Updating positive and negative stimuli in working memory in depression

Difficulties in the ability to update stimuli in working memory (WM) may underlie the problems with regulating emotions that lead to the development and perpetuation of mood disorders such as depression. To examine the ability to update affective material in WM, the authors had diagnosed depressed and never-disordered control participants perform an emotion 2-back task in which participants were presented with a series of happy, sad, and neutral faces and were asked to indicate whether the current face had the same (match-set) or different (break-set or no-set) emotional expression as that presented 2 faces earlier. Participants also performed a 0-back task with the same emotional stimuli to serve as a control for perceptual processing. After transforming reaction times to control for baseline group differences, depressed and nondepressed participants exhibited biases in updating emotional content that reflects the tendency to keep negative information and positive information, respectively, active in WM. Compared with controls, depressed participants were both slower to disengage from sad stimuli and faster to disengage from happy facial expressions. In contrast, nondepressed controls took longer to disengage from happy stimuli than from neutral or sad stimuli. These group differences in reaction times may reflect both protective and maladaptive biases in WM that underlie the ability to effectively regulate negative affect.     

The effects of optimism and pessimism on updating emotional information in working memory

In the present study we elucidate the emotional and executive control interactions that might underlie optimism and pessimism. Participants completed a self-report measure of optimism/pessimism and performed an emotion faces categorisation task and an emotion n-back task in which they indicated whether each of a series of faces had the same or a different emotional expression (happy, sad, neutral) as the face presented two trials before. Trials were structured to measure latency to update emotional content in working memory (WM). More pessimistic individuals formed connections among positive stimuli, and broke connections among positive and sad stimuli, in WM more slowly than did less pessimistic individuals; levels of optimism/pessimism did not affect the rate with which individuals formed and broke connections among neutral representations in WM. It appears, therefore, that levels of pessimism are related to specific affective cognitive mechanisms in WM that may be involved in emotion regulation.     

Attentional Processing of Threat in Bipolar Disorder: Going Beyond Mood-Congruency

Emotional processing in bipolar disorder (BD) entails a complex attentional pattern not merely restricted to happy or sad biases, but also directed towards threatening information. This study examined threat-related bias on attentional orienting when participants were not instructed about the presentation of emotional stimuli (i.e., implicit instructions). An emotional dot-probe task in which an emotional face (i.e., threat, sad, happy) is simultaneously displayed with a neutral face was applied to BD individuals in their different episodes: mania (n?=?26), depression (n?=?24), and euthymia (n?=?28) as well as to a group of healthy controls (n?=?28). Symptomatic BD patients (i.e., in a manic or depressive episode) showed an attentional orienting bias toward threatening faces but not for happy or sad faces, while euthymic BD patients did not exhibit any attentional bias for emotional stimuli. A bias toward happy faces was found in the control group. Threat-related bias was not related to the severity of affective and anxiety symptoms in BD. When attention is not explicitly directed to emotional information, threat-related bias may characterize attentional orienting during mania and depression, but may be attenuated during euthymia.

     

Covert and overt orienting of attention to emotional faces in anxiety

Attentional biases for emotional faces were investigated in high, medium, and low anxiety groups (N = 54) using a probe detection task. Four types of facial expression (threat, sad, happy, neutral) were used to examine the specificity of the bias. Attentional bias measures were derived from manual reaction times (RTs) to probes and the direction of initial eye movement (EM) to the faces. The RT data indicated enhanced vigilance for threat rather than neutral faces in high and medium, but not low, state anxiety. The bias for negative faces appeared to be a combined function of stimulus threat value and the individual's anxiety level. The RT bias did not seem to depend on overt orienting, as many participants made few EMs. However, those who made frequent EMs to the faces showed concordance between the RT and EM bias measures, and so the RT measure of attentional bias for negative versus positive faces at 500 ms appears to provide a valid index of the direction of initial orienting to emotional stimuli. There was no evidence of an anxiety - related bias for happy faces (predicted by the emotionality hypothesis), nor a dysphoria - related bias for sad faces. However, increased dysphoria scores were associated with reduced attentiveness to happy faces.     

