β受体阻滞剂治疗慢性心力衰竭作用机制规律的探讨

β受体阻滞剂作为一种负性肌力药物,其在慢性心力衰竭治疗中的地位于近几十年中发生了戏剧性的改变,由禁忌药转变为指南推荐的重要药.β受体阻滞剂引发了人们对慢性心力衰竭发病机制的重新思考,使人们对疾病及其治疗有了更新更全面的认识,这其中体现了哲学与自然科学间的紧密联系,提示我们运用哲学原理可以指导自然科学的发展.     

中、西医治疗慢性乙型肝炎现状的分析与思考

分析了中、西医肝病临床治疗慢性乙型肝炎的现状,着重探讨了中医药在防治乙肝中的优势和不足.指出多数医生存在对乙肝发病机制认识模糊、不能提供合理的治疗方案和研究方法欠科学等三个误区.倡导用循征医学方法对中医药防治乙肝的疗效进行评价.     

β受体阻滞剂治疗慢性心力衰竭作用机制规律的探讨

β受体阻滞剂作为一种负性肌力药物,其在慢性心力衰竭治疗中的地位于近几十年中发生了戏剧性的改变,由禁忌药转变为指南推荐的重要药。β受体阻滞剂引发了人们对慢性心力衰竭发病机制的重新思考,使人们对疾病及其治疗有了更新更全面的认识,这其中体现了哲学与自然科学间的紧密联系,提示我们运用哲学原理可以指导自然科学的发展。     

帕金森病发病与小胶质细胞老化关系的探讨

帕金森病(PD)是一种中老年常见的神经退行性病变.其发病机制可能与小胶质细胞(MI)的慢性炎症反应有关.老化的M1通过释放炎症介质导致多巴胺(DA)神经元大量死亡,帕金森病临床发病.因此澄清MI老化的原因对于了解PD发病及防治策略具有重要意义.     

个体化降压的临床意义

高血压是由多种病因和发病机制引起的一种慢性疾病,可以导致多种靶器官功能损害,并最终导致严重的心、脑血管并发症,危及人类的健康和生命.如何做到有效的预防和治疗是目前面临的问题.本文分析了高血压控制的现状,以矛盾的特殊性原理为指导,从高血压的病因和发病机制、临床特点以及药物对个体的敏感性等诸多方面出发,阐述了高血压患者个体差异性.高血压患者个体差异性决定每一个个体综合控制策略的不同,运用"具体问题具体分析"的方法,为每一个个体制定个体化的血压控制方案,以期达到理想的高血压整体控制水平.     

心力衰竭国内外指南浅析

近几年随着循证医学证据的不断增加,各国对心力衰竭指南进行了更新.主要是2012年欧洲心脏病学会(ESC)与心衰学会公布的心力衰竭新指南、2011年澳大利亚和新西兰慢性心力衰竭诊治指南、2010年英国国立健康与临床优化研究所(NICE)慢性心力衰竭诊治指南、2009美国心脏病学会(ACC)/美国心脏协会(AHA)实践指南工作组成人心力衰竭诊疗指南及2010年我国的急性心力衰竭指南等.各国指南对心力衰竭的诊断和治疗都提出了具体的意见和建议,其中不乏亮点,如对慢性心力衰竭患者更加重视血运重建的治疗作用、推荐心力衰竭治疗的一种新型β受体阻滞剂奈必洛尔等等.我们对以上几个指南做了浅要分析,以取长补短更规范的诊治心力衰竭患者.     

慢性充血性心力衰竭合并贫血、铁缺乏的研究进展

近年来由于心血管疾病发病率的不断上升,使得慢性充血性心力衰竭发病率也不断升高。最近的研究发现在慢性充血性心力衰竭患者中,有很大比例患者合并铁缺乏或贫血,且二者与慢性充血性心力衰竭预后密切相关。本文就慢性充血性心力衰竭患者与贫血及铁缺乏的相关性,以及慢性充血性心力衰竭合并贫血及铁缺乏的可能发生机制、治疗进展作一概述和总结。     

阻塞性睡眠呼吸暂停低通气综合征与舒张性心力衰竭相关性研究进展

阻塞性睡眠呼吸暂停低通气综合征(OSAHS)可诱发舒张性心力衰竭,引起多种临床症状,对患者预后及生活质量产生更多不良影响.其主要病理生理学变化为慢性间歇性或持续性乏氧和高碳酸血症.舒张性心力衰竭发生机制复杂,OSAHS可通过乏氧、神经系统功能改变、炎症反应及水钠潴留而诱发或加重舒张性心力衰竭.OSAHS与舒张性心力衰竭有密切关系,OSAHS可引起并加重心衰,而心衰患者可能会伴发OSAHS,其互为因果,互相促进.在临床治疗方面,我们应充分重视两者相关性及其危害性,制定合理治疗方案.     

血-前列腺屏障的假说及其对前列腺炎研究的意义

在慢性前列腺炎的研究工作中,血-前列腺屏障的研究是个被忽视的领域.在Pubmed等医学类数据库中找不到一篇关于血-前列腺屏障的研究综述.甚至找不到一个关于它的令人满意的定义.我们的研究目的,就是尝试从不同研究领域的文献中寻找有关"血-前列腺屏障"的理论和实验的依据,提出一个建立在非相关文献间的隐含联系中的假说.我们相信,血-前列腺屏障是客观存在的,而且在前列腺炎的发病机制中扮演着关键性的角色.     

