探讨人乳头瘤病毒L1蛋白功能及其临床意义

高危型别人乳头瘤病毒(HPV)感染在宫颈癌发生发展中具有重要作用.由于HPV L1蛋白结构特征及其精确的抗原特性,在粘附宿主细胞、识别病毒受体、协助病毒DNA的入胞转运中均发挥重要作用.检测患者宫颈损伤组织中L1蛋白的表达将有助于对患者是否具有传染性进行评估.本文将深刻思考HPV L1功能及其在感染机体并引发癌变的机制,以期更好的解读宫颈癌发病原理并最终应用于临床治疗.     

宫颈癌病因及预防

从哲学角度讨论宫颈癌的病因,思考临床工作中如何预防宫颈癌。宫颈癌的发生是内因外因综合作用的结果。实验与临床研究发现人类乳头瘤病毒（HPV）家族中的高危型HPV的持续感染是宫颈癌及其癌前病变发生的主要外因。本文将讨论HPV分型检测作为宫颈癌筛查系统的一个重要元素在预防宫颈癌发生中所处的地位。     

宫颈癌病因及预防

从哲学角度讨论宫颈癌的病因,思考临床工作中如何预防宫颈癌.宫颈癌的发生是内因外因综合作用的结果.实验与临床研究发现人类乳头瘤病毒(HPV)家族中的高危型HPV的持续感染是宫颈癌及其癌前痛变发生的主要外因.本文将讨论HPV分型检测作为宫颈癌筛查系统的一个重要元素在预防宫颈癌发生中所处的地位.     

HPV DNA整合、E2缺失与宫颈癌演变的关系

高危型人乳头瘤病毒（HPV）感染是宫颈癌发病的必要条件,而HPV DNA与宿主基因组的整合及由此导致的E2基因断裂可能是宫颈癌致癌机制的关键。本文将从HPV感染、病毒基因组与宿主染色体整合及宫颈癌的演变历程中以哲学视角思考HPV DNA整合、E2基因缺失及宫颈癌演变的辩证关系,以期更好地解读宫颈癌发病原理并最终应用于临床治疗。     

HPV DNA整合、E2缺失与宫颈癌演变的关系

高危型人乳头瘤病毒(HPV)感染是宫颈癌发病的必要条件,而HPV DNA与宿主基因组的整合及由此导致的E2基因断裂可能是宫颈癌致癌机制的关键.本文将从HPV感染、病毒基因组与宿主染色体整合及宫颈癌的演变历程中以哲学视角思考HPV DNA整合、E2基因缺失及宫颈癌演变的辩证关系,以期更好地解读宫颈癌发病原理并最终应用于临床治疗.     

高危型人类乳头瘤病毒对子宫颈癌筛查的意义

高危型人类乳头瘤病毒（HR—HPV）感染是宫颈癌发生的必要条件,本文就是否将HR—HPV纳入宫颈癌筛查进行探讨。通过对我院行宫颈癌筛查的2505例患者资料分析,结果显示对于经济条件良好或有宫颈癌高危因素的女性,细胞学检查（TCT）联合HR—HPV检测做为宫颈癌的初筛,其临床效益大于成本收益。     

高危型人类乳头瘤病毒对子宫颈癌筛查的意义

高危型人类乳头瘤病毒(HR- HPV)感染是宫颈癌发生的必要条件,本文就是否将HR- HPV纳入宫颈癌筛查进行探讨.通过对我院行宫颈癌筛查的2 505例患者资料分析,结果显示对于经济条件良好或有官颈癌高危因素的女性,细胞学检查(TCT)联合HR- HPV检测做为宫颈癌的初筛,其临床效益大于成本收益.     

人乳头瘤病毒与宫颈癌的关系及启示

分子流行病学明确表明某些特定型别的人乳头瘤病毒(HPV)感染是浸润性宫颈癌和宫颈上皮内病变的主要致病原因.在HPV与宫颈癌的关系研究中无时无刻不渗透着马克思主义哲学原理,从哲学的角度去思考将使我们更科学、更透彻地理解两者的关系.     