抑郁个体对情绪面孔的返回抑制能力不足

探讨抑郁对情绪面孔返回抑制能力的影响。以贝克抑郁量表、自评抑郁量表、CCMD-3和汉密顿抑郁量表为工具筛选出了正常对照组、抑郁康复组和抑郁患者组各17名被试进行了真人情绪面孔线索-靶子任务的行为学实验和事件相关电位(ERP)实验。在线索靶子范式中, 靶子在线索消失后出现, 被试对靶子的位置作出反应。行为学实验显示线索靶子间隔时间(stimulus onset asynchronies, SOA)为14ms时, 正常对照组对中性面孔有返回抑制效应, 抑郁康复组对所有面孔均存在返回抑制效应, 患者组对愤怒、悲伤面孔和中性面孔存在返回抑制效应; SOA为250ms时三组被试均对悲伤面孔存在返回抑制能力不足, 以患者组最突出, 康复组对高兴面孔存在返回抑制能力不足; SOA为750ms时正常组对悲伤面孔存在返回抑制效应, 康复组对高兴和悲伤面孔存在返回抑制能力不足, 患者组对悲伤面孔存在返回抑制能力不足, 对愤怒面孔存在返回抑制效应。在SOA为750ms的条件下, ERP波形特点为正常组对高兴面孔线索P3波幅大于其他组, 对高兴面孔无效提示P1波幅小于其他面孔, 对悲伤面孔有效提示P1波幅小于高兴面孔, 对高兴面孔有效提示P3波幅大于患者组, 对悲伤面孔无效提示P3波幅大于其他组; 康复组对悲伤面孔线索P3波幅大于其他面孔, 对高兴面孔有效提示P3波幅大于患者组, 对悲伤面孔无效提示P3波幅小于正常组; 患者组对悲伤面孔线索P1波幅大于其他组、P3波幅大于其他面孔, 对悲伤面孔无效提示P3波幅小于正常组, 高兴面孔有效提示P3波幅小于其他组。提示抑郁患者对负性刺激有返回抑制能力不足, 这种对负性刺激抑制能力的缺失导致抑郁个体难以抗拒负性事件的干扰而受到不良情绪状态的困扰, 所以他们可能更多的体验到抑郁情绪, 并致使抑郁持续和发展。而抑郁康复个体对高兴、悲伤面孔均有返回抑制能力不足, 这让康复个体能同时感受到正、负性刺激, 从而能保持一种认知和情绪上特定的平衡。     

Individual differences in perceptual sensitivity and response bias in anxiety: Evidence from emotional faces

We investigated the perception of emotional stimuli in anxious individuals and non-anxious cohorts. Signal detection theory analysis was applied to the discrimination of emotionally charged faces at several points along a continuum of emotional intensity. This design permitted the derivation of multiple measures of sensitivity and response bias for fearful and for happy faces. Anxious individuals lacked a conservative bias in judging fearful stimuli and a liberal bias in judging positive stimuli compared with non-anxious individuals. In addition, anxious participants had lower perceptual sensitivity (d′) than non-anxious participants for mildly threatening stimuli, as well as a trend towards lower perceptual sensitivity for moderately positive stimuli. These results suggest that the processing of threat information in anxiety is affected by sensitivity and bias differently at different levels of affective intensity.     

特质焦虑在面部表情前注意加工阶段的影响：来自ERP的证据

为探讨高特质焦虑者在前注意阶段对情绪刺激的加工模式以明确其情绪偏向性特点, 本研究采用偏差-标准反转Oddball范式探讨了特质焦虑对面部表情前注意加工的影响。结果发现: 对于低特质焦虑组, 悲伤面孔所诱发的早期EMMN显著大于快乐面孔, 而对于高特质焦虑组, 快乐和悲伤面孔所诱发的早期EMMN差异不显著。并且, 高特质焦虑组的快乐面孔EMMN波幅显著大于低特质焦虑组。结果表明, 人格特质是影响面部表情前注意加工的重要因素。不同于普通被试, 高特质焦虑者在前注意阶段对快乐和悲伤面孔存在相类似的加工模式, 可能难以有效区分快乐和悲伤情绪面孔。     

Memory for emotional faces in major depression following judgement of physical facial characteristics at encoding

