Development of a magnetic-resonance-compatible photoplethysmograph amplifier for behavioral and emotional studies

The purpose of the present study was to develop a magnetic resonance (MR) compatible photoplethysmograph (PPG) system that can measure the raw PPG signal during MR image acquisition. The system consists of an optic sensor that measures the optic signal, an optic cable that transmits a near-infrared optic signal, a signal amplifier, and a filter for noise removal. To minimize interactive noise, only the optic cable and the optic sensor module are located inside the MR room; the signal amplifier and filter are located outside the MR room. An experiment verified that a reliable PPG signal can be obtained without causing a deterioration in the MR image.     

Increasing distractor strength improves accuracy

Attention enhances task-relevant signals while filtering task-irrelevant signals; however, this selection process is not perfect. It is generally assumed that the stronger the irrelevant signal, the more strongly performance is disrupted. The effect of irrelevant coherent motion signals on performance on a color-discrimination task was systematically examined. Motion direction was either congruent or incongruent with response selection. Performance was most impaired when motion signal strength was just above perceptual threshold and improved when the motion signal strength increased. These results suggest that distractors of higher strength increase attentional modulation and are filtered before they interfere with task performance.     

Detection and discrimination of optical flow components

Observers viewed animation sequences consisting of random dots, some of which moved coherently in a given direction (signal dots) and the rest of which moved randomly (noise dots). Using forced-choice procedures, detectability of weak signals within noise was measured for translation, rotation, and expansion/contraction. Sensitivity to all motion types was approximately equal, with practiced observers reliably detecting coherent motion at signal levels as low as 4%. Observers were able to identify the motion structure presented on a given trial at signal levels corresponding to the detection threshold, implying that the neural signals supporting detection are labeled for motion type. Results are discussed in the context of hierarchical analysis of optic flow in which all motion types are registered as patterns of activity among neurons comprising a single mechanism.     

Isometric force complexity may not fully originate from the nervous system

In humans and animals, spatial and temporal information from the nervous system are translated into muscle force enabling movements of body segments. To gain deeper understanding of this translation of information into movements, we investigated the motor control dynamics of isometric contractions in children, adolescents, young adults and older adults. Twelve children, thirteen adolescents, fourteen young adults, and fifteen older adults completed two minutes of submaximal isometric plantar- and dorsiflexion. Simultaneously, sensorimotor cortex EEG, tibialis anterior and soleus EMG and plantar- and dorsiflexion force was recorded. Surrogate analysis suggested that all signals were from a deterministic origin. Multiscale entropy analysis revealed an inverted U-shape relationship between age and complexity for the force but not for the EEG and EMG signals. This suggests that temporal information in from the nervous system is modulated by the musculoskeletal system during the transmission into force. The entropic half-life analyses indicated that this modulation increases the time scale of the temporal dependency in the force signal compared to the neural signals. Together this indicates that the information embedded in produced force does not exclusively reflect the information embedded in the underlying neural signal.     

An electroluminescent lamp device for critical flicker fusion and apparent motion

A circuit that uses electroluminescent lamps as light sources for the study of critical flicker fusion (CFF) and apparent motion phenomena is described. The technique involves the modulation of a 2- KH z exciting current with a multivibrator-formed pulse adjustable over a suitable range of frequencies. Components are readily available from commercial sources.     

Across-channel masking of changes in modulation depth for amplitude- and frequency-modulated signals

This study examines a form of masking that can take place when the signal and masker are widely separated in frequency and cannot be explained in terms of the traditional concept of the auditory filter or critical band. We refer to this as across-channel masking. The task of the subject was to detect an increment in modulation depth of a 1000-Hz sinusoidal carrier. The carrier could either be sinusoidally amplitude modulated or sinusoidally frequency modulated at a 10-Hz rate. Modulation increment thresholds of this “target” signal were measured for the target alone, and in the presence of two interfering sounds with carrier frequencies of 230 and 3300 Hz. When the interfering sounds were unmodulated, they had no effect on modulation increment thresholds. When the interfering sounds were either amplitude or frequency modulated, thresholds increased. Amplitude modulation (AM) increment thresholds were affected by both amplitude-modulated and frequency-modulated interference. Similarly, frequency modulation (FM) increment thresholds were affected by both amplitude-modulated and frequency-modulated interference. For both types of signal, the interference was tuned for modulation rate; across-channel masking was greatest when the interfering sounds were modulated at rates close to 10 Hz, and declined for higher or lower rates. However, the tuning was rather broad. When the target and interfering sounds were modulated at the same rate, there was no effect of the relative phase of the modulators. Two possible explanations for the results are discussed. One is based on the idea that carriers that are modulated in a similar way tend to be perceptually “grouped”. The other is based on the idea that there are “channels” in the auditory system tuned for AM and FM rate. Neither explanation appears completely satisfactory.     

