Radial arm maze performance of mice: acquisition and atropine effects

CD-1 mice were successfully trained in a six-arm radial maze in which half of the arms were baited, a procedure which had been used to differentiate between reference and working memory. Stable performance was achieved following eight daily training sessions, as measured by decreasing running time and number of errors. This finding strengthens the foraging hypothesis as a basis for the performance of rodents in the radial maze. Acute subcutaneous administration of the cholinergic antagonist atropine sulfate (1-6 mg/kg) to trained mice produced dose-related increases in running time and working memory errors, with a slight decrease in reference memory errors. This is in agreement with other studies on the role of the cholinergic system in memory processes. The peripheral cholinergic blocker, atropine methyl nitrate (4 mg/kg), somewhat increased running time without decreasing performance accuracy. In contrast to the prolonged pharmacological and physiological effects of atropine, behavioral decrements disappeared within 3 hr. It is concluded that mice trained in the radial arm maze may be used for screening of the effects of drugs on cognitive function.     

Stimulus control of spatial behavior on the eight-arm maze in rats

Rats were trained on an eight-arm, elevated radial maze in a large cylindrical chamber where extramaze stimuli could be manipulated. The first experiment indicated that rats could use extramaze stimuli to locate the arms if such stimuli were available, whereas they performed less effectively and tended to employ response chaining if these stimuli were not available. The second experiment demonstrated that maze performance was disrupted by transposition of the stimuli but was relatively unaffected by rotation of the same stimuli. The third experiment suggested that the disruptive effect of stimulus transposition might be due to a “resetting” process elicited by the alteration in the configuration of the stimuli after stimulus transposition. These results suggest that when extramaze stimuli are available, rats tend to use such stimuli in a configurational manner to locate the arms rather than as a list of items processed independently of their spatial relationships to each other.     

Within-trial dynamics of radial arm maze performance in rats

The behavior of rats while solving a 12-arm radial maze was investigated using measures of response bias, choice latencies, and behavioral organization. Response bias decreased as a function of choice number, while the amount of time spent on the center platform between choices increased substantially during the last few choices. This increase in time between choices was largely accounted for by increases in investigatory behavior in the area of the doors leading to the arms. These data indicate that the processes involved in radial maze performance change over the course of each trial. As the choice sequence progresses, there is an increasing reliance on the use of information in memory, and a corresponding decrease in the use of response algorithms. In addition, the mean time taken to run down the chosen arm was shorter for correct choices than for incorrect choices, suggesting that arms are sometimes chosen despite a lowered expectation of finding food.     

Spatial memory and radial arm maze performance of rats

Rats were tested on an elevated radial maze for their ability to choose each of 17 different arms once without repeating any choices. The first experiment indicated that the animals performed well, choosing an average of more than 14 different arms in the first 17 choices. Subsequent experiments demonstrated that: (a) response patterns, general algorithms, or intramaze markings were not necessary for correct choices: (b) there was interference among choices within a test so that the probability of a correct response decreased as the number of choices increased; (c) there was no serial-order effect (primacy or recency); (d) animals tested in a procedure which did not require prior shaping showed no evidence of a general predisposition not to repeat choices. The results are discussed in terms of capacity, accuracy, and other characteristics of working spatial memory.     

Stimulus effects on concurrent performance in transition

Six experimentally naive pigeons were exposed to concurrent variable-interval variable-interval schedules in a three-key procedure in which food reinforcement followed pecks on the side keys and pecks on the center key served as changeover responses. In Phase 1, 3 birds were exposed to 20 combinations of five variable-interval values, with each variable-interval value consistently associated with a different color on the side keys. Another 3 pigeons were exposed to the same 20 conditions, but with a more standard procedure that used a nondifferential discriminative stimulus on the two side keys throughout all conditions. In Phase 2, the differential and nondifferential stimulus conditions were reversed for each pigeon. Each condition lasted for one 5-hr session and one subsequent 1-hr session. In the last 14 conditions of each phase, the presence of differential discriminative stimuli decreased the time necessary for differential responding to develop and increased the sensitivity of behavior to reinforcement distribution in the 1st hr of training; during the last hours of training in each condition, however, the effects of the differential discriminative stimuli could not be distinguished from the effects of reinforcement distribution per se. These results show the importance of studying transitions in behavior as well as final performance. They may also be relevant to discrepancies in the results of previous experiments that have used nonhuman and human subjects.     

Stimulus perseveration in a water maze following exposure to controllable and uncontrollable shock

When placed in a water-filled maze, mice display a pronounced preference for the illuminated over the nonilluminated arm of the maze. Exposure to inescapable shock increased the time spent in the illuminated arm of the maze, and decreased the frequency of entries into the nonilluminated arm. When animals that had received shock entered the nonilluminated arm they exhibited more activity per second than nonstressed animals. Controllability over the stressor enhanced the preference for the illuminated arm; however, the contribution of this variable was dependent on the number of shock trials mice received. Following 180 escapable or inescapable shock presentations the preference for the illuminated arm was enhanced. The propensity to approach the illuminated arm declined following a greater number (360) of escapable shock trials, while the preference for the illuminated arm did not decline in mice that received inescapable shock. Both escapable and inescapable shock were also found to produce a transient disruption of discrimination performance in a task where animals were required to emit a contraprepared response (swim to dark), whereas these treatments were without effect on performance of the highly prepared response of approaching the illuminated arm. It is provisionally suggested that enhancement of the perseveration represents an innate response to stressful stimuli, but as animals learn mastery over the response contingencies, the persistence in adopting such a response strategy wanes. Moreover, despite the differential effects of escapable and inescapable shock on the perseverative tendency, discrimination accuracy may not be differentially affected by these treatments in a task where acquisition progresses quickly and where explicit cues are associated with the correct and incorrect arms of the maze.     

