Habituation and migraine

The most reproducible and ubiquitous interictal abnormality of the migraineurs’ brain is lack of habituation in neuronal information processing. The underlying mechanisms are uncertain. Increased neuronal excitability, decreased inhibition or decreased pre-activation levels have all been proposed as possible culprits.The present review summarizes the available data on habituation in migraine patients obtained with different methodological approaches. We will discuss the change of habituation level over the migraine cycle and we will show that these data congruently indicate that the sensory cortices of migraineurs react excessively to repetitive, but not to a small series of stimuli.Although the precise cellular and molecular mechanisms of this hyper-responsivity must still be determined, we will describe experimental data suggesting that a dysrhythmic thalamo-cortical activity due to inadequate monoaminergic control might be a plausible explanation.     

Exploring the mechanism of dishabituation

In this study we explored elicitation and habituation of the orienting reflex (OR) in the context of indifferent and significant stimuli, particularly aiming to clarify the mechanism driving dishabituation. An in-depth analysis of the mechanisms of electrodermal habituation and dishabituation was conducted, focusing on the role of state measures as determinants of the phasic response profile. Twenty-four young adult participants completed an auditory dishabituation task while electrodermal activity was recorded. Participants listened to a series of 10 innocuous tones of the same frequency (standards), followed by a deviant tone of a different frequency, and succeeded by 2-4 tones of the same frequency as the initial 10 stimuli. All stimuli had a random stimulus onset asynchrony of 5-7 s. Participants completed an indifferent condition in which there was no task in relation to the stimuli, and a significant condition where instruction was given to count the stimuli silently; order was counterbalanced between participants. As predicted, both skin conductance responses (SCRs) and skin conductance levels (SCLs) were larger for the significant than the indifferent condition. The initial phasic ORs were dependent on pre-stimulus arousal level, and there were significant decreases in both SCR and SCL over the first 10 standards in both conditions. Phasic response recovery was apparent to the deviant stimulus, and dishabituation to the following standard stimulus; both effects were enhanced in the significant condition. Sensitisation was apparent in SCL following the initial and deviant stimuli, but the extent of this was confounded with incomplete resolution of the preceding phasic OR in the significant condition. In the indifferent condition, dishabituation was independent of deviant-related sensitisation; this could not be tested in the significant condition. These findings suggest that dishabituation is not a process of sensitisation, but rather, a disruption of the habituation process.     

Stimulus significance effects in habituation of the phasic and tonic orienting reflex

Phasic and tonic measures of electrodermal activity were examined in a simple habituation paradigm, using innocuous visual stimuli. Separate groups were used to investigate the effects of stimulus significance, as manipulated by instructions. One group had no stimulus-related task (indifferent group), while the other was asked to silently count the stimuli to report to the experimenter later (significant group). Prestimulus skin conductance levels were considered as measures of the arousal level at each stimulus presentation, and the subsequent electrodermal responses were taken as the phasic orienting reflex (OR) elicited by each stimulus. Changes in prestimulus arousal were taken as measures of the tonic OR to the experimental series. Marked group differences were found in both phasic and tonic components of the OR. Some, but not all, of the significance effects in the phasic OR were attributable to differences in arousal. The results are discussed in the context of theoretical accounts of the OR.     

Habituation and dishabituation of the electrodermal orienting reflex in relation to extraversion and neuroticism

Orienting reflex (OR) habituation and dishabituation may be influenced by individual difference variables, including Eysenck's Extraversion (E) and Neuroticism (N) dimensions. Ninety subjects formed nine groups based on the crossover of high, medium, and low E and N. Each subject received, at each of two auditory stimulus intensities, two blocks of tone presentations. The last standard stimulus trial was followed by a novel stimulus and four repetitions of the standard stimulus. Using square root SCR, extraverts showed smaller initial response amplitudes than introverts at the low intensity of stimulation, while the reverse was true at high intensity. E and N were unrelated to SCR habituation rate. However, extraverts showed no dishabituation, while introverts did dishabituate.     

