Cognitive,emotional and social development in adolescents born to substance using women

The aim of this article is to investigate the long‐term developmental consequences of being born to a substance‐using mother, focusing on cognitive functions, attention, emotional and social development. The longitudinal sample comprised 48 adolescents aged 12–16 at the time of follow‐up assessments, which included the Wechsler Intelligence Scale for Children‐III, the Test of Everyday Attention for Children, The Tower of London test and the Strengths and Difficulties Questionnaire. The adolescents scored significantly lower than the norms on Wechsler's subtests and Full‐Scale IQ, and on The Everyday Attention test. There were few differences on the Strengths and Difficulties Questionnaire. The girls reported significantly more hyperactivity than the British norms, and the teachers reported higher impact scores in boys, compared to the British norms. Thus, the results on cognitive consequences of maternal substance use appear to be very substantial while the emotional and social consequences do not. The results suggest serious negative effects of substance exposure in utero on attention and cognitive functioning in general.     

Long-Term stress reactions in new immigrants to israel exposed to the chernobyl accident

Abstract

This comparison study examined the relation between presumed level of exposure to the accident at Chernobyl in 1986 to symptoms of post-traumatic stress disorder (PTSD) and other psychological symptoms (depression, somatization, anxiety, obsessive-compulsive style and interpersonal sensitivity), life events and the negative appraisal of the events surrounding the accident. The sample (N = 708) included new immigrants from the former Soviet Union (Confederation of Independent States) who arrived in Israel since 1989 from more exposed areas (n = 137), less exposed (n = 240) and a comparison sample (n = 331) who immigrated from other republics. The exposed groups had higher mean scores on all psychological outcome measures than the comparison group, particularly symptoms of PTSD. Both subsequent stressful life events and a negative, cognitive assessment of events contributed to present psychological distress, independent of exposure.     

Children's cognitive ability from 4 to 9 years old as a function of prenatal cocaine exposure, environmental risk, and maternal verbal intelligence

This study examined the effects of prenatal cocaine exposure, environmental risk, and maternal verbal intelligence on children's cognitive ability. Gender and age were examined as moderators of potential cocaine exposure effects. The Stanford-Binet IV intelligence test was administered to 231 children (91 cocaine exposed, 140 unexposed) at ages 4, 6, and 9 years. Neonatal medical risk and other prenatal exposures (alcohol, cigarettes, and marijuana) were also examined for their unique effects on child IQ. Mixed models analysis indicated that prenatal cocaine exposure interacted with gender, as cocaine-exposed boys had lower composite IQ scores. Age at assessment did not moderate this relation, indicating that cocaine-exposed boys had lower IQs across this age period. A stimulating home environment and high maternal verbal IQ also predicted higher composite IQ scores. Cocaine-exposed boys had lower scores on the Abstract/Visual Reasoning subscale, with trends for lower scores on the Short-Term Memory and Verbal Reasoning subscales, as exposure effects were observed across domains. The findings indicate that cocaine exposure continues to place children at risk for mild cognitive deficits into preadolescence. Possible mechanisms for the Exposure x Gender interaction are discussed.     

Common variance among three measures of nonverbal cognitive ability: WISC-R performance scale,WJPB-TCA reasoning cluster,and Halstead category test

The relationships among two psychometric measures of nonverbal cognitive ability (1) the Wechsler Intelligence Scale for Children-Revised (WISC-R) Performance IQ and (2) the Reasoning Cluster score and two subtests, Analysis-Synthesis and Concept Formation, from the Woodcock-Johnson Psychoeducational Battery-Tests of Cognitive Ability (WJPB-TCA)- and a neuropsychological test of abstract reasoning and concept formation (Halstead Category Test) were examined for a population of 25 children referred for psychoeducational evaluation as a result of learning difficulty. The findings demonstrated that the WISC-R Performance IQ and the Halstead Category Test have a common variance and appear to be sensitive to nonverbal cognitive ability, particularly of a perceptual organization nature. In contrast, the Reasoning Cluster score and the individual subtests from the WJPB-TCA appear to have a substantial g loading, as well as significant language correlates.     

