Developmental changes in infants’ visual short-term memory for location

To examine the development of visual short-term memory (VSTM) for location, we presented 6- to 12-month-old infants (N = 199) with two side-by-side stimulus streams. In each stream, arrays of colored circles continually appeared, disappeared, and reappeared. In the changing stream, the location of one or more items changed in each cycle; in the non-changing streams the locations did not change. Eight- and 12.5-month-old infants showed evidence of memory for multiple locations, whereas 6.5-month-old infants showed evidence of memory only for a single location, and only when that location was easily identified by salient landmarks. In the absence of such landmarks, 6.5-month-old infants showed evidence of memory for the overall configuration or shape. This developmental trajectory for spatial VSTM is similar to that previously observed for color VSTM. These results additionally show that infants’ ability to detect changes in location is dependent on their developing sensitivity to spatial reference frames.     

Protective effect of practice on cognition during aging: implications for predictive characteristics of performance and efficacy of practice

In the present study, the effect of previous experience on spatial memory, which required the retention of information either over long intervals or within a single session, was longitudinally tested in the water maze in male F-344 rats that were from 6 to 24 months of age. Performance in these tasks was found to be age-dependent (Markowska, 1999). Other behavioral tasks in the straight alley and with a visible platform in the water maze controlled the noncognitive components of performance. For all tasks, performance was significantly correlated between 12-month-old and 18-month-old rats, indicating that cognitive performance at the early, but not advanced, stage of aging could be predicted from performance at a younger age if the novelty of the first exposure to the task was eliminated. The protective effect of experience was more robust in the reference memory task as compared to the working memory task and was modified by age when training was initiated. Behavior during the probe trials was more sensitive to the effect of aging and more resistant to the beneficial effect of practice as compared to the performance in the platform trials. The speed of swimming of experienced rats progressively decreased with age only when tested in the cognitive tasks but not in the straight alley. This indicates that speed of swimming during cognitive tasks does not exclusively reflect the ability to swim, but might be also affected by the cognitive demands of the task. Protective effect of experience on cognition was not modified by restriction in diet.     

Who is doing what to whom? Young infants' developing sense of social causality in animated displays

In two different experiments a visual habituation/dishabituation procedure was used to test groups of 3-10-month-old infants for their ability to discriminate the role reversal of two abstract figures (discs of different colors) chasing each other on a computer screen. Results of the first experiment point to a reliable age effect. Only 8-10-month-old infants tended to dishabituate to a role reversal between chaser and chasee. A second experiment shows that in dishabituating to the role reversal, 8-10-month-olds do base this discrimination on relational information between the two discs and not merely on the contrast between their respective vitality or discrete dynamic. By the age of 8-10 months, infants demonstrate sensitivity to information specifying what one disc does to the other, at a distance. These findings point to important changes in perceptual-cognitive development and are discussed in the context of a well described key transition in social-cognitive development occurring at around 9 months of age.     

Choline Uptake in the Frontal Cortex Is Proportional to the Absolute Error of a Temporal Memory Translation Constant in Mature and Aged Rats

The relationship between the magnitude of the error in the content of temporal memory and sodium-dependent high-affinity choline uptake (SDHACU) in the frontal cortex and hippocampus was examined in mature (10- to 16-month-old) and aged (24- to 30-month-old) male rats. The peak time of the response rate distribution that relates the probability of a response to signal duration in a 20-s peak-interval timing procedure was used to index the remembered time of reinforcement. Regression analyses indicated that SDHACU in the frontal cortex of both mature and aged rats and in the hippocampus of aged rats is proportional to the absolute error in the content of temporal memory. These biochemical effects of peak-interval training were also compared with biochemical measures taken from control rats that received random-interval training. This comparison indicated that the observed changes in SDHACU were dependent upon the predictability of the programmed time of reinforcement and age-related changes in memory encoding and retrieval.     

Infant categorization: memory for category-level and specific item information

In an attempt to determine whether it is necessary to postulate abstraction processes in infant categorization, three experiments assessed retention of category-level information and information specific to category members. Using a visual recognition memory procedure, 10- and 13-month-old infants were familiarized with category instances containing both shared dimensional information and idiosyncratic features. The addition of idiosyncratic features to members of the familiarization category enhanced specific item memory for 13-month-old infants. However, this was not the case for the younger infants. The results of within-category test comparisons indicated that 10-month-old infants regarded information common to all members of the category as more familiar than information specific to individual exemplars. This occurred despite evidence that specific item information was retained in memory and available for retrieval during recognition tests. The findings are discussed in relation to exemplar and abstraction models of categorization.     

