Effects of d-amphetamine, cocaine, and phencyclidine on the acquisition of response sequences with and without stimulus fading.

In each of three components of a multiple schedule, monkeys were required to emit a different sequence of four responses in a predetermined order on four levers. Sequence completions produced food on a fixed-ratio schedule. Errors produced a brief timeout. One component of the multiple schedule was a repeated-acquisition task where the four-response sequence changed each session (learning). The second component of the multiple schedule was also a repeated-acquisition task, but acquisition was supported through the use of a stimulus-fading procedure (faded learning). In a third component of the multiple schedule, the sequence of responses remained the same from session to session (performance). At higher doses, d-amphetamine, cocaine, and phencyclidine decreased the overall rate of responding and increased the percent errors in all three components. At lower doses, however, the three drugs produced selective effects on errors. Errors were increased in the learning component at lower doses than those required to disrupt the behavior in the faded-learning component. The performance component tended to be the least sensitive to disruptive drug effects. The data are consistent with the view that stimulus fading can modulate the effects of drugs on acquisition.     

The effects of diazepam and triazolam on repeated acquisition and performance of response sequences with an observing response.

Drugs often disrupt the acquisition of new response sequences at doses that fail to disrupt the performance of a previously acquired response sequence. This selective drug effect may result from differences in the control exerted by the stimuli presented after each response in the acquisition and performance sequences. To examine the function of these stimuli, an observing procedure was incorporated into a multiple schedule of repeated acquisition and performance of response sequences, in which stimulus presentations were contingent upon an observing response. Three experiments were conducted with humans. Experiment 1 compared responding with and without the observing contingency. No difference was found in the overall percentage of errors across the two conditions. Within the observing condition, observing behaviour was maintained in the acquisition component as long as errors occurred, but was not maintained in the performance component. Experiment 2 examined whether a contingency that increased errors also would increase observing in both the acquisition and performance components. Specifically, reinforcer delivery in each component was contingent upon emitting 10 correct responses and one, two, or four errors. Observing responses increased in the acquisition component as the error requirement increased, whereas observing responses in the performance component increased only when the error requirement was four. Experiment 3 assessed the effects of diazepam (0, 7.5, 15, and 30 mg/70 kg, p.o.) and triazolam (0, 0.375, and 0.75 mg/70 kg, p.o.) on repeated acquisition and performance baselines with the observing contingency. Selective drug effects were obtained in this modified procedure; that is, the percentage of errors in the acquisition component increased at doses that failed to affect the percentage of errors in the performance components. Importantly, drug effects were selective, even though observing responses were not emitted in the performance component and, hence, the stimulus presentations did not occur in that component. These findings suggest that alternative explanations for these differential effects are needed; in that regard, a response-unit account of the selective drug effects is discussed.     

The emergence of conditioned reinforcement from observation

We report an experiment in which observations of peers by six 3-5-year-old participants under specific conditions functioned to convert a small plastic disc or, for one participant, a small piece of string, from a nonreinforcer to a reinforcer. Prior to the observational procedure, we compared each participant's responding on (a) previously acquired performance tasks in which the child received either a preferred food item or the disc (string) for correct responses, and (b) the acquisition of new repertoires in which the disc (string) was the consequence for correct responses. Verbal corrections followed incorrect responses in the latter tasks. The results showed that discs and strings did not reinforce correct responses in the performance tasks, but the food items did; nor did the discs and strings reinforce correct responses in learning new repertoires. We then introduced the peer observation condition in which participants engaged in a different performance task in the presence of a peer who also performed the task. A partition blocked the participants from seeing the peers' performance. However, participants could observe peers receiving discs or strings. Participants did not receive discs or strings regardless of their performance. Peer observation continued until the participants either requested discs or strings repeatedly, or attempted to take discs or strings from the peers. Following the peer observation condition, the same performance and acquisition tasks in which participants had engaged prior to observation were repeated. The results showed that the discs and strings now reinforced correct responding for both performance and acquisition for all participants. We discuss the results with reference to research involving nonhuman subjects that demonstrated the observational conditioning of reinforcers.     

