基于眼动研究的孤独症谱系障碍早期预测

孤独症谱系障碍是一组以社交困难为主要特征的神经发育障碍, 涵盖孤独症、阿斯伯格综合症及分类不明确的广泛型精神发育障碍。ASD预测研究集中在神经生理学、遗传学及心理学领域。在心理学研究中, 眼动技术的运用使得相关测量更为细微、精确, 测量过程更严谨, 预测关系更可信。现有的眼动预测主要着眼于注视时间、首视点和扫视反应时指标的研究。这些研究揭示注视面部和眼睛时间短、注视眼睛时间随年龄增长递减、注视追随时间短、注视重复物理性刺激时间长、视觉搜索优势及注意解除困难均可以预测ASD。未来研究应强化眼动特征预测作用的追踪性考证, 加大与其它发展障碍的预测区分, 控制视觉接受能力对眼动行为的影响, 建立综合性预测体系。     

孤独症谱系障碍者的情绪韵律识别

情绪韵律识别是从声学线索变化中提取情绪信息,进而推断他人情绪状态的过程。情绪韵律识别缺陷是孤独症谱系障碍者的一种常见表现,此缺陷会受到情绪韵律强度、字面语义、情景语境、心理声学能力和共患疾病的影响。目前,该人群情绪韵律识别缺陷的原因探析集中于心智化能力不足、社会动机缺失和经验匮乏假说等。孤独症谱系障碍者情绪韵律识别的神经机制研究主要集中于与健康人群的比较,相关发现包括情绪韵律识别的右半球优势效应、局部脑区激活增多、大脑网络连接不足和早期注意模式异常。未来,应该进一步提高实验范式的生态效度,注重孤独症个体差异因素,整合相关理论解释,并开发有效的测评工具和干预策略。     

CHRM3基因与孤独症谱系障碍

孤独症谱系障碍是一类具有遗传基础的儿童发展障碍疾病。近些年, 研究者们从分子病理学层面发现中枢胆碱能神经系统异常与孤独症患者认知和行为异常存在相关性。尸检研究、临床案例、动物模型研究均发现毒蕈碱型(M型)乙酰胆碱受体异常和孤独症的发生有着密切的关系。在以小鼠为模型的行为学研究中, 编码毒蕈碱型乙酰胆碱受体Ⅲ亚型的CHRM3基因突变会导致小鼠出现认知障碍、刻板行为等孤独症样表现。深入了解CHRM3基因的功能将能够帮助研究者进一步解释孤独症的相关行为特征, 为孤独症儿童教育方案的制定提供新的思路和方法。     

社交机器人在孤独症谱系障碍儿童中的应用

孤独症谱系障碍(AutisticSpectrumDisorders,ASD)儿童的核心症状之一是社交互动障碍。早期干预对ASD儿童的社交能力发展至关重要,而传统康复干预方法存在耗时长、花费高昂、专业康复治疗师短缺等诸多局限性。随着人工智能技术的发展,社交机器人被广泛应用于ASD儿童社交能力的干预研究。通过梳理社交机器人在ASD儿童干预中的可行性,分析社交机器人在ASD儿童社交互动中的研究现状,探讨社交机器人在ASD儿童干预中实验环境、方法等方面存在的优势与挑战。未来社交机器人在ASD儿童中的研究可考虑从探索人机双方特点开发新的社交场景,结合多模态和脑科学技术揭示人机互动的心理过程以及关注人工智能技术发展构建社交机器人闭环系统等方面展开。     

孤独症儿童潜在早期识别标志——发声异常及原因探析

孤独症谱系障碍(Autism Spectrum Disorder, ASD)儿童的早期识别及早期干预对其发育结果至关重要。发声是指儿童学会说话之前发出的声音。已有研究表明, 非类言语和类言语发声异常是ASD儿童2岁前的潜在识别标志。ASD儿童发声异常的理论解释主要有动机导向、神经运动导向、感知觉导向和社会反馈导向理论。未来研究可考虑探讨发声异常作为ASD儿童独特的早期识别标志的可能性, 加强哭声在ASD儿童早期筛查中的研究, 探索基于最具预测性声学参数集的自动学习分类模型, 探究内在动机与社会动机对ASD儿童类言语发声的影响和进一步探究ASD儿童类言语发声异常的神经机制。从而为ASD儿童的早期识别及早期干预提供更加客观的理论依据。     

