An EEG alpha-detection,feedback stimulation,and data analysis system

A two-channel general-purpose EEG alpha-detection system is described, along with the associated computer hardware and software. A specific application for the study of the human orienting response using alpha-contingent visual stimulation is presented. Limitations are discussed.     

Some models of observer behavior in two-channel auditory signal detection

Five models of 0 behavior in a two-channel exclusive-or (XOR) detection task were evaluated. The models included two types of single-channel and three types of two-channel O. Only the most efficient two-channel model adequately described human performance in a set of monaural and dichotic XOR conditions. Detectability measures derived from the XOR task matched those obtained from separate single-channel control conditions. We concluded that. in this two-channel task. the O’s performance was not limited by any inability to monitor signals arriving simultaneousl.v in two different earphone or two different frequency channels. The implications of this result for two-channel information processing and for multicomponent and sequential signal detectmn are discussed.     

An inexpensive circuit for beta,alpha, theta,or delta EEG biofeedback

An inexpensive circuit is described for EEG biofeedback or measurement. The circuit is designed to interface easily with most basic EEG machines. It taps the output from a single recording channel of the basic EEG instrument and provides the following for each EEG band (beta, alpha, theta, and delta): (a) very selective bandpass discrimination, (b) variable center frequency, (c) variable threshold at which feedback will be provided, or the measurement made, and (d) use with any biofeedback stimulus or measurement device that one wishes to switch contingent with S’s EEG rhythms.     

Stable linear modulation of glow-modulator tubes

A circuit is described that permits modulation of the luminance of glow-modulator tubes with high accuracy and with no change in spectral distribution. Characteristics of a typical glow modulator are discussed in terms of its applications in visual research. Serious discrepancies were found between new measurements of spectral energy distributions and values that appear in the literature.     

A test-signal generator for low-frequency instrumentation

An instrument for generating simultaneous sinusoidal test signals m the range of 1–32 Hz for EEG equipment checkout procedures is described. A composite signal is produced by a method that separates the functions of waveform generation and control of output frequencies at which that waveform appears. The general technique may be applicable in a number of situations involving low-frequency instrumentation, as with other types of physiological monitoring. Possibilities and methods for elaboration or modification of the circuit are suggested.     

An integrated circuit for stepwise or continuous microdrive advancement

A circuit for inexpensive automation of a hydraulic microdrive is described. The circuit uses two integrated timing circuits with output periods defined by resistance-capacitance circuits. The output of this circuit operates a relay that controls a small electric motor that runs the microdrive. This system can operate in either a continuous mode for long-term infusion of solutions or in a stepwise fashion for lowering electrodes. When attached to an appropriate microdrive, the circuit can be employed in experiments in which brain-behavior relationships are investigated within anatomical, pharmacological, or electrophysiological paradigms.     

A simple electrode to record fetal EEG for optimal signal analysis

A simple EEG electrode for Intrauterine use In the human fetus is described. The stainless steel screw electrode possesses low noise characteristics, is constructed from commercially available material, and is easily attached to the fetal head during labor. Principles of optical signal analysis as an improved method of spectral analysis of the fetal EEG are also presented. The optical system provides visual display and hard copy output of the fetal EEG.     

A microcomputer-based software package for eye monitoring research

A software package is described that collects and reduces eye behavior (eye position and pupil size) data using an IBM-compatible personal computer. Written in the C language for speed and portability, the package includes several unique features: data can be collected simultaneously from other sources (e.g., EEG, EMG), logically defined events can be detected in real time on any data channel, and either of two types of data matrix can be produced. Data reduction algorithms and data structures are described.     

From single-channel recordings to brain-mapping devices: the impact of electroencephalography on experimental psychology

Since its discovery in 1920, the electroencephalogram (EEG) has become a widely used tool in experimental psychology. Although originally the merits of the method were seen first of all in an improvement of medical diagnostics it was soon understood by psychologists that EEG can also be used to study psychic processes in healthy participants. This article summarizes important events in the history of EEG research that laid the ground for this development, as fast Fourier transformation to analyze the spontaneous activity and signal averaging to improve the signal-to-noise ratio. The article shows how general technological developments were the prerequisite for these methodological improvements in EEG research and how they inspired new research questions. Key discoveries that proved unequivocally that psychic processes do become manifest in EEG signals are briefly reviewed, and the emerging paradigm of cognitive psychophysiology, which is closely linked to the development of EEG research, is described.     

