Startle modulation in non-incarcerated men and women with psychopathic traits

Past research has demonstrated that individuals with psychopathic characteristics are under-responsive to aversive stimuli, however, much of this work has failed to include non-incarcerated samples, or to examine gender differences in this relationship. Additionally, few studies have examined the role of specific personality characteristics, as they relate to both psychopathic behavior and emotional responsiveness. The current study assessed emotional modulation of the startle response in a community sample of 108 men and women (99 with usable startle data) during perception of emotion-laden photographs. Consistent with previous work, men reporting high levels of psychopathy failed to show the typical increase in the startle response when exposed to aversive photographs, but only when responses were elicited relatively early in picture viewing (i.e., 2.0 s as compared to 4.5 s post-photograph onset). Additionally, both genders showed a significant effect of harm avoidance and anxiety on modulation of the startle response, such that individuals reporting low levels of each trait failed to show significant responses to aversive photographs. These results suggest that while deficits in emotional processing extend to non-incarcerated samples, the relationship may be influenced by additional factors including gender, personality, and attributes related to incarceration.     

Startle modulation in non-incarcerated men and women with psychopathic traits

Past research has demonstrated that individuals with psychopathic characteristics are under-responsive to aversive stimuli, however, much of this work has failed to include non-incarcerated samples, or to examine gender differences in this relationship. Additionally, few studies have examined the role of specific personality characteristics, as they relate to both psychopathic behavior and emotional responsiveness. The current study assessed emotional modulation of the startle response in a community sample of 108 men and women (99 with usable startle data) during perception of emotion-laden photographs. Consistent with previous work, men reporting high levels of psychopathy failed to show the typical increase in the startle response when exposed to aversive photographs, but only when responses were elicited relatively early in picture viewing (i.e., 2.0 s as compared to 4.5 s post-photograph onset). Additionally, both genders showed a significant effect of harm avoidance and anxiety on modulation of the startle response, such that individuals reporting low levels of each trait failed to show significant responses to aversive photographs. These results suggest that while deficits in emotional processing extend to non-incarcerated samples, the relationship may be influenced by additional factors including gender, personality, and attributes related to incarceration.     

Stability and predictors of psychopathic traits from mid‐adolescence through early adulthood

High levels of psychopathic traits in youth are associated with multiple negative outcomes including substance misuse, aggressive behavior, and criminality. Evidence regarding stability of psychopathic traits is contradictory. No previous study has examined long‐term stability of psychopathic traits assessed with validated clinical measures. The present study examined the stability of psychopathic traits from mid‐adolescence to early adulthood and explored adolescent factors that predicted psychopathic traits five years later. The sample included 99 women and 81 men who had consulted a clinic for substance misuse in adolescence. At an average age of 16.8 years, the adolescents were assessed using the Psychopathy Checklist: Youth Version (PCL: YV) and five years later using the PCL‐Revised (PCL‐R). Additionally, extensive clinical assessments of the adolescents and their parents were completed in mid‐adolescence. Among both females and males, moderate to high rank‐order stability was observed for total PCL and facet scores. Among both females and males, there was a decrease in the mean total PCL score, interpersonal facet score, affective facet score, and lifestyle facet score. However, the great majority of females and males showed no change in psychopathy scores over the five‐year period as indicated by the Reliable Change Index. Despite the measures of multiple family and individual factors in adolescence, only aggressive behavior and male sex predicted PCL‐R total scores in early adulthood after taking account of PCL:YV scores. Taken together, these results from a sample who engaged in antisocial behavior in adolescence suggest that factors promoting high psychopathy scores act early in life.     

Early temperamental and psychophysiological precursors of adult psychopathic personality

Emerging research on psychopathy in children and adolescents raises the question of whether indicators, such as temperament or psychophysiology, exist very early in life in those with a psychopathic-like personality in adulthood. This study tests the hypothesis that individuals who are more psychopathic in adulthood would be less fearful and inhibited and more stimulation seeking/sociable at age 3 and that they would also show reduced age 3 skin-conductance (SC) responsivity. In a community sample of 335 3-year-olds, behavioral measures of temperament were taken and electrodermal activity was recorded in response to both orienting and aversive tones. R. D. Hare's (1985) Self-Report Psychopathy scale (SRP-II) was administered at follow-up at age 28. Individuals scoring higher on the measure were significantly less fearful and inhibited, were more sociable, and displayed longer SC half-recovery times to aversive stimuli compared with controls at age 3. Contrary to predictions, they also showed increased autonomic arousal and SC orienting. Findings appear to be the first to suggest that a prospective link may exist between temperament and psychophysiology in very young children and psychopathic personality in adulthood.     