The aim of the present study was to establish if patients with major depression (MD) exhibit a memory bias for sad faces, relative to happy and neutral, when the affective element of the faces is not explicitly processed at encoding. To this end, 16 psychiatric out-patients with MD and 18 healthy, never-depressed controls (HC) were presented with a series of emotional faces and were required to identify the gender of the individuals featured in the photographs. Participants were subsequently given a recognition memory test for these faces. At encoding, patients with MD exhibited a non-significant tendency towards slower gender identification (GI) times, relative to HC, for happy faces. However, the GI times of the two groups did not differ for sad or neutral faces. At memory testing, patients with MD did not exhibit the expected memory bias for sad faces. Similarly, HC did not demonstrate enhanced memory for happy faces. Overall, patients with MD were impaired in their memory for the faces relative to the HC. The current findings are consistent with the proposal that mood-congruent memory biases are contingent upon explicit processing of the emotional element of the to-be-remembered material at encoding.     

Understanding associations between negatively biased attention and depression and social anxiety: positively biased attention is key

ABSTRACT

Background and objectives: Although research supports the premise that depressed and socially anxious individuals direct attention preferentially toward negative emotional cues, little is known about how attention to positive emotional cues might modulate this negative attention bias risk process. The purpose of this study was to determine if associations between attention biases to sad and angry faces and depression and social anxiety symptoms, respectively, would be strongest in individuals who also show biased attention away from happy faces.

Methods: Young adults (N?=?151; 79% female; M?=?19.63 years) completed self-report measures of depression and social anxiety symptoms and a dot probe task to assess attention biases to happy, sad, and angry facial expressions.

Results: Attention bias to happy faces moderated associations between attention to negatively valenced faces and psychopathology symptoms. However, attention bias toward sad faces was positively and significantly related to depression symptoms only for individuals who also selectively attended toward happy faces. Similarly, attention bias toward angry faces was positively and significantly associated with social anxiety symptoms only for individuals who also selectively attended toward happy faces.

Conclusions: These findings suggest that individuals with high levels of depression or social anxiety symptoms attend preferentially to emotional stimuli across valences.     

Looking at the eyes of happiness: Positive emotions mediate the influence of life satisfaction on attention to happy faces

Despite significant advancements in the research of subjective well-being (SWB), little is known about its connection with basic cognitive processes. The present study explores the association between selective attention to emotional stimuli (i.e. emotional faces) and both the emotional and cognitive components of SWB (i.e. emotional well-being and satisfaction in life, respectively). Participants (N?=?83) were asked to freely watch a series of 84 pairs of emotional (happy, angry, or sad) and neutral faces from the Karolinska Directed Emotional Faces database. Eye-tracking methodology measured first fixations, number of fixations, and the time spent looking at emotional faces. Results showed that both the emotional and cognitive components of SWB were related to a general bias to attend to happy faces and avoid sad faces. Yet, bootstrapping analyses showed that positive emotions, rather than life satisfaction, were responsible for the positive information-processing bias. We discuss the potential functionality of these biases and their implications for research on positive emotions.     

The power of a smile: Stronger working memory effects for happy faces in adolescents compared to adults

Theories of adolescent behaviour attribute increases in risk-taking and sensation-seeking in this age group to a heightened sensitivity to emotional stimuli on the one hand and a relatively immature cognitive control system on the other hand. However, little research has outlined to what extent relevant and irrelevant emotional stimuli bias the imbalance between affective processing and cognitive control. Thirty-three adolescents (19 females, aged 12–14) and 37 adults (18 females, aged 18–29) completed two attentional conditions of an emotional face working memory (WM) 0-back/2-back task. Participants were asked to attend to the emotional facial expression in the “relevant” emotion condition, and to the gender of the face in the “irrelevant” condition. The results revealed a WM improvement for happy faces in the relevant condition in both age groups, and an impairment for irrelevant happy faces in adolescents, but not adults. Furthermore, the difference between both attentional conditions for happy faces was larger in adolescents than adults. Results are discussed within the framework of theories of adolescent behaviour.     

