Advances in experimental psychopatholinguistics: What can we learn from simulation of disorder-like symptoms in human volunteers?

For more than a century, work on patients with acquired or developmental language disorders has informed psycholinguistic models of normal linguistic processing in healthy persons. On the other hand, such models of healthy language processing have been used as blue-prints to gain further insights into the impairments of patients with language pathologies. Against the exemplary background of language production, the first part of this paper reflects this relationship and formulates a desideratum for naturalistic albeit controlled experimental settings. Two recent examples of behavioural and neurofunctional research are presented in which aphasia-like speech symptoms were elicited in healthy control subjects. In the second part, this idea to investigate disorder-like symptoms which are being experimentally induced for the course of the study is further pursued in the field of reading and dyslexia research. Here, it is argued, again on the basis of behavioural and neurofunctional data, that such an approach is advantageous in at least two respects:1. It allows a much more stringent control of experimental factors and confounds than could be potentially achieved in a clinical setting.2. It allows in-extenso piloting of experiments with healthy volunteers before actually recruiting selected (and sometimes rare) patients.It will be concluded that the experimental simulation of disorder-like symptoms in easily accessible healthy volunteers may be a useful approach to understand novel aspects of a language disorder on the basis of a human neurocognitive model of this disorder.     

A penny for your thoughts: Patterns of sleep-related beliefs, insomnia symptoms and treatment outcome

The aim of this study was to determine how distinctive patterns of unhelpful beliefs about sleep endorsed by insomnia patients relate to their presenting symptoms and treatment responses. A sample of 281 primary insomnia sufferers completed items comprising the Dysfunctional Beliefs About Sleep scale (DBAS-16). Their resultant scores on the four DBAS-16 subscales were then subjected to a cluster analysis, which resulted in the identification of four distinctive age-matched subgroups. Two subgroups were characterized by pathologically elevated scores on at least two of the DBAS-16 subscales, whereas the other two subgroups had subscale scores that closely resembled those of a normative sample. Subsequent comparisons showed the insomnia subgroups differed in regard to their insomnia severity, use of prescribed medication for sleep, depression and anxiety symptoms, and daytime sleepiness. Furthermore, comparisons of treatment outcomes (i.e. analysis of change scores and normative comparisons) across clusters showed that the subgroups did not benefit equally from a standardized form of Cognitive-Behavioral Therapy (CBT) for insomnia. Findings demonstrate the contribution of specific sleep-related beliefs on presenting insomnia symptoms and suggest the potential usefulness of tailoring CBT protocols to match the needs of distinctive insomnia subtypes.     

Perceptual anomalies in schizophrenia co-occur with selective impairments in the gamma frequency component of midlatency auditory ERPs

This study aimed to establish concordance between phenomenological and psychophysiological indices of sensory gating disturbance in schizophrenia. Perceptually normal and deviant subgroups of schizophrenia (SZ) and healthy comparison (HC) participants were empirically determined on the basis of self-rated Sensory Gating Inventory scores. Contrasts by diagnosis and subgroup classification were conducted on event-related brain potential (ERP) response attenuation to paired auditory stimuli, measured in time (P50 ERP) and frequency (low frequency, 1-20 Hz; gamma band, 20-50 Hz) domains. The SZ sample evidenced significantly less low-frequency response attenuation than did HC but comparable P50 and gamma responses. The low-frequency response, however, appeared insensitive to variation in perceptual experience between SZ subgroups. Conversely, smaller P50 amplitude and weaker gamma response attenuation distinguished deviant SZ (n=17) from normal SZ (n=9) and normal HC (n=29) subgroups. Perceptually normal SZ and normal HC subgroups were statistically equivalent across all comparisons. These findings support hypotheses relating perceptual disturbance in schizophrenia to an early sensory input dysfunction, which is thought to involve gamma-mediated thalamocortical integration of sensory stimuli.     