Neural underpinnings of the relationships between sensation seeking and emotion regulation in adolescents

There is little neurological evidence linking sensation seeking and emotion regulation in adolescence, which is characterised as an emotionally fluctuant period. The present study examined the relationship between sensation seeking and emotion regulation in adolescents. Electroencephalograms were recorded from 22 high sensation-seeking adolescents (HSSs, M_age = 12.36) and 24 low sensation-seeking adolescents (LSSs, M_age = 12.84) during the reactivity and regulation-image task. Group differences in event-related brain potentials (ERPs) associated with the regulation of negative and neutral stimuli were analysed. The results showed that (a) the P2 of HSSs were larger than LSSs during emotion regulation; (b) in down-regulation conditions, the LPP in all time windows were smaller than no-regulation in LSSs. However, there was no significant difference in HSSs; (c) the LPP 300–600 and LPP 1000–1500 of down-regulation were smaller in LSSs than HSSs; (d) for LPP 600–1000, HSSs induced larger LPP than LSSs in the negative down-regulation and negative no-regulation conditions. The results provide neurological evidence that higher sensation seeking is related to the high reactivity to emotional stimuli and poor cognitive control during the regulation of emotions.     

Individual differences in ERPs during mental rotation of characters: Lateralization,and performance level

The cognitive process of imaging an object turning around is called mental rotation. Many studies have been put forward analyzing mental rotation by means of event-related potentials (ERPs). Event-related potentials (ERPs) were measured during mental rotation of characters in a sample (N = 82) with a sufficient size to obtain even small effects. A bilateral ERP amplitude modulation as a function of angular displacement was observed at parietal leads without any lateralization. Sex had no effect on mental rotation of characters, neither with respect to performance nor with respect to brain potentials. When the sample was split into groups of high- and low-performers, however, the results indicated (a) in line with the idea of neural efficiency substantially larger amplitudes for low-performers; (b) that the smaller amplitudes of the high-performers involved larger parietal networks; and (c) a left-parietal disengagement of neural activity for high-performers but a right-parietal disengagement for low-performers. The latter finding became evident through an analysis of internal consistencies of ERP amplitudes across conditions and performance levels, showing that internal consistencies were reduced at all three leads in the high-performance group for the biggest rotation angle, relative the other conditions and the low-performing group.     

The development of and interaction among alerting,orienting, and executive attention in children

A sex-balanced sample (N = 96) of children from age 6.5 to age 12.5 completed a modified Attention Network Test. Across these ages, we found evidence for developmental changes to alerting and executive control but stable orienting. Additionally, we found that the youngest members of our sample manifested an interaction between alerting and executive control that is opposite to that typically found in adults; a reversal that diminishes with age to achieve the adult pattern by the older end of the age range of our sample.     

Keeping the end in mind: Preliminary brain and behavioral evidence for broad attention to endpoints in pre-linguistic infants

Infants must learn to carve events at their joints to best understand who is doing what to whom or whether an object or agent has reached its intended goal. Recent behavioral research demonstrates that infants do not see the world as a movie devoid of meaning, but rather as a series of sub-events that include agents moving in different manners along paths from sources to goals. This research uses behavioral and electrophysiological methods to investigate infants’ (10–14 months) attention to disruptions within relatively unfamiliar human action that does not rely on goal-objects to signal attainment (i.e., Olympic figure skating). Infants’ visual (Study 1, N = 48) and neurophysiological (Study 2, N = 21) responses to pauses at starting points, endpoints, and within-action locations were recorded. Both measures revealed differential responses to pauses at endpoints relative to pauses elsewhere in the action (i.e., starting point; within-action). Eye-tracking data indicated that infants’ visual attention was greater for events containing pauses at endpoints relative to events with pauses at starting points or within-actions. ERP activity reflecting perceptual processes in early-latency windows (<200 ms) and memory updating processes in long-latency windows (700−1000 ms) showed differential activation to disruptions at the end of a figure-skating action compared to other locations. Mid-latency windows (250−750 ms), in contrast, showed enhanced activation at frontal regions across conditions, suggesting electrophysiological resources may have been recruited to encode disruptions within unfamiliar dynamic human action. Combined, results hint at broad sensitivity to endpoints as a mechanism that supports infants’ proclivity for carving continuous and complex event streams into meaningful units. Findings have potential implications for language development as these units are mapped onto budding linguistic representations. We discuss empirical and methodological contributions for action perception and address potential merits and pitfalls of applying behavioral techniques in conjunction with brain-based measures to study infant development.     