双通路理论视角下孤独症谱系障碍者的视线加工障碍

临床行为观察发现, 孤独症谱系障碍个体普遍存在不能与他人建立视线接触, 不能追随他人视线看向目标物体等视线加工(gaze processing)障碍。然而已有实验研究发现该群体在实验情境中普遍存在视线接触(eye contact)异常, 但其视线追随行为(gaze following)则存在正常与异常并存的现象。基于视线加工双通路理论的启示, 该障碍可能是由于视线加工皮下通路先天功能异常而皮层通路后天发展异常所致。然而, 该理论尚缺乏皮下通路先天功能异常是视线接触障碍潜在神经机制的直接证据, 还需进一步考察皮下通路先天功能异常对视线追随障碍的影响作用, 以及皮层通路后天发展异常即其补偿机制的神经回路及早期形成过程。     

母亲依恋风格与孤独症谱系障碍儿童母子依恋:母亲教养方式的中介作用

早期依恋对孤独症谱系障碍（Autism Spectrum Disorders,简称ASD）儿童的心理健康、人际关系以及未来的社会融合有重要影响。本研究采用问卷调查法,对从北京、青岛、郑州、武汉、无锡和赤峰市等地28所融合幼儿园中筛选出来的210名ASD儿童及其母亲进行施测,考察母亲的依恋风格对ASD儿童母子依恋的影响,以及母亲教养方式在其中的中介作用。研究发现：（1）总体而言,ASD儿童与母亲之间的依恋关系总体状况良好;轻度ASD儿童的母子依恋水平显著高于中度、重度ASD儿童;（2）母亲依恋回避、依恋焦虑与ASD儿童母子依恋均呈显著负相关;母亲关爱、鼓励自主与ASD儿童母子依恋均呈显著正相关,母亲控制与ASD儿童母子依恋呈显著负相关;母亲依恋回避、依恋焦虑与母亲关爱均呈显著负相关,与母亲控制均呈显著正相关;（3）母亲关爱在母亲依恋回避与ASD儿童母子依恋之间起部分中介作用,母亲关爱、母亲控制在母亲依恋焦虑与ASD儿童母子依恋之间起完全中介作用。     

孤独症谱系障碍者的生物运动探测障碍：基于行为与神经的证据

关于孤独症谱系障碍个体探测生物运动的能力是否受损,已有行为研究尚存分歧。导致分歧的原因可能是实验刺激、实验任务和测量指标存在差异。然而,神经研究却一致证实其潜在的神经机制存在异常。领域特殊性观点认为该障碍可能是基于后侧颞上沟功能异常的社会性功能障碍,也可能是基于镜像神经元功能异常的社会性功能障碍;而领域一般性观点认为该障碍可能是基于背侧视觉流功能异常的视运动知觉障碍,也可能基于脑功能联结异常的弱中央统合障碍。据此,本文将从研究范式、行为表现及潜在机制三个方面梳理相关研究,以期为后续研究提供新方向。     

言语行为的关系框架理论视角:孤独症谱系障碍的新探索

语言功能异常是孤独症谱系障碍(ASD)的典型症状之一。1957年,斯金纳从行为学角度提出"言语行为",认为人们获得表达和理解语言的能力与学会走路、跳舞等行为的原理相同。2001年,海斯等人在斯金纳的基础上提出关于人类语言和认知的新视角——关系框架理论(Relational Frame Theory,RFT),澄清了语言的推衍性实质,认为言语行为是将一个刺激与其他刺激建立关系框架的过程。研究表明基于RFT的多范例训练可以提升ASD患者的推衍关系反应水平,且推衍关系反应与语言和认知功能的发展高相关。未来RFT的研究可以探索如何通过推衍关系反应训练修复ASD患者的语言和认知功能缺陷。     