Enhancement of conditioned reinforcement by uncertainty

Pigeons were trained in three conditions. In the baseline condition, the birds responded on a fixed-interval schedule with the response key white. When the interval was completed, the key turned either red or green for a delay interval that was terminated by a grain presentation dependent on no key pecks during the final 2 sec. In the uncertainty condition, no grain was presented at the end of the delay periods when the key was red. In the certainty condition, the white light appeared only on occasions when pecking would turn the key green and produce food. Otherwise, the key was illuminated red throughout the total time period. The highest response rate in white occurred in the uncertainty condition, the next highest in the certainty condition, and the lowest in baseline. The results suggest that uncertainty facilitated responding, although uncertainty is not a necessary condition for conditioned reinforcement.     

Uncertainty reduction, conditioned reinforcement, and observing

In a concurrent-chains procedure, pigeons chose between equivalent mixed and multiple fixed-interval schedules of reinforcement. In the first experiment, preference for the multiple schedule was higher when the probability of the shorter fixed interval was less than .50 than for complementary points, an outcome consistent with the delay-reduction hypothesis of conditioned reinforcement and observing, but inconsistent with the uncertainty-reduction hypothesis which requires symmetrical preferences with a maximum when the two intervals are equiprobable. A second experiment assessed preference for equivalent mixed and multiple schedules when each choice outcome resulted in two reinforcements, one on the longer and one on the shorter fixed interval. The order of the two fixed intervals was determined probabilistically. Pigeons again preferred multiple to mixed schedules, although multiple-schedule preference did not vary systematically with the likelihood of the shorter fixed interval occurring first. The results from these choice procedures are consistent with those from the observing-response literature in suggesting that the strength of a stimulus cannot be well described as a function of the degree of uncertainty reduction the stimulus provides about reinforcement.     

An experimental analysis of the effects of d-amphetamine and cocaine on the acquisition and performance of response chains in monkeys.

In one component of a multiple schedule of food presentation, monkeys acquired a different four-response chain each session by responding sequentially on three keys in the presence of four geometric forms (learning). In the other component, the four-response chain was the same each session (performance). Both d-amphetamine and cocaine, at the higher doses, disrupted the behavior in the learning component; the overall response rate decreased, the overall accuracy was impaired (i.e., percent errors increased), and there was less within-session error reduction. The performance component was generally less sensitive than the learning component to the disruptive effects of both drugs on rate and accuracy. After pre-feeding or during an extended session, the response rate decreased in both components, but accuracy was generally unaffected. When the four discriminative stimuli in both components were removed, the behavior was disrupted to a greater extent in the performance component. The disruptive effects of both drugs on behavior in the learning component were attenuated when the drugs were administered during the session after the response chain had been acquired. It was concluded that the greater sensitivity of the learning component to disruptive drug effects is related to the relatively weak stimulus control and/or the lower rate of reinforcement associated with that component.     

The paradox of preference for unreliable reinforcement: The role of context and conditioned reinforcement

We discuss Belke and Spetch's (1994) work on choice between reliable and unreliable reinforcement. The studies by Belke and Spetch extend a line of basic research demonstrating that under certain experimental conditions in a concurrent chains procedure, pigeons prefer an alternative that produces unreliable reinforcement. The authors describe the variables that influence preference for unreliable reinforcement, including the signaling and the duration of the reinforcement schedules, the context in which the signaling stimuli occur, and the effects of conditioned reinforcement. Hypothetical applied examples that address these variables are provided, and their influence on preference for unreliable reinforcement in humans is discussed. We conclude by suggesting a line of applied research to examine the relationship between these variables and a preference for unreliable reinforcement.     

Effects of delayed conditioned reinforcement in chain schedules.

The contingency between responding and stimulus change on a chain variable-interval 33-s, variable-interval 33-s, variable-interval 33-s schedule was weakened by interposing 3-s delays between either the first and second or the second and third links. No stimulus change signaled the delay interval and responses could occur during it, so the obtained delays were often shorter than the scheduled delay. When the delay occurred after the initial link, initial-link response rates decreased by an average of 77% with no systematic change in response rates in the second or third links. Response rates in the second link decreased an average of 59% when the delay followed that link, again with little effect on response rates in the first or third links. Because the effect of delaying stimulus change was comparable to the effect of delaying primary reinforcement in a simple variable-interval schedule, and the effect of the unsignaled delay was specific to the link in which the delay occurred, the results provide strong evidence for the concept of conditioned reinforcement.     

Effects of cocaine and d-amphetamine on the repeated acquisition and performance of conditional discriminations.

