The role of BIS/BAS in the vulnerability for depression in adolescent girls

Reinforcement Sensitivity Theory (RST), the original (i.e. Gray, 1982) or revised (Gray & McNaughton, 2000), has yet to be used as a framework for investigating vulnerability to Major Depressive Disorder (MDD) in adolescents. The present study employed a high-risk design to examine whether aberrant BIS-FFFS/BAS activity was similarly present in both depressed girls and girls at high risk for depression.MethodsN = 85 age-matched biological daughters of mothers with differential MDD status: (a) MDD (n = 17), (b) high-risk (n = 34), and (c) healthy controls (n = 34) completed measures of the BIS/BAS, depression, and anxiety.ResultsMDD girls scored significantly higher on BIS than healthy controls but not high-risk girls, and the high-risk and control groups did not differ. No group differences were found on BAS or FFFS-Fear.ConclusionsElevated BIS was not identified as a vulnerability factor for MDD; however, it does distinguish depressed adolescents from healthy controls.     

Motivation and goal orientation in vulnerability to depression

Depression may be related to motivational systems that govern approach and avoidance behaviour such as temperament and goal orientation. Using a remitted depression design we found that previously depressed and never-depressed individuals did not differ on number of approach goals generated, degree of goal commitment or extent of planning to reach goals. However, previously depressed individuals generated more avoidance goals indicating that the tendency to set avoidance goals may be a trait-like vulnerability to depression. Previously depressed individuals also reported higher activation of the behavioural approach system (BAS) raising the possibility that this system is energising approach behaviour in the service of avoiding aversive consequences.     

Revised Reinforcement Sensitivity Theory and Laboratory Assessment of BIS and BAS in Children

There is considerable interest in Gray’s reinforcement sensitivity theory. However, few measures of the behavioral approach (BAS) and inhibition systems (BIS) exist for children. Moreover, the theory was substantially revised a decade ago and measurement instruments are still largely based on the old theory. Our aim was to revise questionnaire and laboratory assessments of BIS and BAS for children. Performance on the Point Scoring Reaction Time Task for Children-Revised (PSRTT-CR) conformed to theoretical expectations. Caregiver reports of BIS and BAS were associated with corresponding PSRTT-CR indices, suggesting cross-method convergent and discriminant validity. There was convergence with physiological correlates of BAS, but not physiological correlates of BIS. Overall, our revised measures represent promising instruments of children’s BIS and BAS.     

Childhood abuse and vulnerability to depression: Cognitive scars in otherwise healthy young adults

Models of depression vulnerability posit that negative early experiences, such as exposure to childhood abuse (CA), increase vulnerability to depression later in life. Though most victims of CA do not go on to develop depression, the question remains as to whether these individuals retain cognitive ‘scars’ that may contribute to depression vulnerability. The present study examined the relationship between self-reported, retrospective CA and cognitive vulnerability to depression in a carefully selected sample of young adults without current or past psychopathology. We measured cognitive vulnerability with both a self-report questionnaire, the Dysfunctional Attitudes Scale (DAS), and a measure of information processing bias, the Scrambled Sentences Test (SST). Self-reported severity of CA was associated with increased cognitive vulnerability to depression on both the DAS and SST. Vulnerability to depression as measured by the SST, but not by the DAS, prospectively predicted increases in depressive symptoms over a 6-month period. Scores on the SST also interacted with CA to predict increases in depressive symptoms. These findings demonstrate the pernicious effects of CA even in those without current or past psychopathology.     

Motivation,depression, and naturalistic time-based prospective remembering

This study investigated the effect of a motivational manipulation on naturalistic time-based prospective memory (PM) task performance. The association between depression and PM task performance was also investigated. First-year psychology students were required to send mobile phone text messages (SMSs) at a specific time 3 days and 6 days after an initial meeting. During the delay period participants recorded details of the retrieval whenever they remembered the SMS task. Participants given the incentive of extra course credit (motivation condition) outperformed their counterparts on the PM tasks, and showed a greater increase in the reported frequency of self-initiated retrievals on target days. Depression was negatively correlated with PM task performance. The findings suggest that motivational instructions impact the controlled processes underlying PM.     