眼睛注视方向对自闭症谱系障碍儿童面孔情绪识别的影响

为探究自闭症谱系障碍(ASD)儿童在不同眼睛注视方向下对面孔情绪的识别能力及视线加工特征,研究选取ASD儿童和普通儿童各17名为被试。结果发现,ASD儿童识别面孔情绪的正确率显著低于普通儿童,而对高兴情绪识别的正确率最高;ASD儿童识别面孔情绪的反应时不受眼睛注视方向影响,而普通儿童表现出对正视面孔情绪更快的识别速度。研究认为,ASD儿童的情绪识别能力偏低,受情绪类型影响显著,且在面孔情绪识别过程中,可能存在一定的视线加工障碍或缺少对眼部线索的关注。     

人工智能辅助的自闭症早期患者的筛查与诊断

自闭症谱系障碍(AutisticSpectrumDisorders,ASD)的症状早在婴幼儿期就会显现,越早发现,越早干预,治疗效果越好。传统自闭症早期筛查与诊断在评估方法、流程上存在局限,无法满足大规模筛查和诊断需求。随着人工智能技术的快速发展,使用智能化方法进行自闭症早期大规模无感筛查与诊断逐渐成为可能。近10年间,国内外对自闭症智能化识别方法的探索在经典任务行为、面部表情和情绪、眼动、脑影像、运动控制和运动模式、多模态6个领域积累了丰富的研究成果。未来研究应围绕构建国内自闭症早期智能医学筛查与诊断体系,开发针对婴幼儿患者的筛查工具,构建融合多模态数据的自闭症婴幼儿智能化识别模型,建立结合脑影像技术的自闭症精细化诊断方法等方面来开展。     

Reinforcing the prospective remembering of children with autism spectrum disorder

Prospective memory is remembering to carry out a behavior on a particular occasion or at a specific time in the future. This form of remembering is critical for the daily functioning of children with autism spectrum disorder (ASD) and their functional independence from caregivers. We used a single-subject design to investigate whether reinforcement increased the accuracy of prospective remembering in the context of a computerized board game, Virtual Week, of four 6- to 7-year-old children diagnosed with ASD. Reinforcement increased accuracy for all participants compared to baseline performance and effects were maintained after reinforcement was discontinued for three of four children. This is the first study of which we are aware to use a reinforcement-based behavioral intervention to improve the prospective remembering of children with ASD. Limitations and areas for future research are discussed.     

An extension of commonly used toilet-training procedures to children with autism spectrum disorder

The current study evaluated a toilet-training treatment package described by Greer et al. (2016) with children diagnosed with autism spectrum disorder (ASD). Most of the current research on toilet-training interventions for children with ASD are replications and modifications of Azrin and Foxx (1971) or (more recently) LeBlanc et al. (2005). However, these procedures are composed of components that are not included in studies with typically developing (TD) children. For example, Greer et al. evaluated the effectiveness of three typical components within a toilet-training package, mostly with TD participants: a 30-min sit schedule, placing participants in underwear, and differential reinforcement. The primary purpose of the current study was to replicate and extend the treatment package described by Greer et al. to children with ASD. A secondary purpose was to evaluate modifications necessary for individualized toilet training when the commonly used components were ineffective. The results of Greer et al. were replicated for 11 participants with ASD in the current study, suggesting that intensive toileting interventions (e.g., interventions requiring overcorrection, reprimands, and dense sit schedules) may only be necessary for a subset of individuals with ASD.     

Telehealth parent training for a young child at risk for autism spectrum disorder

The global pandemic has highlighted the importance of telehealth to access behavioral interventions. Face-to-face parent training improves the development and behaviors of young children at risk for autism spectrum disorder (ASD). We evaluated a telehealth parent training intervention for a child at risk for ASD. Two parents identified possible early ASD symptoms in their 30-month-old son (lack of imitation, pointing, and vocal manding). Both parents simultaneously received telehealth behavioral skills training on the Parent Intervention for Children at Risk for Autism program for 1 hour per week over 29 weeks. Multiple baseline designs across parent and child behaviors showed that both parents improved their parent teaching fidelity above 80% and the child improved on all trained behaviors. This study expands the utility of telehealth behavioral parent training to young children at risk for ASD to mitigate early symptoms of ASD.     