从炎症在心力衰竭进展中的作用谈心力衰竭治疗策略的制订

心力衰竭是一个以免疫激活和低程度的慢性炎症为特点的疾病.一些炎症因子能通过促进心肌细胞肥厚、恶化心肌收缩功能以及诱导凋亡,在心衰的发展过程中具有重要作用.炎症因子能成为心衰治疗的重要目标.但炎症因子还有心脏代偿和保护作用.制订新的心衰治疗策略时需要进一步了解心衰中炎症反应激活的机制.     

Together – apart: in touch in a time of separation

This paper explores the experience of working as a Jungian analyst through the various phases of the global COVID-19 pandemic, examining the importance of the physical containing space alongside the analyst’s internal mind and how technology can both help and hinder understanding. A number of clinical vignettes illustrate the challenge of communicating over a distance, paying particular attention to the way countertransference phenomena can become re-attuned. Reference is made to mythology and symbols of hope, and consideration given to the meaning and purpose of the pandemic.     

The Possibility of Meaning in Human Evolution

Science undermines the certitude of non-naturalistic answers to the question of whether human life has meaning. I explore whether evolution can provide a naturalistic basis for existential meaning. Using the work of philosopher Daniel Dennett and scientist Ursula Goodenough, I argue that evolution is the locus of the possibility of meaning because it has produced intentionality, the matrix of consciousness. I conclude that the question of the meaning of human life is an existentialist one: existential meaning is a product of the individual and collective tasks human beings undertake.     

Phenotypic plasticity and archetype: a response to common objections to the biological theory of archetype and instinct

Since Jung’s death in 1961, scholars have attempted to integrate growing biological science data into Jungian concepts such as the collective unconscious, instincts and the archetypes. This enterprise has been challenging due to persistent false dichotomies of gene and environment occasionally arising. Recent works by Roesler (2022a, 2022b) for example, have raised objections to the biological theory of archetypes, but the objections are plagued by such dichotomies. The concept of phenotypic plasticity, however, helps to both avoid this problem as well as bridge the gap between competing theories into a more integrated model with solid biological foundations.     

When is it time to stop? When good enough becomes bad enough

This article draws on Winnicott’s concept of the good enough mother to discuss how to know whether a therapeutic situation is good enough to continue or bad enough to end. This dilemma is explored in terms of clinical syndromes, such as anorexia and pathological gambling, but focuses mainly on analyst-initiated endings, which are termed the ‘Casablanca dilemma’, based on an amplification of the ending of the film Casablanca. The author goes on to discuss such one-sided endings, drawing on interviews with 40 analysts and therapists about their clinical experience. A typology of bad enough endings is presented. The psychological differences between a good enough analysis as opposed to a bad enough one are explored through the ideas of Winnicott and Neumann.     

Kann Es Ein Argument Für Den Skeptizismus Geben? Das Epistemische Problem Der Irrtumsmöglichkeit

Summary  Is there any argument for scepticism? The epistemic problem of the possibility of error. Arguments for scepticism rest on the assumption that knowledge claims are fallible. For this reason the concept of knowledge appears to be questionable. Since it is necessary to distinguish doubts from possible doubts, the arguments for scepticism appear to be unconvincing. If we take it into account that we know something that is immune to doubt, we should draw the conclusion that, contrary to scepticism, knowledge claims have to be compatible with being fallible. Thus any knowledge claim is capable of being doubted.     

The transcendent function in Spitteler’s Prometheus and Epimetheus

In August 2020, John Beebe and Steve Myers met via Zoom to discuss their differing interpretations of psychological typology and the different sources within Jung’s writings that influenced their books: Integrity in Depth: Energies and Patterns in Psychological Type (Beebe), and Myers-Briggs Typology vs Jungian Individuation (Myers). The discussion centred on Spitteler’s epic poem Prometheus und Epimetheus, which forms the basis of chapter V of Psychological Types. This is both the largest chapter and one of two chapters that Jung highlighted in the Argentine foreword as containing the essence of the book. Jung’s book is primarily about the transformation of personality rather than the categorization of people. Although it contains a critical psychology that deconstructs the nature of consciousness, that is only one half of the book and a stepping-stone to the other half, which is the reconciliation of opposites with particular emphasis on the relation of consciousness and the unconscious. Jung assumed that readers were already familiar with Prometheus und Epimetheus, an understanding of which sheds light on the nature of the transformation that Jung described – the development of a new attitude towards attitude itself.     

Chapter 6: Biblical Foundations for a Practical Theology of Aging

SUMMARY

This article reviews Biblical sources pertaining to the elderly, particularly the frail elderly. Founded on these sources, implications for elderly with Alzheimer's Disease and other forms of dementia are addressed through a personal perspective informed by writings of Christian mystics.     

Seeing in the Dark: A View into Dissociation and Healing

In this paper, I will explore the role of art-making, the experience of trauma and dissociation, and the process of working with self-states from an analytic and creative frame. Relevant literature on dissociation, trauma, and the use of art will be discussed. A case involving my work with an adolescent girl who had experienced sexual abuse from a family member will be shared, with an emphasis on the meaningful role images played during the therapeutic process. Both Jungian and psychoanalytic models of conceptualizing and working with dissociation are included, following Donald Kalsched’s (2013) recommendation for a “binocular stance” to treatment, including both a focus on the inner, intrapsychic world and the interpersonal, relational realm, and how art images both illuminated and expressed these realms. Within the therapeutic process, art images allowed the therapist a view into the client’s unconscious process, and created a meeting ground for dissociative barriers to be gradually seen, felt and known, by both therapist and client. The experience of dissociation, in images and in session, provided a reference point for myself and my client, Taylor, to develop a shared understanding and a framework for growth.