人类颞叶皮层与视、听信息加工:Ⅱ.左颞叶癫痫病人的脑事件相关电位

记录7名左颞叶癫痫病人和9名正常人在四种实验条件下的事件相关电位：（1）听觉脑子诱发电位,（2）红色闪光刺激,（3）陌生人嗓音识别,（4）陌生人面孔识别。实验结果发现,两组被试在视觉信息加工中无差异,在嗓音识别中病人的N150和P300波潜伏期大于正常人,表明其复杂听觉认知功能受到影响．红色闪光刺激和噪音识别条件下,病人的P100波幅大于正常人,说明病人对强刺激的物理强度有较高的反应水平,不易习惯化。     

人类颞叶皮层与视,听信息加工:II.左颞叶癫痫病人的脑事件相关电位

记录７名左颞叶癫痫病人和９名正常人在四种实验条件下的事件相关电位：（１）听觉脑干诱发电位,（２）红色闪光刺激,（３）陌生人噪音识别,（４）陌生人面孔识别。实验结果发现,两组被试在视觉信息加工中无差异,在噪音识别中病人的Ｎ１５０和Ｐ３００波潜伏期大于正常人,表明其复杂听觉认知功能受到影响。红色闪光刺激和噪音识别条件下,病人的Ｐ１００波幅大于正常人,说明病人对强刺激的物理强度有较高的反应水平,不易习惯     

抑制控制在极小概率目标搜索任务中的作用

以往研究表明在视觉搜索任务中靶呈现的概率会显著影响搜索正确率, 尤其是在靶概率极小时, 漏报率极高。针对此现象存在截然不同的解释, 其中Wolfe等的“阈限”论最为盛行。本研究几个实验虽然验证了这一概率效应, 然而, 我们发现并不能将之归因于“阈限”变化, 相反, 这一效应的产生与抑制控制失败有直接的因果关系。在实验中, 如果要求被试按不同键对靶或非靶做出反应, 会因为非靶概率太高而产生优势反应, 导致漏报率较高; 相反, 当要求被试对靶进行计数或作标记时, 优势反应得到控制, 漏报率大幅度下降。另外, 本研究证明, 如果被试有较强控制优势反应的能力, 他们的搜索成绩也更好。这些结果说明, 抑制控制能力在靶概率较小的任务中会显著影响搜索正确率, 如果采用恰当的反应方式和招募有较强抑制控制能力的靶检测人员均能有效避免漏报错误。     

诱发ERP的概率对P3和RT影响的实验研究

脑事件相关电位(ERP)特别是其内源性的P3(或称P300)成分,与认知过程密切相关,能够反映人脑信息加工的过程,是“窥视”心理活动内容的一个“窗口”。但是在对ERP的研究过程中,诱发ERP的刺激模式及其各种参数的设置,各个实验室却不尽相同,特别是靶刺激(Ts)和非靶刺激(NTs)的概率问题是P3所有变量中最主要的问题。在诱发     

驾驶疲劳对听觉注意影响的ERP研究

目的:探讨驾驶疲劳对于听觉注意的影响.方法:采用组间对照,对照组为12名充分休息的出租车司机,实验组为15名连续驾驶10h的司机.采用听觉Oddball范式,标准刺激:800Hz,概率80%;靶刺激:1000Hz,概率10%;新异刺激:计算机产生的噪声或其他声音,概牢10%.声音强度均为85dBL,刺激间隔(SOA)1000ms,刺激呈现时间100ms.要求被试对靶刺激按鼠标反应.结果:P3a分布以额中央区为主,驾驶疲劳后新异刺激引起的P3a潜伏期没有显著变化,幅值显著降低;P3b以中央顶区为主,驾驶疲劳后靶刺激引起的P3b潜伏期没有显著变化,幅值显著降低.结论:驾驶疲劳后听觉非随意注意能力、注意加工能力下降.     

