Cognitive and serotonergic vulnerability to depression: convergent findings

Cognitive reactivity (CR) is a psychological vulnerability marker of depression, whereas response to acute tryptophan depletion (ATD; a serotonergic challenge procedure) is a biological vulnerability marker. The aim of this study was to investigate the relationship between these markers. Thirty-nine remitted depressed patients participated in 2 ATD sessions in a double-blind crossover design. CR, assessed prior to the ATD sessions, predicted depressive response to high-dose ATD. CR also diminished the effects of 2 known predictors of ATD response: gender and residual symptoms. Neuroticism and behavioral inhibition were unrelated to ATD response. CR is associated with an increased sensitivity to reductions of serotonin concentrations. These findings present a small step toward unifying cognitive and neurobiological theories of depression.     

Resistance to persuasion and attitude certainty: the moderating role of elaboration

Recent research has demonstrated that when people resist persuasive attacks, they can under specifiable conditions become more certain of their initial attitudes. The present research explores the role of elaboration in determining when this effect will occur. Using both self-reported differences in situational elaboration (Study 1) and chronic individual differences in the need for cognition (Study 2), it is demonstrated that resisting persuasion increases attitude certainty primarily when elaboration is high. When elaboration is low, resisting persuasion does not appear to impact attitude certainty. These findings shed light on the role of metacognitive factors in resistance to persuasion, pinpointing the conditions under which these factors come into play.     

Cognitive vulnerability to depression: a taxometric analysis

Although there is increasing support for the hypothesis that negative cognitive styles contribute vulnerability to depression, it remains unclear how best to conceptualize the heterogeneity in cognitive vulnerability to depression. Specifically, does this heterogeneity reflect quantitative or qualitative differences among individuals? The goal of this study was to address this question by examining whether the underlying structure of cognitive vulnerability to depression is best conceptualized as dimensional or categorical. Taxometric analyses provided consistent support for the dimensional nature of negative cognitive styles. It appears, therefore, that cognitive vulnerability to depression is best conceptualized as a dimensional construct, present to a greater or lesser extent in all individuals. Despite this, the strength of the relationship between negative cognitive styles and depressive symptoms does appear to vary as a function of where along the cognitive style continuum one falls.     

Unpacking attitude certainty: attitude clarity and attitude correctness

Attitude certainty has been the subject of considerable attention in the attitudes and persuasion literature. The present research identifies 2 aspects of attitude certainty and provides evidence for the distinctness of the constructs. Specifically, it is proposed that attitude certainty can be conceptualized, and empirically separated, in terms of attitude clarity (the subjective sense that one knows what one's attitude is) and attitude correctness (the subjective sense that one's attitude is correct or valid). Experiment 1 uses factor analysis and correlational data to provide evidence for viewing attitude clarity and attitude correctness as separate constructs. Experiments 2 and 3 demonstrate that attitude clarity and attitude correctness can have distinct antecedents (repeated expression and consensus feedback, respectively). Experiment 4 reveals that these constructs each play an independent role in persuasion and resistance situations. As clarity and correctness increase, attitudes become more resistant to counterattitudinal persuasive messages. These findings are discussed in relation to the existing attitude strength literature.     

Cognitive vulnerability to depression in never depressed subjects

The purpose of this study was to investigate whether dysfunctional cognitions could be measured in never-depressed individuals after a sad mood prime, and if these dysfunctional cognitions would predict future depression. Subjects were first screened for current or past depression. Never-depressed subjects were randomly assigned to a prime or no-prime condition and completed the Dysfunctional Attitudes Scale. After one month, subjects completed the Beck Depression Inventory. The mood induction was successful in producing a sad mood, but had no effect on accessibility of dysfunctional cognition. Dysfunctional cognitions did predict depressive symptoms one month later, for the women in the sample, but not the men. These results were actually stronger for the unprimed subjects. The results provide some support for the cognitive diathesis-stress model, and suggest that cognitive vulnerability to depression may exist prior to a clinically significant depressive episode. However, mood priming does not appear to be a useful strategy with never-depressed subjects.     

Perceiving stability as a means to attitude certainty: The role of implicit theories of attitudes

This research introduces the concept of implicit theories of attitude stability. Across three studies, individuals are shown to vary both naturally and situationally in their lay theories about the stability of attitudes. Furthermore, these general theories are shown to impact people's certainty in their specific attitudes by shaping their perceptions of the stability of the attitude under consideration. By affecting attitude certainty, implicit theories of attitude stability also influence the extent to which people rely on their attitude when committing to future attitude-relevant behavior. Moreover, following exposure to a persuasive attack, implicit theories are shown to interact with situational perceptions of attitude stability to determine attitude certainty. Collectively, these findings suggest that implicit theories of attitude stability have an important influence on people's attitude certainty, subsequent behavioral intentions, and resistance to persuasive messages. Future directions concerning the potential impact of these theories for other attitudinal phenomena are discussed.     

