordinates; the set of the coordinates of the relevant articulations build a high-dimensional configuration. These configurations--or "patterns"--give reason for analysing movements by means of neural networks: The Kohonen Feature Map (KFM) is a special type of neural network, which (after having been coined by training with appropriate pattern samples) is able to recognize single patterns as members of pattern clusters. This way, for example, the particular configurations of a given movement can be identified as belonging to respective configuration clusters, where the sequence of clusters to which the time-depending configurations belong, characterizes the process as a 2-dimensional trajectory. The advantages of this method are that: the high dimensionality of the original processes is reduced to two dimensional trajectories, the clusters are automatically determined by the network, and all data for further analyses can automatically be transferred into a data base. Thus, the processes can either be visualized and analysed by an expert or again processed by further automatic analysing tools, as has been done with similarity matrices. The disadvantage is that a KFM-training needs a huge amount of information, which normally is not available from experiments. However, the Dynamically Controlled Network DyCoN (a special type of KFM) makes it possible to reduce the amount of original training data substantially--e.g., by adding stochastically generated ones. Currently, DyCoN is used in several projects in order to generally support analyses of processes in sport. It should be emphasized that the presented approach is not meant to improve the understanding or to develop models of human movement but to give a survey of the advantages and methodological aspects of net-based movement analysis.     

Input integration and input weighting in decisions on allocations of gains and losses

Although the concept of relevance (or weight) of inputs plays a central role in equity theory, it has not been clearly defined. The present investigation attempts to answer the question of when, and which, inputs are taken into account in allocation decisions. Subjects were given a stimulus story in which two fictitious persons had, through joint work, produced a monetary gain or loss; further, information was provided on the relative effort (amount of time worked intensively) and /or ability (as determined by a test) that each stimulus person had contributed. Subjects were asked how they would allocate the gain or loss. Empirical evidence for the following three codeterminants of allocation decisions was obtained: (1) the type of input—personal and behavioural characteristics are [relevant] for allocation if they are perceived as (a) causallv important for outcome production, (b) variable, and (c) under the person's volitional control; (2) the type of outcome to be allocated—more equal allocations are observed when loss as opposed to gain must be allocated; and (3) the constellation of individual inputs on given dimensions—information is given on several input dimensions, a dimension which should be [irrelevant] according to criteria (a), (b), and (c) does codetermine allocations when recipients have contributed equally with respect to this dimension. The latter finding is discussed from the perspective of [cognitive algebra].     

Tree inference with factors selectively influencing processes in a processing tree

We show how to systematically construct a processing tree using data from an experiment in which two experimental factors are intended to selectively influence two different processes. Only two arrangements are possible for the two selectively influenced processes: ordered and unordered. We show that there are only two standard trees that need be considered, one for each arrangement. Necessary and sufficient conditions are given for each tree to be applicable. If the conditions do not hold, no tree is possible. If the selectively influenced processes are ordered, their order is sometimes determined by the data. We consider two factors that selectively influence two processes in every tree in a set of trees, such that on a given trial, a tree is selected from the set at random. We show that if the influenced processes are ordered in every tree or unordered in every tree, then the mixture of trees is equivalent to one of the two standard trees. To illustrate the method, a tree is constructed from simulated data from a model of Batchelder and Riefer [Batchelder, W.H., Riefer, D.M. (1980). Separation of storage and retrieval factors in free recall of clusterable pairs. Psychological Review, 87, 375–397].     

Punishment as restoration of group and offender values following a transgression: value consensus through symbolic labelling and offender reform

Justice theory has suggested that transgressions pose a threat to the shared values that underlie broken rules or laws, suggesting that in order to address concerns over the values violated by an offence, perceived consensus regarding those values must be reaffirmed. However, little empirical research has been conducted examining how legal responses can address those value concerns. In the current research we argue that punishments, as a common response to injustice, can reaffirm perceived value consensus through two routes: (1) by symbolically labelling the offence as against group values, thus reinforcing values towards observers and (2) by attempting to reform the offender, thus reinforcing values towards the offender. Consistent with this argument, three empirical studies showed that the public and inclusive nature of punishment helps restore a perceived value consensus as such characteristics facilitate these two processes. Moreover, these characteristics had a positive effect on perceived punishment appropriateness particularly when value concerns were heightened. These findings implicate symbolic labelling and offender reform as two processes by which punishments can restore the perception of value consensus and suggest that these processes are integral to justice restoration through punishment when value consensus is a dominant concern. Copyright © 2008 John Wiley & Sons, Ltd.     