The acute and chronic effects of cocaine and d-amphetamine on food-reinforced behavior were investigated in pigeons responding on a two-component multiple schedule. In one component, the behavioral task consisted of the same chain of conditional discriminations each session (performance). In the other component, the chain of conditional discriminations was changed from session to session (learning). In comparison to control sessions, both acute cocaine and d-amphetamine increased errors in each component of the multiple schedule. Responding in the learning component, however, was generally disrupted at lower doses than those that affected responding in the performance component. At high doses, both drugs produced pauses in responding in each component in three of the four subjects. Pausing engendered by d-amphetamine was approximately twice as long as that under cocaine. Upon chronic administration, both the pausing and error-increasing effects of each drug diminished. Drug-induced changes in timeout responding, however, did not decrease during chronic administration. Redeterminations of the d-amphetamine dose-effect curves following chronic cocaine administration suggested the existence of cross-tolerance between cocaine and d-amphetamine. Both the acute and chronic data are consistent with the view that conditions of stimulus control may modulate the behavioral effects of drugs.     

Devaluation of stimuli contingent on choice: evidence for conditioned reinforcement

Pigeons were presented a concurrent-chains schedule of reinforcement that had terminal links of equal duration. The initial links of the schedule were periodically interrupted by 15-s periods during which an extinction schedule was in effect. The extinction periods were presented on either a response-contingent or a noncontingent basis. Relative response rate for the left alternative decreased when the extinction periods were accompanied by the left terminal-link stimulus. Relative response rate for the right alternative decreased when the extinction periods were accompanied by the right terminal-link stimulus. Relative response rate varied inversely with the frequency of presentation of the extinction periods but was unaffected by presence versus absence of the response contingency in the schedule of extinction-period presentation. Furthermore, relative response rate was unaffected by presentation of extinction periods accompanied by a novel stimulus. When the extinction periods were presented after reinforcement in the left terminal link instead of as interruptions of the initial links, relative response rate for the left alternative was reduced if the postreinforcement extinction period was accompanied by the terminal-link stimulus for the left chain and reduced less if the extinction period was accompanied by the terminal-link stimulus for the right chain. The results demonstrate that the correlation between the terminal-link stimulus and extinction influenced the relative response rate in the initial link.     

Dual effects on choice of conditioned reinforcement frequency and conditioned reinforcement value

Pigeons were presented with a concurrent‐chains schedule in which the total time to primary reinforcement was equated for the two alternatives (VI 30 s VI 60 s vs. VI 60 s VI 30 s). In one set of conditions, the terminal links were signaled by the same stimulus, and in another set of conditions they were signaled by different stimuli. Choice was in favor of the shorter terminal link when the terminal links were differentially signaled but in favor of the shorter initial link (and longer terminal link) when the terminal links shared the same stimulus. Preference reversed regularly with reversals of the stimulus condition and was unrelated to the discrimination between the two terminal links during the nondifferential stimulus condition. The present results suggest that the relative value of the terminal‐link stimuli and the relative rate of conditioned reinforcer presentation are important influences on choice behavior, and that models of conditioned reinforcement need to include both factors.     

Preference for unreliable reinforcement in children with mental retardation: the role of conditioned reinforcement

We examined the effects of conditioned reinforcement on children's choice between reliable (100%) and unreliable (50%) reinforcement under various stimulus conditions in a concurrent-chains procedure. The study was conducted across three experiments. Experiments 1 and 2 were conducted under conditions similar to basic laboratory work and consisted of participants selecting from one of two black boxes (placed on a table) that were correlated with different reinforcement schedules. In Experiment 3, we assessed a participant's preference for unreliable reinforcement during conditions in which the target responses were aggression and mands. Results of the three experiments showed that the participants preferred unreliable reinforcement under certain conditions. Findings are discussed regarding the role of specific stimuli (i.e., items correlated with a reinforcement schedule, adult reactions) as conditioned reinforcers and how they may influence children's preference for a response (e.g., aggression, self-injury) that produces reinforcement on a leaner schedule than a socially desirable response (e.g., mands).     

Delayed reinforcement of fixed-ratio performance without mediating exteroceptive conditioned reinforcement

The performance of pigeons was studied under conditions in which the completion of a fixed-ratio requirement was not contiguous with the presentation of a reinforcer. Timein and timeout periods alternated throughout the experimental sessions. Responses made by an experimental bird during the timein period were accumulated, and when a fixed-ratio requirement had been met, grain was presented to the experimental bird and a yoked control following their first response in the next timein period. Across most manipulations of the fixed-ratio requirement and of the duration of the timeout period, the response rates of the experimental birds were considerably higher than those of their controls, suggesting that the response-reinforcer dependency controlled the behavior of the experimental bird in the absence of a close temporal association between responding on the ratio schedule and reinforcer presentations.     

