Metabolic syndrome and Alzheimer's disease: a link to a vascular hypothesis?

Current evidence from epidemiological, neuroimaging, pathological, pharmacotherapeutic, and clinical studies indicate an association of Alzheimer's disease with risk factors of vascular atherosclerotic disease either in isolation or in aggregate. "Metabolic syndrome" (MetS) is the name for a clustering of risk factors for cardiovascular disease and type 2 diabetes that are of metabolic origin. These include central obesity, elevated plasma glucose, high blood pressure, atherogenic dyslipidemia, a prothrombotic state, and a proinflammatory state. In this article, we provide an overview of the relevant literature with regard to the relationship of Alzheimer's disease with MetS. Accumulating evidence suggests a "vascular hypothesis" to be related to the pathology of Alzheimer's disease. In the light of this evidence, clinician may consider lifestyle interventions toward an early and effective cardiovascular risk-factor management to reduce the cardiometabolic and the cognitive decline risk, while further research of other preventive strategies may be warranted.     

Selective migration— Still a viable hypothesis

Kamin (1980) has contended that arguments presented in Wolff (1979) are too weak to justify “resuscitating the selective migration debate.” Although Kamin's (1980) critique points up the need for closer scrutiny of the cumulative-deficit phenomenon, it fails to refute Wolff's (1979) conclusion that selective migration is partly responsible for the North-South black IQ differential.     

Information selection and use in hypothesis testing: What is a good question,and what is a good answer?

The process of hypothesis testing entails both information selection (asking questions) and information use (drawing inferences from the answers to those questions). We demonstrate that although subjects may be sensitive to diagnosticity in choosing which questions to ask, they are insufficiently sensitive to the fact that different answers to the same question can have very different diagnosticities. This can lead subjects to overestimate or underestimate the information in the answers they receive. This phenomenon is demonstrated in two experiments using different kinds of inferences (category membership of individuals and composition of sampled populations). In combination with certain information-gathering tendencies, demonstrated in a third experiment, insensitivity to answer diagnosticity can contribute to a tendency toward preservation of the initial hypothesis. Results such as these illustrate the importance of viewing hypothesis-testing behavior as an interactive, multistage process that includes selecting questions, interpreting data, and drawing inferences.     

Thomas and Legge’s matching hypothesis for

Thomas and Legge have proposed amatching hypothesis for two-alternative detection and recognition tasks. Given symmetric payoff, S is supposed to match his unconditional response probabilities to the presentation probabilities. More generally, even when payoff is asymmetric, S is supposed to keep his unconditional response probabilities constant across different discriminability levels. Time series analysis is applied here to the response sequences from two auditory amplitude recognition tasks to test both hypotheses. Experiment I obtains a single sequence from each of 16 Ss. Experiment II obtains two sequences at different discriminability levels from each of 24 Ss. Departures from the matching hypothesis are extremely gross in both cases. In addition, Experiment II shows clear changes in the response probabilities across discriminability conditions, though these are not systematic in direction across Ss.     

The ‘I’ and the ‘Me’ in self-referential awareness: a neurocognitive hypothesis

The nature of the ‘self’ and self-referential awareness has been one of the most debated issues in philosophy, psychology and cognitive neuroscience. Understanding the neurocognitive bases of self-related representation and processing is also crucial to research on the neural correlates of consciousness. The distinction between an ‘I’, corresponding to a subjective sense of the self as a thinker and causal agent, and a ‘Me’, as the objective sense of the self with the unique and identifiable features constituting one’s self-image or self-concept, suggested by William James, has been re-elaborated by authors from different theoretical perspectives. In this article, empirical studies and theories about the ‘I’ and the ‘Me’ in cognition and self-related awareness are reviewed, including the relationships between self and perception, self and memory, the development of the self, self-referential stimulus processing, as well as related neuroimaging studies. Subsequently, the relations between self and different aspects of consciousness are considered. On the basis of the reviewed literature and with reference to Block’s distinction between phenomenal and access consciousness, a neurocognitive hypothesis is formulated about ‘I’-related and ‘Me’-related self-referential awareness. This hypothesis is extended to metacognitive awareness and a form of non-transitive consciousness, characteristic of meditation experiences and studies, with particular reference to the notion of mindfulness and other Buddhist constructs.     

Attenuated hypothesis or attenuated test of hypothesis?

After discussing several of the criticisms made by Professor Jensen, it is concluded that the Spearman hypothesis, as currently worded, has been disconfirmed. The near-zero correlation between blacks and low socio-economic status (SES) whites is not an artifact of the methodology. Neither is it a sampling fluke. The logic of sampling error does not apply to the arbitrary selection of intercorrelated tests from an undefined population. It is important also that low and high SES white differences are highly correlate with general factor loadings in a very heterogeneous selection of tests. Research attention should be turned to the difference in outcome of the race and SES comparisons.     

Conflict monitoring and the affective-signaling hypothesis—An integrative review

Psychonomic Bulletin & Review - Conflict-monitoring theory proposes that conflict between incompatible responses is registered by a dedicated monitoring system, and that this conflict signal...     