Cognitive control of language production in bilinguals involves a partly independent process within the domain-general cognitive control network: evidence from task-switching and electrical brain activity

In highly proficient, early bilinguals, behavioural studies of the cost of switching language or task suggest qualitative differences between language control and domain-general cognitive control. By contrast, several neuroimaging studies have shown an overlap of the brain areas involved in language control and domain-general cognitive control. The current study measured both behavioural responses and event-related potentials (ERPs) from bilinguals who performed picture naming in single- or mixed-language contexts, as well as an alphanumeric categorisation task in single- or mixed-task context. Analysis of switch costs during the mixed-context conditions showed qualitative differences between language control and domain-general cognitive control. A 2 × 2 ANOVA of the ERPs, with domain (linguistic, alphanumeric) and context (single, mixed) as within-participant factors, revealed a significant interaction, which also suggests a partly independent language-control mechanism. Source estimations revealed the neural basis of this mechanism to be in bilateral frontal-temporal areas.     

Olfaction as a model system for the neurobiology of mammalian short-term habituation

Olfaction represents an ideal model system for the study of mammalian habituation given that it is an anatomically relatively simple system with strong reciprocal connections to the limbic system, driving both reflexive and non-reflexive (motivated) behaviors that are easily quantifiable. Data are reviewed here demonstrating short-term habituation of the odor-evoked heart-rate orienting reflex described according to the criteria for habituation outlined by Thompson and Spencer [Thompson, R. F., & Spencer, W. A. (1966). Habituation: A model phenomenon for the study of neuronal substrates of behavior. Psychological Reviews, 73(1), 16–43]. A necessary and sufficient mechanism of short-term habituation is then described, which involves a metabotropic glutamate receptor mediated depression of afferent input to the piriform (primary olfactory) cortex. Finally, evidence for, and a mechanisms of, dishabituation of the orienting reflex and cortical adaptation are described.     

Psychophysiological evidence of response conflict and strategic control of responses in affective priming

This experiment investigated the role of conflict in the response and evaluative categorization systems in the affective congruency effect using event-related brain potentials (ERPs). Participants completed a primed evaluative decision task in which the proportion of congruent to incongruent trials was manipulated. The size of the affective congruency effect increased along with the proportion of congruent trials. ERP data identified the locus of this effect in the response system: the lateralized readiness potential (LRP) showed that preferential response activation occurred in motor cortex following prime onset, and the fronto-central N2 (conflict monitoring) component indicated that conflict occurred when the response activated by the prime differed from the target response, irrespective of the affective congruency of the prime and target. The extent of this conflict covaried with strategic processing of primes, as participants directed less attention to primes that were likely to elicit conflict. These data support a response conflict account of affective congruency effects in the evaluative decision task and indicate that strategic control of attention is important in determining the extent to which conflict occurs.     

Event-related potentials reveal the development of stable face representations from natural variability

Natural variability between instances of unfamiliar faces can make it difficult to reconcile two images as the same person. Yet for familiar faces, effortless recognition occurs even with considerable variability between images. To explore how stable face representations develop, we employed incidental learning in the form of a face sorting task. In each trial, multiple images of two facial identities were sorted into two corresponding piles. Following the sort, participants showed evidence of having learnt the faces performing more accurately on a matching task with seen than with unseen identities. Furthermore, ventral temporal event-related potentials were more negative in the N250 time range for previously seen than for previously unseen identities. These effects appear to demonstrate some degree of abstraction, rather than simple picture learning, as the neurophysiological and behavioural effects were observed with novel images of the previously seen identities. The results provide evidence of the development of facial representations, allowing a window onto natural mechanisms of face learning.     

Temporal dynamics of interference in Simon and Eriksen tasks considered within the context of a dual-process model

Behavioral and brain potential measures were employed to compare interference in Eriksen and Simon tasks. Assuming a dual-process model of interference elicited in speeded response tasks, we hypothesized that only lateralized stimuli in the Simon task induce fast S–R priming via direct unconditional processes, while Eriksen interference effects are induced later via indirect conditional processes. Delays to responses for incongruent trials were indeed larger in the Eriksen than in the Simon task. Only lateralized stimuli in the Simon task elicited early S–R priming, maximal at parietal areas. Incongruent flankers in the Eriksen task elicited interference later, visible as a lateralized N2. Eriksen interference also elicited an additional component (N350), which accounted for the larger behavioral interference effects in the Eriksen task. The findings suggest that interference and its resolution involve different processes for Simon and Eriksen tasks.     