The Accuracy of the DSM-IV Pain Disorder and the ICD-10 Persistent Somatoform Pain Disorder in Chronic Pain Patients

Objectives. In this investigation we studied the relationships between different psychological relevant subgroups and the presence of different psychosomatic symptoms in a sample of chronic pain patients, testing the accuracy of the DSM- and ICD classification systems.Results. We found no evidence for a “pure” pain syndrome according to the DSM- and ICD systems. On the contrary, we found highly significant evidence of a mixed psychosomatic condition.Conclusion. The results suggest a broad somatoform classification, with subgroups based on personality characteristics taking a stress—coping model into account, including interpersonal attachment behaviour. An alternative model of a diagnostic approach is presented.     

Language and the latent structure of cognitive development (1)

A cross-cultural method was used to explore theoretical implications of the reported association between mastery of the comparative forms in language and development of competency in dealing with difference and equality relations (such as those of Piaget's conservation problems). Since Turkish allows comparisons to be made without the use of a morphologically distinct form (equivalent to: John is to Mary tall), it was selected for contrastive study along with English and Greek which share a similar system for comparisons. One hundred and ten English, Turkish-Cypriot and Greek-Cypriot children (age 4–11) attending school in London were tested on a variety of language, conservation, and multiple classification problems. The results of this testing indicated that language competency does play a significant role during the course of cognitive development, and that variations in language structure can engender parallel variations in the structure of development. Statistical analyses suggested the following specific conclusions: (1) the concrete operations stage is not functionally unified; (2) the structure of development during this stage is multidimensional; and (3) constancy across cultures in the ordering of development during this stage arises, in part, from similarities between their languages in the representation of attribute and difference relations.     

Schools can improve motivational quality: Profile transitions across early foreign language learning experiences

Elementary school is as much about developing attitudes as competence. With this fact in mind, the Japanese national government established a plan to enhance elementary school students’ motivation for learning English. The success of this program has, however, not been empirically tested. This study aimed to assess the longitudinal, discrete development of Japanese elementary school students’ motivation for learning English as a foreign language. A cohort of 513 Japanese elementary students participated in the study across 2 years of school. Students responded to surveys regarding the quality of their motivation at three time points, and their engagement at two time points. Latent profile analysis followed by latent profile transition analysis was used to assess the sample for latent subgroups. With subgroups established at three time points, a Mover–Stayer model was tested to estimate the movement of students among the subgroups across three time points and 2 years of elementary school education. Three theoretically consistent latent subgroups were observed at each of the time points. Based on theory and past empirical research, the subgroups (presented from least to most adaptive) were labeled: Poor Quality, High Quantity, and Good Quality. Across the three measurements, an overall shift of students to higher quantity and quality motivational subgroups was observed. This study provides evidence that the low-stakes, high-interest approach currently undertaken may have the desired effect of improving students’ motivation to learn across 2 years of schooling. Implications for both practice and national policy are discussed.     

Transient versus enduring depression among alcoholics in inpatient treatment

The purposes of this study are (1) to determine the incidence of significant clinical depression among alcoholics at treatment intake at a Veterans Medical Center, (2) to subdivide alcoholics who show significant clinical depression into enduring and transient depressive subgroups, and (3) to identify demographic and psychometric variables useful in discriminating between these two subgroups. Results indicate that of the 60% of VA inpatient alcoholics who showed evidence of significant clinical depression at intake, approximately equal numbers met criteria for inclusion in transient and enduring depressive subgroups. Patients with enduring and transient depression, as defined in this study, were differentiated on the basis of age, drinking pattern, and selected scales from two psychometric instruments which measure depression, confused and disorganized thinking, and an avoidant personality style. These findings may be useful in assisting clinicians in differentiating between alcoholic patients with transitory depression associated with alcohol consumption and/or withdrawal and alcoholic patients with more serious and enduring depression, which may require additional pharmacologic and/or psychotherapeutic intervention.     

Handedness and sex of children with developmental language disorders

The handedness and sex of 4- and 5-year-old children with developmental language disorders were studied through a comparison of language disordered children and a normal control group and through a comparison of six linguistically homogeneous subgroups of language disordered children. Differences between the handedness of a generalized language disordered group and a normal control group were not found, possibly due to the multiple etiologies of developmental language disorders. Children with severe language disorders, however, were non-right-handed more often than children with mild language disorders. Furthermore, certain types of linguistic deficits were associated with non-right-handedness, whereas age and cognitive abilities were not. Males were more often language disordered than females; however, sex ratios did not significantly differ among the subgroups, possibly due to the small number of language disordered females in this study. Implications for cerebral laterality in developmental language disorders are discussed.     