奖赏环路与阿片成瘾:喙内侧被盖核的调节作用

喙内侧被盖核(RMTg)位于腹侧被盖区(VTA)的尾部, 富含抑制性的γ-氨基丁酸(GABA)能神经元.RMTg是中脑边缘多巴胺系统的一个综合调节器.它的GABA能神经元接受外侧缰核(LHb)的输入, 然后投射到VTA多巴胺能神经元, 进而抑制多巴胺的释放.这三个脑区是奖赏环路的重要组成部分, 其中RMTg在阿片类物质激活的奖赏环路中尤为重要.阿片类物质主要通过抑制RMTg GABA能神经元使VTA多巴胺能神经元去抑制, 进而激活奖赏系统.因此, RMTg有望成为治疗药物成瘾(尤其是阿片成瘾)的一个重要靶点.此外, 胆碱类物质作用于RMTg的毒蕈碱受体能够抑制阿片类物质诱导的奖赏效应.未来研究应深入探讨RMTg调控的负性奖赏环路, 这对弱化觅药动机,促进消退和戒断具有重要意义.     

An on-line integrator for alpha quantification

A system for the on-line graphic quantification of alpha frequencies (or other frequency bands extracted from EEG signals) is described. Alpha-frequency components (8 to 13 Hz) are actively filtered from complex EEG waveforms and presented to a laboratory-developed solid state integrator. The high-level output of the integrator, which is compatible with all popular EEG and polygraph recorders, is in the form of an ascending analog voltage ramp, reset at a predetermined level, to provide a rapid quantitative determination of alpha activity and variability. The design of the integrator permits an alternate mode of operation where time-synchronized resets, in lieu of voltage-dependent resets, produce variable height voltage ramps, whose amplitude is a direct function of the accumulated alpha activity per unit time. This method of preprocessing and signal conditioning the alpha components of the EEG waveform provides a simple analog registry of on-line real-time correlation of alpha activity with various physiological and behavioral activity.     

Cortical arousal and mentation in sleeping and waking subjects

Cognitive variables and cortical arousal levels were examined in order to determine whether differences in cortical arousal levels within REM and waking could account for different aspects of mentation derived from the two states. Cognitive variables were derived from mentation reports collected from 30 subjects in both the waking state and after being awakened from REM sleep. Mentation reports were independently scored on seven content rating scales, by two judges blind to the conditions. These scales include among others, Total Recall Count (TRC), a count of all words in which the subject described his/her experience during the previous interval. The EEG activity, obtained from left and right midtemporoparietal and central sites, was recorded for 5-min periods before obtaining mentation reports. The absolute power of the EEG activity was calculated for each of six bandwidths. EEG power data from both waking and REM were entered into multiple linear regression equations to predict TRC. No relationships were found between TRC and general cortical activation, as measured by the EEG. Other statistical analyses, including relationships between EEG and scales of visual imagery, are discussed.     

Basic Principles of Quantitative EEG

Principles of quantitative electroencephalography (EEG) relevant to neurotherapy are reviewed. A brief history of EEG, the general properties of human EEG, and the issues and obstacles associated with quantitative methods are discussed. Fourier analysis is also described.     

The classical conditioning of sleep and wakefulness

Using a metronome beat as conditioned stimulus three cases are described in which this stimulus was presented in close temporal contiguity with experimentally-induced sleep or waking. Drugs or fatigue consequent upon sleep deprivation were used as unconditioned stimuli for sleep. One of the subjects was an anxiety neurotic, one had narcolepsy and the third was a student volunteer. No EEG indication of conditioned sleep was obtained but there was evidence of conditioned relaxation in the anxiety neurotic and conditioned arousal in the other two cases.     

Neurotherapy with Adults

Several possible conceptualizations of neurotherapy are discussed: EEG operant conditioning; EEG homeostatic normalization; and utilization of EEG biofeedback as a means of accessing particular states of consciousness. Attention is given to how neurotherapy is actually done and when it may be a useful adjunct to psychological or medical therapies. Integration of neurotherapy with the larger framework of cognitive behavior therapy and the biopsychosocial model is discussed. Three case studies of adults involving the use of neurotherapy are described.     

