Behavioral economics of drug self-administration. II. A unit-price analysis of cigarette smoking.

In behavioral economics, the ratio of response requirement to reinforcer magnitude is referred to as unit price. Previous research with nonhuman subjects has demonstrated that (a) comparable amounts of food are consumed at the same unit price even though different response requirements and reinforcer magnitudes comprise that unit price and (b) increases in unit price decrease food consumption in a positively decelerating fashion. The present study assessed the generality of these findings to the cigarette smoking of 5 human volunteers. During approximately 18 3-hr sessions, various combinations of response requirement (fixed-ratio 200, 400, and 1,600) and reinforcer magnitude (1, 2, and 4 puffs per bout) were arranged. Consumption (i.e., the number of puffs) generally was comparable at the same unit price independent of the response requirement and reinforcer magnitude comprising that unit price. In addition, increasing unit price generally decreased consumption in a positively decelerating fashion. These results extend the generality of the unit-price analysis to human cigarette smoking. Moreover, these results further support the position that reinforcer magnitude and response requirement are functionally equivalent and interact to determine consumption. The concept of unit price, by integrating and summarizing the effects of those two operations, provides a more parsimonious explanation of the results than do separate evaluations of the effects of response requirement and reinforcer magnitude.     

A selectionist approach to reinforcement.

We describe a principle of reinforcement that draws upon experimental analyses of both behavior and the neurosciences. Some of the implications of this principle for the interpretation of behavior are explored using computer simulations of adaptive neural networks. The simulations indicate that a single reinforcement principle, implemented in a biologically plausible neural network, is competent to produce as its cumulative product networks that can mediate a substantial number of the phenomena generated by respondent and operant contingencies. These include acquisition, extinction, reacquisition, conditioned reinforcement, and stimulus-control phenomena such as blocking and stimulus discrimination. The characteristics of the environment-behavior relations selected by the action of reinforcement on the connectivity of the network are consistent with behavior-analytic formulations: Operants are not elicited but, instead, the network permits them to be guided by the environment. Moreover, the guidance of behavior is context dependent, with the pathways activated by a stimulus determined in part by what other stimuli are acting on the network at that moment. In keeping with a selectionist approach to complexity, the cumulative effects of relatively simple reinforcement processes give promise of simulating the complex behavior of living organisms when acting upon adaptive neural networks.     

Extinction training regulates neuroadaptive responses to withdrawal from chronic cocaine self-administration

Cocaine produces multiple neuroadaptations with chronic repeated use. Many of these neuroadaptations can be reversed or normalized by extinction training during withdrawal from chronic cocaine self-administration in rats. This article reviews our past and present studies on extinction-induced modulation of the neuroadaptive response to chronic cocaine in the mesolimbic dopamine system, and the role of this modulation in addictive behavior in rats. Extinction training normalizes tyrosine hydroxylase levels in the nucleus accumbens (NAc) shell, an effect that could help ameliorate dysphoria and depression associated with withdrawal from chronic cocaine use. Extinction training also increases levels of GluR1 and GluR2/3 AMPA receptor subunits, while normalizing deficits in NR1 NMDA receptor subunits, in a manner consistent with long-term potentiation of excitatory synapses in the NAc shell. Our results suggest that extinction-induced increases in AMPA and NMDA receptors may restore deficits in cortico-accumbal neurotransmission in the NAc shell and facilitate inhibitory control over cocaine-seeking behavior. Other changes identified by gene expression profiling, including up-regulation in the AMPA receptor aggregating protein Narp, suggest that extinction training induces extensive synaptic reorganization. These studies highlight potential benefits for extinction training procedures in the treatment of drug addiction.     

A randomized trial of employment-based reinforcement of cocaine abstinence in injection drug users

High-magnitude and long-duration abstinence reinforcement can promote drug abstinence but can be difficult to finance. Employment may be a vehicle for arranging high-magnitude and long-duration abstinence reinforcement. This study determined if employment-based abstinence reinforcement could increase cocaine abstinence in adults who inject drugs and use cocaine during methadone treatment. Participants could work 4 hr every weekday in a workplace where they could earn about $10.00 per hour in vouchers; they were required to provide routine urine samples. Participants who attended the workplace and provided cocaine-positive urine samples during the initial 4 weeks were invited to work 26 weeks and were randomly assigned to an abstinence-and-work (n = 28) or work-only (n = 28) group. Abstinence-and-work participants had to provide urine samples showing cocaine abstinence to work and maintain maximum pay. Work-only participants could work independent of their urinalysis results. Abstinence-and-work participants provided more (p = .004; OR = 5.80, 95% CI = 2.03-16.56) cocaine-negative urine samples (29%) than did work-only participants (10%). Employment-based abstinence reinforcement can increase cocaine abstinence.     

A microcomputer interface to control reinforcement delivery

A method for interfacing a PET microcomputer to an operant arena is described.     

OTS: A program for converting Noldus Observer data files to SDIS files

A program for converting Noldus Observer data files (ODF) to sequential data interchange standard (SDIS) files is described. Observer users who convert their data files can then take advantage of various flexible and powerful data modification and computational procedures available in the Generalized Sequential Querier, a program that assumes SDIS-formatted files.     

A comparison of noncontingent reinforcement,other competing stimulation,and liquid rescheduling for the treatment of rumination

Modified versions of three popular nonaversive treatments for rumination in a person with profound developmental delay were evaluated using an alternating treatments design (ATD) as a component of an ABAB design. Results showed that the most effective intervention involved noncontingent feeding every 20 s for the 30 min immediately following a meal. Further analysis demonstrated that no significant increase in rumination occurred during the 60 min after the treatment procedure had expired, thus indicating that rumination was not merely postponed. Results are discussed in terms of their relation to currently popular (satiation) interventions for the treatment of rumination in individuals with developmental disability. Future research needs are proposed from an analysis of known behavioral and physiological variables and their possible interactions. ©1997 by John Wiley & Sons, Ltd.     

A simple BASIC program to generate values for variable-interval schedules of reinforcement

A BASIC program to generate values for variable-interval (VI) schedules of reinforcement is presented. A VI schedule should provide access to reinforcement with a constant probability over a time horizon. If the values in a VI schedule are calculated from an arithmetic progression, the probability of reinforcement is positively correlated with the time since the last reinforcer was delivered. Fleshler and Hoffman (1962) developed an iterative equation to calculate VI schedule values so that the probability of reinforcement remains constant. This easy-to-use program generates VI schedule values according to the Fleshler and Hoffman equation, randomizes the values, and saves the values in ASCII to a disk file.     

A versatile dispenser for commercial monkey chow reinforcement

A dispenser is described that can deliver a wide variety of foodstuffs of almost any consistency. Despite compact size, storage capacity is sufficient for several days of unattended operation. Computer-compatible logic allows flexible applications in animal housing facilities and experimental setups. Its application in delivering regular monkey chow as reinforcement in experiments is discussed.