Retributive and restorative justice: Importance of crime severity and shared identity in people's justice responses

Retributive and restorative justice present two different responses to wrongdoing: one that focuses on addressing the moral wrong through punitive sanctions (retribution) and one that focuses on addressing the harm that has been caused through reparative sanctions (restoration). Psychological investigations of what factors influence which justice outcome that people desire (retributive, restorative, or both) have focused on two constructs: crime severity and shared identity. The crime severity approach contends that people can have multiple justice goals, and which justice goals people want to fulfil is dependent on the salient features of the situation (such as offence seriousness). The shared identity approach argues that people's desire for restoration or retribution is dependent on the shared identity and perceptions of value consensus between offender and victim in the judgement context. The findings related to both of these factors are reviewed, and possibilities for future research integrating these two approaches are discussed.     

Glutamate as a transmitter in the CNS and its presumed significance in the pathogenesis of cerebral seizure forms--recent aspects

Glutamate is believed to be quantitatively the most outstanding of the excitatory transmitters in the CNS. Certain conformationally related analogues, e. g. kainate, N-methyl-D-aspartate, ibotenate, and homocysteate, act as glutamate agonists. The local or systemic administration of these "excitotoxic" compounds induces epileptiform activity pointing out new and deeper insights into the epileptic process. Additionally, the glutamate transmitter hypothesis is expected to give a chance of a causal comprehension for choreatic processes as well as for the mode of action of anticonvulsant and antispastic agents.     

Prospective memory training in older adults and its relevance for successful aging

In research on cognitive plasticity, two training approaches have been established: (1) training of strategies to improve performance in a given task (e.g., encoding strategies to improve episodic memory performance) and (2) training of basic cognitive processes (e.g., working memory, inhibition) that underlie a range of more complex cognitive tasks (e.g., planning) to improve both the training target and the complex transfer tasks. Strategy training aims to compensate or circumvent limitations in underlying processes, while process training attempts to augment or to restore these processes. Although research on both approaches has produced some promising findings, results are still heterogeneous and the impact of most training regimes for everyday life is unknown. We, therefore, discuss recent proposals of training regimes aiming to improve prospective memory (i.e., forming and realizing delayed intentions) as this type of complex cognition is highly relevant for independent living. Furthermore, prospective memory is associated with working memory and executive functions and age-related decline is widely reported. We review initial evidence suggesting that both training regimes (i.e., strategy and/or process training) can successfully be applied to improve prospective memory. Conceptual and methodological implications of the findings for research on age-related prospective memory and for training research in general are discussed.     

A ganglionic model of “learned helplessness”

The phenomenon known as “learned helplessness” (LH) is seen broadly across the animal kingdom. Some of the basic characteristics of this behavior are: failure to escape shock when it is possible to do so following non-escapable shock; reversion to non-escape behavior even after successful escape; if the animal is given escape/avoidance training prior to being given inescapable shocks, the latter will not interfere with its ability to later show normal escape/avoidance behavior (generally described as an immunization effect); following inescapable shock training the animals often become “passive and still” when confronted with an escapable shock. These behaviors are seen in intact mammals, lower vertebrates, and invertebrates. In fact, the basic characteristics are even seen in a spinal rat and, with the exception of one characteristic not yet examined, in an isolated thoracic ganglion of an insect. The brain is evidently not essential either in mammals or in invertebrates for demonstrating this behavior. Not only can an insect ganglion show the behavioral characteristics of LH, but the neural information underlying the phenomenon of LH can be shown to transfer from one ganglion innervating one pair of legs to another ganglion innervating a different pair of legs. Thus, how CNS information underlying LH is coded and transferred from one site to another within the CNS can be examined in such a system. The LH model has provided valuable insights into the physiology of depression. This model suggests that human depression is caused by one’s lack of control over traumatic events. It is supported by a number of parallels between depression and LH behavior. Tricyclic antidepressants, MAO inhibitors, and ECT, which are effective in treating depression, also can prevent and reverse LH in mammals. It would be important to find out if they are also effective in invertebrate models. The fact that the characteristics of the behavior called LH are seen in invertebrates such as slugs, cockroaches, and locusts provokes other intriguing questions about the presence of cognition at these phylogenetic levels, as well as what animal or preparation constitutes an appropriate model for human depression.     

Are there control processes,and (if so) can they be studied?

Generally, so-called control processes are thought to be necessary when we must perform one out of several competing actions. Some examples include performance of a less well-practiced action instead of a well-practiced one (prepotency); learning a new action (novelty); and rapidly switching from one action to another (task-switching). While it certainly is difficult to perform the desired action in these circumstances, it is less clear that a separate set of processes (e.g., control processes) are necessary to explain the observed behavior. Another way to approach the study of control processes is to investigate physiological dependent measures (e.g., electrophysiological or neuroimaging measures). Although these offer another avenue of inquiry into control processes, they have yet to furnish unambiguous evidence that control processes exist. While this might suggest that there are no control processes, it is also possible that our methods are insufficiently sensitive to measure control processes. We have investigated this latter possibility using tasks that are neuroanatomically distinct, though within the same modality (vision). This approach did not yield evidence for a separable set of control processes. However, recent works using a task-switching paradigm in which subjects switch between a visual and an auditory task suggest that switching both task and modality may be importantly different than switching task within a given modality. This may represent a way forward in the study of control processes.     