Facial affect recognition in college students with psychopathic traits: A comparison using tests matched in discriminating power

Research has provided inconsistent evidence for the relationship between psychopathy and facial affect recognition. We examined whether some of the previous findings could reflect a psychometric artifact in which deficits are more easily detected with very discriminating measures than with less discriminating measures, an issue not addressed in prior psychopathy studies. We developed measures of facial affect recognition matched in discriminating power and administered these measures to 194 college students who had also completed the Psychopathic Personality Inventory. Results indicate that high levels of Coldheartedness were associated with poorer recognition of the specific emotion of disgust. These findings demonstrate that some affective processing deficits associated with psychopathic traits cannot be attributed to psychometric artifacts.     

Neuropsychological correlates of psychopathic traits in a non-incarcerated sample

The present study examined the association between neuropsychological behavioral performance and psychopathic personality traits, measured via the Psychopathic Personality Inventory (PPI), in a non-incarcerated sample. Specifically, performance involving general executive cognitive functioning (ECF) and response inhibition was investigated in regards to the two main psychopathy factors (affective-interpersonal and social deviance) of the PPI. A group of 95 student volunteers were administered the PPI and a variety of neuropsychological measures. Analyses revealed that total PPI scores were related to deficits in response inhibition but not general ECF. However, this relationship was qualified by the differential associations observed for the two PPI factors. The social deviance factor was associated with deficits in general ECF and response inhibition, whereas the affective-interpersonal facet was associated with enhanced general ECF performance but not response inhibition. The results suggest that cognitive functioning shows predicted associations with a self-report measure of psychopathy among non-incarcerated young adults, providing further evidence for psychopathy conceptualizations from a normal-range personality perspective.     

Psychopathic traits associated with abnormal hemodynamic activity in salience and default mode networks during auditory oddball task

Psychopathy is a personality disorder accompanied by abnormalities in emotional processing and attention. Recent theoretical applications of network-based models of cognition have been used to explain the diverse range of abnormalities apparent in psychopathy. Still, the physiological basis for these abnormalities is not well understood. A significant body of work has examined psychopathy-related abnormalities in simple attention-based tasks, but these studies have largely been performed using electrocortical measures, such as event-related potentials (ERPs), and they often have been carried out among individuals with low levels of psychopathic traits. In this study, we examined neural activity during an auditory oddball task using functional magnetic resonance imaging (fMRI) during a simple auditory target detection (oddball) task among 168 incarcerated adult males, with psychopathic traits assessed via the Hare Psychopathy Checklist-Revised (PCL-R). Event-related contrasts demonstrated that the largest psychopathy-related effects were apparent between the frequent standard stimulus condition and a task-off, implicit baseline. Negative correlations with interpersonal-affective dimensions (Factor 1) of the PCL-R were apparent in regions comprising default mode and salience networks. These findings support models of psychopathy describing impaired integration across functional networks. They additionally corroborate reports which have implicated failures of efficient transition between default mode and task-positive networks. Finally, they demonstrate a neurophysiological basis for abnormal mobilization of attention and reduced engagement with stimuli that have little motivational significance among those with high psychopathic traits.     

Neuroticism and psychopathy predict brain activation during moral and nonmoral emotion regulation

Functional neuroimaging has identified brain regions associated with voluntary regulation of emotion, including the prefrontal cortex and amygdala. The neural mechanisms underlying individual differences in emotion regulation have not been extensively studied. We investigated the neural correlates of neuroticism and psychopathic personality traits in the context of an emotion regulation task. Results showed that amygdala activity elicited by unpleasant pictures was positively correlated with neuroticism and negatively correlated with a specific psychopathic trait related to emotional underreactivity. During active attempts to decrease emotional responses to unpleasant pictures, superior and ventrolateral prefrontal activity was positively correlated with psychopathy, but not with neuroticism. In contrast, dorsolateral prefrontal activity was positively correlated with neuroticism, but not with psychopathy. Psychopathy was also negatively correlated with medial prefrontal activity in response to pictures depicting moral violations, suggesting reduced emotional responses to moral stimuli in individuals with high levels of psychopathic traits. These results demonstrate dissociable influences of different personality traits on neural activity associated with responses to emotional stimuli and on the recruitment of regulation-related brain activity during the active down-regulation of responses to negative emotional stimuli. These results have implications for the etiology of trait-based psychopathology involving emotional dysregulation.     