Hussearle's Representationalism and the “hypothesis of the Background”

John Searle's hypothesis of the Background seems to conflict with his initial representationalism according to which each Intentional state contains a particular content that determines its conditions of satisfaction. In Section I of this essay I expose Searle's initial theory of Intentionality and relate it to Edmund Husserl's earlier phenomenology. In Section II I make it clear that Searle's introduction of the notion of Network, though indispensable, does not, by itself, force us to modify that initial theory. However, a comparison of this notion to the notion of horizon from Husserl's later phenomenology and an interpretation of Husserl's conception of the determinable X as providing a solution to the problem of perceptual misidentification lead me to conclude that in his discussion of 'twin examples' Searle had better modified his initial theory. Finally, I critically examine Searle's claim that anyone who tries seriously to follow out the threads in the Network will eventually reach a bedrock of non-Intentional capacities. In Section III I show in detail, partly in a rather Husserlian vein, that Searle's four official arguments for the Background thesis, though containing some very valuable contributions to a theory of linguistic skills, are not convincing at all if they are to be understood as going beyond the scope of (Hus)Searle's 'content-cum-Network' picture of Intentionality. The upshot of these considerations is that the Background thesis should be read as a thesis concerning the causal neurophysiological preconditions of human Intentionality rather than concerning the logical properties of Intentional states in general. Recently Searle himself has come to the same result, but he does not say for which reasons. The present essay makes it clear why Searle just had to arrive at this important result.     

The growth hypothesis and self‐actualization: An existential alternative

Abstract

Examining the process of becoming from an existential perspective, we describe the existence of the self in non‐biological terms as a product of its own intentionality. In this context, there is no need to postulate a growth hypothesis in order to (1) to describe a person as a process of becoming, and (2) to explain self‐actualization. While the process of becoming is a static process, self‐actualization is a dynamic process. In the first case, the self deterministically and naively merely becomes. In the second, case, the process results from becoming the object of personal choices, whereby we become authentic. While the self is “a being in the process of mere becoming,” self‐actualization is “a being in the process of authentic becoming.” In this view, humanistic psychotherapy aims at making the self's mere becoming an authentic process. Existential crisis, in particular confrontation with death, is often the transformational medium.     

The growth hypothesis and self‐actualization: An existential alternative

Abstract

Examining the process of becoming from an existential perspective, we describe the existence of the self in non‐biological terms as a product of its own intentionality. In this context, there is no need to postulate a growth hypothesis in order to (1) to describe a person as a process of becoming, and (2) to explain self‐actualization. While the process of becoming is a static process, self‐actualization is a dynamic process. In the first case, the self deterministically and naively merely becomes. In the second, case, the process results from becoming the object of personal choices, whereby we become authentic. While the self is “a being in the process of mere becoming,” self‐actualization is “a being in the process of authentic becoming.” In this view, humanistic psychotherapy aims at making the self's mere becoming an authentic process. Existential crisis, in particular confrontation with death, is often the transformational medium.     

“Violent propensity,strain, and violent intentions: a test of Agnew’s revised conditioning hypothesis”

General Strain Theory’s (GST) mediating and conditioning hypotheses suggest that emotions mediate the strain-crime relationship and that personality traits condition the effects of strain. Individual-level research provides weak-to-mixed support for these hypotheses, leading to calls to revise GST. Yet, the mediating and conditioning hypotheses provide situational predictions which are largely untested at the situational-level. Further, Agnew (2013) recently suggested a modified method of testing the conditioning hypothesis. This research, using factorial survey data from 734 college students, presents a situational test of this revised version of GST. Results are generally, but not fully, supportive of the mediating and conditioning hypotheses. This indicates that Agnew’s most recent theoretical revision may be better suited for capturing the conditioning effect and that it is important to conduct more situational research on GST.     

Who gets a mentor? A longitudinal assessment of the rising star hypothesis

This study assessed the rising star hypothesis, which proposes that individuals who are on the fast track to career success are more likely to gain mentors than others. The study used a sample of employees who had never been mentored and examined the relationship between rising star attributes measured at Time 1 and the attainment of a mentor a year later. In support of the hypothesis, individuals who were on the fast-track for promotion, had higher advancement expectations, and engaged in more proactive career behaviors were more likely to gain a mentor than individuals lacking these attributes. Implications of these results for the theory, research and practice of mentoring are discussed.     

Is variability in mate choice similar for intelligence and personality traits? Testing a hypothesis about the evolutionary genetics of personality

This study tests the hypothesis presented by Penke, Denissen, and Miller (2007a) that condition-dependent traits, including intelligence, attractiveness, and health, are universally and uniformly preferred as characteristics in a mate relative to traits that are less indicative of condition, including personality traits. We analyzed between-culture mean standard deviations of preference ratings and rankings provided by nearly 10,000 people in 37 cultures for 18 characteristics in a potential mate. Contrary to the hypothesis, preferences for traits indicating agreeableness and conscientiousness were not more variable than preferences for intelligence, and preferences for traits indicating low neuroticism were more uniform than preferences for intelligence. Discussion addresses implications of these results for hypotheses about the evolutionary genetics of intelligence and personality.     