Cognitive schemas and thought as determinants of attitude change

It was hypothesized that thought would result in greater attitude polarization than distraction and that this effect would be more pronounced with better developed schemas (naive theories) for thinking about the attitude object. In Study 1, it was reasoned that persons have better developed schemas (e.g., implicit personality theories) for thinking about individuals than for thinking about groups. In Study 2, it was reasoned that men have better developed schemas for thinking about football and women have better developed schemas for thinking about women's fashions. In both studies, the hypothesis was significantly confirmed.     

Cognitive and temperamental vulnerability to depression: Longitudinal associations with regional cortical activity

Posterior cortical activity may be related to individual differences in temperamental emotionality, especially traits implicated in depression vulnerability. We previously reported that electroencephalographic (EEG) indices of cortical activity in posterior regions were associated with temperamental positive emotionality (PE) in early childhood. This project examined whether EEG indices of regional cortical activity, assessed at age 5–6, were associated with child temperament and cognitive vulnerability to depression, assessed at age 7. Asymmetry in posterior cortical activity measured at age 5–6 was associated with PE at follow-up at age 7, and with greater helplessness during a standardised laboratory task simulating a mild interpersonal rejection. Findings provide further support for the notion that low PE and depression are associated with similar patterns of cortical activity. Furthermore, these patterns of activity may have observable behavioural and cognitive correlates that are meaningfully linked to the phenomenology of depression.     

Cognitive vulnerability to depression in individuals with borderline personality disorder

The goal of the current study was to examine whether individuals with comorbid Major Depressive Disorder (MDD) and Borderline Personality Disorder (BPD) exhibit greater severity of depressive symptoms than (1) individuals with MDD without BPD and (2) individuals with neither MDD nor BPD. One hundred and forty-one individuals participated in a semi-structured clinical interview assessing MDD and BPD. They also completed measures assessing depressive symptoms, depressogenic attributional style, hopelessness, self-esteem, rumination, and dysfunctional attitudes. In line with hypotheses, individuals with BPD and MDD exhibited higher levels of depressive symptoms and cognitive vulnerability than individuals in the other two groups. In addition, after controlling for the effects of cognitive vulnerability, the effect of group membership on depressive symptoms was reduced, suggesting that the increased severity of depressive symptoms experienced by those with BPD is partially due to their possessing higher levels of cognitive vulnerability to depression.     

The role of thought suppression in building mental blocks

This research examined the role of thought suppression in the formation of mental blocks. In Experiment 1, participants were asked to generate a series of creative associates for two target words after initially suppressing a word that was semantically related to one of the two target words. Participants produced fewer responses, and experienced a greater sensation of being mentally blocked, when attempting to produce associates for the target word that was semantically related to the suppressed word. In Experiment 2, participants either thought about or suppressed a series of words prior to completing a word fragment completion task. Each word either corresponded exactly to one of the word fragment solutions (target primes) or resembled one of the solutions but was slightly different in its orthographic properties (negative primes). Participants performed most poorly on the items for which they had initially suppressed negative primes.     

Childhood abuse and vulnerability to depression: Cognitive scars in otherwise healthy young adults

Models of depression vulnerability posit that negative early experiences, such as exposure to childhood abuse (CA), increase vulnerability to depression later in life. Though most victims of CA do not go on to develop depression, the question remains as to whether these individuals retain cognitive ‘scars’ that may contribute to depression vulnerability. The present study examined the relationship between self-reported, retrospective CA and cognitive vulnerability to depression in a carefully selected sample of young adults without current or past psychopathology. We measured cognitive vulnerability with both a self-report questionnaire, the Dysfunctional Attitudes Scale (DAS), and a measure of information processing bias, the Scrambled Sentences Test (SST). Self-reported severity of CA was associated with increased cognitive vulnerability to depression on both the DAS and SST. Vulnerability to depression as measured by the SST, but not by the DAS, prospectively predicted increases in depressive symptoms over a 6-month period. Scores on the SST also interacted with CA to predict increases in depressive symptoms. These findings demonstrate the pernicious effects of CA even in those without current or past psychopathology.     

Cognitive vulnerability to depression during middle childhood: Stability and associations with maternal affective styles and parental depression

Theories of cognitive vulnerability to depression (CVD) imply that CVD is early-emerging and trait-like; however, little longitudinal work has tested this premise in middle childhood, or examined theoretically relevant predictors of child CVD. We examined test–retest correlations of self-referent encoding task performance and self-reported attributional styles and their associations with parental characteristics in 205 seven-year-olds. At baseline, child CVD was assessed, structured clinical interviews were conducted with parents, and ratings of observed maternal affective styles were made. Children’s CVD was re-assessed approximately one and two years later. Both measures of children’s CVD were prospectively and concurrently associated with children’s depressive symptoms and showed modest stability. Multilevel modeling indicated that maternal criticism and paternal depression were related to children’s CVD. Findings indicate that even early-emerging CVD is a valid marker of children’s depression risk.     