Choice with probabilistic reinforcement: effects of delay and conditioned reinforcers.

Two experiments measured pigeons' choices between probabilistic reinforcers and certain but delayed reinforcers. In Experiment 1, a peck on a red key led to a 5-s delay and then a possible reinforcer (with a probability of .2). A peck on a green key led to a certain reinforcer after an adjusting delay. This delay was adjusted over trials so as to estimate an indifference point, or a duration at which the two alternatives were chosen about equally often. In all conditions, red houselights were present during the 5-s delay on reinforced trials with the probabilistic alternative, but the houselight colors on nonreinforced trials differed across conditions. Subjects showed a stronger preference for the probabilistic alternative when the houselights were a different color (white or blue) during the delay on nonreinforced trials than when they were red on both reinforced and nonreinforced trials. These results supported the hypothesis that the value or effectiveness of a probabilistic reinforcer is inversely related to the cumulative time per reinforcer spent in the presence of stimuli associated with the probabilistic alternative. Experiment 2 tested some quantitative versions of this hypothesis by varying the delay for the probabilistic alternative (either 0 s or 2 s) and the probability of reinforcement (from .1 to 1.0). The results were best described by an equation that took into account both the cumulative durations of stimuli associated with the probabilistic reinforcer and the variability in these durations from one reinforcer to the next.     

Factors influencing responding under multiple schedules of conditioned and unconditioned reinforcement

Two experiments examined pigeons' responses under multiple schedules of conditioned and unconditioned reinforcement. In one component, responses produced food according to a fixed-interval schedule; in a second component, responses produced brief stimuli according to a fixed-ratio schedule. When brief-stimulus presentations were paired with food in the first component, rates in the second component were usually higher than 10 responses per minute. When pairing in the first component was eliminated, responding continued to be maintained in the second component. Elimination of food presentation from the first component substantially decreased responding in the second component, even though the brief stimulus had not been paired with food. Experiment II demonstrated that response rate was affected by the duration of both the second component and the brief stimulus. The results suggest that three conditions are important in maintaining responding with brief-stimulus presentations: (1) pairing the brief stimulus, at least initially, with food, (2) maintaining unconditioned reinforcement in one component, and (3) employing optimal brief-stimulus and component durations.     

Conditioned reinforcement and discrimination in second-order schedules

Pigeons were exposed to multiple second-order schedules in which responding on the “main key” was reinforced according to either a variable-interval or fixed-interval schedule by production of a brief stimulus on the “brief-stimulus key”. A response was required to the brief stimulus during its fourth (final) presentation to produce food; responses to the earlier brief stimuli indicated the extent to which the final brief stimulus was discriminated from preceding ones. Main-key response rates were higher in early components of paired brief-stimulus schedules, in which each brief stimulus was the same as that paired with reinforcement, than in comparable unpaired brief-stimulus or tandem schedules. Poor discrimination occurred between paired brief stimuli (Experiment I). When chain stimuli on the main key induced a discrimination between the first two and second two brief stimuli, the response-rate enhancement in the paired brief-stimulus schedule persisted (Experiment II). Rate enhancement diminished when the initial link of the chain included the first three components (Experiment IV). Eliminating the contingency between responding and brief-stimulus production also diminished rate enhancement (Experiment III). The results show that the discriminative and conditioned reinforcing effects of food-paired brief stimuli may be selectively manipulated and suggest that the reinforcing effects are modulated by other reinforcers in the situation.     

Conditioned reinforcement and choice

In a series of three experiments, rats were exposed to successive schedule components arranged on two levers, in which lever pressing produced a light, and nose-key pressing produced water in 50% of the light periods. When one auditory signal was presented only during those light periods correlated with water on one lever, and a different signal was presented only during those light periods correlated with nonreinforcement on the other lever, the former lever was preferred in choice trials, and higher rates of responding were maintained on the former lever in nonchoice (forced) trials. Thus, the rats preferred a schedule component that included a conditioned reinforcer over one that did not, with the schedules of primary reinforcement and the information value of the signals equated. Preferences were maintained when one or the other of the auditory signals was deleted, but were not established in naive subjects when training began with either the positive or negative signal only. Discriminative control of nose-key pressing by the auditory signals was highly variable across subjects and was not correlated with choice.     