Why does a mirror image look left-right reversed? A hypothesis of multiple processes

This paper proposes a solution to the mirror reversal problem: Why does a mirror reverse left and right but not up and down? The paper first reviews past hypotheses and shows that none of them has succeeded in explaining all the related phenomena. It then proposes a multiprocess hypothesis based on the insight that what is called a mirror reversal is actually composed of three different types of reversal: The Type I reversal is produced by the discrepancy between an orientational framework that is aligned with a viewer’s body and the one that is assumed in the viewer’s mirror image; the Type II reversal is produced by the discrepancy between the mental representation of an object and its mirror image; and the Type III reversal is produced by a mirror’s optical transformation. The proposed hypothesis is shown to provide reasonable accounts for all the related phenomena disputed in the past literature.     

Which mechanical invariants are associated with the perception of length and heaviness of a nonvisible handheld rod? Testing the inertia tensor hypothesis

It has been suggested that the inertia tensor governs many instances of haptic perception. However, the evidence is inconclusive because other candidate mechanical parameters (i.e., invariants) were not or were insufficiently controlled for in pertinent experiments. By independently varying all candidate mechanical parameters, the authors were able to test the role of the inertia tensor relative to that of other mechanical parameters. The results showed that length perception during rod wielding is not governed by the inertia tensor alone but also by the static moment. In contrast to previous reports, length perception during rod holding and heaviness perception during rod wielding were found to be unrelated to the inertia tensor and strongly related to the static moment.     

The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease

Alzheimer's disease (AD) is the 3rd most costly disease and the leading cause of dementia. It can linger for many years, but ultimately is fatal, the 6th leading cause of death. Alzheimer's disease (AD) is fatal and affected individuals can sometimes linger many years. Current treatments are palliative and transient, not disease modifying. This article reviews progress in the search to identify the primary AD-causing toxins. We summarize the shift from an initial focus on amyloid plaques to the contemporary concept that AD memory failure is caused by small soluble oligomers of the Aβ peptide, toxins that target and disrupt particular synapses. Evidence is presented that links Aβ oligomers to pathogenesis in animal models and humans, with reference to seminal discoveries from cell biology and new ideas concerning pathogenic mechanisms, including relationships to diabetes and Fragile X. These findings have established the oligomer hypothesis as a new molecular basis for the cause, diagnosis, and treatment of AD.     

Anomalous experiences and schizotypy: which comes first? The Hermit Crab syndrome hypothesis

This study confirms findings of previous research as they state that some triggering events or anomalous experiences can give rise to a disruption of cognitive processes and emotional changes in a predisposed person. Furthermore, our research states that the cognitive process and change of world view (paradigm shift (PS)) accompanying some paranormal experiences (PEs) could facilitate the development of a schizotypal personality structure. For the purposes of this study, 675 young people aged between 13 and 25 years old (M?=?16.8, SD?=?1.9) completed the Schizotypal Personality Questionnaire, the Revised and Modified Paranormal Belief Scales, the measurement of eight kinds of PE and a self-reported measurement of change of world view. The results confirm the mediating role of PS between paranormal practices and schizotypy as the cognitive process contributing to symptom formation as well as to symptom maintenance. The said results also confirm the existence of cognitive–emotional stages, also called Hermit Crab syndrome, in the process of the “paranormalisation” of reality.     

Can a manager have a life and a career? International and multisource perspectives on work-life balance and career advancement potential

The present study was the first cross-national examination of whether managers who were perceived to be high in work-life balance were expected to be more or less likely to advance in their careers than were less balanced, more work-focused managers. Using self ratings, peer ratings, and supervisor ratings of 9,627 managers in 33 countries, the authors examined within-source and multisource relationships with multilevel analyses. The authors generally found that managers who were rated higher in work-life balance were rated higher in career advancement potential than were managers who were rated lower in work-life balance. However, national gender egalitarianism, measured with Project GLOBE scores, moderated relationships based on supervisor and self ratings, with stronger positive relationships in low egalitarian cultures. The authors also found 3-way interactions of work-life balance ratings, ratee gender, and gender egalitarianism in multisource analyses in which self balance ratings predicted supervisor and peer ratings of advancement potential. Work-life balance ratings were positively related to advancement potential ratings for women in high egalitarian cultures and men in low gender egalitarian cultures, but relationships were nonsignificant for men in high egalitarian cultures and women in low egalitarian cultures.     

Frequency of occurrence as a psychophysical continuum: Weber’s fraction,Ekman’s fraction,range effects,and the phi-gamma hypothesis

Using the continuum of frequency of occurrence of words in English, it was found that: (1) errors in judgment are distributed lognormally rather than normally, and therefore the standard method of calculating Weber’s fraction underestimates its definition, (2) Weber’s fraction has an extremely large value of 3.3, (3)Ekman’s fraction equals 1.81, not .03 as with sensory continua, and (4)the logarithm of the dynamic range times Stevens’ law exponent equals 3.83, not 1.53 as with sensory continua. The last two results favor Teghtsoonian’s underlying sensory scale interpretation over Poulton’s range effects interpretation of the range-exponent relation.