Stimulus selection and memory strategies in concept problems

Ss were allowed to use zero, one, two, four, or eight markers to signify the category (positive or negative) of previously selected stimuli in an attribute identification problem. The more markers available and used, the fewer trials were required for problem solution. Ss were indifferent to marker valence (positive or negative) in disjunctive problems but showed a definite preference for (the more informative) negative markers in conditionals. Performance of Ss was correlated with their tendency to move markers from lesser to more informative instances. An interpretation of results based on individual differences in information processing activities is suggested.     

Stimulus selection and the number of stimulus components

The number of word components in the compound stimuli of paired-associate lists were varied, and the words within a compound were presented either in a constant or in a variable order from trial to trial. The number of components, above one, had no appreciable effect on the difficulty of learning, and the variable order lists were more difficult than the constant order. Recall with the word components as cues showed that the amount of selection decreased with the variable order lists as the number of components increased. With the constant order lists, selection tended to remain constant as number of components increased. This was interpreted as the result of the availability of a rule for selection in the constant order conditions.     

Stimulus suffix effects in recognition memory

Recall of auditory items can be disrupted by presentation of an irrelevant auditory stimulus (a stimulus suffix). Previous researchers have suggested that suffix effects are not found on recognition tests. Two experiments are presented here that demonstrate suffix effects on recognition tests. These results suggest that suffixes interfere with item information and that suffix effects cannot be attributed solely to retrieval processes.     

Golden hamsters on the eight-arm maze in light and darkness: The role of dead reckoning

This paper examines whether golden hamsters can rely on dead reckoning (getting positional information from updated signals generated during locomotion) on an eight-arm maze. Two groups of hamsters were tested: Group L under ordinary room light, Group D in darkness. To enhance the role of dead reckoning, each subject could climb from its own home cage onto the central platform of the maze. In a first experimental phase (15 trials), the L subjects learned to master the maze through developing a locomotor rule (arm chaining) after three to four trials. The D subjects developed arm chaining less readily and fluctuated more in their performance than did the L subjects. In a second experimental phase (15 trials), four arms were blocked at the beginning of each trial. In both experimental groups the performance decreased, yet remained well above chance level. Success and arm chaining were positively correlated in Phase 1 and negatively correlated with success in Phase 2. We assume that in Phase 2 the L subjects switched to the predominant use of visual cues, and the D subjects to dead reckoning.     

Domestic dogs (Canis familiaris) and the radial arm maze: Spatial memory and serial position effects

The present study investigated spatial memory in domestic dogs (Canis familiaris) through the use of a radial arm maze. The study consisted of a total of three separate experiments. In the first two experiments, the ability of the dogs to successfully remember previously unentered arms was evaluated. The third experiment was similar to the first two, but also examined the nature of the serial position effect. Performance in all three experiments was better than expected solely by random choices. Dogs showed a much better memory for spatial locations presented earlier in a spatial list compared with those presented in the middle. Based on the present results, we suggest that the radial arm maze assesses canine spatial memory and that dogs show a primacy effect. (PsycINFO Database Record (c) 2012 APA, all rights reserved).     

5HT antagonists attenuate MK801-impaired radial arm maze performance in rats

Glutamatergic hypofunction occurs in Alzheimer's disease (AD). MK801, a noncompetitive blocker of glutamate N-methyl-D-aspartate receptors, was used to disrupt the cognitive performance of rats trained on a delayed nonmatching to sample radial maze task. Drugs which act by blocking serotonin (5-HT) receptors were evaluated for their ability to reduce the cognitive impairment produced by MK801. Specifically, WAY-100635, a selective 5-HT1A receptor antagonist, buspirone, a 5-HT1A partial agonist, ritanserin, a 5-HT2 antagonist, and ondansetron, a 5-HT3 antagonist, were assessed. In addition, the muscarinic agonist arecoline was evaluated for its potential cognitive benefit in this model. It was found that WAY-100635 significantly reduced the cognitive impairment induced by MK801. Treatment with single doses of ritanserin, ondansetron, or arecoline in combination with MK801 did not result in a cognitive impairment, indicating that these drugs attenuated the MK801 impairment. The combination of buspirone and MK801 resulted in an inability of the animals to complete the task. These results suggest that interactions between 5-HT and glutamate may mediate the beneficial effects of reducing cognitive impairment and that 5-HT antagonists, especially selective 5-HT1A antagonists, may be useful in treating AD. Further, it is indicated that the MK801 model of cognitive impairment may add to the armamentarium of tools available to predict treatment efficacy in AD.     

Performance of normal and neurological mutant mice on radial arm maze and active avoidance tasks

The objectives of the present study are to assess the import of gene-imposed structural alterations on behavioral performance and obtain performance data preliminary to studies of experimental mouse chimera behavior. Reeler, staggerer, and weaver neurological mutant, and control B6C3 and ichthyosis mice were tested on radial arm maze and active avoidance tasks. Weaver mice had incapacitating seizures while performing the radial arm maze task and were, therefore, removed from further testing. Staggerer mice displayed a significant deficit on both tasks compared to control mice. Homozygous reeler mice (rl/rl) also had a significant deficit on the active avoidance task compared to +/rl control mice but not significantly poorer than ichthyosis mice. However, their performance on the radial arm maze task, while initially poor, improved so that they performed the task similar to wild-type controls. Three of the reeler mice reached criterion for solving the radial arm maze task. None of the staggerer mice reached criterion. These data are discussed in terms of the value of using neurologically mutant mice in dissecting structural-functional relationships. It is suggested that the behavior of these mutants might point toward specific components of cerebellar involvement in behavioral acts.