Self-esteem reconsidered: unstable self-esteem outperforms level of self-esteem as vulnerability marker for depression

Previous studies have built up evidence that an unstable self-esteem is associated with vulnerability to depression and that it outperforms level of self-esteem as a predictor for symptoms of depression. However, most of these studies have used student samples exclusively to investigate the role of self-esteem instability in depression vulnerability. Our present study used samples of currently depressed inpatients, formerly depressed individuals, and never-depressed controls to investigate the relationship between self-esteem instability and depression. In addition, we examined the predictive validity of self-esteem instability in predicting future depressive symptoms. The results indicate that self-esteem instability is associated with depression and vulnerability to depression. Furthermore, self-esteem instability interacted with perceived stress variability and depressed mood variability in predicting future depressive symptomatology at six months follow-up. These results are in line with the diathesis-stress model and support the hypothesis that self-esteem instability might be more important than level of self-esteem in predicting vulnerability to depression.     

On the role of goal relevance in emotional attention: Disgust evokes early attention to cleanliness

Prior evidence has shown that aversive emotional states are characterised by an attentional bias towards aversive events. The present study investigated whether aversive emotions also bias attention towards stimuli that represent means by which the emotion can be alleviated. We induced disgust by having participants touch fake disgusting objects. Participants in the control condition touched non-disgusting objects. The results of a subsequent dot-probe task revealed that attention was oriented to disgusting pictures irrespective of condition. However, participants in the disgust condition also oriented towards pictures representing cleanliness. These findings suggest that the deployment of attention in aversive emotional states is not purely stimulus driven but is also guided by the goal to alleviate this emotional state.     

Vicissitudes of goal commitment: Satisfaction,investments, and alternatives

Constructs typically used to understand commitment between individuals were used to elucidate individual differences in goal commitment. In Study 1, 299 college students completed assessments of goal satisfaction, investments, alternatives and commitment regarding an academic goal. Structural equation modeling demonstrated confirmatory evidence for satisfaction’s, investments’, and alternatives’ collective impact on people’s goal commitment. In Study 2, the model components were manipulated by having 236 college students considered the goal to learn a new language and read information suggesting they were high or low in satisfaction, investments, and alternatives. Results demonstrated all three factors had a causal impact on people’s level of goal commitment. Both studies found an individual’s level of goal commitment was strongest when satisfaction and investments were high and the impact of alternatives was low.     

Underlying motivation in the approach and avoidance goals of depressed and non-depressed individuals

Neurobiological theories predict decreased approach motivation and increased avoidance motivation in depression, but the results of previous studies have been equivocal. This study addressed a key limitation of previous research by assessing participants' underlying motivation for adopting their goals. Depressed (N=26) and non-depressed (N=33) participants listed approach and avoidance goals and wrote down their underlying reasons for adopting those goals. The groups did not differ on either the number of goals or underlying reasons but when underlying reasons were coded for approach or avoidance motivation depressed participants, compared to controls, showed less approach motivation and more avoidance motivation in relation to their approach goals. There were no effects related to avoidance goals. The results suggest that while the goals of depressed persons appear to be similar to those who are not depressed there are important differences at the level of underlying motivation.     

Temperament and Vulnerability to Psychopathology: Introduction to the Special Section

Several authors have highlighted associations with temperament as promising avenues for understanding vulnerability to psychopathology (e.g., Muris and Ollendick, Clinical Child and Family Psychology Review, 8, 271–289, 2005; Nigg, Journal of Child Psychology and Psychiatry, and Allied Disciplines, 47, 395–422, 2006). The successful integration of models of temperament and models of psychopathology will undoubtedly increase our understanding of both. The current special section intends to present important new ideas and evidence in this field and tries to formulate answers to a couple of emerging questions. To set the stage for the papers, we provide a brief state of the art of research on temperament—psychopathology associations. After that, we discuss emerging questions in the field, some of which are addressed in the papers of this special section. To conclude, we point out a couple of future research perspectives.     