Individual differences in neural mechanisms of selective auditory attention in preschoolers from lower socioeconomic status backgrounds: an event‐related potentials study

Selective attention, the ability to enhance the processing of particular input while suppressing the information from other concurrent sources, has been postulated to be a foundational skill for learning and academic achievement. The neural mechanisms of this foundational ability are both vulnerable and enhanceable in children from lower socioeconomic status (SES) families. In the current study, we assessed individual differences in neural mechanisms of this malleable brain function in children from lower SES families. Specifically, we investigated the extent to which individual differences in neural mechanisms of selective auditory attention accounted for variability in nonverbal cognitive abilities in lower SES preschoolers. We recorded event‐related potentials (ERPs) during a dichotic listening task and administered nonverbal IQ tasks to 124 lower SES children (77 females) between the ages of 40 and 67 months. The attention effect, i.e., the difference in ERP mean amplitudes elicited by identical probes embedded in stories when attended versus unattended, was significantly correlated with nonverbal IQ scores. Larger, more positive attention effects over the anterior and central electrode locations were associated with superior nonverbal IQ performance. Our findings provide initial evidence for prominent individual differences in neural indices of selective attention in lower SES children. Furthermore, our results indicate a noteworthy relationship between neural mechanisms of selective attention and nonverbal IQ performance in lower SES preschoolers. These findings provide the basis for future research to identify the factors that contribute to such individual differences in neural mechanisms of selective attention.     

Media violence exposure in aggressive and control adolescents: differences in self‐ and parent‐reported exposure to violence on television and in video games

The purpose of present study was to investigate differences in media violence exposure between groups of adolescents with and without Disruptive Behavior Disorders with Aggressive Features, using a case‐controlled design and multimethod assessment. Samples of 27 adolescents aged 13‐17 with Disruptive Behavior Disorder with Aggressive Features and 27 age‐gender‐IQ matched controls completed a semistructured interview about exposure to violence on television and video games; parents completed a corresponding questionnaire measure. Moderate intercorrelations were found between most self‐ and parent‐report television and video game violence exposure measures. Compared to control adolescents, adolescents with Disruptive Behavior Disorder with Aggressive Features had higher aggregate media violence exposure, higher exposure to video game violence, and higher parent‐reported exposure to television violence. Results show that adolescents and parents agree about the adolescent's level of media violence exposure, that exposure to violence on television tends to be accompanied by exposure to violence in video games, and that the association between media violence exposure and Disruptive Behavior Disorder with Aggressive Features is not due to a spurious effect of gender or IQ. Aggr. Behav. 31:000–000, 2005. © 2005 Wiley‐Liss, Inc.     

Verbal–spatial IQ discrepancies impact brain activation associated with the resolution of cognitive conflict in children and adolescents

Verbal–spatial discrepancies are common in healthy individuals and in those with neurodevelopmental disorders associated with cognitive control deficits including: Autism Spectrum Disorder, Non‐Verbal Learning Disability, Fragile X, 22q11 deletion, and Turner Syndrome. Previous data from healthy individuals suggest that the magnitude of the difference between verbal IQ (VIQ) and performance IQ (PIQ) scores (the VIQ>PIQ discrepancy) is associated with reduced thickness in frontal and parietal cortices (inferior frontal, anterior cingulate, inferior parietal lobule, and supramarginal gyrus) that support cognitive control. Unknown is whether the VIQ>PIQ discrepancy is associated with functional deficits in these areas in healthy or ill children and adolescents. We assessed the effects of the VIQ>PIQ discrepancy on fMRI BOLD response during the resolution of cognitive conflict in 55 healthy children and adolescents during performance of a Simon Spatial Incompatibility task. As the magnitude of the VIQ>PIQ discrepancy increased, activation of fronto‐striatal, limbic, and temporal regions decreased during conflict resolution (p < .05, corrected). In exploratory analyses, the VIQ>PIQ discrepancy was associated with reduced functional connectivity from right inferior frontal gyrus to right thalamus and increased functional connectivity to right supramarginal gyrus (ps < .03, uncorrected). The VIQ>PIQ discrepancy may be an important aspect of an individual's cognitive profile and likely contributes to, or is associated with, deficient cognitive control processes characteristic of many childhood disorders.     

Neuropsychological Effects at Early School Age of Fetal Alcohol Exposure of Varying Duration

A comprehensive neuropsychological assessment was performed with forty-six 5- to 9-year-old children exposed to alcohol in utero for varying durations. The children were subdivided according to duration of maternal alcohol abuse, as follows: during trimester I (n = 16), during trimesters I and II (n = 16), and throughout pregnancy (n = 14). A control group (n = 26) consisted of unexposed children. Fetal alcohol exposure throughout pregnancy had significant, diffuse effects on the development of the children, whereas exposure only during early pregnancy did not. Observed cognitive deficits included problems in naming, receptive language, attention, and visual-motor functions. Verbal and visual memory and manual motor precision did not significantly differ between the groups.     