Differential involvement of hippocampal calcineurin during learning and reversal learning in a Y-maze task

The regulation and function of the calcium-dependent phosphatase calcineurin (CaN, protein phosphatase 2B) in learning and memory remain unclear, although recent work indicates that CaN may play a differential role in training and reversal training. To gain more insight into the involvement of CaN in these two types of learning, hippocampal CaN activity, protein levels, and expression patterns were studied in mice subjected to a reference memory version of the Y-maze task. We show that (1) training but not habituation induces a decrease in cytosolic CaN activity, (2) the recovery of cytosolic CaN activity is reversal training specific and does not reflect normal restoration of basal levels unrelated to subsequent learning, (3) cytosolic protein levels for the catalytic subunit of CaN (CaNA) are decreased at the early phase of training, but not at the early phase of reversal training, (4) CaNA immunoreactivity in the dorsal hippocampus is enhanced in the CA1 and CA3 area (but not in the dentate gyrus [DG] or subiculum [SUB]) only during reversal training. These findings indicate that memory formation is accompanied by reduced CaN activity, whereas adapting to changes in a familiar environment is accompanied by restored CaN activity. Moreover, reversal training selectively affects hippocampal CA3 and CA1 regions, suggesting a specific function of these hippocampal subregions in reversal learning.     

Effects of pharmacological manipulations of NMDA-receptors on deliberation in the Multiple-T task

Both humans and non-human animals have the ability to navigate and make decisions within complex environments. This ability is largely dependent upon learning and memory processes, many of which are known to depend on NMDA-sensitive receptors. When humans come to difficult decisions they often pause to deliberate over their choices. Similarly, rats pause at difficult choice points. This behavior, known as vicarious trial and error (VTE), is hippocampally dependent and entails neurophysiological representations of expectations of future outcomes in hippocampus and downstream structures. In order to determine the dependence of VTE behaviors on NMDA-sensitive receptors, we tested rats on a Multiple-T choice task with a reward-delivery reversal known to elicit VTE. Rats under the influence of NMDA-receptor antagonists (CPP) showed a significant reduction in VTE, particularly at the reward reversal, implying a role for NMDA-sensitive receptors in the generation of vicarious trial and error behaviors.     

Rapid development of feature binding in visual short-term memory

The binding of object identity (color) and location in visual short-term memory (VSTM) was examined in 6.5- to 12.5-month-old infants (N= 144). Although we previously found that by age 6.5 months, infants can represent both color and location in VSTM, in the present study we observed that 6.5-month-old infants could not remember trivially simple color-location combinations across a 300-ms delay. However, 7.5-month-old infants could bind color and location as effectively as 12.5-month-old infants. Control conditions confirmed that the failure of 6.5-month-old infants was not a result of perceptual or attentional limitations. This rapid development of VSTM binding between 6.5 and 7.5 months occurs during a period of rapid increase in VSTM storage capacity and just after a period of dramatic neuroanatomical changes in parietal cortex. Thus, the ability to bind features and the ability to store multiple objects may both depend on a process that is mediated by posterior parietal cortex and is perhaps related to focused attention.     

Change in the relative contributions of habit and working memory facilitates serial reversal learning expertise in rhesus monkeys

Functionally distinct memory systems likely evolved in response to incompatible demands placed on learning by distinct environmental conditions. Working memory appears adapted, in part, for conditions that change frequently, making rapid acquisition and brief retention of information appropriate. In contrast, habits form gradually over many experiences, adapting organisms to contingencies of reinforcement that are stable over relatively long intervals. Serial reversal learning provides an opportunity to simultaneously examine the processes involved in adapting to rapidly changing and relatively stable contingencies. In serial reversal learning, selecting one of the two simultaneously presented stimuli is positively reinforced, while selection of the other is not. After a preference for the positive stimulus develops, the contingencies of reinforcement reverse. Naïve subjects adapt to such reversals gradually, perseverating in selection of the previously rewarded stimulus. Experts reverse rapidly according to a win-stay, lose-shift response pattern. We assessed whether a change in the relative control of choice by habit and working memory accounts for the development of serial reversal learning expertise. Across three experiments, we applied manipulations intended to attenuate the contribution of working memory but leave the contribution of habit intact. We contrasted performance following long and short intervals in Experiments 1 and 2, and we interposed a competing cognitive load between trials in Experiment 3. These manipulations slowed the acquisition of reversals in expert subjects, but not naïve subjects, indicating that serial reversal learning expertise is facilitated by a shift in the control of choice from passively acquired habit to actively maintained working memory.     