High psychopathic trait females exhibit reduced startle potentiation and increased p3 amplitude

While there has been steady progress in identifying psychophysiological traits associated with psychopathy, most of the existing research has been carried out using incarcerated male participants, and data that include females are particularly rare. This study examined both affective startle blink modulation and P3 amplitude in a sample of female undergraduates grouped by scores on the Psychopathic Personality Inventory-Revised (PPI-R). Those scoring high for psychopathic traits lacked startle blink potentiation and demonstrated larger P3 amplitudes during auditory and visual oddball tasks. These data support the generalizability of deficient startle potentiation to non-incarcerated females with psychopathic traits, and add to a growing body of literature suggesting that psychopathic traits are associated with distinctive information-processing characteristics as indexed by P3 amplitude.     

Differential effects of psychopathy and antisocial personality disorder symptoms on cognitive and fear processing in female offenders

Psychopathy and antisocial personality disorder (APD) have long been considered important risk factors for criminal behavior and incarceration. However, little is known about the psychobiological underpinnings that give rise to the disinhibited behavior of female offenders. Using an instructed fear-conditioning paradigm and a sample of incarcerated female offenders, we manipulated attentional focus and cognitive load to characterize and differentiate between the dysfunctional cognitive and affective processes associated with these syndromes. We used fear-potentiated startle (FPS) and event-related potentials as measures of affective and cognitive processing, respectively. After controlling for APD symptoms, psychopathic women displayed greater FPS while attending directly to threat-relevant stimuli and displayed less FPS while performing a demanding task that directed attention to threat-irrelevant information. Conversely, controlling for psychopathy, women with high APD symptoms displayed less overall FPS, especially when instructed to focus on threat-relevant stimuli. However, as the demands on cognitive resources increased, they displayed greater FPS. For both psychopathy and APD, analysis of the event-related potentials qualified these findings and further specified the abnormal cognitive processes associated with these two syndromes. Overall, simultaneous analysis of psychopathy and APD revealed distinct patterns of cognitive processing and fear reactivity.     

Inhibitory control and negative emotional processing in psychopathy and antisocial personality disorder

The field of personality disorders has had a long-standing interest in understanding interactions between emotion and inhibitory control, as well as neurophysiological indices of these processes. More work in particular is needed to clarify differential deficits in offenders with antisocial personality disorder (APD) who differ on psychopathic traits, as APD and psychopathy are considered separate, albeit related, syndromes. Evidence of distinct neurobiological processing in these disorders would have implications for etiology-based personality disorder taxonomies in future psychiatric classification systems. To inform this area of research, we recorded event-related brain potentials during an emotional-linguistic Go/No-Go task to examine modulation of negative emotional processing by inhibitory control in three groups: psychopathy (n = 14), APD (n = 16), and control (n = 15). In control offenders, inhibitory control demands (No-Go vs. Go) modulated frontal-P3 amplitude to negative emotional words, indicating appropriate prioritization of inhibition over emotional processing. In contrast, the psychopathic group showed blunted processing of negative emotional words regardless of inhibitory control demands, consistent with research on emotional deficits in psychopathy. Finally, the APD group demonstrated enhanced processing of negative emotion words in both Go and No-Go trials, suggesting a failure to modulate negative emotional processing when inhibitory control is required. Implications for emotion-cognition interactions and putative etiological processes in these personality disorders are discussed.     

Empathy,morality and psychopathic traits in women

Empathic and moral processing correlates of psychopathic personality have seldom been studied in women. In this study, we experimentally tested associations between psychopathic personality traits and empathic and moral processing in a female sample, and further directly compared them to results from a male sample. We found that high levels of affective-interpersonal traits were associated with diminished affective response to sad and fearful emotions in others; lower propensity to feel moral emotions; higher endorsement of utilitarian solutions to moral dilemmas involving direct harm; and less self-reported difficulty when performing moral decision making. Overall, our findings strengthen the view that the two dimensions of psychopathy make distinct contributions to emotional and moral processing; and demonstrate that, in women, psychopathic personality traits are associated with a similar pattern of empathic and moral processing biases as the one that has been previously reported in men.     