职前教师情绪觉察能力对情绪信息注意偏向的影响

采用修订的情绪觉察水平量表（LEAS）对315名职前教师进行调查,并从中筛选出高、低情绪觉察能力组被试各60人,分别完成情绪面孔Stroop任务（研究1）和情绪词Stroop任务（研究2）。（1）研究1的正确率上,中性面孔最高,愉快面孔次之,悲伤面孔最差;反应时上,悲伤面孔最长,愉快面孔次之,中性面孔最短;高分组仅在愉快和中性面孔上的反应时长于低分组;消极面孔的干扰效应高于积极面孔的干扰效应。（2）研究2的反应时上,消极词的反应时最长,显著长于中性和积极词;高分组仅在积极词和中性词上的反应时长于低分组,且高分组在积极词上的干扰效应高于低分组。研究结果表明与中性刺激相比,高低情绪觉察能力组均对情绪刺激产生了注意偏向,尤其是负性情绪刺激;与低情绪觉察能力组相比,高情绪觉察能力职前教师不仅对消极情绪信息产生注意偏向,还对积极情绪信息产生注意偏向。     

Memory for emotional faces in naturally occurring dysphoria and induced sadness

The aim was to establish if the memory bias for sad faces, reported in clinically depressed patients (Gilboa-Schechtman, Erhard Weiss, & Jeczemien, 2002; Ridout, Astell, Reid, Glen, & O'Carroll, 2003) generalises to sub-clinical depression (dysphoria) and experimentally induced sadness. Study 1: dysphoric (n = 24) and non-dysphoric (n = 20) participants were presented with facial stimuli, asked to identify the emotion portrayed and then given a recognition memory test for these faces. At encoding, dysphoric participants (DP) exhibited impaired identification of sadness and neutral affect relative to the non-dysphoric group (ND). At memory testing, DP exhibited superior memory for sad faces relative to happy and neutral. They also exhibited enhanced memory for sad faces and impaired memory for happy relative to the ND. Study 2: non-depressed participants underwent a positive (n = 24) or negative (n = 24) mood induction (MI) and were assessed on the same tests as Study 1. At encoding, negative MI participants showed superior identification of sadness, relative to neutral affect and compared to the positive MI group. At memory testing, the negative MI group exhibited enhanced memory for the sad faces relative to happy or neutral and compared to the positive MI group. Conclusion: MCM bias for sad faces generalises from clinical depression to these sub-clinical affective states.     

Effects of emotional response on the Stroop‐like task in preschool children and young adults

This study investigated the effects of emotional response on an inhibitory task, the Stroop‐like day‐night task, in which participants are presented with two pictures. They are then requested to inhibit naming what the card shown to them represents and instead state what the other card represents. Specifically, 35 4‐ to 6‐year‐old children and 15 young adults were administered the emotion‐related happy‐sad task and the emotion‐unrelated up‐down task using the same stimulus set (happy and sad cartoon faces). The results suggested that vulnerability to errors in the happy‐sad task was not derived from increased inhibitory demand. The results also suggested that the happy‐sad task is more inhibitory‐demanding in terms of response time. These results suggested that the happy‐sad task elicits interference more than other variants of this task, not because the task involves emotional stimuli per se but because the task involves both emotional stimuli and emotional responses.     

Selective attention to emotional faces following recovery from depression

This study was designed to examine attentional biases in the processing of emotional faces in currently and formerly depressed participants and healthy controls. Using a dot-probe task, the authors presented faces expressing happy or sad emotions paired with emotionally neutral faces. Whereas both currently and formerly depressed participants selectively attended to the sad faces, the control participants selectively avoided the sad faces and oriented toward the happy faces, a positive bias that was not observed for either of the depressed groups. These results indicate that attentional biases in the processing of emotional faces are evident even after individuals have recovered from a depressive episode. Implications of these findings for understanding the roles of cognitive and interpersonal functioning in depression are discussed.     

Misremembering emotion: Inductive category effects for complex emotional stimuli

Memories of objects are biased toward what is typical of the category to which they belong. Prior research on memory for emotional facial expressions has demonstrated a bias towards an emotional expression prototype (e.g., slightly happy faces are remembered as happier). We investigate an alternate source of bias in memory for emotional expressions – the central tendency bias. The central tendency bias skews reconstruction of a memory trace towards the center of the distribution for a particular attribute. This bias has been attributed to a Bayesian combination of an imprecise memory for a particular object with prior information about its category. Until now, studies examining the central tendency bias have focused on simple stimuli. We extend this work to socially relevant, complex, emotional facial expressions. We morphed facial expressions on a continuum from sad to happy. Different ranges of emotion were used in four experiments in which participants viewed individual expressions and, after a variable delay, reproduced each face by adjusting a morph to match it. Estimates were biased toward the center of the presented stimulus range, and the bias increased at longer memory delays, consistent with the Bayesian prediction that as trace memory loses precision, category knowledge is given more weight. The central tendency effect persisted within and across emotion categories (sad, neutral, and happy). This article expands the scope of work on inductive category effects to memory for complex, emotional stimuli.     

