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Additive and Synergetic Contributions of Neuroticism and Life Events to Depression and Anxiety in Women 下载免费PDF全文
In this genetically informative and longitudinal study of women, we investigated the nature of individual differences in tendencies to depression (TD) and anxiety (TA) as well as in the probability to develop unipolar mood disorders (UMDs), anxiety disorders (ADs) or both. Specifically, we examined the roles of neuroticism, negative and positive life events and their interplay as heritable and environmental factors of variance in TD and TA. Cross‐sectional data from a total of 1200 women including 232 patients (suffering from UMDs and/or ADs) and longitudinal data from 630 female twins including 260 complete pairs were analysed. The analyses yielded that variance in neuroticism mediated the vast majority of the genetic variance in both TD (about 85–90%) and TA (about 70–75%). Negative life events additionally contributed as risk factors accounting for common and specific environmental variance in both TD and TA, whereas positive life events only acted as protective factors in the case of TD. Moreover, TD but not TA was associated with both the probability of exposure and the sensitivity to negative life events and a negative life‐event balance (i.e. more negative than positive experiences). The results were discussed within the framework of additive, dynamic and synergetic diathesis–stress models. Copyright © 2016 European Association of Personality Psychology 相似文献
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Natural Disaster and Depression: A Prospective Investigation of Reactions to the 1993 Midwest Floods
A statewide sample of 1735 Iowa residents, approximately half of whom were victims of the 1993 Midwest Floods, participated in interviews 1 year prior to, and 30 to 90 days after, the disaster. Employing a rigorous methodology including both control-group comparisons and predisaster assessments, we performed a systematic evaluation of the disaster's impact. Overall, the disaster led to true but small rises in depressive symptoms and diagnoses 60–90 days postflood. The disaster–psychopathology effect was not moderated by predisaster depressive symptoms or diagnostically defined depression; rather, predisaster symptoms and diagnoses uniquely contributed to increases in postdisaster distress. However, increases in symptoms as a function of flood impact were slightly greater among respondents with the lowest incomes and among residents living in small rural communities, as opposed to on farms or in cities. Implications for individual- and community-level disaster response are discussed. 相似文献
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对321名大学生施测青少年生活事件量表(ASLEC)、自动思维问卷(ATQ)、特质应对方式问卷(TCSQ)及流调中心用抑郁量表(CESD),以探讨生活事件、负性自动思维及应对方式对抑郁的影响模式。结果:(1)相关分析发现:生活事件、负性自动思维、消极应对方式均与抑郁呈显著正相关(p<0.01),生活事件与负性自动思维及消极应对方式呈显著正相关(p<0.01)。(2)路经分析发现:有六条显著路径影响抑郁。应对方式对抑郁产生直接的影响;自动思维可以直接影响抑郁,同时也可通过应对方式间接影响抑郁;生活事件对抑郁的直接影响不显著,其影响是经由负性自动思维及应对方式的中介作用而间接实现的。 相似文献
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为了探讨生活事件、自尊、反刍思维和初中生抑郁之间的关系,研究采用青少年生活事件量表、自尊量表、反刍思维量表和儿童抑郁量表对684名初中生进行调查。结果显示:(1)生活事件与初中生抑郁呈显著正相关;(2)自尊和反刍思维在生活事件和初中生抑郁间起链式中介作用。生活事件不仅是触发初中生抑郁的重要外部因素,而且生活事件还会通过影响自尊和经由反刍思维对初中生抑郁产生间接作用。因此,减少和避免生活事件对初中生心理的冲击,增强其自尊水平,调整其负性认知方式是改善和预防初中生抑郁的重要途径。 相似文献
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Kyunghee Lee 《Journal of child and family studies》2003,12(4):425-437
In this study, I report secondary analyses using data from the Infant Health and Development Program (IHDP). The IHDP included parent-targeted as well as child-targeted components as an integral part of early intervention programs. I examined three questions: (1) Do the IHDP early intervention services enhance adaptive maternal coping skills? (2) Do maternal coping skills moderate the relationship between stressful life events and maternal depression? (3) Are maternal coping skills associated with children's behavioral scores? Mothers in the treatment group have more adaptive coping skills than follow-up only mothers, and these effects are moderated by maternal characteristics. Adaptive coping skills moderate the effects of negative life events on maternal depression. Adaptive maternal coping skills are significantly associated with fewer behavioral problems for children at age three. These effects are moderated by the intervention. Implications for early intervention programs are discussed. 相似文献