The Relationship Between Blood Lead,Bone Lead and Child Intelligence

We report associations between serial measures of blood lead and intelligence in children age 10–12 years, half heavily exposed to lead from the prenatal period onward, and half relatively unexposed. For a subsample, we examine bone lead-IQ associations, comparing them with blood lead associations. Both blood and bone lead levels were associated with intelligence decrements, small relative to the contribution of social factors. For each doubling of Tib-Pb, Full Scale, Performance, and Verbal IQ decreased by an estimated 5.5, 6.2, and 4.1 points, respectively. Bone lead-IQ associations were stronger than those for blood lead, which nonetheless provide robust analogues. Current BPb, easy to obtain, provides a useful means for assessing Pb exposure/IQ associations.     

The relationship between blood lead, bone lead and child intelligence.

We report associations between serial measures of blood lead and intelligence in children age 10-12 years, half heavily exposed to lead from the prenatal period onward, and half relatively unexposed. For a subsample, we examine bone lead-IQ associations, comparing them with bone lead associations. Both blood and bone lead levels were associated with intelligence decrements, small relative to the contribution of social factors. For each doubling of Tib-Pb, Full Scale, Performance, and Verbal IQ decreased by an estimated 5.5, 6.2, and 4.1 points, respectively. Bone lead-IQ associations were stronger than those for blood lead, which nonetheless provide robust analogues. Current BPb, easy to obtain, provides a useful means for assessing Pb exposure/IQ associations.     

Formula: see text]Substance exposure in utero and developmental consequences in adolescence: A systematic review

Background: The impacts of maternal substance use have been observed in both research and clinical experience. Several studies have shown that preschool children are at heightened risk of developing various cognitive, behavioral, and socioemotional difficulties. Most knowledge has been generated concerning alcohol consumption during pregnancy and the postnatal effects thereof. Less is known about substance use other than alcohol (for instance, opiates, marijuana, and cocaine) during pregnancy and the long-term developmental consequences. Objective: The aims of this review are to identify relevant published data on adolescents who have been exposed in utero to alcohol and/or other substances and to examine developmental consequences across functions and mental health at this point in life. Methods: PubMed, Embase, and PsychInfo were searched for publications during the period of 1980-2011 and titles and abstracts selected according to prespecified broad criteria. Results: Twenty-five studies fulfilled all of the specific requirements and were included in this review. Most research covered prenatal alcohol exposure. Other substances, however, included cocaine, marijuana, opiates, and poly-substances. Results showed that prenatal exposure to alcohol has long-term cognitive, behavioral, social, and emotional developmental consequences depending on amount and timing of exposure in utero. Less evidence exists for long-term consequences of exposure in utero to other substances than alcohol. However, recent brain-imaging studies have provided important evidence of serious effects of other substance exposure on the developing brain and recent follow-up studies have found an association with deficits in language, attention, areas of cognitive performance and delinquent behavior in adolescence.     

Antisocial Behavior: Exploring Behavioral,Cognitive, and Environmental Influences on Expulsion

We investigated the role of three significant potential contributors to antisocial behavior (ASB)—behavior, cognitive, and environmental influences—and their impact on expulsion. The following measures were administered to a community sample of antisocial adolescents: nonverbal ability and working memory, behavioral profile (rated by the social worker and self‐rated), and environmental background (socio‐economic background and family structure). The data indicated that their working memory performance was in the average range; however, group means were significantly lower in the nonverbal ability test. Although social workers' assessments of the adolescents' behavior were closely related to their self‐reports, it was the latter that was best able to correctly classify those who had been expelled from their non‐expelled ASB peers. Environmental background did not appear to have a strong role in expulsion rates. The results are discussed in the context of persistency of ASB and ways forward to provide support and intervention for adolescents. Copyright © 2013 John Wiley & Sons, Ltd.     

