A twin study of the association between pathological gambling and antisocial personality disorder

Many individuals with a history of pathological gambling (PG) also have a history of engaging in antisocial behaviors, and this has often been interpreted as a result of the former causing the latter. In a sample of 7,869 men in 4,497 twin pairs from the Vietnam Era Twin Registry, the authors examined (a) the association between PG and antisocial personality disorder (ASPD), (b) the extent to which PG might be differentially associated with childhood conduct disorder (CD) and adult antisocial behavior (AAB), and (c) the contribution of genetic and environmental factors to the association of PG with ASPD, CD, and AAB. PG was significantly associated with all 3 antisocial behavior disorders, and the association of PG with ASPD, CD, and AAB was predominantly explained by genetic factors. The results of this study suggest that the greater-than-chance co-occurrence of PG and antisocial behavior disorders is partially due to their sharing a common genetic vulnerability. The antisocial behavior observed among many individuals with PG probably cannot be interpreted as being simply a consequence of the PG.     

Sex differences in the genetic and environmental influences on childhood conduct disorder and adult antisocial behavior

Sex differences in the genetic and environmental influences on childhood conduct disorder and adult antisocial behavior were examined in a large community sample of 6,383 adult male, female, and opposite-sex twins. Retrospective reports of childhood conduct disorder (prior to 18 years of age) were obtained when participants were approximately 30 years old, and lifetime reports of adult antisocial behavior (antisocial behavior after 17 years of age) were obtained 8 years later. Results revealed that either the genetic or the shared environmental factors influencing childhood conduct disorder differed for males and females (i.e., a qualitative sex difference), but by adulthood, these sex-specific influences on antisocial behavior were no longer apparent. Further, genetic and environmental influences accounted for proportionally the same amount of variance in antisocial behavior for males and females in childhood and adulthood (i.e., there were no quantitative sex differences). Additionally, the stability of antisocial behavior from childhood to adulthood was slightly greater for males than females. Though familial factors accounted for more of the stability of antisocial behavior for males than females, genetic factors accounted for the majority of the covariation between childhood conduct disorder and adult antisocial behavior for both sexes. The genetic influences on adult antisocial behavior overlapped completely with the genetic influences on childhood conduct disorder for both males and females. Implications for future twin and molecular genetic studies are discussed.     

MAOA and male antisocial behavior: A review

Of all the risk factors for the development of antisocial behavior, “maleness” is by far the most robust predictor. Among the numerous biological factors that have been identified as increasing risk for antisocial behavior, one of the most well-supported has inexplicably received very little attention with regard to implications for explaining why maleness is such a robust predictor. That factor is the low activity form of the monoamine oxidase-A gene. A major reason for this inattention to the MAOA-L gene appears to be the failure to appreciate that its location on the X chromosome reflects the enormous biological disadvantage of the male compared to the female. This article, after presenting a brief overview of the research which establishes that MAOA-L is one of the most well-supported biological risk factors for antisocial behaviors, explained how the enormous male biological disadvantage related to the sex difference in the prevalence of MAOA-L and thus helped explain why maleness is the most robust predictor of antisocial behavior.     

Preventing antisocial behavior in the schools

Multiple correlates and determinants of antisocial behavior within the home, community, and school are reviewed. Due to the school's pivotal role in our society, an emphasis is placed on how our schools contribute to antisocial behavior, and what educators can do to prevent anti-social behavior and related attendance problems. A variety of contextual factors and setting events within our schools appear to be major contributors to antisocial behavior, and some of the same factors identified within the schools also have been identified within the home. These setting events, rather than quick restrictive fixes, must be given more attention if we are to provide safe school environments-environments that durably prevent antisocial behavior and related attendance problems.     

Factors Influencing the Development of School Bonding Among Middle School Students

The goal of this research is to examine the trajectory of school bonding over the middle school period and how factors such as gender, substance use, antisocial peers, delinquent behavior, and academic achievement affect this developmental process. Data from 4 waves of measurement of 2,902 adolescents are analyzed using hierarchical growth curve modeling. Results suggest that school bonding decreases in a non-linear fashion from Grade 6-8. However, school bonding development varies based on inter-individual differences. Boys have lower initial levels and greater decreases in school bonding than girls. Student deviant behavior, having antisocial peers, and low academic achievement are associated with lower levels of school bonding at Grade 6. Low grades and an increase in substance use are associated with a steeper decrease of school bonding over time. Increases in substance use and being male are also associated with a curvilinear pattern of school bonding. Implications for interventions are discussed.     

