A Study of the Effects of Restraint Stress on Colitis Induced by Dextran Sulphate Sodium in Singly Housed Rats

The inflammatory bowel diseases (Crohn's disease and ulcerative colitis) are multifactorial diseases. Clinical reports indicate that emotional stress may contribute to the onset, progression and remission of these diseases. Using an experimental animal model of ulcerative colitis, the effect of stress on the development of and recovery from symptoms was studied prospectively. Singly housed rats received 4 percent dextran sulphate sodium orally until fecal blood was detected, indicating the presence of colonic erosions. Tap water was then administered until there were no signs of fecal blood. Two hours of restraint stress were administered daily over four successive days, either prior to or after the induction of colitis. Latencies in days to symptom development and recovery were compared to an unstressed group. Daily measures of fluid-intake, body-weight, and hemoglobulin in feces were made. RESULTS: Rats exposed to restraint stress procedures prior to induction of colitis had shorter latencies to development of symptoms. There was no significant difference in latency to recovery. The amount of fluid-intake did not significantly differ between groups, nor did the groups differ in body-weight. CONCLUSION: There is an effect of stress on the latency to develop colitis induced by dextran sulphate sodium. This preliminary study suggests that the impact of stress may be one factor underlying the emergence of ulcerative colitis.     

Restraint and Cancellation: Multiple Inhibition Deficits in Attention Deficit Hyperactivity Disorder

We used variations of the stop signal task to study two components of motor response inhibition—the ability to withhold a strong response tendency (restraint) and the ability to cancel an ongoing action (cancellation)—in children with a diagnosis of attention deficit hyperactivity disorder (ADHD) and in non-ADHD controls of similar age (ages 7–14 years). The goal was to determine if restraint and cancellation were related and if both were deficient in ADHD. The stop signal task involved a choice reaction time task (go task) which required a rapid response. The demand for inhibitory control was invoked through the presentation of a stop signal on a subset of go trials which required that the ongoing response be suspended. The stop signal was presented either concurrently with the go signal (restraint version) or after a variable delay (cancellation version). In Study 1, we compared ADHD and control children on the cancellation version of the stop task; in Study 2, we compared ADHD and controls on the restraint version. In Study 3, a subset of ADHD and control participants completed both tasks so that we could examine convergence of these dimensions of inhibition. Compared to control participants, ADHD participants showed a deficit both in the ability to cancel and to restrain a speeded motor response. Performance on the restraint version was significantly correlated with performance on the cancellation version in controls, but not in ADHD participants. We conclude that ADHD is associated with deficits in both restraint and cancellation subcomponents of inhibition.     

Clergy Role Stress: Interactive Effects of Role Ambiguity and Role Conflict on Intrinsic Job Satisfaction

The present study examined relationships between role conflict, role ambiguity, and three facets of clergy job satisfaction: Relationships and Support, Denominational Involvement, and Intrinsic Aspects. Web survey data from 179 United Methodist clergy indicated that role ambiguity and role conflict had negative relationships with each of the three facets of job satisfaction, as well as with overall job satisfaction. Interactions between role conflict and ambiguity were not significant for overall job satisfaction or for two of the three facets, suggesting that the effects of role conflict and role ambiguity on these aspects of job satisfaction were linear and cumulative. However, the effects of role ambiguity and role conflict considered together were nonlinear and interactive for the Intrinsic Aspects facet of job satisfaction, indicating that when role ambiguity was low, the relationship between role conflict and intrinsic job satisfaction was not significant, whereas when role ambiguity was high, there was a significant negative relationship between role conflict and intrinsic job satisfaction.     

返回抑制的容量研究：回顾与展望

返回抑制是指当注意返回到先前注意过的位置或客体时人们的反应变慢的一种抑制现象。自20世纪90年代中期以来,越来越多的返回抑制研究开始关注最多能在多少个线索化位置上观测到返回抑制效应,即返回抑制的容量问题。文章着重从序列线索化和同时线索化两方面介绍了当前返回抑制容量研究的主要成果,总结了该领域研究的特点及存在的问题,并对未来研究方向予以展望     

Inhibition of ad Libitum Feeding in Rats by Salt Injections and Water Deprivation

Inhibition of ad libitum feeding in rats was induced by hypertonic NaCl injections. Though osmotic loads of sufficient size were capable of abolishing feeding completely for a time, the effect was not as large as had been predicted from a hypothesis of strictly linear subtractive inhibition. Feeding at a low level of hunger seems to be somewhat less affected by osmotic inhibition than feeding on a deprivation schedule. Inhibition of feeding was also produced by deprivation of water, and both the inhibition of food intake during deprivation, and the disinhibition by subsequent drinking indicated that the amount of inhibition of food intake is a non-linear (accelerating) function of water deficit. A model of the process indicating that the thirst signal undergoes a non-linear transformation before being subtracted from the signal corresponding to food demand is proposed.     

Effects of Predator-Induced Stress and Age on Working Memory in Rats

The Psychological Record - The effects of age and predator-induced stress, by exposing rats to a cat, were examined during subsequent testing of spatial working memory. Male rats (3 months and 20...     