Individual differences in the shape bias in preschool children with specific language impairment and typical language development: theoretical and clinical implications

We investigated whether preschool children with specific language impairment (SLI) exhibit the shape bias in word learning: the bias to generalize based on shape rather than size, color, or texture in an object naming context (‘This is a wek; find another wek’) but not in a non‐naming similarity classification context (‘See this? Which one goes with this one?’). Fifty‐four preschool children (16 with SLI, 16 children with typical language [TL] in an equated control group, and 22 additional children with TL included in individual differences analyses but not group comparisons) completed a battery of linguistic and cognitive assessments and two experiments. In Experiment 1, children made generalization choices in object naming and similarity classification contexts on separate days, from options similar to a target object in shape, color, or texture. On average, TL children exhibited the shape bias in an object naming context, but children with SLI did not. In Experiment 2, we tested whether the failure to exhibit the shape bias might be linked to ability to detect systematicities in the visual domain. Experiment 2 supported this hypothesis, in that children with SLI failed to learn simple paired visual associations that were readily learned by children with TL. Analyses of individual differences in the two studies revealed that visual paired‐associate learning predicted degree of shape bias in children with SLI and TL better than any other measure of nonverbal intelligence or standard assessments of language ability. We discuss theoretical and clinical implications.     

Variants of the MMPI 2-7-8 Code Type: Schizotypal Correlates of High Point 2,7, or 8

Our study sought to evaluate whether examination of the high-point scale among subjects with a 2-74 parent configuration on the MMPI could assist in the identification of individuals with schizotypal features. Additionally, this study compared male 2-74 subjects to female 2-74 subjects to determine whether gender mediates endorsement of items associated with these features. Subjects (N = 106) who produced a 2-7-8 parent profile were subdivided according to high point (2, 7, or a), and the three subgroups were subsequently compared on other self-report measures associated with schizotypal attributes. Subgroup comparisons revealed that the High 8 and High 2 groups produced a pattern of responding consistent with schizotypal characteristics. In contrast, the at-risk status of the High 7 group appears doubtful. Comparisons based on gender generally revealed no differences among female and male 2-74 subjects.     

Language and orthography as irrelevant features in colour-word and picture-word stroop interference

Based on evidence that Chinese yields more interference than English, Biederman and Tsao (1979) have suggested that the processes involved in reading Chinese are more similar to those involved in colour naming than are the processes involved in reading English. In three experiments conducted to evaluate the empirical foundation for this hypothesis it was found that: (1) Chinese yielded less interference than English (and French) in between-subjects comparisons involving Chinese-English bilinguals and English monolinguals or English-French bilinguals; (2) Chinese print did not yield more interference than English print in within-subjects comparisons involving the orthogonal combination of print language (Chinese or English) and naming language (Chinese or English) among Chinese-English bilinguals; and (3) compared with syntactic category, both language and orthography were relatively impotent variables in the object naming version of the Stroop task.     

Quantitative and Qualitative Evaluation of Patterns of Cerebral Language Dominance : An Amobarbital Study