Age-of-Onset or Behavioral Sub-Types? A Prospective Comparison of Two Approaches to Characterizing the Heterogeneity within Antisocial Behavior

There are two common approaches to sub-typing the well-documented heterogeneity within antisocial behavior: age-of-onset (i.e., childhood-onset versus adolescence-onset; see Moffitt 1993) and behavioral (i.e., physical aggression versus non-aggressive rule-breaking). These approaches appear to be associated, such that aggression is more characteristic of childhood-onset antisocial behavior whereas rule-breaking is linked to both child- and adolescence-onset antisocial behavior. However, it remains unclear which approach, if either, better explains the heterogeneity within antisocial behavior. We examined this question in a prospective sample of male twins, assessed at the ages of 11, 14, 17, and 24 years. Although the age-of-onset subtypes predicted adult antisocial behavior in the expected direction when analyzed alone, this association dissipated once we controlled for aggression and rule-breaking. Such findings suggest that the behavioral sub-types of antisocial behavior may be a stronger predictor of later antisocial outcomes than is its age-of-onset.     

Men,shame and antisocial behavior: A psychodynamic perspective

This paper discusses the psychosocial factors that contribute to male antisocial behavior. The role of shame and related affects is emphasized. Compensatory defenses associated with these affects are also described. Developmental concepts are reviewed in the light of recent research. Finally, some of the issues involved in doing psychotherapy with this population are discussed, with an emphasis on the value of group therapy.Parts of this paper were presented at the second annual conference onCulture, Race and Ethnicity in Group and Family Therapy which was sponsored by the Eastern Group Psychotherapy Society and New York University and was held in New York City, March 20–22, 1987.     

Structural and functional MRI- findings in children and adolescents with antisocial behavior

BACKGROUND: The developmental course of children with conduct disorder (CD) is heterogeneous. Especially children who exhibit symptoms early in their lifetimes are characterized by a negative outcome. Neurobiological aspects of CD have been investigated in these children but little is known about structural and functional brain aberrations. METHODS: We describe the developmental taxonomy of children with CD and focus on those with the early onset subtype. Structural MRI data of these children and antisocial adults are recapitulated. The impact of investigating neurobiological underpinnings of antisocial behavior and how this might contribute to future forensic and psychiatric assessments is discussed. RESULTS/ CONCLUSION: Children display similar structural aberrations of fronto-limbic structures to adults with antisocial behavior, and amygdala dysfunction might be closely related to dysregulated emotions. Though the investigation of biological factors in antisocial subjects has made great progress in recent years, today MRI is still a rather complex, expensive and indistinct method for forensic assessment.     

From correlates to causes: can quasi-experimental studies and statistical innovations bring us closer to identifying the causes of antisocial behavior?

Longitudinal, epidemiological studies have identified robust risk factors for youth antisocial behavior, including harsh and coercive discipline, maltreatment, smoking during pregnancy, divorce, teen parenthood, peer deviance, parental psychopathology, and social disadvantage. Nevertheless, because this literature is largely based on observational studies, it remains unclear whether these risk factors have truly causal effects. Identifying causal risk factors for antisocial behavior would be informative for intervention efforts and for studies that test whether individuals are differentially susceptible to risk exposures. In this article, we identify the challenges to causal inference posed by observational studies and describe quasi-experimental methods and statistical innovations that may move researchers beyond discussions of risk factors to allow for stronger causal inference. We then review studies that used these methods, and we evaluate whether robust risk factors identified from observational studies are likely to play a causal role in the emergence and development of youth antisocial behavior. There is evidence of causal effects for most of the risk factors we review. However, these effects are typically smaller than those reported in observational studies, suggesting that familial confounding, social selection, and misidentification might also explain some of the association between risk exposures and antisocial behavior. For some risk factors (e.g., smoking during pregnancy, parent alcohol problems), the evidence is weak that they have environmentally mediated effects on youth antisocial behavior. We discuss the implications of these findings for intervention efforts to reduce antisocial behavior and for basic research on the etiology and course of antisocial behavior.     