Development of a simple MR-compatible vibrotactile stimulator using a planar-coil-type actuator

For this study, we developed a magnetic resonance (MR)-compatible vibrotactile stimulator using a planar-coil-type actuator. The newly developed vibrotactile stimulator consists of three units: control unit, drive unit, and planar-coil-type actuator. The control unit controls frequency, intensity, time, and channel, and transfers the stimulation signals to the drive unit. The drive unit operates the planar-coil-type actuator in response to commands from the control unit. The planar-coil-type actuator, which uses a planar coil instead of conventional electric wire, generates vibrating stimulation through interaction of the current of the planar coil with the static magnetic field of the MR scanner. Even though the developed tactile stimulating system is small, simple, and inexpensive, it has a wide range of stimulation frequencies (20 ~ 400 Hz, at 40 levels) and stimulation intensities (0 ~ 7 V, at 256 levels). The stimulation intensity does not change due to frequency changes. Since the transient response time is a few microseconds, the stimulation time can be controlled on a scale of microseconds. In addition, this actuator has the advantages of providing highly repeatable stimulation, being durable, being able to assume various shapes, and having an adjustable contact area with the skin. The new stimulator operated stably in an MR environment without affecting the MR images. Using functional magnetic resonance imaging, we observed the brain activation changes resulting from stimulation frequency and intensity changes.     

A fiber-optic system for recording skin conductance in the MRI scanner

The acquisition of the skin conductance response (SCR) during functional magnetic resonance imaging (fMRI) raises significant safety issues, as well as practical ones, which need to be addressed in order for these experiments to be conducted safely and successfully. Metallic and conductive wires in the presence of time-varying gradient magnetic fields such as those present in fMRI experiments may induce heating, as well as electric fields, in these components and, if in contact with the subject, could produce severe burns and electric shocks. Moreover, these metallic and conductive components can significantly distort the magnetic field, resulting in image artifacts. A system for recording the SCR in humans simultaneously with fMRI is presented. The device is a fiber-optic-based transducer, which records the SCR from two fingers of the same hand, using electrodes containing inline radio frequency (RF) suppression filters and protective resistive loads. The fiber-optic SCR transducer was tested using 1.5 and 3.0 Tesla MRI scanners running EPI sequences. This system was able to safely record SCRs free of RF interference during an fMRI experiment, and the fiber-optic design of the transducer eliminated any artifacts on the MRI scan.     

Nonretinotopic processing is related to postdictive size modulation in apparent motion

The present study briefly examined how the perceived size of a leading flash would be modulated by trailing motion signals. Observers were presented with two vertical green bars that were followed by white bars with different lengths, which were presented at different locations from the green bars. The task of observers was to discriminate which of the green bars was shorter than the other (Experiment 1) or whether the lengths of the green bars were equal or not (Experiments 2 and 3). One green bar producing apparent motion with the following shorter white bar was reported to be shorter than the other green bar producing apparent motion with the following longer white bar, not only when motion correspondence was determined on the basis of retinal proximity (Experiments 1 and 2),but also when motion correspondence was determined on the basis of nonretinotopic information-that is, a relative location within each perceptual group of bars (Experiment 3). These results indicate that motion processing involving object updating or motion deblurring in the nonretinotopic frame of reference is related to postdictive size modulation.     

The Neural Basis of Selective Attention: Cortical Sources and Targets of Attentional Modulation

ABSTRACT— Selective attention is an intrinsic component of perceptual representation in a visual system that is hierarchically organized. Modulatory signals originate in brain regions that represent behavioral goals; these signals specify which perceptual objects are to be represented by sensory neurons that are subject to contextual modulation. Attention can be deployed to spatial locations, features, or objects, and corresponding modulatory signals must be targeted within these domains. Open questions include how nonspatial perceptual domains are modulated by attention and how abstract goals are transformed into targeted modulatory signals.     