Beneath the veil of thought suppression: Attentional bias and depression risk

Although cognitive theory predicts that depression-prone individuals possess negative information-processing biases, the reliable detection of this type of cognitive vulnerability has proved difficult. The present study tested the idea that depression-relevant, cognitive biases are often elusive because at-risk individuals actively try to suppress depressive thinking. The study employed a novel measure of information processing that involves the identification of words imbedded in a letter grid. A cognitive load - designed to disrupt thought suppression - caused a negative attentional shift among individuals at risk for depression (because of a previous episode), leading them to identify negative words at a rate equivalent to currently dysphoric participants. The hypothesised role of mental control was further supported by the fact that the load-related, attentional shift was strongly associated with chronic thought suppression.     

Cognitive vulnerability in children at risk for depression

Cognitive, developmental, and psychodynamic theories all hypothesize that negative self-concepts acquired in childhood may induce vulnerability to depression. Children at risk because of maternal major affective disorder, compared with children of medically ill and normal mothers, were examined for evidence of negative cognitions about themselves, and were found to have more negative self-concept, less positive self-schemas, and more negative attributional style. It was further predicted that negative cognitions about the self would be related to maternal depression and chronic stress, and to the quality of perceived and actual interactions with the mother. In general, the predicted associations were obtained, supporting speculations about how maternal affective disorder is associated with stress and with relatively negative and unsupportive relationships with children that in turn diminish children's self-regard.This research was supported by a William T. Grant Foundation award to Dr. Hammen and a Veterans Administration Merit Award to Dr. Hiroto.     

The perils of double consciousness: The role of thought suppression in stereotype threat

The goal of the present research is to demonstrate, and then alleviate, the role of thought suppression in depressing women’s math performance under stereotype threat. We hypothesize that when taking a math test, women (but not men) attempt to suppress thoughts of the math-related gender stereotype. Suppression leads to underperformance when it uses up cognitive resources. In Study 1, women underperform on a math test and show postsuppressional rebound of the stereotype when cognitive resources are reduced. In Study 2, women suppress the stereotype after a math test begins, but show rebound when the test is complete. In Study 3, making the stereotype irrelevant to the test improves performance and reduces postsuppressional rebound. In Studies 4 and 5, we test a strategy women can use to make suppression easier, and show that it restores math performance. Theoretical and practical implications are discussed.     

Cognitive vulnerability to depression: a comparison of the weakest link, keystone and additive models

Multiple theories of cognitive vulnerability to depression have been proposed, each focusing on different aspects of negative cognition and utilising different measures of risk. Various methods of integrating such multiple indices of risk have been examined in the literature, and each demonstrates some promise. Yet little is known about the interrelations among these methods, or their incremental validity in predicting changes in depression. The present study compared three integrative models of cognitive vulnerability: the additive, weakest link, and keystone models. Support was found for each model as predictive of depression over time, but only the weakest link model demonstrated incremental utility in predicting changes in depression over the other models. We also explore the correlation between these models and each model's unique contribution to predicting onset of depressive symptoms.     

Cognitive vulnerability to depression: A comparison of the weakest link,keystone and additive models

Multiple theories of cognitive vulnerability to depression have been proposed, each focusing on different aspects of negative cognition and utilising different measures of risk. Various methods of integrating such multiple indices of risk have been examined in the literature, and each demonstrates some promise. Yet little is known about the interrelations among these methods, or their incremental validity in predicting changes in depression. The present study compared three integrative models of cognitive vulnerability: the additive, weakest link, and keystone models. Support was found for each model as predictive of depression over time, but only the weakest link model demonstrated incremental utility in predicting changes in depression over the other models. We also explore the correlation between these models and each model's unique contribution to predicting onset of depressive symptoms.     

A multisource approach to self-critical vulnerability to depression: the moderating role of attachment

The present study investigated the effects of self-criticism, dependency, and attachment variables in depression among couples. We utilized a multisource design that involved self-reports and spouse reports of personality and depression. This approach enabled us to explore the patterns of relations between self-reported and the spouse's report of the partner's view of self-criticism, dependency, and attachment dimensions, as well as the contribution of the latter to the moderation of distress. Participants were 120 couples in their first marriages. It was found that: (1) Self- and spouses' reported self-criticism are both associated with depression; (2) negative assessments of personality factors and attachment models by the self and spouse contribute uniquely in predicting depressive symptomatology; and (3) beyond the covariation between target's depression and marital maladjustment, attachment models of self and of other as reported by both the self and spouse moderate the effects of self-reported personality vulnerability on depressive symptomatology. Our results indicate that self-ratings and ratings by others must both be considered in the context of depression in close interpersonal relationships. Beyond the methodological implications of multisource data, our findings support the view of depression as an interpersonal process.     

The malleable influence of social consensus on attitude certainty

People often reflect on the opinions of others and express greater attitude certainty when they perceive their attitudes to be shared by others (high attitude consensus). The present research tests the possibility that either high or low attitude consensus can increase attitude certainty depending on people's salient social identification needs. In particular, high attitude consensus with a target group is found to be more validating when people seek to belong to the group, as this identification motive promotes a search for similarities between themselves and the group. In contrast, low attitude consensus with a target group is found to be more validating when people seek to be unique from a group, as this identification motive promotes a search for dissimilarities between themselves and the group. Two experiments support these hypotheses, offering insight into the intra-personal motives that alter the diagnostic value of social consensus information.