Relationships Between Parental Negativity and Childhood Antisocial Behavior over Time: A Bidirectional Effects Model in a Longitudinal Genetically Informative Design

This study examined the direction and etiology underlying the relationships between parental negativity and early childhood antisocial behavior using a bidirectional effects model in a longitudinal genetically informative design. We analyzed parent reports of parental negativity and early childhood antisocial behavior in 6,230 pairs of twins at 4 and 7 years of age. Results from a cross-lagged twin model contribute to the understanding of the mechanisms underlying the bidirectional processes involved in parental negativity and childhood antisocial behavior. Specifically, the findings of this study suggest that the association between parenting and child antisocial behavior is best explained by both parent-driven and child-driven effects. We found support for the notion that parent's negative feelings towards their children environmentally mediate the risk for child antisocial behavior. We also found evidence of genetically mediated child effects; in which genetically influenced antisocial behavior evoke parental negativity towards the child.     

The Media and Violent Behavior in Young People: Effects of the Media on Antisocial Aggressive Behavior in a Spanish Sample1

This study discusses the relation between television, computer games, and the Internet and antisocial aggressive behavior in under‐18s. Given that the media are an important source of socialization for children, this research examines which variables in media exposure lead to antisocial behavior in under‐18s. A sample of 93 participants (male and female), aged 13–18, answered an antisocial behavior inventory and a survey on computer gaming and TV viewing. Results show gender differences in the relation between media use and preference for violent media and direct and indirect aggressive behaviors. These findings support the idea that lack of interaction and role taking leads to deprived socialization and, in turn, to antisocial behavior.     

Religiousness, antisocial behavior, and altruism: genetic and environmental mediation

Although religiousness is considered a protective factor against antisocial behaviors and a positive influence on prosocial behaviors, it remains unclear whether these associations are primarily genetically or environmentally mediated. In order to investigate this question, religiousness, antisocial behavior, and altruistic behavior were assessed by self-report in a sample of adult male twins (165 MZ and 100 DZ full pairs, mean age of 33 years). Religiousness, both retrospective and current, was shown to be modestly negatively correlated with antisocial behavior and modestly positively correlated with altruistic behavior. Joint biometric analyses of religiousness and antisocial behavior or altruistic behavior were completed. The relationship between religiousness and antisocial behavior was due to both genetic and shared environmental effects. Altruistic behavior also shared most all of its genetic influence, but only half of its shared environmental influence, with religiousness.     

Risk Factors for Misconduct in a Navy Sample

Understanding antisocial behavior and organizational misconduct is an important objective, because these maladaptive behaviors are disruptive and costly to organizations and to society as a whole. The objective of this study was to identify psychosocial risk factors for misconduct and antisocial behavior in a sample of Navy personnel. A group of sailors (n = 158) who had engaged in significant misconduct were compared with a demographically similar group of sailors (n = 288) who had not engaged in misconduct and who were in good standing with the Navy. The psychosocial variables that emerged as the most important risk factors for antisocial behavior were alcohol use (odds ratio [OR] = 2.42), high impulsivity (OR = 2.20), high trait hostility (OR = 1.79), and antisocial behavior of friends (OR = 1.65). The implications of these results for the military and for research on antisocial behavior are discussed.     

Moral disengagement among serious juvenile offenders: a longitudinal study of the relations between morally disengaged attitudes and offending

The present study investigates the relation between moral disengagement-one's willingness to conditionally endorse transgressive behavior-and ongoing offending in a sample of adolescent male felony offenders (N = 1,169). In addition, the study attempts to rule out callous-unemotional traits as a third variable responsible for observed associations between moral disengagement and offending. A bivariate latent change score analysis suggests that reduction in moral disengagement helps to speed decline in self-reported antisocial behavior, even after adjusting for the potential confound of callous-unemotional traits. Declines in moral disengagement are also associated with declining likelihood of offending, based on official records. Given that both moral disengagement and offending tend to decrease over time, these findings suggest that changing attitudes toward antisocial behavior contribute to desistance from offending among delinquent youth.     

Infectious and immune factors in the pathogenesis of neurodevelopmental disorders: epidemiology, hypotheses, and animal models

Both genetic and environmental factors contribute to the pathogenesis of a wide variety of neurodevelopmental disorders, including autism, mental retardation, and schizophrenia. Some heritable disorders approach 100% penetrance; nonetheless, even in these disorders, subtle aspects of clinical disease expression may be influenced by the environment. In other disorders with genetic influences, exogenous factors, and the timepoint(s) during nervous system development at which they are introduced, modulate expression of disease. Elucidation of the mechanisms guiding this intricate interplay between host response genes, environmental agents, and the neurodevelopmental context within which these interactions occur, is necessary to understand the continuum of clinical outcomes. This chapter will review the evidence that infectious and immune factors may contribute to the pathogenesis of neurodevelopmental disorders, describe an animal model of neurodevelopmental disorders based upon viral infection, identify processes by which neural circuitry may be compromised, and outline areas for future research.     