Acting in our interests: Relational self-construal and goal motivation across cultures

Relationally-autonomous reasons (RARs) are motives for behavior that take into account one’s close relationships. A cross-cultural model tested the hypotheses that (a) people with a highly relational self-construal will pursue their goals for RARs, and (b) RARs will predict positive goal outcomes after controlling for variance explained by personally-autonomous reasons (PARs) and social support. One hundred seventy Americans and 219 Japanese completed a well-being and self questionnaire then generated and rated seven goals on several attributes. Results showed that relational self-construal was associated with RARs for goals. RARs predicted effort directly and predicted progress and purpose in life indirectly for both groups. In addition, Americans and Japanese differed in the types of goals they pursued and the degree to which social support predicted effort. Implications for self, culture, and motivation research are discussed.

Environmental attitudes mediate the link between need for cognition and pro-environmental goal choice

Need for cognition is a form of cognitive motivation, which reflects the extent that one actively seeks information and enjoys critical thinking about information. Accordingly, those high in need for cognition seek out and acquire information, resulting in stronger and more stable attitudes. However, need for cognition has yet to be examined in the domain of goal pursuit. Toward that end, we examined how this form of cognitive motivation impacts goal related cognitions. Specifically, how need for cognition influences goal choice. Because need for cognition is a domain-general form of cognitive motivation, we hypothesized that domain-specific attitudes would mediate the relationship between need for cognition pro-environmental goals. This hypothesis was tested in two separate studies. Results demonstrate consistent evidence in support of our hypothesis that environmental attitudes mediate the relationship between need for cognition and pro-environmental goal choice. Results hold implications for goal pursuit research, such that need for cognition can be empirically studied in relation to goal related cognitions and behaviors to the same extent as other forms of cognitive motivation. Moreover, these results suggest that need for cognition can be considered along side previously investigated antecedents of pro-environmental behavior.     

Epistemic curiosity and self-regulation

Relationships between Interest (I) and Deprivation (D) type epistemic curiosity (EC) and self-regulation were evaluated in two studies. In Study 1 (Italians, N = 151), I-type EC correlated positively with positive outcome-expectancies and risk-taking, but negatively with thinking about negative outcomes. D-type EC correlated positively with emotional restraint, thoughtful evaluation, and concern over negative outcomes and potential risks. In Study 2 (Americans, N = 218; Germans, N = 56), I-type EC correlated positively with behavioral activation, especially fun seeking, whereas D-type correlated negatively with fun seeking. Neither EC scale correlated significantly with behavioral inhibition. These findings suggest that I-type EC corresponds to fun, carefree and optimistic approaches to learning, while D-type EC reflects greater thoughtfulness and caution regarding knowledge-search.     

Reduced goal specificity is associated with reduced memory specificity in depressed adults

Models of autobiographical memory suggest a close association between memories, future imagination and setting specific personal goals. However this association has yet to be tested with depressed individuals. The aim of this study was to examine whether the specificity of remembering past and imagining future personal events is associated with the specificity of approach and avoidance goals in depressed individuals. Two samples comprising adults who met criteria for major depressive disorder (MDD; N=30) and adults who had no prior history or current depression (N=30) completed autobiographical memory and future event tests, and a personal goal task. In the depressed sample, the specificity with which participants remembered the past was significantly associated with the specificity with which they generated future goals. The depressed sample also elicited fewer specific approach and avoidance goals compared to the non-depressed sample. These findings suggest that an overgeneral memory deficit extends to impairments in goal specificity.     

The relationship between Revised Reinforcement Sensitivity Theory (rRST), handedness and indecision

Indecisiveness is an inability to make a decision, manifest across a number of behaviours. We explore the influence that both direction and strength of hand preference may have on this construct, examining it in relation to the revised Reinforcement Sensitivity Theory (rRST). Frost and Shows’ (1993) Indecisiveness Scale was administered to 328 undergraduates (221 females), alongside the Edinburgh Handedness Inventory (Oldfield, 1971) and Carver and White’s (1994) BIS/BAS scales. Simple correlations showed left-handers had a positive relationship between strength of handedness and BIS. In right-handers, strength and aversive indecision were positively correlated. Regression analysis demonstrated no significant relationship between hand strength and indecision, but that indecision was related to all three measures of rRST. Consistent with previous work, BIS was positively related to all indecision but particularly aversive, while BAS was negatively related to indecision but most strongly the avoidant category. We found that FFFS is more closely related to aversive than avoidant indecision. The relationship between rRST and indecision may be influenced by handedness; for right-handers the same pattern was found, but in left-handers BAS was not a significant predictor of indecision, BIS only predicted aversive indecision and FFFS predicted all three categories.     