As a part of presurgical evaluation, 173 patients received bilateral intracarotid amobarbital tests for determination of cerebral language dominance. Language testing during intracarotid amobarbital procedures (IAP) consisted of the following tasks: automatic speech, sentence comprehension, body commands, naming, repetition, reading, and spontaneous speech. Patterns of cerebral language dominance were evaluated and discussed on five levels of analysis: (1) quantification of language dominance on the basis of a lateralization index derived from the total language scores in each IAP; (2) determination of five dominance subpatterns (left or right dominant, strongly bilateral, and incomplete left or right dominant) according to quantification performed on level (I) and clinical judgment; (3) qualitative differentiation of three kinds of bilaterality (positive, negative, and general) according to total language performance in left and right IAP; (4) analysis of grouped linguistic subfunctions extracted from performance in specific IAP subtests; (5) extraordinary individual case histories. The distribution of lateralization indices revealed only partially continuous degrees of lateralization, especially between the left-dominant and bilateral subgroups. As for the clinically oriented classification, incomplete left dominance is frequent (16.2%), while incomplete right dominance does not occur at all. Atypical dominance patterns are mostly correlated to bilateral and/or extratemporal foci. Concerning grouped subfunctions, a rotated factor matrix statistic yields an analysis of clusters of IAP subtests, where functions involving expressive language capacities are separated from those that are purely receptive. Further analyses of bilaterality subpatterns suggest that there are mainly four bilaterality phenomena, namely interhemispheric dissociation, double representation, unilateal representation of subfunctions, and partial representation of subfunctions in either hemisphere. Application of these differentiations to individual cases yields additional evidence that can be used in patient selection for operation in order to avoid postoperative neuropsychological deficits, especially in candidates for extratemporal surgery. In conclusion, a multilevel analysis of LAP language data is recommended since it permits a detailed account of varieties of language dominance patterns and contributes to more adequate presurgical decision-making in planned operations in cognitively relevant brain areas.     

探索语言水平测验的认知诊断改造和深度分析： 以广州市英语学业考试为例

本研究探索在通用认知诊断模型和相关检验方法的基础上对现有语言水平测验进行诊断改造和分析,分三步进行探索：1）探索对语言水平测试不同的属性和Q矩阵构建途径;2）探索对语言水平测试基于通用模型的建模和效度验证;3）探索对语言水平测试建模后续的深入分析。研究发现：属性分布和总分分布划分的学生水平一致性较高;学生对属性掌握存在性别差异且属性间的难易层级不同;属性模式分布进一步验证了语言属性间关联程度较高以及通用认知诊断模型和相关检验方法对语言测验的适用性。三步式的建模分析可作为对语言水平测验进行认知诊断改造的参考。     

A mixed-effects expectancy-valence model for the Iowa gambling task

The Iowa gambling task (IGT; Bechara, Damasio, Damasio, & Anderson, 1994) was developed to simulate real-life decision making under uncertainty. The task has been widely used to examine possible neurocognitive deficits in normal and clinical populations. Busemeyer and Stout (2002) proposed the expectancy-valence (EV) model to explicitly account for individual participants’ repeated choices in the IGT. Parameters of the EV model presumably measure different psychological processes that underlie performance on the task, and their values may be used to differentiate individuals across different populations. In the present article, the EV model is extended to include both fixed effects and subject-specific random effects. The mixed-effects EV model fits the nested structure of observations in the IGT naturally and provides a unified procedure for parameter estimation and comparisons among groups of populations. We illustrate the utility of the mixed-effects approach with an analysis of gender differences using a real data set. A simulation study was conducted to verify the advantages of this approach.     

Obsessive-compulsive disorder subtypes: an attempted replication and extension of a symptom-based taxonomy

A symptom-based subgroup taxonomy for obsessive-compulsive disorder (OCD) was evaluated and refined. The Yale-Brown Obsessive-Compulsive Scale symptom checklist was scored and cluster analysis was conducted with a sample of OCD patients (N = 114). Results were compared to Calamari et al.'s (Behaviour Research and Therapy 37 (1999) 113) five subgroup model. Rules for determining the number of subgroups supported a more complex model. In between sample comparisons, a stable contamination subgroup was found in both a five and seven subgroup taxonomy. Between sample stability was not as strong for Harming, Obsessionals, Symmetry, and Certainty subgroups. Hoarding, as a distinctive subgroup, was unstable in separate samples. When the Calamari et al. sample and the present sample were combined (N = 220), we found a reliable Hoarding subgroup. More interpretable and stable models emerged with the combined samples suggesting that large clinical samples are needed to identify OCD subgroups. Greater support was found for a seven subgroup taxonomy based subgroup interpretability and validation measure differences. The potential utility of symptom-based subgroup models of OCD and alternative approaches are discussed. Identification of reliable and valid OCD subtypes may advance theory and treatment.     