The criminal and personality profile of patients with schizophrenia and comorbid psychopathic traits

Sixty-one male forensic patients who met the DSM-IV criteria for schizophrenia were categorised into high and low psychopathic trait groups using the Psychopathy Checklist: Screening Version. The groups were compared on their criminal history, symptom profile, personality style, risk scores and subsequent institutional violence. Patients with high scores on the PCL:SV had a greater number of previous convictions and were more likely to have a family history of criminality. The high psychopathy-scoring group had higher levels of Positive and Negative Syndrome Scale grandiose and hostile symptomatology, and higher scores on trait impulsivity and aggression. They also had a more coercive, less compliant interpersonal style than the low-psychopathy scoring group. The high-psychopathy scoring group were more likely to be involved in institutional aggression and had higher levels of risk for violence. Patients with schizophrenia and high levels of comorbid psychopathy have a distinctive interpersonal style that may contribute to their greater risk of disruptive institutional behaviour.     

The Hannibal Lecter Myth: Psychopathy and Verbal Intelligence in the MacArthur Violence Risk Assessment Study

Due to the intriguing nature of the psychopathy construct, it is not surprising that psychopathic characters would appear in popular culture. At times, media portrayals of psychopathic personality are consistent with scholarly research, others times they are not. In the case of Hannibal Lecter, the psychopathic killer was framed as an individual with superior intelligence—an omnibus intelligence that enhanced his ability to manipulative and victimize others. Contrary to this popular conception and based on data from 840 cases selected from the MacArthur Violence Risk Assessment Study, ordinary least squares and ordered logistic regression models showed inverse relationships between verbal intelligence and psychopathy for eight of twelve items of the disorder in this exploratory study. Due to the uniqueness of the MacArthur sample and concern about generalizeability, further research on verbal intelligence and psychopathy is recommended.     

Psychopathic personality traits are linked to reduced false memories for negative events

Individuals scoring high on psychopathic personality traits process emotional material to a different extent than individuals with few psychopathic traits. Evidence exists that these individuals have impaired emotional memory. The question arises whether this emotional memory impairment has ramifications for the production of emotional false memories. In the present study, we investigated the production of false and true memories for emotional events in a community sample (N = 120) of individuals varying in psychopathic traits (evaluated with the Psychopathic Personality Inventory–Revised [PPI-R] questionnaire). The fearless dominance (FD) component of psychopathy interacted with the emotional impact of to-be-remembered events in the production of false memories, showing fewer negative false memories with increasing levels of FD. At the subjective level, negative false memories were not perceived as vivid memory experiences in high FD individuals. Concerning true memories, higher scores in cold-heartedness were related to fewer true memories for neutral and negative (but not positive) events. These results show that individuals with high psychopathy traits – in particular, FD – do not have a general emotional memory impairment but they process negative material in a different way than individuals with low psychopathic traits and thus are less susceptible to producing false memories for negative events.     

Psychopathic Traits in Youth: Is There Evidence for Primary and Secondary Subtypes?

The current study employed model-based cluster analysis in a sample of male adolescent offenders (n = 94) to examine subtypes based on psychopathic traits and anxiety. Using the Psychopathy Checklist: Youth Version (PCL:YV; Forth et al. 2003) and the self-report Antisocial Process Screening Device (APSD; Caputo et al. 1999), analyses identified three clusters in males that varied in the severity of psychopathic traits (low, moderate, and high) and anxiety. The high psychopathic group exhibited more negative personality traits and was judged to be at greater risk for dangerousness whereas the low psychopathic group exhibited more positive personality traits and was judged to be at lower risk for dangerousness. Implications regarding potential developmental differences between adolescent and adult psychopathy, as well as treatment considerations are discussed.     

Emotional processing in psychopathic personality

Emotional‐processing deficits may be one of the characteristic features of impaired affect in individuals with psychopathy. These include shallowness and profound lack of remorse or empathy. Performances on standardized emotion discrimination tasks and mood induction tasks were compared between 17 patients with antisocial personality disorder (DSM‐IV) and 17 nonpsychopaths. Subjects with psychopathic personality demonstrated poorer performance on emotion‐discrimination tasks compared with controls. However, higher scores on factor “emotional detachment” of the Psychopathy Checklist (PCL‐R) were associated with better discrimination ability. Subjective ratings were comparable between groups during mood induction. Although the findings support the hypothesis of a significant association between impaired emotional processing and psychopathy, they also suggest a relationship between emotional discrimination and the core personality features of psychopathy. Aggr. Behav. 28:394–400, 2002. © 2002 Wiley‐Liss, Inc.     