Instrumental learning and cognitive flexibility processes are impaired in children exposed to early life stress

Children who experience severe early life stress show persistent deficits in many aspects of cognitive and social adaptation. Early stress might be associated with these broad changes in functioning because it impairs general learning mechanisms. To explore this possibility, we examined whether individuals who experienced abusive caregiving in childhood had difficulties with instrumental learning and/or cognitive flexibility as adolescents. Fifty‐three 14–17‐year‐old adolescents (31 exposed to high levels of childhood stress, 22 control) completed an fMRI task that required them to first learn associations in the environment and then update those pairings. Adolescents with histories of early life stress eventually learned to pair stimuli with both positive and negative outcomes, but did so more slowly than their peers. Furthermore, these stress‐exposed adolescents showed markedly impaired cognitive flexibility; they were less able than their peers to update those pairings when the contingencies changed. These learning problems were reflected in abnormal activity in learning‐ and attention‐related brain circuitry. Both altered patterns of learning and neural activation were associated with the severity of lifetime stress that the adolescents had experienced. Taken together, the results of this experiment suggest that basic learning processes are impaired in adolescents exposed to early life stress. These general learning mechanisms may help explain the emergence of social problems observed in these individuals.     

Intelligence profiles in children and adolescents with left temporal lobe epilepsy: relationship to language laterality

Pre- and postoperative IQ profiles were examined in children and adolescents with left temporal-lobe epilepsy. Participants were grouped according to their pattern of speech dominance, as indicated by the intracarotid sodium amobarbital procedure. Seven participants with typical (left hemisphere) speech representation were matched for age and sex to seven participants with atypical (bilateral or right hemisphere) speech representation. The group with atypical speech representation tended to perform worse pre- and postoperatively on several verbal and nonverbal subtests. Unlike Strauss et al.'s (1990) sample, however, the groups did not differ significantly on pre- or postoperative Performance IQ. The results suggest that when individuals are matched closely for age and sex, there may only be limited support for a nonverbal "crowding" hypothesis. Atypical speech representation in children and adolescents with early temporal-lobe epilepsy appears to be associated with lowered performance on both verbal and nonverbal IQ subtests.     

Implicit theories of intelligence and IQ test performance in adolescents with Generalized Anxiety Disorder

During the past decade, several studies have reported positive effects of cognitive-behavioral therapy (CBT) in the treatment of children and adolescents with mental disorders. One of the most important CBT interventions is to teach children and adolescents to challenge negative thoughts that lead to maladjusted behaviors. Based on the implicit theories of intelligence framework, the main purpose of this study was to test whether an incremental theory manipulation could be used to affect IQ test performance in adolescents with Generalized Anxiety Disorder (GAD). Results showed that patients demonstrated enhanced IQ performance and experienced less state anxiety when they were exposed to an incremental theory of intelligence manipulation. Our findings suggest that incremental theory manipulation provides a useful cognitive strategy for addressing school-related anxiety in adolescents with mental disorders such as GAD.     

The race that precedes coactivation: development of multisensory facilitation in children

Rationale: The facilitating effect of multisensory integration on motor responses in adults is much larger than predicted by race‐models and is in accordance with the idea of coactivation. However, the development of multisensory facilitation of endogenously driven motor processes and its relationship to the development of complex cognitive skills in school‐age children is largely unexplored. Method: Twenty adults and 95 children where allocated into six age groups: 6, 7, 8, 9, 10–11 and adults. Participants’ motor reaction times (MRTs) and accuracy in response to the detection of auditory, visual and audiovisual stimuli were recorded. Children's reading accuracy and nonverbal IQ were also assessed. Results: In general, MRTs of children were significantly slower with greater variability than those of adults. Although the average level of multisensory facilitation was similar for all age groups, mean cumulative density functions (CDFs) showed that multisensory facilitation in 6 and 10–11‐year‐olds is within the predictive limits of race‐models. Where coactivation was seen in the CDF of individual children it was not as strong or as consistent as that in adults. The degree of multisensory facilitation did not correlate with age, reading accuracy or IQ. Conclusion: The average level of multisensory facilitation to endogenously driven motor responses does not change gradually with age nor is it related to intelligence or reading accuracy. In general, multisensory integration remains immature until 10–11 years of age and lies within the predicted confines of race‐models.     