Structural Equation Modeling With AMOS,EQS, and LISREL: Comparative Approaches to Testing for the Factorial Validity of a Measuring Instrument

Using a confirmatory factor analytic (CFA) model as a paradigmatic basis for all comparisons, this article reviews and contrasts important features related to 3 of the most widely-used structural equation modeling (SEM) computer programs: AMOS 4.0 (Arbuckle, 1999), EQS 6 (Bentler, 2000), and LISREL 8 (Joreskog & Sorbom, 1996b). Comparisons focus on (a) key aspects of the programs that bear on the specification and testing of CFA models-preliminary analysis of data, and model specification, estimation, assessment, and misspecification; and (b) other important issues that include treatment of incomplete, nonnormally-distributed, or categorically-scaled data. It is expected that this comparative review will provide readers with at least a flavor of the approach taken by each program with respect to both the application of SEM within the framework of a CFA model, and the critically important issues, previously noted, related to data under study.     

语言理解中句法加工的脑机制

大量研究表明左侧额叶和颞叶的多个脑区与句法加工有关, 已有的理论模型分别从不同的角度对句法加工的脑机制进行了解释。通过文献比较与分析发现, 对句法加工的操作定义、实验任务、被试个体差异以及语言差异等均可能导致研究结果出现差异。在将来的研究中, 可以通过跨语言、多任务比较, 不同层面的句法加工的操作, 在方法上将个体功能定位分析与传统的组分析相结合, 以及从神经网络的角度来更准确和全面地揭示句法加工的脑机制。     

Exploring Differential Subgroup Functioning on SAT Writing Items: What Happens When English Is Not a Test Taker's Best Language?

The purpose of this study is to explore patterns in model-data fit related to subgroups of test takers from a large-scale writing assessment. Using data from the SAT, a calibration group was randomly selected to represent test takers who reported that English was their best language from the total population of test takers (N = 322,011). A reference scale for the items was constructed based on EBL responses. Response behaviors of test takers who reported that English was not their best language (ENBL) were examined in relationship to this reference scale. This study illustrates the use of differential subgroup analyses to identify patterns related to person misfit within subgroups, as well as subsets of items, that may affect the validity of writing scores for ENBL test takers. The methodology described here offers an approach that can be used to explore, understand, and improve the validity of scores obtained from ENBL test takers in large-scale writing assessments.     

An Idiographic Examination of Day-to-Day Patterns of Substance Use Craving,Negative Affect,and Tobacco Use Among Young Adults in Recovery

Psychological constructs, such as negative affect and substance use cravings that closely predict relapse, show substantial intraindividual day-to-day variability. This intraindividual variability of relevant psychological states combined with the “one day at a time” nature of sustained abstinence warrant a day-to-day investigation of substance use recovery. This study examines day-to-day associations among substance use cravings, negative affect, and tobacco use among 30 college students in 12-step recovery from drug and alcohol addictions. To account for individual variability in day-to-day process, it applies an idiographic approach. The sample of 20 males and 10 females (mean age = 21) was drawn from members of a collegiate recovery community at a large university. Data were collected with end-of-day data collections taking place over an average of 26.7 days. First-order vector autoregression models were fit to each individual predicting daily levels of substance use cravings, negative affect, and tobacco use from the same 3 variables 1 day prior. Individual model results demonstrated substantial interindividual differences in intraindividual recovery process. Based on estimates from individual models, cluster analyses were used to group individuals into 2 homogeneous subgroups. Group comparisons demonstrate distinct patterns in the day-to-day associations among substance use cravings, negative affect, and tobacco use, suggesting the importance of idiographic approaches to recovery management and that the potential value of focusing on negative affect or tobacco use as prevention targets depends on idiosyncratic processes.     

Classification of Attempted Suicide: A Review of Empirical Studies, 1963–1993

A review was carried out on empirical studies on the classification of attempted suicide over the period 1963-1993. Our aim was to investigate whether there is research evidence for a valid classification of homogeneous subgroups of suicide attempters. After assessment of the research quality, 32 studies were selected for comparison. Although there is lack of consistency among the studies, indications were found for two clearly distinguished subgroups characterized by mild and severe suicide attempts, which constitute the opposite poles of a one-dimensional concept of severity.