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Lamia P. Barakat Anne E. Kazak Paul R. Gallagher Kathleen Meeske Margaret Stuber 《Journal of clinical psychology in medical settings》2000,7(4):189-196
Objectives: To examine prospectively the impact of posttraumatic stress symptoms (PTSS) in response to childhood cancer and treatment on general adjustment while accounting for the role of other stressful life events and appraisal of life threat and treatment intensity. Methods: As part of a larger study assessing PTSS, 56 childhood cancer survivors, aged 8 to 18, and 65 mothers completed self-report measures of PTSS and appraisal of the intensity and life threat associated with cancer treatment at time 1 and self-report measures of stressful life events and general adjustment at time 2 (approximately 18 months after time 1). Results: For child survivors and their mothers, posttraumatic stress at time 1 significantly predicted general adjustment at time 2, over and above the significant contribution of lifetime stressful events. The life events variable did not function as a mediator in the association of PTSS and general adjustment. Conclusions: Trauma responses to childhood cancer and its treatment have implications for the long-term adaptation of children and their families. Early signs and symptoms of posttraumatic stress and stressful life experiences require early assessment and intervention. 相似文献
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Three types of variable have been used to explain brand preference changes: consumer characteristics, marketing mix factors and situational influences. The study presented in this paper focuses on the relationship between life events experienced by individuals, resultant stress and lifestyle changes and changes in brand preferences. Based on theory and past research, a model is proposed and tested. The data support the notion that brand preference changes may be viewed as the outcome of adjustments to new life conditions and changes in consumption lifestyles that reflect consumer efforts to cope with stressful life changes. Implications for consumer research are also discussed. Copyright © 2003 Henry Stewart Publications. 相似文献
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This study examined the effects of life events and social support on depression in 200 dialysis patients. The instruments used included the Beck Depression Inventory, a modified version of Sarason's Life Experiences Survey and a Social Support Inventory (SSI) constructed by the authors. The SSI consisted of five quantitative measures and three measures of perceived social support. These measures were found to be internally consistent and stable over time. Results showed that clinically depressed dialysis patients reported fewer positive life events and appraised life events more negatively than non‐depressed patients. The total number of life events and the number of negative life events were not found to differentiate between depressed and non‐depressed patients. With regard to social support variables, results showed that depressed patients reported less frequent actual contact and telephone contact with others and perceived a smaller amount and less availability of social support and less satisfaction with perceived social support along the functional dimensions of emotional, informational, appraisal and instrumental support and social companionship. The results were found to provide support for a main effect model of social support and not for a buffering model. Copyright © 1999 John Wiley & Sons, Ltd. 相似文献
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摘 要 5-HTTLPR是5-羟色胺转运蛋白基因启动子区域上的多态性位点,对其转录效率具有调节作用。5-HTTLPR基因型与抑郁存在相关,但必须把二者的关系置于一个多基因与环境交互作用的框架下考察。一方面,环境因素的作用不容忽视:S等位基因携带者暴露于负性生活事件时,表现出更多情绪问题,更易发生抑郁。另一方面,CYP2C9、BDNF等基因与5-HTTLPR有交互作用,共同影响抑郁的发生。此外,年龄、性别等因素会对研究结果造成混淆。未来研究应侧重于对机制的探讨。 相似文献
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Eva Sández María I. Vázquez Esther Romero-Frais Marina Blanco-Aparicio Isabel Otero Héctor Verea 《Journal of clinical psychology in medical settings》2005,12(2):175-184