Choice for reinforced behavioral variability in children with autism spectrum disorder

Although individuals with autism spectrum disorder (ASD) tend to behave repetitively, certain reinforcement contingencies (e.g., lag schedules) can be used to increase behavioral variability. In a lag schedule, reinforcers only follow responses that differ from recent responses. The present study was designed to promote variable play behavior in preschoolers with ASD interacting with playsets and figurines and to assess preference for variability and repetition contingencies. Data have shown a preference for variability in pigeons and college students, but this effect has not been explored in clinical populations. In this experiment, preschoolers with ASD were taught to discriminate between variability and repetition contingencies. Only play behaviors that met a lag schedule were reinforced in the presence of one color, and only repetitive behaviors were reinforced in the presence of another. After differential performance was established, participants experienced a concurrent chains schedule. Participants chose between the colors taught in training and then completed a play session with the selected contingency. One participant selected variability and repetition equally. The other participants showed a slight preference for variability. These results indicate that some individuals with ASD may play repetitively, not because they prefer repetition, but because they require additional teaching to play variably.     

Teaching children with autism spectrum disorder to tact olfactory stimuli

Research on tact acquisition by children with autism spectrum disorder (ASD) has often focused on teaching participants to tact visual stimuli. It is important to evaluate procedures for teaching tacts of nonvisual stimuli (e.g., olfactory, tactile). The purpose of the current study was to extend the literature on secondary target instruction and tact training by evaluating the effects of a discrete‐trial instruction procedure involving (a) echoic prompts, a constant prompt delay, and error correction for primary targets; (b) inclusion of secondary target stimuli in the consequent portion of learning trials; and (c) multiple exemplar training on the acquisition of item tacts of olfactory stimuli, emergence of category tacts of olfactory stimuli, generalization of category tacts, and emergence of category matching, with three children diagnosed with ASD. Results showed that all participants learned the item and category tacts following teaching, participants demonstrated generalization across category tacts, and category matching emerged for all participants.     

孤独症儿童动作发展障碍的神经机制

动作发展障碍(Developmental motor disorders)是孤独症谱系障碍的常见特征。通过系统回顾孤独症儿童动作发展障碍的神经科学研究, 发现γ-氨基丁酸和5-羟色胺浓度的改变及γ-氨基丁酸相关蛋白和Shank蛋白的表达异常不仅会损害中枢神经系统的发育, 而且还能导致突触兴奋性与抑制性失衡, 进而改变孤独症儿童小脑和大脑皮层运动区的功能连接。孤独症儿童小脑、基底神经节和胼胝体结构的改变对全脑的连通性产生了负面影响。神经生化机制和脑结构的异常共同导致了脑功能的异常, 最终造成孤独症儿童的动作发展障碍。此外, 动作发展障碍与孤独症核心症状共同的神经基础主要包括镜像神经元系统紊乱, 丘脑、基底神经节和小脑异常以及SLC7A5和PTEN 基因突变。未来研究需要关注与运动密切相关的其他神经递质, 如乙酰胆碱和多巴胺; 探索动作发展障碍神经网络的动态机制及其形成; 剖析该障碍的神经机制和自闭症核心症状神经机制的相互作用。     

Caregiver-implemented toilet training procedures for children with autism spectrum disorder

Children with Autism Spectrum Disorder often exhibit deficits in daily living skills, including toileting skills. Previous studies have evaluated components of common toilet training practices, including differential reinforcement, sit schedules, fluid loading, underwear, and wet alarms. The purpose of this study was to replicate and extend previous work by delivering all coaching remotely. Three caregiver-child dyads participated in this study. A researcher coached caregivers on the implementation of the protocol using a modified behavioral skills training approach via telehealth. Caregivers submitted daily toileting data and weekly audio recordings for treatment integrity checks. The sit schedule fading was individualized to meet the needs and preferences of each family. All caregivers implemented the protocol with high integrity. Two participants met the mastery criteria at the 90-min sit schedule and maintained performance at the 1- and 6-week maintenance follow up probes. The third participant, despite an interruption of treatment, also reached mastery.