An empirical study of object relations and defensive operations in antisocial personality disorder

This study assessed the object relations, defensive operations, and level of psychopathy and narcissism in a group of antisocial personality disordered offenders. The Rorschach protocols of 33 subjects who met the Diagnostic and Statistical Manual of Mental Disorders (3rd ed., rev. [DSM-III-R], American Psychiatric Association, 1987) criteria for antisocial personality disorder were analyzed utilizing Kwawer's (1980) criteria for borderline object relations categories (borderline phenomena), the Lerner and Lerner (1980) Defense Scale, and a number of experimental criteria including Cooper and Arnow's (1986) defense criteria. Level of narcissism was assessed utilizing Exner's (1973) Self-Focus Sentence Completion Test. Hare's Psychopathy Checklist was used as an independent variable to determine a subject's level of psychopathy. Those subjects scoring 30 or more on the psychopathy checklist were compared to subjects scoring less than 30. The level of narcissism or proportion of defenses did not differ significantly between the severe psychopaths (greater than or equal to 30) and the moderate psychopaths (less than 30). The severe psychopaths produced a significantly greater number of borderline object relations. I conclude that antisocial individuals tend to be highly egocentric, and that narcissism is one component of psychopathy. Severe psychopaths, as a group, tend to be more borderline in their functioning than those exhibiting moderate levels of psychopathic disturbance. I also conclude that individuals who are incarcerated for felony offenses and also meet the DSM-III-R criteria for antisocial personality disorder exhibit degrees of borderline personality organization.     

Effects of comorbid psychopathy on criminal offending and emotion processing in male offenders with antisocial personality disorder

Antisocial personality disorder (ASPD) and psychopathy are two syndromes with substantial construct validity. To clarify relations between these syndromes, the authors evaluated 3 possibilities: (a) that ASPD with psychopathy and ASPD without psychopathy reflect a common underlying pathophysiology; (b) that ASPD with psychopathy and ASPD without psychopathy identify 2 distinct syndromes, similar in some respects; and (c) that most correlates of ASPD reflect its comorbidity with psychopathy. Participants were 472 incarcerated European American men who met Diagnostic and Statistical Manual (4th ed., American Psychiatric Association, 1994) criteria for ASPD and Psychopathy Checklist criteria for psychopathy, who met the criteria for ASPD but not for psychopathy, or who did not meet diagnostic criteria for either ASPD or psychopathy (controls). Both individuals with ASPD only and those with ASPD and psychopathy were characterized by more criminal activity than were controls. In addition, ASPD with psychopathy was associated with more severe criminal behavior and weaker emotion facilitation than ASPD alone. Group differences in the association between emotion dysfunction and criminal behavior suggest tentatively that ASPD with and ASPD without prominent psychopathic features may be distinct syndromes.     

Psychophysiological and Neuropsychological Characteristics of Non-Incarcerated Adult Males with Higher Levels of Psychopathic Personality Traits

Although much research on psychopathic individuals has been conducted in incarcerated settings, there is increasing interest in studying adults with higher levels of psychopathic traits in the general population. The present study investigated differences in psychophysiological response and neuropsychological functioning between undergraduate males with higher levels of psychopathic traits (higher-p) and undergraduate males with lower levels of psychopathic traits (lower-p). Participants completed self-report measures and neuropsychological measures, and skin conductance response was measured during a risk-taking and affective-picture viewing task. Consistent with previous findings among samples of incarcerated psychopaths, higher-p adults exhibited diminished responses to aversive and positive affective stimuli and were more disinhibited on a motoric response inhibition task. Contrary to expectations, higher-p adults made marginally better decisions on a risky decision making task. Findings were discussed in relation to Gao and Raines’ (Behavioral Sciences & the Law 28(2) 194–210, 2010) model of the neurobiological underpinnings of adults with higher levels of psychopathic traits in non-incarcerated settings, and offer evidence that higher-p adults have both adaptive and non-adaptive traits.