The aim of this study was to assess the relationships between depressive symptoms and symptom-centered panic-fear (P-F), and reports of health-related quality of life (HRQOL), in persons with near-fatal asthma (NFA), controlling for age, gender, and pulmonary function. Forty persons with NFA were interviewed. Sociodemographic and clinical asthma-related information were collected. HRQOL was assessed by the SF-36 Health Questionnaire, depressive symptoms were assessed by the Beck Depression Inventory, and P-F was assessed by the P-F scale of the Asthma Symptom Checklist. Multiple regression analyses were carried out with the Physical Component Summary (PCS) and the Mental Component Summary (MCS) of the SF-36 as a dependent variable, and depressive symptoms, P-F, age, gender, and pulmonary function as independent variables. Results showed that P-F and age were associated with PCS, whereas depressive symptoms accounted for a marked percentage of the variance explained in MCS. Neither gender nor pulmonary function were related to HRQOL. In conclusion, depressive symptoms and P-F play an important role in how persons with NFA assess their HRQOL. These patient-centered variables are potentially modifiable and may offer new ways to intervene in order to improve HRQOL in persons with NFA. 相似文献
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早期应激对抑郁相关行为及神经内分泌反应的长期影响 总被引:12,自引:0,他引:12
临床研究发现,早期创伤性经历是导致成年抑郁症易感性增加的高风险因素之一。但早期应激通过何种途径对抑郁发病产生长期的影响,目前尚不清楚。本文综述了近年来有关的实验动物研究,从早期应激的动物模型建立、早期应激对成年动物抑郁相关行为及神经内分泌反应的长期影响等方面进行了系统论述和分析,进而提出了早期应激并不影响动物的本能行为,但早期应激影响与行为动机和应激应对等认知相关的行为的观点,进一步论证了早期应激是通过增加个体潜在的易患病素质对抑郁症发病产生影响 相似文献
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Constance Hammen 《Anxiety, stress, and coping》2016,29(4):335-351
Background and Objectives: Stress is well known as a trigger of depressive reactions, fear, anxiety, and behavioral disorders. However, there are many gaps in the conceptualization and measurement of environmental stress. Results: Exciting developments in the neuroscience of stress have increasingly expanded our knowledge of mechanisms by which stress may affect emotional and behavioral adjustment. Ironically, environmental stress has often been a silent player in human studies of stress processes. There is a significant need for increased efforts to include environmental stress variables in models of internalizing and other disorders. Measurement and conceptualization issues are prominent, and this article makes the case for improved methods of measuring acute, chronic, and early life stress, and for additional conceptualization of the dynamically changing and bidirectional effects of stress on disorder over time. Conclusions: There is a critical need for greater focus on and better measurement of the environment and its impact on emotional and other disorders, with emphasis on developmentally informed hypotheses. Empirical findings and new perspectives may contribute enormously to our understanding of normal and abnormal outcomes, and also to the challenge of effective interventions to promote mental health and optimal functioning. 相似文献
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目的:考察早期适应不良图式、负性生活事件在童年期创伤与大学生抑郁间的影响机制。方法:采用童年期创伤问卷、Young图式问卷短版中文修订版、青少年生活事件量表及90项症状自评量表对1423名大学生进行调查,结果表明:(1)童年期创伤既可以直接正向预测大学生抑郁,也可以通过早期适应不良图式中的分离和拒绝、自主性及能力受损两大图式类别间接地正向预测大学生抑郁;(2)负性生活事件调节了早期适应不良图式在童年期创伤与抑郁间的中介作用 相似文献
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Background and Objectives: Stressful life events are known to contribute to development of depression; however, it is possible this link is bidirectional. The present study examined whether such stress generation effects are greater than the effects of stressful life events on depression, and whether stress generation is also evident with anxiety. Design: Participants were two large age cohorts (N = 732 aged 44 years; N = 705 aged 63 years) from the West of Scotland Twenty-07 study. Methods: Stressful life events, depression, and anxiety symptoms were measured twice five years apart. Cross-lagged panel analysis examined the mutual influences of stressful life events on depression and on anxiety over time. Results: Life events predicted later depressive symptomatology (p = .01), but the depression predicting life events relationship was less strong (p = .06), whereas earlier anxiety predicted life events five years later (p = .001). There was evidence of sex differences in the extent to which life events predicted later anxiety. Conclusions: This study provides evidence of stress causation for depression and weaker evidence for stress generation. In contrast, there was strong evidence of stress generation for anxiety but weaker evidence for stress causation, and that differed for men and women. 相似文献