Can fluency be interpreted as novelty? Retraining the interpretation of fluency in recognition memory

Stimuli that are processed fluently tend to be regarded as more familiar and are more likely to be classified as old on a recognition test compared with less fluent stimuli. Recently it was shown that the standard relationship between fluency and positive recognition judgments can be reversed if participants are trained that previously studied stimuli are associated with lower levels of fluency. Under such conditions, fluent stimuli are more likely to be classified as new on a recognition test (C. Unkelbach, 2006), which suggests that the interpretation of fluency is malleable and context dependent. Five experiments investigated the resilience of this reversed fluency effect. Using 2 different fluency manipulations, the finding of a reversed fluency effect after training was replicated. However, it was also found that the reversal depends on explicit feedback during training and is specific to the particular fluency manipulation used during training. Moreover, it was found that the reversal did not generalize to similar memory judgments. The balance of experimental results suggest that the standard interpretation of fluency as indicating higher levels of familiarity is quite stable and is resistant to reinterpretation.     

The effects of meaningful irrelevant speech and road traffic noise on teachers' attention, episodic and semantic memory

The aim of the present experiment was to examine the effects of meaningful irrelevant speech and road traffic noise on attention, episodic and semantic memory, and also to examine whether the noise effects were age-dependent. A total of 96 male and female teachers in the age range of 35-45 and 55-65 years were randomly assigned to a silent or the two noise conditions. Noise effects found in episodic memory were limited to a meaningful text, where cued recall contrary to expectations was equally impaired by the two types of noise. However, meaningful irrelevant speech also deteriorated recognition of the text, whereas road traffic noise caused no decrement. Retrieval from two word fluency tests in semantic memory showed strong effects of noise exposure, one affected by meaningful irrelevant speech and the other by road traffic noise. The results implied that both acoustic variation and the semantic interference could be of importance for noise impairments. The expected age-dependent noise effects did not show up.     

Early maternal availability and prefrontal correlates of reward-related memory

Early emotional experiences affect developing brain systems that subsequently mediate adult learning and memory in rodents. Here we test for similar effects in squirrel monkeys (Saimiri sciureus) four years after disruptions in early maternal availability. These conditions were previously shown to generate differences in emotional behavior, hypothalamic-pituitary-adrenal stress physiology, and right ventral medial prefrontal volumes determined in adulthood by magnetic resonance imaging. This report identifies in the same monkeys variability in reward-related memory on tests with a spatial reversal. Adult monkeys that more often selected locations repeatedly rewarded before each reversal had larger right ventral medial prefrontal volumes, but not hippocampal nor dorsolateral prefrontal volumes on the left or right brain side. Differences in performance were also discerned after each spatial reversal. These findings indicate that maternal availability alters developing ventral medial prefrontal brain regions involved in reward-related memory.     

Effects of reserpine on retention of escape reversal in mice: absence of state-dependent learning.

A discriminated escape training paradigm was used to study the effects of reserpine on learning and memory in mice. Intraperitoneal injection of reserpine before reversal training had no effect on acquisition but did produced a time-and dose-dependent impairment of retention test performance 10 days later. These results suggested that reserpine may have interfered with some aspect of memory storage. Retention impairments observed when a 2.0 mg/kg reserpine injection was given 2 hr before reversal training were not attenuated by readministering the drug before testing, a finding that provides no support for a state-dependency interpretation. Furthermore, animals treated with reserpine exhibited inferior retention of previous training, regardless of the pharmacological state present during that learning. This was interpreted as a drug-induced impairment of memory retrieval. In addition, performance during the initial discriminated escape training session suggested that reserpine may also impair acquisition under some conditions. In the last experiment, it was found that when the catecholamine precursor L-dihydroxyphenylalamine (100 mg/kg) and the indole amine precursor D,L-5-hydroxytryptophan (125 mg/kg) were both given after reserpine treatment, subsequent retention performance was not significantly impaired. The results are discussed in terms of the possible roles of biogenic amines in arousal, learning, and memory.     

Role of the biogenic amines in the reversal of cycloheximide-induced amnesia.

Amnesia was induced by pretraining injections of cycloheximide (CYC) in a food motivated discrimination reversal task. Magnitude of amnesia varied as a function of the amount of training on both the initial discrimination and the reversal and also as a function of the length of intertrial interval used on both the reversal and the test. Memory spontaneously recovered 48 hr. following reversal training. Recovery from amnesia was induced by pretesting injections of d-amphetamine and 2 monoamine oxidase inhibitors, pargyline and catron. This enhanced performance was a true recovery of the memory and not a result of enhanced learning or increased arousal. Depletion of catecholamines by alpha-methyl-para-tyrosine, a tyrosine hydroxylase inhibitor, and diethyldithiocarbamate, a dopamine beta hydroxylase inhbitor, resulted in an amnesia quantitatively and qualitatively similar to amnesia induced by CYC. These data support the hypothesis that CYC-induced amnesia is mediated via central catecholamines.     