Maternal and infant affect at 4 months predicts performance and verbal IQ at 4 and 7 years in a diverse population

Using existing longitudinal data from 570 infants in the Maternal Lifestyle Study, we explored the predictive value of maternal and infant affect and maternal vocalizations during 2 minutes of face‐to‐face interactions at 4 months on IQ scores at 4.5 and 7 years. After controlling for demographic factors, maternal depression, and prenatal drug exposure, maternal positive affect and maternal positive vocalizations emerged as predictors of both verbal and performance IQ at 4.5 and 7 years. Although infant positive affect during the interaction with the mother was not predictive of these outcome measures, infant positive affect towards an examiner predicted verbal but not performance IQ at 4.5 years. These results suggest that maternal positive affect may index emotional engagement in interaction that facilitates both verbal and nonverbal cognitive development, while infant social positive affect is specifically related to the acquisition of verbal reasoning abilities. These findings are significant because they are based on a discrete snapshot of observable behavior in infancy (just 2 minutes of interaction), because they extend the range of maternal behaviors and characteristics known to support positive developmental outcomes, and because they are derived from high‐risk infants where prevention efforts may be beneficial. Potential mechanisms for these associations are discussed, as are the clinical implications for identifying dyads most in need of targeted interventions.     

Adolescents Exposed to Suicidal Behavior of Others: Prevalence of Self‐Harm and Associated Psychological,Lifestyle, and Life Event Factors

Exposure to suicidal behavior of others was examined among 3,881 Irish adolescents in the Child and Adolescent Self‐harm in Europe (CASE) study. One third of the sample had been exposed to suicidal behavior, and exposed adolescents were eight times more likely to also report own self‐harm. Exposed adolescents shared many risk factors with those reporting own self‐harm. Those reporting both exposure and own self‐harm presented the most maladaptive profile on psychological, life event, and lifestyle domains, but neither anxiety nor depression distinguished this group. Exposed adolescents are burdened by a wide range of risk factors and in need of support.     

Functional brain organization of working memory in adolescents varies in relation to family income and academic achievement

Working memory (WM) capacity reflects executive functions associated with performance on a wide range of cognitive tasks and education outcomes, including mathematics achievement, and is associated with dorsolateral prefrontal and parietal cortices. Here we asked if family income is associated with variation in the functional brain organization of WM capacity among adolescents, and whether that variation is associated with performance on a statewide test of academic achievement in mathematics. Participants were classified into higher‐income and lower‐income groups based on family income, and performed a WM task with a parametric manipulation of WM load (N‐back task) during functional magnetic resonance imaging (fMRI). Behaviorally, the higher‐income group had greater WM capacity and higher mathematics achievement scores. Neurally, the higher‐income group showed greater activation as a function of WM load in bilateral prefrontal, parietal, and other regions, although the lower‐income group exhibited greater activation at the lowest load. Both groups exhibited positive correlations between parietal activations and mathematics achievement scores, but only the higher‐income group exhibited a positive correlation between prefrontal activations and mathematics scores. Most of these findings were maintained when higher‐ and lower‐income groups were matched on WM task performance or nonverbal IQ. Findings indicate that the functional neural architecture of WM varies with family income and is associated with education measures of mathematics achievement.     

Comparing the Performance of Native North Americans and Predominantly White Military Recruits on Verbal and Nonverbal Measures of Cognitive Ability

This study compared the cognitive ability of adult Canadian First Nations (American Indian) aboriginals (N=101) living in remote areas to recruits (N=131) undergoing military training in the Canadian Forces. Comparisons involved both verbal and nonverbal measures: The Canadian Forces Aptitude Test (CFAT), Wonderlic Personnel Test, (WPT), Raven's Standard Progressive Matrices (SPM) and Mill Hill Vocabulary (MHV) test. All measures were examined for differential test and item functioning; as well, the CFAT was analyzed for adverse impact. Confirming past research, First Nations (FNs) members scored, on average, 18 points lower in IQ estimates based on the WPT, a verbal measure of cognitive ability; however, the differences between the groups were less on the nonverbal tests: SPM (5 points lower) and the MHV (9 points lower). Differential Item Functioning (DIF) analysis detected a few items from the CFAT, SPM and MHV that displayed DIF, but none from the WPT. The SPM and WPT appear to be unbiased measures with respect to differential test functioning (DTF), once language and education are controlled. Making employment decisions solely on verbal cognitive ability test scores, however, is likely to produce adverse impact against members of FN, unless verbal ability is a bona fide occupational requirement for the positions under consideration. Both the verbal and nonverbal cognitive ability tests assessed the same latent structure suggesting that the nonverbal tests could be used in place of the verbal tests with little loss in predictive ability for occupations involving a high degree of spatial ability.