BIS/BAS responses to emotional cues: Self report, autonomic measure and alpha band modulation

The study explored the effect of the subjective evaluation and of BIS/BAS (Behavioral Inhibition and Activation System) differences on psychophysiological and brain oscillation measures, in response to pleasant/unpleasant and high/low arousing stimuli. Skin conductance response, heart rate, and electromyography, and alpha frequency band, were registered, during viewing IAPS figures. Both BIS and BAS measures were significant in modulating behavioral, autonomic and brain responses, with a clear dichotomy BAS-appetitive/positive BIS-withdrawal/negative sensitivity. Withdrawal (BIS) and appetitive (BAS) behavior showed opposite patterns of responses by the subjects within the frontal cortical site more than other sites. In addition, a specific frontal lateralization effect was found as a function of BIS (more right-side activation for negative cues) and BAS (more left-side activation for positive cues). Moreover, autonomic variables and frequency band were found to be effected by arousal rating per se, with an increased response to high arousal in comparison with low arousal and neutral stimuli. The effects of subjective evaluation and individual differences were discussed in the light of the coping activity of emotion comprehension.     

Midline theta dissociates agentic extraversion and anhedonic depression

The agency facet of extraversion is related to individual differences in reward anticipation and has been linked to the neurotransmitter dopamine. Dopamine has also been associated with components of anhedonia, which is one of the cardinal symptoms of depression and refers to lack of responsiveness to pleasurable stimuli. This raises the question whether low agency is associated with anhedonia symptoms in depression and if agency and anhedonia are characterized by similar neurobiological mechanisms. To address this hypothesis, we tested whether questionnaire measures of agency and anhedonia are correlated within depressed (n = 20) and non-depressed (n = 22) participants. Further, we investigated whether dopamine-related signatures in the EEG recorded during a gambling task (feedback-evoked theta activity, and frontal versus posterior theta activity) similarly relate to agency and anhedonia. Results indicated that anhedonia was significantly elevated in the depression group, and negatively correlated with agency. However, while theta activity evoked by negative vs. positive feedback was sensitive to anhedonia and depression status but unrelated to agency, frontal versus parietal theta activity predicted agency, but was unrelated to anhedonia and depression. Together, this double dissociation suggests that in spite of considerable phenotypical overlap, anhedonia and agency may be linked to partially distinct neurobiological markers.     

Eyes as windows to the soul: Gazing behavior is related to personality

Gazing is a fundamental human behavior with important cognitive, affective, motivational, and social underpinnings that is likely to have produced individual differences linking it to major personality traits. If traits play a substantial role in gazing, they should predict eye movement parameters above and beyond stimuli without meaningful and topical information. The current eye-tracking study (N = 242) demonstrated with linear mixed models that personality (Big Five, Behavioral Inhibition System/Behavioral Activation System) predicts number of fixations, mean fixation duration, and dwelling time in two different abstract animations. Specifically, neuroticism, extraversion, openness, and the Behavioral Activation System were related to eye movement parameters. Prospective research in studying links between dispositions and gazing is discussed.     

Cognitive vulnerability to depression during middle childhood: Stability and associations with maternal affective styles and parental depression

Theories of cognitive vulnerability to depression (CVD) imply that CVD is early-emerging and trait-like; however, little longitudinal work has tested this premise in middle childhood, or examined theoretically relevant predictors of child CVD. We examined test–retest correlations of self-referent encoding task performance and self-reported attributional styles and their associations with parental characteristics in 205 seven-year-olds. At baseline, child CVD was assessed, structured clinical interviews were conducted with parents, and ratings of observed maternal affective styles were made. Children’s CVD was re-assessed approximately one and two years later. Both measures of children’s CVD were prospectively and concurrently associated with children’s depressive symptoms and showed modest stability. Multilevel modeling indicated that maternal criticism and paternal depression were related to children’s CVD. Findings indicate that even early-emerging CVD is a valid marker of children’s depression risk.