The prediction of violent and nonviolent criminal behavior in a methadone maintenance population

The utility of traits associated with Antisocial Personality Disorder in making risk assessments of violent and nonviolent crimes was examined in 254 subjects sampled from a methadone maintenance population. A factor analysis of a number of baseline measures resulted in five factors measuring hostility, insecure attachment, impaired reality testing, antisocial personality, and empathy. These factors were used in logistic regression analysis to predict charges for violent and nonviolent crimes over a 2-year period. Individuals with high scores on the antisocial personality factor had an increased risk of both violent and nonviolent criminal charges. Individuals with low scores on the empathy factor were at high risk for violent crimes. In an analysis using the factor components rather than the factors, the measures of perspective-taking and a socialization were associated with violent criminal charges, and the measure of psychopathy, but not antisocial behavior, was associated with nonviolent criminal charges. The results support the use of measures of personality traits in addition to measures of a history of antisocial behavior in making violence risk assessments in substance-dependent patients. The DSM construct and diagnosis of Antisocial Personality Disorder may be enhanced by greater emphasis on personality traits associated with antisocial behavior.     

The Genetic and Psychophysiological Basis of Antisocial Behavior: Implications for Counseling and Therapy

The notion that crime may have a genetic and biological basis has been resisted due to the assumption that this view necessitates a deterministic attitude to crime. This article argues that this assumption is unwarranted, and that an understanding of the genetic and psychophysiological basis of crime and antisocial behavior has important implications for counselors dealing with antisocial individuals. The interaction between genetic and environmental factors suggests that environmental changes may reduce the expression of any genetic predisposition. Psychophysiological factors interact with social factors in producing antisocial behavior, and recent psychophysiological studies have identified enhanced attentional ability in antisocial individuals that can be capitalized on by counselors in diverting clients from an antisocial way of life.     

Commentary: causal processes leading to antisocial behavior

Conceptual, and empirical, questions are raised regarding the notion that physical aggression is the main individual risk factor for antisocial behavior, that language impairment also constitutes a risk factor, the meaning of the male preponderance for antisocial behavior, the findings on environmentally mediated risk; the role of biosocial interplay; social context effects; the construct of antisocial behavior, developmental trends; processing of experiences; and transactional effects. The main blocks to using research to develop policy are the lack of evidence on (a) the mediators of the causal processes, (b) what is needed to bring about change, (c) ways to ensure that individuals who need interventions actually receive them, and (d) differences in levels of antisocial behavior.     

An evolutionary hypothesis of suicide: why it could be biologically adaptive and is so prevalent in certain occupations

From an evolutionary perspective, suicide is a puzzle, because it has serious adverse effects, yet is remarkably common and heritable. An hypothesis is proposed to explain this puzzle, by explaining how suicide could be adaptive through reducing risk that individuals will transmit infections to kin. Empirical evidence supports four predictions from the hypothesis. There are well-established mechanisms by which infections and immune factors increase risk for mental disorders that contribute to suicide. Suicide is more prevalent in occupations with greater exposure to infection and immune-compromising factors and at higher latitudes, where key environmental factors increase vulnerability to infection. In several other highly social species, suicide-like behaviors have evolved to reduce transmission of infections. If the hypothesis is correct, detection and treatment of underlying infections and immune dysfunction should help predict and prevent suicidal behavior, while also combating spread of infectious diseases.     

Romantic relationships of young people with childhood and adolescent onset antisocial behavior problems

Using prospective longitudinal data from the Christchurch Health and Development Study, this paper examines the extent to which early onset, life course persistent and adolescent limited antisocial behavior problems place young people at risk of violent and unsatisfactory romantic relationships in early adulthood. Results revealed the presence of clear linear associations between the developmental timing of antisocial behavior and later partnership risks, with these risks including partner violence perpetration and victimization, interpartner conflict, and increased ambivalence about the relationship. Young people with childhood onset antisocial behavior problems reported higher rates of partnership difficulties than young people with adolescent limited antisocial behavior problems, while those with adolescent limited antisocial behavior reported higher levels of partnership difficulties than young people without a history of antisocial behavior problems. These associations persisted even after extensive control for a range of social, family, and individual factors that were correlated with the timing of antisocial behavior. Results highlight the importance of distinguishing between early and late onset antisocial behavior, and provide further support for existing life course models of the development of antisocial behavior problems in children and adolescents.