损毁大鼠双侧内嗅皮质对束缚应激反应的影响

采用大鼠急性束缚应激动物模型,用鹅羔氨酸损毁大鼠双侧内嗅皮质来建立内嗅皮质损伤模型,观察束缚应激1小时后下丘脑室旁核快反应基因c-Fos表达情况以及应激后血浆促肾上腺皮质激素含量的动态变化,并与对照组相比较,探讨内嗅皮质与束缚应激反应的关系。结果表明,损毁内嗅皮质,明显抑制了应激诱导的下丘脑室旁核c-Fos的表达和血浆促肾上腺皮质激素含量的上升。结果提示,内嗅皮质参与调节束缚应激反应时HPA轴功能。     

抑制机制发展研究述评

近年来,抑制机制的发展问题已成为认知心理学界研究的热点问题之一。本文主要从儿童早期抑制发展和抑制机制老化两方面介绍了抑制机制发展研究的新进展,并阐述了目前抑制研究领域中存在的问题和不足之处。     

Effects of Stress on Nonassociative Learning Processes in Male and Female Rats

In this study we assessed habituation and sensitization of the acoustic startle response (ASR) to discern whether intense, inescapable stress affects nonassociative learning differently in male and female rats. Rats were inescapably stressed 2 hours per day over 3 consecutive days. ASR magnitudes were measured at several times post-stress (1, 4, 8, and 15 days after cessation). Females generally showed greater ASR magnitudes (compared to males), but both sexes exhibited short and long-term habituation across the testing days. ASR magnitudes were only affected by stress in male subjects. The effect in males was an increase in short-term sensitization of the ASR on post-stress day-4. The results suggest that stressed males and females react differently to ASR testing, in that stress males appear to develop an exaggerated ASR response over repeated test sessions due to short-term sensitization. The source of the short-term sensitization is discussed with regards to possible stress-induced enhanced contextual learning during ASR testing on post-stress day-1.     

生命性在句子加工中作用的ERP研究

生命性广泛地渗透到人类语言系统中发挥其作用。本文主要结合最新和经典的有关生命性的ERP研究探讨了生命性信息起作用的模式和时间进程。在句子加工过程中,生命性影响论元的加工并影响题元结构的建构和解释。以往研究表明,生命性违反有时引发的是N400效应,有时引发的是P600效应,少数情况还表现出N400-P600的双相模式。生命性在句子加工中的作用还跟多种变量存在交互作用,语境、题元可逆性、论元之间的语义关系、动词类型和其固有的题元结构都可能影响生命性信息起作用的模式。文章最后进行总结和展望,并提出未来研究仍有必要继续探讨生命性信息加工的时间神经动态性及其在句子加工中的具体作用机制。     

Spirituality and Trauma: The Role of Clergy in the Treatment of Posttraumatic Stress Disorder

An increased awareness of the spiritual aspects of health and illness has recently led to changes in psychiatry residency training as well as hospital accreditation requirements. The spiritual impact of trauma has been an area of particular interest, as trauma evokes certain existential questions and crises. It is estimated that from 5–11% of trauma survivors will go on to develop posttraumatic stress disorder (PTSD). Given the spiritual challenges of the experience of trauma, patients with PTSD could benefit from spiritual assessment and intervention as part of their overall treatment plan, and clergy can be utilized to perform this. The literature exploring the spiritual impact of trauma and the use of clergy in the treatment of trauma survivors is reviewed. The methods used by three chaplains in a residential treatment program for PTSD at one facility are described and discussed. Both the literature and the experiences of the clergy suggest that exploration of trauma-related existential conflicts in patients with PTSD is beneficial. However, there is a notable dearth of controlled scientific studies evaluating the effectiveness of spiritual interventions with this treatment population. The need for controlled studies to verify the usefulness of spiritual assessment and intervention in patients with PTSD is noted, and a more rigorous analysis of how clergy can best serve this treatment population is encouraged.     

Combination Effects of Forced Mild Exercise and GABAB Receptor Agonist on Spatial Learning,Memory, and Motor Activity in Striatum Lesion Rats

Basal ganglia (BG) lesions cause impairments of different mammalian’s movement and cognition behaviors. Motor circuit impairment has a dominant role in the movement disorders. An inhibitory factor in BG is GABA neurotransmitter, which is released from striatum. Lesions in GABAergic neurons could trigger movement and cognition disorders. Previous evidence showed that GABA_B receptor agonist (Baclofen) administration in human improves movement disorders and exercise can improve neurodegenerative and cognitive decline; however, the effects of both Baclofen and mild forced treadmill exercise on movement disorders are not well known. The main objective of this study is to investigate the combined effects of mild forced treadmill exercise and microinjection of Baclofen in the internal Globus Pallidus on striatum lesion-induced impairments of spatial learning and motor activity. We used Morris water maze and open filed tests for studying spatial learning, and motor activity, respectively. Results showed that mild exercise and Baclofen microinjection could not lonely affect the spatial learning, and motor activity impairments while the combination of them could alleviate spatial learning, and motor activity impairments in striatum-lesion animals. Our results suggest that striatum lesion-induced memory and motor activity impairments can improve with combination interaction of GABA_B receptor agonist and exercise training.     