自我相关信息的加工优势：来自网名识别的证据

以网名为材料, 通过三项视觉搜索实验考察了与自我相关的网络信息可能存在的加工优势。结果发现, 自己的网名在作为靶刺激时可以更快且更准确地被探测出来; 而在作为干扰刺激时, 其对于靶刺激却并未表现出比对照刺激更强的抑制作用。在与真实人名进行的直接比较中, 自己的网名与真实人名的加工成绩未出现显著差异, 且都好于作为对照的名人名字。这些结果证明了与自我相关的网络信息具有和物理世界中的自我信息相似的加工优势, 且与以真实人名为材料的多项实验结果完全一致, 从而表明自己的网名与真实人名可能具有相同的加工机制。     

事件提示和时间提示对新异干扰的影响—— 来自听视跨通道和听通道的证据

采用Oddball范式考察听视跨感觉通道和听感觉通道中“无关刺激”或“无关属性”的信号提示对新异干扰的影响。实验1和实验2分别比较了听视跨通道和听通道中时间事件提示、时间提示和事件提示三种条件。结果表明：(1)时间提示条件下新异干扰效应消失, 而事件提示条件下新异干扰效应仍存在。无关刺激意外变化引起的靶任务行为受损, 不仅与偏差刺激的小概率和新颖性有关, 而且与干扰刺激与靶子间提示信号关联有关, 这种提示关联中事件发生的提示功能比时间间隔的提示功能更为重要。(2)听通道下新异干扰与视听跨通道结果一致, 无关属性也会起到提示信号作用, 同样事件提示功能比时间提示功能更重要。     

视觉追踪作业心理负荷的多变量评估研究

敏感性是心理负荷测量技术可靠性的基本要求。该研究利用主任务绩效、次任务绩效、主观“加权负荷”评定和心率变异变化率四项指标,在计算机模拟情境下对视觉追踪作业心理负荷进行多变量评估实验。结果发现,以上述四项指标为基础建立的“综合加权评估指数”是一项较有效的评估指标,其敏感性远高于任何单独的评定。     

人视觉反应时的性别差异及分析

１前言微机技术的普及应用为探索和分析视觉反应时的性别差异提供了便捷有效的手段。２实验方法６７名生物系学生（男３５名,女３２名）接受了我们自编程序的微机视觉反应时的测验。受试者坐于距离１４英才显示屏约２５—３５ｃｍ前,注视屏幕中央,手触微机键盘的空格键应试。微机间隔２～５秒随机地显示边长约为４ｍｍ的“十”字光符。光符闪现在屏幕中央固定位置的测验称为ＦＩＸ测验,光符闪现在屏幕中线的左侧或右侧区域的测验称为ＲＡＮＤＯＭ测验。光符闪现时,微机同步计时。受试者受光符刺激后立即按动空格键,中断计时和光符显示…     

视觉搜索左右视野靶时脑两半球加工特点

研究视觉分别搜索在左右视野靶时,脑两侧前额叶视觉加工的机制。14名有偿被试参加实验。实验任务是从正圆中所存在的垂直方向的箭头,搜索出水平方向箭头,并判断箭头方向。靶所在左右视野经过镜面处理完全对应。结果发现当靶出现约220ms后左右两侧脑区ERP出现分叉点,靶对侧与靶同侧的前脑区相比有非常显著的负向电位活动,对侧和同侧的N2延续40-80ms。分析认为靶对侧前额脑区N2负向活动增强是注意的等级提高,聚焦点收窄,使所要加工的靶在主效应脑区(靶视野对侧脑区)“跃显”出来,在得到正反馈诱导的同时,也得到更多的资源,靶同侧脑区N2可能与中断或阻止其他无关信息的涌入有关。     

Methylphenidate influences on both early and late ERP waves of ADHD children in a continuous performance test

Although it has frequently been reported that hyperactive children have abnormally small P3 amplitudes of the event-related potential (ERP), which are normalized by the stimulant drug methylphenidate (MPH), the literature is inconsistent concerning earlier ERP waves. The aim of the present study was to investigate whether the normalizing effect of a 10-mg dose of MPH was also apparent on earlier waves, such as the N1, the P2, and the N2, besides the P3. Twelve attention deficit with hyperactivity disorder (ADHD) children performed a Continuous Performance Test involving a button-press response to the letter X (CPT-X) under the influence of MPH in a double-blind placebo controlled acute dosage design. ERPs were recorded at Oz, Pz, Cz, and Fz. The expected increase of the parietal P3, both to targets and nontargets, was apparent, as well as a significant increase in percentage of hits. There also was a significant increase of an earlier, negative going, wave, the N2, with a frontal maximum, under the influence of MPH. This wave was probably a manifestation of an increase in processing negativity for target stimuli only, after the intake of the stimulant drug. No effect of MPH was found on the N1 or the P2.     