Landau-Kleffner syndrome, electrical status epilepticus in slow wave sleep, and language regression in children

The Landau-Kleffner syndrome (LKS) and electrical status epilepticus in slow wave sleep (ESES) are rare childhood-onset epileptic encephalopathies in which loss of language skills occurs in the context of an epileptiform EEG activated in sleep. Although in LKS the loss of function is limited to language, in ESES there is a wider spectrum of cognitive impairment. The two syndromes are distinct but have some overlap. The relationship between the epileptiform EEG abnormalities and the loss of cognitive function remains controversial, even in LKS which is the most widely accepted as an acquired epileptic aphasia. Language regression also occurs in younger children, frequently in the context of a more global autistic regression. Many of these children have epileptiform EEGs. The term autistic regression with epileptiform EEG has been proposed for these children. Whether these children are part of an extended LKS spectrum is very controversial, because there are differences in age of onset, clinical phenotype, and EEG findings. An understanding of the available data on clinical characteristics, EEG findings, pathology, prognosis, and treatment of these syndromes is essential for further progress in this area.     

Reduced electroencephalographic coherence asymmetry in the Chernobyl accident survivors

An electroencephalograph (EEG) study was carried out from 1990 to 2006, using power spectra, averaged coherence, and integral EEG coherence asymmetry coefficients to compare 189 clean-up workers of the Chernobyl accident with 63 age-matched healthy controls. Most of the Chernobyl workers showed three abnormal EEG patterns, as indicated by EEG power mapping. The higher power, most prominent in slow alpha and theta bands, or in fast alpha frequencies, were observed in persons 3-5 years after the clean-up works (the early stage). The lower EEG power in alpha band was found in Chernobyl workers 10 or more years after the accident (the late stage). EEG coherence analysis revealed the existence of two stages in EEG alterations following the Chernobyl clean-up. In the early stage, an increase of EEG coherence in the central brain areas was observed, whereas at the later stage, a decrease of EEG coherence, most prominent in the frontal brain areas, and reduced brain asymmetry prevailed. These results allow us to propose that the described EEG signs may be a reflection of radiation-induced brain dysfunction at the late period after the Chernobyl clean-up and were similar to the EEG markers of brain ageing. The results, in comparison to data of the literature, provide additional support to the premature brain ageing hypothesis in Chernobyl survivors as a result of the radiation brain damage after-effect.     

Detection in a four-observation two-channel task

Two models are proposed for a four-observation two-channel forced-choice paradigm of signal detection. The first model, an extension of signal detection theory, fails, while the second model, an extension of the classical decision threshold model, succeeds.     

Examining the neural antecedents of tics in Tourette syndrome using electroencephalography

Tourette syndrome (TS) is a neurodevelopmental disorder characterized by the occurrence of motor and vocal tics. TS is associated with cortical–striatal–thalamic–cortical circuit dysfunction and hyper-excitability of cortical limbic and motor regions that lead to the occurrence of tics. Importantly, individuals with TS often report that their tics are preceded by premonitory sensory/urge phenomena (PU) that are described as uncomfortable bodily sensations that precede the execution of a tic and are experienced as an urge for motor discharge. While tics are most often referred to as involuntary movements, it has been argued by some that tics should be viewed as voluntary movements that are executed in response to the presence of PU. To investigate this issue further, we conducted a study using electroencephalography (EEG). We recorded movement-related EEG (mu- and beta-band oscillations) during (1) the immediate period leading up to the execution of voluntary movements by a group of individuals with TS and a group of matched healthy control participants, and (2) the immediate period leading up to the execution of a tic in a group of individuals with TS. We demonstrate that movement-related mu and beta oscillations are not reliably observed prior to tics in individuals with TS. We interpret this effect as reflecting the greater involvement of a network of brain areas, including the insular and cingulate cortices, the basal ganglia and the cerebellum, in the generation of tics in TS. We also show that beta-band desynchronization does occur when individuals with TS initiate voluntary movements, but, in contrast to healthy controls, desynchronization of mu-band oscillations is not observed during the execution of voluntary movements for individuals with TS. We interpret this finding as reflecting a dysfunction of physiological inhibition in TS, thereby contributing to an impaired ability to suppress neuronal populations that may compete with movement preparation processes.     

Digital filtering in EEG/ERP analysis: Some technical and empirical comparisons

A general approach to time domain digital filtering is described, and examples of some filters used in EEG/ERP research are presented. Simulations are reported that evaluate the impact of the relative length of the filter weight series and the signal cycle to be filtered, the span and real-time density of the filter weights, and slow drift across the epoch being filtered. Results indicate that some filters commonly used in the EEG/ERP literature are inadequate. Frequency domain digital filtering is also briefly discussed. The fast Hartley transform, a fast but relatively unknown computational method for frequency domain filtering of ERP/EEG data, is introduced and compared with time domain filtering. Some practical recommendations are provided.