Modulator and filter circuits for EEG biofeedback

Inexpensive designs for two components of an EEG biofeedback system are described. A two-channel modulator accepts a pair of input signals for modulation of two audio carrier frequencies a musical fifth apart. Carrier suppression is obtained with a simple balanced modulator circuit for each channel. The filter circuit is an integrated circuit adaptation of a successful vacuum tube design reported by other investigators a number of years ago. Various configurations of this equipment for two-channel EEG biofeedback are described.     

A low-cost spatial contrast sensitivity display driver

The circuit described here can provide the line and frame signals to drive anx, y display scope or oscilloscope at high resolution (1,000 lines) and repetition rate (50 Hz). Synchronizing circuitry at the input of the circuit allows the raster scan to be locked to an input signal, such as the square-wave output from a function generator, while another waveform from the same function genera-tor, the sine output, drives the z (intensity) input of the display scope. A stable spatial contrast display results. Spatial contrast depth is a direct function of z input modulation voltage. Spatial frequency is a direct function of the function generator frequency. The circuit can be used with a programmable function generator under computer control.     

Perception of self-motion from visual flow

Accurate and efficient control of self-motion is an important requirement for our daily behavior. Visual feedback about self-motion is provided by optic flow. Optic flow can be used to estimate the direction of self-motion (‘heading’) rapidly and efficiently. Analysis of oculomotor behavior reveals that eye movements usually accompany self-motion. Such eye movements introduce additional retinal image motion so that the flow pattern on the retina usually consists of a combination of self-movement and eye movement components. The question of whether this ‘retinal flow’ alone allows the brain to estimate heading, or whether an additional ‘extraretinal’ eye movement signal is needed, has been controversial. This article reviews recent studies that suggest that heading can be estimated visually but extraretinal signals are used to disambiguate problematic situations. The dorsal stream of primate cortex contains motion processing areas that are selective for optic flow and self-motion. Models that link the properties of neurons in these areas to the properties of heading perception suggest possible underlying mechanisms of the visual perception of self-motion.     

A high-sensitivity drinkometer circuit with 60-Hz filtering

This article describes a drinkometer circuit designed to (1) detect licks even if the resistance of the skin on the animal’s feet becomes quite high due to low humidity, (2) automatically adjust its triggering threshold and increase its gain so that it will continue to detect licks when the water delivery spout is partially shorted to ground by high ambient humidity, (3) reject 60-Hz signals so they will not be treated as rapid licks by the data-recording system, and (4) tolerate the high voltages that can occur if the subject receives an electric shock while drinking. This lickometer will be especially useful in situations where it is not practical to monitor for possible signal failure due to high or low humidity, or where 60-Hz artifacts may contaminate the signal provided to a recording computer.     

The representation of uniform motion in vision

For veridical detection of object motion any moving detecting system must allocate motion appropriately between itself and objects in space. A model for such allocation is developed for simplified situations (points of light in uniform motion in a frontoparallel plane). It is proposed that motion of objects is registered and represented successively at four levels within frames of reference that are defined by the detectors themselves or by their movements. The four levels are referred to as retinocentric, orbitocentric, egocentric, and geocentric. Thus the retinocentric signal is combined with that for eye rotation to give an orbitocentric signal, and the left and right orbitocentric signals are combined to give an egocentric representation. Up to the egocentric level, motion representation is angular rather than three-dimensional. The egocentric signal is combined with signals for head and body movement and for egocentric distance to give a geocentric representation. It is argued that although motion perception is always geocentric, relevant registrations also occur at the three earlier levels. The model is applied to various veridical and nonveridical motion phenomena.     

Limbic hypertension induced by stress and septal stimulation

For this study, it was postulated that hypertension of emotional origin is generated within the limbic system. To validate this thesis, septal induced blood pressure elevations were combined with a stressful experience in adult rats (spontaneously hypertensive and Wistar Kyoto rats). Stress consisted of intermittent confinement in a plexiglass tube. The results revealed that hypertension induced by electric stimulation of the septum during the stressful state could subsequently be elicited by the stressful state alone, without electric stimulation of the septum. It was postulated that the cortically modulated stress circuit converged with the electrically activated limbic pressor circuit at the level of the septum. This convergence resulted in the formation of one cortico-limbic circuitry which could be activated by stress alone. This underlying mechanism may be considered as a model of neural sensitization in the production of stress-induced limbic hypertension.     