自主性动机对创造力的预测：认知抑制的调节作用

执行功能和动机是构成创造力个体差异的重要因素。本研究采用Stroop任务、自主性动机和创造力量表对372名大学生进行问卷调查及实验室研究,以考察认知抑制在自主性动机预测创造力中的调节作用。结果发现：（1）自主性动机显著正向预测流畅性/灵活性/独创性。（2）认知抑制调节自主性动机对流畅性与灵活性的预测作用。具体表现为对高认知抑制能力者,自主性动机显著正向预测流畅性和灵活性,对低认知抑制能力者这一预测作用不显著。该研究深化了自主性动机与创造力关系的研究。     

Latent Inhibition of Contextual Stimuli Reduces the US Preexposure Effect in Rats

Two experiments are reported which utilized latent inhibition of contextual stimuli prior to administering unsignaled presentations of the Us in an attempt to further assess the role of contextual stimuli in the US preexposure effect. Specifically in Experiment 1, rats received either 0-, 5-, 10-, or 15-minute exposure to the context in which the unsignaled Uss were to occur (latent inhibition). Following preexposure to the US, animals were trained in a CER paradigm with a tone CS. Measures of suppression to the tone indicated that the greatest US preexposure effect occurred in the 0 group and that no US preexposure effect was evident in the 15 group. Experiment 2 includec two important control groups which were omitted in Experiment 1 (no US preexposures) and an additional dependent variable (time to initiate licking) to measure fear to contextual stimuli. These results are discussed in terms of the role context conditioning may play in US preexposure.

     

惊反射在创伤后应激障碍研究中的应用:高唤醒与恐惧抑制

创伤后应激障碍(PTSD)是唯一在诊断标准中包含惊反射改变的精神疾病.相比自我报告法,对惊反射的实验室测量与总体症状关联更紧密,并已积累了较多神经机制研究成果,可作为连接前临床与临床研究的桥梁.在惊反射应用于PTSD研究的初期,它主要作为PTSD患者高唤醒症状的客观指标,但是尚未发现惊反射强度的变化与总体症状的明确关系.近年来,惊反射与情境性焦虑、恐惧抑制等新范式结合,发现特定情境下惊反射改变是PTSD患者特有的表现.惊反射在创伤应激障碍研究中所取得的新进展对PTSD病理机制的探索和临床诊断都有所启发和推进.     

Personality and Charismatic Leadership in Context: The Moderating Role of Situational Stress

We adopt an interactionist perspective and extend previous work on personality and charismatic leadership by considering the relationship between them across contexts. Based on Gray's reinforcement sensitivity theory, we expected the relationships between approach‐oriented dispositions and charisma to diminish under conditions of high workload‐induced stress. In a large‐scale lab study with 201 groups (Study 1, N = 721 participants), we manipulated conditions of stress and tested the interaction of stress with leaders’ extraversion and openness to experience in predicting their charismatic behaviors. We then tested, in a field study of 71 executives (Study 2, N = 256 participants), the interaction of employees’ reported stress with leaders’ stimulation values in predicting their charismatic behavior. In support of our hypotheses, the relationships between approach‐oriented dispositions and charisma were significantly weaker when stress was high. We discuss theoretical and practical implications of this finding, in particular given that it is in stressful conditions under which charismatic leadership is said to be most important.     

慢性心理应激对大鼠淋巴细胞热休克蛋白70表达和凋亡的影响

为了探讨慢性心理应激对热休克蛋白70（Hsp70）、淋巴细胞的凋亡及其两者之间关系的影响,将实验SD大鼠分为对照组、中等强度心理应激组和高强度心理应激组。分别对三组大鼠给予相应的干预3周,采用流式细胞仪定量检测各组大鼠外周血淋巴细胞Hsp70的表达水平和凋亡量。结果发现,与对照组比较,中等和高强度心理应激组淋巴细胞内Hsp70表达水平显著增加;中等强度心理应激组凋亡量增加但没有出现统计学意义,高强度心理应激组淋巴细胞凋亡显著增加;中等强度心理应激组的淋巴细胞Hsp70表达与凋亡量变化成显著正相关,高强度心理应激组两者变化成不显著正相关。研究结果提示心理应激能诱发淋巴细胞Hsp70表达和凋亡升高,且随心理应激强度增加,Hsp70表达升高趋势减缓、凋亡量增加加剧,最终造成机体免疫损伤加深     

认知抑制与人际宽恕:特质宽恕的调节作用

采用《特质宽恕量表》测量了102名大学生的特质宽恕能力,并通过Flanker任务和情景回忆法评估了被试的认知抑制和人际宽恕水平,目的是探讨特质宽恕、认知抑制与人际宽恕三者之间的关系。结果发现:(1)认知抑制、特质宽恕与人际宽恕各维度之间存在两两显著相关(除认知抑制与仁慈动机之外);(2)特质宽恕对回避、报复和仁慈动机均具有预测作用,而认知抑制则只对报复动机具有预测作用;(3)特质宽恕与认知抑制对回避动机具有负向的调节作用,对仁慈动机具有正向的调节作用。