人乳头瘤病毒与宫颈癌的关系及启示

分子流行病学明确表明某些特定型别的人乳头瘤病毒（HPV）感染是浸润性宫颈癌和宫颈上皮内病变的主要致病原因。在HPV与宫颈癌的关系研究中无时无刻不渗透着马克思主义哲学原理,从哲学的角度去思考将使我们更科学、更透彻地理解两者的关系。     

宫颈癌病毒病因学说的确立及其发展

德国病毒学家Harald zur Hausen博士创立的宫颈癌人乳头瘤病毒（HPV）病因学说荣获2008年度诺贝尔生理学/医学奖。笔者从辩证唯物主义认识论角度,回顾了该学说的确立及其发展。宫颈癌将有望成为人类通过疫苗接种、筛查和早诊早治等综合措施来预防乃至消除的第一个恶性肿瘤。     

Personality factors and cervical premalignancy

The purpose of the study was to attempt a discrimination between stages of cervical premalignancy in terms of the four Eysenckian dimensions. It consisted of a quasi-prospective design applied to the presumed continuum of cervical premalignancy. The Ss were 88 women addressed by a physician or self-addressed for Pap smear examinations. Prior to the Pap smear they completed a demographic questionnaire and the Eysenck Personality Questionnaire providing scores of extraversion (E), neuroticism (N), psychoticism (P) and lie (L). By the Pap smear results there were four groups of women: healthy, suffering from vaginal or cervical inflammations, suffering from human papillomaviruses (HPV), and suffering from dysplasias or cervical intraepithelial neoplasms (CIN). ANOVA and discriminant analyses showed that the Eysenckian dimensions discriminated correctly with above chance significance between the groups, mainly between the healthy and inflammatory, on the one hand, and the HPV and CIN, on the other hand (on the basis of N and E scores), and less well between the healthy and inflammatory (on the basis of L scores), and least between the HPV and CIN (on the basis of P scores). As expected, in the healthy and inflammatory groups as compared with the HPV and CIN groups, N and P scores were higher whereas E and L scores were lower. The results indicate the correspondence between physiological and psychological characteristics and suggest especially the alternating relation between neuroticism and physical pathology.     

Using message framing to promote acceptance of the human papillomavirus vaccine.

OBJECTIVE: Use of message framing for encouraging vaccination, an increasingly common preventive health behavior, has received little empirical investigation. The authors examined the relative effectiveness of gain-versus loss-framed messages in promoting acceptance of a vaccine against human papillomavirus (HPV)-a virus responsible for virtually all cases of cervical cancer. DESIGN: Undergraduate women (N = 121) were randomly assigned to read a booklet describing the benefits of receiving (gain-framed message) or the costs of not receiving (loss-framed message) a prophylactic HPV vaccine. After reading the booklet, participants indicated their intent to obtain the HPV vaccine. MAIN OUTCOME MEASURE: A 5-item composite representing intentions to obtain the HPV vaccine. RESULTS: The effect of message framing on HPV vaccine acceptance was moderated by risky sexual behavior and approach avoidance motivation. A loss-framed message led to greater HPV vaccination intentions than a gain framed message but only among participants who had multiple sexual partners and participants who infrequently used condoms. The loss-frame advantage was also observed among participants high in avoidance motivation. CONCLUSION: Findings highlight characteristics of the message recipient that may affect the success of framed messages promoting vaccine acceptance. This study has practical implications for the development of health communications promoting vaccination.     

Public health, public trust and lobbying

Each year, infection with Human Papillomavirus (HPV) leads to millions of abnormal Pap smears and thousands of cases of cervical cancer in the US. Throughout the developing world, where Pap smears are less common, HPV is a leading cause of cancer death among women. So when the international pharmaceutical giant Merck developed a vaccine that could prevent infection with several key strains of HPV, the public health community was anxious to celebrate a major advance. But then marketing and lobbying got in the way. Merck chose to pursue an aggressive lobbying campaign, trying to make its new vaccine mandatory for young girls. The campaign stoked public mistrust about how vaccines come to be mandated, and now it's not just Merck's public image that has taken a hit. The public health community has also been affected. What is the lesson to be learned from this story? Public health communication relies on public trust.