Effects of GABA modulators on the repeated acquisition of response sequences in squirrel monkeys

The present study investigated the effects of positive and negative GABA(A) modulators under three different baselines of repeated acquisition in squirrel monkeys in which the monkeys acquired a three-response sequence on three keys under a second-order fixed-ratio (FR) schedule of food reinforcement. In two of these baselines, the second-order FR schedule and the discriminative stimuli for the response sequence were manipulated ("chain-strained" and "tandem-strained"). In the third baseline condition, response-independent tail shock was presented during acquisition of the response sequence. All of these baselines maintained high error levels and produced slow rates of acquisition. Under both the chain-strained and tandem-strained conditions, the positive GABA(A) modulator triazolam (0.0032-0.1 mg/kg) and the negative GABA(A) modulators beta-CCE (ethyl-beta-carboline-3-carboxylate; 0.01-1 mg/kg), beta-CCM (methyl-beta-carboline-3-carboxylate; 0.0032-0.1 mg/kg), and FG-7142 (methyl-beta-carboline-3-carboxamide; 0.18-10 mg/kg) dose-dependently decreased overall response rate compared to administration of saline (control). Under the same two conditions, triazolam and the negative GABA(A) modulators also increased the percentage of errors; however, the effects on accuracy frequently depended on the baseline condition and the particular modulator. In contrast, triazolam only decreased errors and enhanced acquisition in the presence of concurrent response-independent tail shock when compared to saline administration under this condition. The neutral GABA(A) modulator, flumazenil (1 mg/kg), had no effect on rate or accuracy of responding when administered alone, but antagonized the rate-decreasing and error-increasing effects produced by the negative GABA(A) modulators. Together, these data suggest that the effects of both the positive and negative GABAA modulators on acquisition can be similar in squirrel monkeys (i.e., both types of modulator may produce rate-decreasing and error-increasing effects) and that their effects on acquisition depend, in part, on the environmental conditions maintaining acquisition.     

Matching and conditioned reinforcement rate

Attempts to examine the effects of variations in relative conditioned reinforcement rate on choice have been confounded by changes in rates of primary reinforcement or changes in the value of the conditioned reinforcer. To avoid these problems, this experiment used concurrent observing responses to examine sensitivity of choice to relative conditioned reinforcement rate. In the absence of observing responses, unsignaled periods of food delivery on a variable-interval 90-s schedule alternated with extinction on a center key (i.e., a mixed schedule was in effect). Two concurrently available observing responses produced 15-s access to a stimulus differentially associated with the schedule of food delivery (S+). The relative rate of S+ deliveries arranged by independent variable-interval schedules for the two observing responses varied across conditions. The relation between the ratio of observing responses and the ratio of S+ deliveries was well described by the generalized matching law, despite the absence of changes in the rate of food delivery. In addition, the value of the S+ deliveries likely remained constant across conditions because the ratio of S+ to mixed schedule food deliveries remained constant. Assuming that S+ deliveries serve as conditioned reinforcers, these findings are consistent with the functional similarity between primary and conditioned reinforcers suggested by general choice theories based on the concatenated matching law (e.g., contextual choice and hyperbolic value-added models). These findings are inconsistent with delay reduction theory, which has no terms for the effects of rate of conditioned reinforcement in the absence of changes in rate of primary reinforcement.     

Response acquisition under direct and indirect contingencies of reinforcement

We compared the effects of direct and indirect reinforcement contingencies on the performance of 6 individuals with profound developmental disabilities. Under both contingencies, completion of identical tasks (opening one of several types of containers) produced access to identical reinforcers. Under the direct contingency, the reinforcer was placed inside the container to be opened; under the indirect contingency, the therapist held the reinforcer and delivered it to the participant upon task completion. One participant immediately performed the task at 100% accuracy under both contingencies. Three participants showed either more immediate or larger improvements in performance under the direct contingency. The remaining 2 participants showed improved performance only under the direct reinforcement contingency. Data taken on the occurrence of "irrelevant" behaviors under the indirect contingency (e.g., reaching for the reinforcer instead of performing the task) provided some evidence that these behaviors may have interfered with task performance and that their occurrence was a function of differential stimulus control.