Comparing perception of signals in different modalities during the cycling task: A field study

Cyclists are considered to be amongst the most vulnerable road users and the number of cyclists involved in crashes is increasing. One possibility to improve bicycle safety is the implementation of assistance systems, for instance by providing the information needed to avoid critical situations. However, it is not known how and what kind of signals can reliably be transmitted to cyclists, in particular as warnings. This study has the objective to investigate which signal type dependent of the modality and the route type can be perceived during the cycling task. Therefore, we conducted a semi-naturalistic cycling study with 56 participants where a 10 km long, pre-defined route was individually cycled while 36 signals (visual, auditory and vibro-tactile) were transmitted. The participants signalled the perception of a signal by pressing a button. Response rates differed significantly between signal modalities. While auditory signals performed best closely followed by vibro-tactile signals, visual signals were frequently missed. The route type had an effect on the perception of the signals. The influence of the route segments with haptic interference was not expected to be this large on the perception of vibro-tactile signals. The obtained results indicate how and in which situations the different modalities are suited to transmit information to cyclists.     

Independent detectors for expansion and rotation, and for orthogonal components of deformation.

It is well known that optic flow--the smooth transformation of the retinal image experienced by a moving observer--contains valuable information about the three-dimensional layout of the environment. From psychophysical and neurophysiological experiments, specialised mechanisms responsive to components of optic flow (sometimes called complex motion) such as expansion and rotation have been inferred. However, it remains unclear (a) whether the visual system has mechanisms for processing the component of deformation and (b) whether there are multiple mechanisms that function independently from each other. Here, we investigate these issues using random-dot patterns and a forced-choice subthreshold summation technique. In experiment 1, we manipulated the size of a test region that was permitted to contain signal and found substantial spatial summation for signal components of translation, expansion, rotation, and deformation embedded in noise. In experiment 2, little or no summation was found for the superposition of orthogonal pairs of complex motion patterns (eg expansion and rotation), consistent with probability summation between pairs of independent detectors. Our results suggest that optic-flow components are detected by mechanisms that are specialised for particular patterns of complex motion.     

Extraretinal and retinal amplitude and phase errors during Filehne illusion and path perception

Pursuit eye movements give rise to retinal motion. To judge stimulus motion relative to the head, the visual system must correct for the eye movement by using an extraretinal, eye-velocity signal. Such correction is important in a variety of motion estimation tasks including judgments of object motion relative to the head and judgments of self-motion direction from optic flow. The Filehne illusion (where a stationary object appears to move opposite to the pursuit) results from a mismatch between retinal and extraretinal speed estimates. A mismatch in timing could also exist. Speed and timing errors were investigated using sinusoidal pursuit eye movements. We describe a new illusion--the slalom illusion--in which the perceived direction of self-motion oscillates left and right when the eyes move sinusoidally. A linear model is presented that determines the gain ratio and phase difference of extraretinal and retinal signals accompanying the Filehne and slalom illusions. The speed mismatch and timing differences were measured in the Filehne and self-motion situations using a motion-nulling procedure. Timing errors were very small for the Filehne and slalom illusions. However, the ratios of extraretinal to retinal gain were consistently less than 1, so both illusions are the consequence of a mismatch between estimates of retinal and extraretinal speed. The relevance of the results for recovering the direction of self-motion during pursuit eye movements is discussed.     

不同注意形式调节听感觉门控的神经机制

前脉冲抑制(prepulse inhibition, PPI)是听感觉门控的测量模型, 反映了听觉系统的早期信息选择功能。尽管PPI的主要神经环路位于脑干, 研究发现PPI可以被注意自上而下调节。然而, 已有研究并未区分不同注意(特征注意和空间注意)对PPI的特异性调节, 并且神经机制方面的研究集中于听皮层区域, 仍缺乏对皮层下机制的探讨。在以往研究的成果基础之上, 借助听觉信息加工的双通路模型, 采用行为测量、脑电和脑成像技术, 揭示特征和空间两种注意调节PPI的神经活动在听觉系统中的层次性神经表达。包括1)建立特征注意和空间注意调节PPI的统一行为模型, 考察两种注意调节PPI的时间动态性异同; 2)两种注意调节PPI的脑干分离机制, 即前脉冲刺激包络和精细结构成分加工在注意调节PPI中的作用差异; 3)两种注意调节PPI的关键脑区和脑网络差异。