GKT范式在确定犯罪嫌疑人中的应用：一项ERP测谎研究

刑事犯罪已成为当今各国面临的普遍性社会问题,因此急需可靠有效的测谎技术以适应当前打击犯罪的严峻形势。本研究采用犯罪知识测试范式（Guilty knowledge test, GKT）,以犯罪嫌疑人为对象,以真实犯罪现场为素材,探究真实环境下与测谎探测相关的脑电指标（P300、CNV）的有效性和可靠性。行为数据显示,目标刺激的反应正确率显著小于探测和无关刺激,探测刺激的反应时显著小于目标刺激和无关刺激。脑电数据显示,相较于目标刺激和无关刺激,探测刺激诱发的P300波幅最大且P300的检出率为92.5%,而在CNV指标上目标刺激诱发的波幅最大, 无关刺激次之,探测刺激最小。结果表明,与CNV相比,P300能够有效检测被试所隐藏的犯罪细节信息,且检出率较高,稳定性较好,是一种较为可靠的测谎指标。     

卡通面孔分类与识别加工的ERP比较研究

通过ERP方法,考察卡通面孔分类（人和动物）的脑机制及其与卡通面孔识别（人与车）的差异。结果表明,分类任务中,动物面孔VPP潜伏期显著长于人,N170潜伏期主效应不显著、波幅半球效应显著,LPP波幅在顶叶和中央区最大;分类任务VPP和LPP波幅均显著大于识别。结论：卡通面孔分类比识别速度慢、强度大,消耗心理资源多。顶叶和中央区可能是执行分类任务的主要脑区,且加工人类面孔具有优势。面孔加工中结构编码和特征编码可能部分是并行的。     

Event-related potentials in adolescents with combined ADHD and CD disorder: a single stimulus paradigm

Some studies of the event-related potentials demonstrated a reduction of the voluntary component P3 (P300 or P3b) in youngsters with the attention deficit/hyperactivity disorder (ADHD) or in conduct disorders (CD), and a reduction of the automatic processing component, mismatch negativity, in patients with both ADHD and CD (ADHD+CD). Recently, a passive auditory P3 potential has been elicited by a single stimulus. We therefore tried this potential study in 20 healthy subjects and 20 teenagers with ADHD+CD to search for further evidence of the altered automatic cerebral processing in the latter. Subjects also answered a self-report Dimensional Assessment of Personality Pathology (DAPP). The patient group scored significantly higher on most DAPP traits that reflect problems of emotion control, showed significantly prolonged P2, N2, and P3, and reduced P3. In all subjects Stimulus Seeking was positively correlated with P3 latencies at Fz, Cz, and Pz, and with P3 amplitude at Cz. This study suggests that youngsters with ADHD+CD had pronounced emotion dysregulation, and prominent deficit in passive attention, as reflected by the automatic processing of auditory stimuli.     

Word-to-word variation in ERP component latencies: spoken words

Data were collected shedding light on the brain electrical activity underlying word recognition. Subjects listened to a list of 48 spoken words in six random orders under two instructional sets: first to "think about the meanings of the words," and second, to learn the list. The scalp EEG associated with hearing and identifying the words was recorded at F3, F4, Cz, P3, P4, Pz, and Oz. Standard within-subjects time-locked averaging across words showed a late negative-positive complex with N2-P3 topography, the negative component peaking around 480 msec, the positive component peaking around 830 msec. Averaging within words across subjects uncovered considerable latency variability in both components. Within-word N2 and P3 component latencies covaried with word durations and with the "recognition points" predicted for the words by the "cohort theory" of word recognition. N2 latencies corresponded closely to the "N400" effect elicited with semantically incongruous sentence-final spoken words. Implications for ERP investigations of language processing are discussed.     