Neural correlates of attention to emotional facial expressions in dysphoria

The present study investigated whether dysphoric individuals have a difficulty in disengaging attention from negative stimuli and/or reduced attention to positive information. Sad, neutral and happy facial stimuli were presented in an attention-shifting task to 18 dysphoric and 18 control participants. Reaction times to neutral shapes (squares and diamonds) and the event-related potentials to emotional faces were recorded. Dysphoric individuals did not show impaired attentional disengagement from sad faces or facilitated disengagement from happy faces. Right occipital lateralisation of P100 was absent in dysphoric individuals, possibly indicating reduced attention-related sensory facilitation for faces. Frontal P200 was largest for sad faces among dysphoric individuals, whereas controls showed larger amplitude to both sad and happy as compared with neutral expressions, suggesting that dysphoric individuals deployed early attention to sad, but not happy, expressions. Importantly, the results were obtained controlling for the participants' trait anxiety. We conclude that at least under some circumstances the presence of depressive symptoms can modulate early, automatic stages of emotional processing.     

Healthy brooders employ more attentional resources when disengaging from the negative: an event-related fMRI study

Depressive brooding is considered a maladaptive ruminative-thinking style that has been shown to be highly correlated with major depression. The present study in healthy participants employed event-related fMRI to uncover the neural underpinnings of emotional disengagement as it relates to depressive brooding. Thirty-four healthy, never depressed individuals performed an emotional go/no-go task with a rapid presentation of emotional faces. We focused on the contrast of inhibiting sad (happy/no-go) versus inhibiting happy (sad/no-go) information. This contrast allowed us to assess possible difficulties in disengaging from emotionally negative, as compared with emotionally positive, faces. At the behavioral level, only in high brooders were higher self-reported brooding scores correlated with more errors when sad information was inhibited, relative to happy information. At the neural level, across all participants, brooding scores were positively correlated with activity in the right dorsolateral prefrontal cortex (DLPFC; BA 46), implying that high brooders show higher DLPFC involvement when successfully disengaging from a series of negative stimuli. These results may suggest that healthy individuals who report a high brooding thinking style need to recruit more attentional control in order to disengage successfully from negative information, in a way that may be related to emotion regulation strategies. These mechanisms might protect them from developing depressive symptoms.     

Adult attachment and attentional inhibition of interpersonal stimuli

In two studies, we used a negative affective priming task with pictures of angry (Study 1), sad (Study 2), and happy faces (Studies 1 and 2) to measure attentional inhibition of emotional stimuli as a function of attachment style. Results showed that attachment avoidance was associated with a stronger inhibition of both angry and sad faces. This indicates that the regulatory strategies of avoidant individuals involve inhibition of different types of negative, but not positive, stimuli. Attachment anxiety, on the other hand, showed no association with inhibitory responding to negative stimuli, although we did find indications of impaired inhibitory processing of happy faces in Study 1. The results are discussed in relation to current evidence on avoidant affect-regulation strategies.     

Emotional Contagion and Social Judgment

This study examined the influence of another's emotional expressions and individual differences in responsiveness to afferent feedback on attention, evaluations, and memory. In a mixed design, participants (N = 71) rated pictures following exposure to a sender in a neutral mood and then in either a happy or sad mood. Attention, ratings, and recall evidenced a bias characteristic of the sender's mood: Participants spent more time viewing happy and sad pictures following exposure to the happy and sad sender, respectively; ratings by participants exposed to the happy and sad sender were more positive and negative, respectively, and this effect was greater for those more cue-responsive; participants recalled more pictures congruent with the sender's mood and those more cue-responsive exposed to the sad sender exhibited impaired memory characteristic of the effect of sadness on memory. Findings suggest that exposure to even mild emotional expressions can influence cognition and behavior and this effect is greater for those more responsive to cues generated by afferent feedback.