Continuity between waking activities and dream activities

Empirical studies largely support the continuity hypothesis of dreaming. Despite of previous research efforts, the exact formulation of the continuity hypothesis remains vague. The present paper focuses on two aspects: (1) the differential incorporation rate of different waking-life activities and (2) the magnitude of which interindividual differences in waking-life activities are reflected in corresponding differences in dream content. Using a correlational design, a positive, non-zero correlation coefficient will support the continuity hypothesis. Although many researchers stress the importance of emotional involvement on the incorporation rate of waking-life experiences into dreams, formulated the hypothesis that highly focused cognitive processes such as reading, writing, etc. are rarely found in dreams due to the cholinergic activation of the brain during dreaming. The present findings based on dream diaries and the exact measurement of waking activities replicated two recent questionnaire studies. These findings indicate that it will be necessary to specify the continuity hypothesis more fully and include factors (e.g., type of waking-life experience, emotional involvement) which modulate the incorporation rate of waking-life experiences into dreams. Whether the cholinergic state of the brain during REM sleep or other alterations of brain physiology (e.g., down-regulation of the dorsolateral prefrontal cortex) are the underlying factors of the rare occurrence of highly focused cognitive processes in dreaming remains an open question. Although continuity between waking life and dreaming has been demonstrated, i.e., interindividual differences in the amount of time spent with specific waking-life activities are reflected in dream content, methodological issues (averaging over a two-week period, small number of dreams) have limited the capacity for detecting substantial relationships in all areas. Nevertheless, it might be concluded that the continuity hypothesis in its present general form is not valid and should be elaborated and tested in a more specific way.     

Visual prediction: psychophysics and neurophysiology of compensation for time delays

A necessary consequence of the nature of neural transmission systems is that as change in the physical state of a time-varying event takes place, delays produce error between the instantaneous registered state and the external state. Another source of delay is the transmission of internal motor commands to muscles and the inertia of the musculoskeletal system. How does the central nervous system compensate for these pervasive delays? Although it has been argued that delay compensation occurs late in the motor planning stages, even the earliest visual processes, such as phototransduction, contribute significantly to delays. I argue that compensation is not an exclusive property of the motor system, but rather, is a pervasive feature of the central nervous system (CNS) organization. Although the motor planning system may contain a highly flexible compensation mechanism, accounting not just for delays but also variability in delays (e.g., those resulting from variations in luminance contrast, internal body temperature, muscle fatigue, etc.), visual mechanisms also contribute to compensation. Previous suggestions of this notion of "visual prediction" led to a lively debate producing re-examination of previous arguments, new analyses, and review of the experiments presented here. Understanding visual prediction will inform our theories of sensory processes and visual perception, and will impact our notion of visual awareness.     

Neurodevelopmental assessment of the young child: the state of the art

A wide variety of tests are available to assess the central nervous system (CNS) function of the toddler and preschool-aged child. These tests vary as to function; qualities and abilities tapped; facility with which they can be learned, administered, and scored; availability of test materials and manuals or training videos; and strength of standardization and validation data. Some were developed to screen development of large numbers of children. Others were developed to evaluate a child for diagnosis of disability or delineation of a child's strengths and weaknesses. Some broadly screen or assess multiple aspects of development, while some focus on specific abilities. A limitation of all these tests is that they tap only a small portion of a child's abilities at a given point in time. Administration of a variety of different tests provides a more complete evaluation of a child's abilities. Tests that can follow a child's development over time tap into the continuum of human development. The ability to measure various aspects of CNS functional development is a first step in addressing our greatest challenge, how to promote and support a child's development.     

Developmental Improvements in Perceptual Restoration: Can Young Children Reconstruct Missing Sounds in Noisy Environments?

Young children are frequently exposed to sounds such as speech and music in noisy listening conditions, which have the potential to disrupt their learning. Missing input that is masked by louder sounds can, under the right conditions, be ‘filled in’ by the perceptual system using a process known as perceptual restoration. This experiment compared the ability of 4‐ to 6‐year‐old children, 9‐ to 11‐year‐old children and adults to complete a melody identification task using perceptual restoration. Melodies were presented either intact (complete input), with noise‐filled gaps (partial input; perceptual restoration can occur) or with silence‐filled gaps (partial input; perceptual restoration cannot occur). All age groups could use perceptual restoration to help them interpret partial input, yet perception was the most detrimentally affected by the presentation of partial input for the youngest children. This implies that they might have more difficulty perceiving sounds in noisy environments than older children or adults. Young children had particular difficulty using partial input for identification under conditions where perceptual restoration could not occur. These findings suggest that perceptual restoration is a crucial mechanism in young children, where processes that fill in missing sensory input represent an important part of the way meaning is extracted from a complex sensory world. Copyright © 2011 John Wiley & Sons, Ltd.