语言熟练度对Stroop效应的影响——不平衡双语者的任务态fMRI研究

目的:探讨语言熟练度对Stroop效应的影响及其背后的脑机制。材料与方法:17位被试参与本研究。被试母语为汉语,第二语言为英语。在被试完成中英文的stroop色字的任务过程中对被试进行fMRI扫描。结果:在色字相一致的条件下,中文任务与英文任务相比,双侧背侧枕叶及右侧背外侧前额叶有更强的激活; 反向比较,双侧腹侧枕叶有更强的激活。在色字不一致的条件下,中文任务与英文任务相比,双侧背外侧前额叶、右侧枕下回有更强的激活; 反向比较,并无显著激活的脑区。此外,中文Stroop效应引起左侧额下回显著的激活。英文Stroop效应中,左侧额下回无显著激活。结论:结合前人研究,我们得出,语言熟练度影响了对注意控制有重要作用的背外侧前额叶以及与反应抑制有关的左侧额下回在Stroop任务中的参与程度,进而影响了Stroop任务的表现     

概率贴现和时间贴现在人脑中的分离

本研究运用ERP技术来检验概率贴现和时间贴现是否反映了相同的神经机制过程。在本研究中,我们在一个刺激中同时操纵概率贴现（风险vs.安全）和时间贴现（1个月后vs.今天）水平。通过对两个过程上的ERN以及全时间段的ERP分析来确定它们是否反映了相同的认知过程。结果发现,这两者在ERN上存在差异,同时这两个效应在ERP的时程和出现的电极点上都存在差异。这些差异表明这两者可能包含着不同的神经机制过程。     

Brain Function Associated with Cooccurring Trauma and Depression Symptoms in College Students

The goal of this pilot study was to determine if functional brain differences are present among individuals with high and low cooccurring trauma and depression symptoms. This pilot study examined how the P300 latency component of event-related potentials (ERPs), measured using electroencephalography (EEG) while participants performed a go/no-go task, might be associated with cooccurring self-report of trauma and depression symptoms in a sample of college students (N = 38). Alpha-corrected independent sample t tests revealed statistically significant differences in ERP P300 peak latencies between those in the high cooccurring trauma and depression symptoms group (n = 12) and those in the low group (n = 26) for all 3 midline electrode sites (Fz, Cz, and Pz). This pilot study provides preliminary evidence of differential brain functioning in individuals experiencing cooccurring trauma and depression symptoms. Accordingly, these findings support future research examining brain functioning in cooccurring symptoms.     

Founder of the Journal of Genetic Psychology

Fifteen college-level readers (2 men and 13 women) were given 34 passages from the Test of English as a Foreign Language (TOEFL) for reading. During reading, event-related potentials (ERPs) were recorded from the midline sites (Fz, Cz, and Pz) of the participants' scalps. The first 17 passages were read by the participants at their own natural rate (self-paced condition). The second 17 passages were read at a fast-paced rate determined by the fastest reading rate recorded on an adequately comprehended trial from the preceding passages. Results indicated that accelerating reading rate increased the readers' comprehension. Additionally, the increase in reading rate and improvement in comprehension were reflected in the ERP measures. This finding confirms this study's assumption that there is a disparity between reading ability and routine performance, and that this disparity is manifested in measures of neurocognitive functioning as reflected by the ERPs. Specifically, the ERP waveforms discriminated not only reading rate (specifically manifested by differences in speed of processing), but also the level of comprehension attained by the participants.     

Hemodynamic and electrophysiological relationship involved in human face processing: evidence from a combined fMRI-ERP study

Functional magnetic resonance imaging (fMRI) and event-related potential (ERP) experiments were conducted in the same group of subjects and with an identical task paradigm to investigate a possible relationship between hemodynamic and electrophysiological responses within the brain. The subjects were instructed to judge whether visually presented stimuli were faces or houses and then press the corresponding button. Functional MRI identified face- and house-related regions in the lateral and medial part of the fusiform gyrus, respectively, while ERP showed significantly greater N170 negativity for face than for house stimuli in the temporo-occipital electrodes. Correlation analysis between the BOLD signal in the fusiform gyrus and ERP parameters demonstrated a close relationship between the signal and both latency and amplitude of N170 across the subjects. These correlations may indicate that the variation in cognitive demand and hemodynamic responses during the face/house discrimination task is coupled with the variation of N170 peak latency/amplitude across the subjects. Thus, integrative analysis of spatial and temporal information obtained from the two experimental modalities may help in studying neural correlates involved in a particular cognitive task.