Mental image reversal and verbal recoding: When ducks become rabbits

A recent debate has concerned whether classical bistable configurations (e.g., duck/rabbit) can be reinterpreted using mental imagery. Research in this field indicates that image reversal is possible only when subjects change their specification of orientation. In a series of four experiments, we demonstrate that mental reversal of classical bistable configurations( CBCs) is impeded by verbally recoding the visual pattern at the time of input. When subjects were prevented from verbally recoding visual stimuli in short-term memory, they fared systematically better in mentally reversing the CBC, even when they received no instructions to change their reference frame or specification of orientation. On this basis, we suggest a model of image reversal that takes into account the interaction between memory codes and provides a new perspective on verbal recoding, verbal overshadowing, and mental discoveries.     

Olfactory context and memory retrieval in 3-month-old infants

Three experiments examineed whether olfactory stimuli can produce context-dependent effects in infant memory. In eash, 3-month-old infants learned to kick to control the movement of an overhead modile in the presence of an ambient odor. Retention was assessed 1, 3, or 5 days later. During the retention test, the olfactory context was either the same odor, a different odor, or “no odor.” At 1 day, infants exhibited retention when tested in the presence of the same odor. Infants in the no odor condition exhibited partial retention, whereas memory retrieval was completely disrupted for infants tested in the presence of the different odor. After the 3- and 5-day intervals, all groups showed forgetting. These results were not consistent with recent studies of 3-month-old infants trained and tested in the presence of a distinctive visual and auditory context. The findings suggest that olfactory stimuli are a silent feature of the environment for 3-month-old infants, but that they function as context cues in a way that differs from other sensory modalities.     

Successive reversal of concurrent discriminations by macaques (Macaca mulatta): proactive interference effects

Rhesus monkeys received concurrent within-session training on eight, two-choice object pairs and then underwent successive reversals of these problems. Initially, reversals required about six times more training than acquisition with no improvement over seven successive reversals. Surprisingly, performance on these eight problems was unimpaired if they were embedded in different eight-problem tasks, thereby indicating a release from proactive interference. When the original eight problems again underwent successive reversal, no improvement was seen over seven reversals, although there was significantly less error-per-reversal than in the initial test. Subsequently, monkeys appeared to be developing a learning set for successive reversal because performance on successive reversal of eight novel problems was not different from that seen with the old familiar task. Set acquisition was confirmed when proficient reversal was eventually achieved on both old and new concurrent tasks. Thus, concurrent reversal set did develop, but it required arduous training to overcome proactive interference effects on memory. The ubiquitous influence of measurement context on organization of monkey memory was noted.     

Phonetic analysis of speech and memory codes in beginning readers

Two experimental tasks, a speech segmentation and a short-term memory task, were presented to children who began to learn to read following either the “phonic” or the “wholeword” method. The segmentation task required the child to reverse two segments (either two phones or two syllables) in an utterance. The phonic group performed significantly better than the whole-word group in the “phonic reversal” task, but no difference appeared in the “syllable reversal” task. This indicated (1) that most children by the age of 6 years are ready to discover that speech consists of a sequence of phones and (2) that the moment at which they do it is influenced by the way they are taught to read. In the memory task, the children recalled series of visually presented items whose names either rhymed or did not. The difference in performance for the rhyming and nonrhyming series was significant in both groups. It was no greater for the phonic than for the whole-word group and was uncorrelated with the “phonic reversal” task. These results are discussed in connection with the distinction between ways of lexical access and ways of representing verbal information in short-term memory.     

Causal perception of action-and-reaction sequences in 8- to 10-month-olds

Four experiments with 202 8- to 10-month-old infants studied their sensitivity to causation-at-a-distance in schematic events seen as goal-directed action and reaction by adults and whether this depends on attributes associated with animate agents. In Experiment 1, a red square moved toward a blue square without making contact; in “reaction” events blue moved away while red was approaching, whereas in “delay” events blue started after red stopped. Infants were habituated to one event and then tested on its reversal. Spatiotemporal features reversed for both events, but causal roles changed only in reversed reactions. Infants dishabituated more to reversed reaction events than to reversed delay events. Squares moved rigidly or in a nonrigid animal-like fashion. Infants discriminated these, but motion pattern did not affect responses to reversal. Infants also discriminated reactions from launching and dishabituated to reversed reactions lacking self-initiated motion. These results suggest that sensitivity to causation-at-a-distance depends on the event structure but not pattern or onset typical of animal motion.