Word category and verb--argument structure information in the dynamics of parsing

One of the core issues in psycholinguistic research concerns the relationship between word category information and verb-argument structure (e.g. transitivity) information of verbs in the process of sentence parsing. In two experiments (visual versus auditory presentation) using event-related brain potentials (ERPs), we addressed this question by presenting sentences in which the critical word simultaneously realized both a word category and a transitivity violation. ERPs for sentences with both types of violation clustered with the patterns for sentences with a word category violation only, but were different from the patterns elicited by argument structure violations in isolation, since only the latter elicited an N400 ERP component. The finding that an argument structure violation evoked an N400 only if the phrase structure of the respective sentence was correct suggests that a successful integration of the word category information of a verb functionally precedes the application of its argument structure information.     

情绪性注意瞬脱的认知机制:来自行为与ERP的证据

从过度投入理论与激活反弹理论对瓶颈理论的质疑出发,采用ERP技术检验了情绪性注意瞬脱的加工过程及其神经机制。行为结果显示,以恐惧面孔为T1,中性场景图片为T2,则恐惧面孔T1相对中性面孔T1显著降低了中性T2的识别正确率,进而诱发了情绪性注意瞬脱。ERP结果进一步显示,相较于中性面孔T1,恐惧面孔T1诱发的情绪加工影响了代表中枢加工资源的两阶段P3波幅,使得其始终高于代表标准注意瞬脱的中性面孔T1条件和代表非注意瞬脱的单任务基线条件。以上结果证明,情绪性注意瞬脱形成自情绪性T1加工所诱发的中枢资源过度投入,而非源自中枢资源瓶颈。     

三字字谜顿悟的时频特征与源定位

运用事件相关电位(ERPs)技术,采用猜谜任务范式,从字谜问题解决中谜底“催化”所诱发顿悟的时间过程和源定位两方面来探讨顿悟的认知神经机制。脑电时程分析显示,在320-550ms内,“有顿悟”较“无顿悟”的ERP波形有一个更大的负向偏移,且在“有顿悟-无顿悟”差异波中,该负成分的潜伏期约为380ms,差异波的脑电峰值锁定在Cz点。EEG时频则显示N380主要表现为减弱的高频gamma波和beta波的频谱特征。独立成分溯源结果显示,N380存在四个独立源,主要分布在右侧额中回、左侧顶下小叶、右侧颞上回和右侧额下回。这些结果表明,三字字谜顿悟的N380就是N400,且主要负责三字顿悟字谜外显含义到内隐隐喻意义的表征转换加工。     

Behavioral and electrophysiological evidence for the impact of regional variation on phoneme perception

This event-related potential (ERP) study examined the impact of phonological variation resulting from a vowel merger on phoneme perception. The perception of the /e/-/ε/ contrast which does not exist in Southern French-speaking regions, and which is in the process of merging in Northern French-speaking regions, was compared to the /ø/-/y/ contrast, which is stable in all French-speaking regions. French-speaking participants from Switzerland for whom the /e/-/ε/ contrast is preserved, but who are exposed to different regional variants, had to perform a same-different task. They first heard four phonemically identical but acoustically different syllables (e.g., /be/-/be/-/be/-/be/), and then heard the test syllable which was either phonemically identical to (/be/) or phonemically different from (/bε/) the preceding context stimuli. The results showed that the unstable /e/-/ε/ contrast only induced a mismatch negativity (MMN), whereas the /ø/-/y/ contrast elicited both a MMN and electrophysiological differences on the P200. These findings were in line with the behavioral results in which responses were slower and more error-prone in the /e/-/ε/ deviant condition than in the /ø/-/y/ deviant condition. Together these findings suggest that the regional variability in the speech input to which listeners are exposed affects the perception of speech sounds in their own accent.     

Glucose regulation and face recognition deficits in older adults: the role of attention

The present study investigated the perceptual, attentional, and memory processes underlying face recognition deficits observed in older adults with impaired glucoregulation. Participants were categorized as good glucoregulators or poor glucoregulators on the basis of an oral glucose tolerance test. Using event-related potential (ERP) methodology, 23 participants (62–88 years) performed a 2-stimulus oddball task. Participants were asked to rate and memorize 10 “target” faces, which were then presented amongst 120 unfamiliar foils. Behavioral results indicated that good glucoregulators were significantly more accurate at recognizing target faces. ERP markers of early visual perception (P1 and N170 components) and memory formation (P3 component) were unaffected by glucoregulatory efficiency. The P2 component, an index of attentional processing, was larger and delayed in the poor glucoregulators. To the best of our knowledge, this study is the first to suggest that face recognition deficits in poor glucoregulators may be due to impairments in attentional processing.