Exploring face perception in disorders of development: Evidence from Williams syndrome and autism

Individuals with Williams syndrome (WS) and autism are characterized by different social phenotypes but have been said to show similar atypicalities of face‐processing style. Although the structural encoding of faces may be similarly atypical in these two developmental disorders, there are clear differences in overall face skills. The inclusion of both populations in the same study can address how the profile of face skills varies across disorders. The current paper explored the processing of identity, eye‐gaze, lip‐reading, and expressions of emotion using the same participants across face domains. The tasks had previously been used to make claims of a modular structure to face perception in typical development. Participants with WS (N=15) and autism (N=20) could be dissociated from each other, and from individuals with general developmental delay, in the domains of eye‐gaze and expression processing. Individuals with WS were stronger at these skills than individuals with autism. Even if the structural encoding of faces appears similarly atypical in these groups, the overall profile of face skills, as well as the underlying architecture of face perception, varies greatly. The research provides insights into typical and atypical models of face perception in WS and autism.     

Social and attention‐to‐detail subclusters of autistic traits differentially predict looking at eyes and face identity recognition ability

This study distinguished between different subclusters of autistic traits in the general population and examined the relationships between these subclusters, looking at the eyes of faces, and the ability to recognize facial identity. Using the Autism Spectrum Quotient (AQ) measure in a university‐recruited sample, we separate the social aspects of autistic traits (i.e., those related to communication and social interaction; AQ‐Social) from the non‐social aspects, particularly attention‐to‐detail (AQ‐Attention). We provide the first evidence that these social and non‐social aspects are associated differentially with looking at eyes: While AQ‐Social showed the commonly assumed tendency towards reduced looking at eyes, AQ‐Attention was associated with increased looking at eyes. We also report that higher attention‐to‐detail (AQ‐Attention) was then indirectly related to improved face recognition, mediated by increased number of fixations to the eyes during face learning. Higher levels of socially relevant autistic traits (AQ‐Social) trended in the opposite direction towards being related to poorer face recognition (significantly so in females on the Cambridge Face Memory Test). There was no evidence of any mediated relationship between AQ‐Social and face recognition via reduced looking at the eyes. These different effects of AQ‐Attention and AQ‐Social suggest face‐processing studies in Autism Spectrum Disorder might similarly benefit from considering symptom subclusters. Additionally, concerning mechanisms of face recognition, our results support the view that more looking at eyes predicts better face memory.     

注意线索对自闭特质个体疼痛共情的影响：来自事件相关电位的证据

自闭特质个体在日常生活中表现出共情缺损, 但其程度较自闭症谱系障碍个体低, 并且注意线索和特异性的面孔加工可能会影响他们的共情加工进程。因此, 本研究采用事件相关电位(ERP)技术, 以疼痛面孔图片作为刺激材料, 让自闭特质组和控制组分别完成疼痛判断任务(该任务中被试的注意指向疼痛线索)和吸引力判断任务(该任务中被试的注意不指向疼痛线索)。结果发现, 相比控制组, 自闭特质组在吸引力判断任务中疼痛面孔图片诱发的P3波幅更大, 而在疼痛判断任务中两组没有显著差异。这表明注意线索会影响自闭特质个体对他人疼痛面孔的共情反应, 当自闭特质个体不注意他人面孔的疼痛线索时, 其疼痛共情能力会减弱。     

Social cognition and real-life functioning in patient samples with 22q11.2 deletion syndrome with or without psychosis,compared to a large sample of patients with schizophrenia only and healthy controls

Patients with the 22q11.2 deletion syndrome (DS) show an increased risk of developing a psychotic illness lifetime. 22q11.2DS may represent a reliable model for studying the neurobiological underpinnings of schizophrenia. The study of social inference abilities in a genetic condition at high risk for psychosis, like 22q11.2DS, may shed light on the relationships between neurocognitive processes and patients' daily general functioning. The study sample consisted of 1736 participants, divided into four groups: 22q11.2DS patients with diagnosis of psychotic disorder (DEL SCZ, N = 20); 22q11.2DS subjects with no diagnosis of psychosis (DEL, N = 43); patients diagnosed with schizophrenia without 22q11.2DS (SCZ, N = 893); and healthy controls (HC, N = 780). Social cognition was assessed through The Awareness of Social Inference Test (TASIT) and general functioning through the Specific Levels of Functioning (SLoF) scale. We analysed data through regression analysis. The SCZ and DEL groups had similar levels of global functioning; they both had significantly lower SLoF Total scores than HC (p < .001); the DEL SCZ group showed significantly lower scores compared to the other groups (SCZ, p = .004; DEL, p = .003; HC, p < .001). A significant deficit in social cognition was observed in the three clinical groups. In the DEL SCZ and SCZ groups, TASIT scores significantly predicted global functioning (p < .05). Our findings of social cognition deficit in psychosis-prone patients point to the possible future adoption of rehabilitation programmes, like Social Skills Training and Cognitive Remediation, during premorbid stages of psychosis.     

The development and flexibility of gaze alternations in bonobos and chimpanzees

Infants’ early gaze alternations are one of their first steps towards a sophisticated understanding of the social world. This ability, to gaze alternate between an object of interest and another individual also attending to that object, has been considered foundational to the development of many complex social‐cognitive abilities, such as theory of mind and language. However, to understand the evolution of these abilities, it is important to identify whether and how gaze alternations are used and develop in our closest living relatives, bonobos (Pan paniscus) and chimpanzees (Pan troglodytes). Here, we evaluated the development of gaze alternations in a large, developmental sample of bonobos (N = 17) and chimpanzees (N = 35). To assess the flexibility of ape gaze alternations, we tested whether they produced gaze alternations when requesting food from a human who was either visually attentive or visually inattentive. Similarly to human infants, both bonobos and chimpanzees produced gaze alternations, and did so more frequently when a human communicative partner was visually attentive. However, unlike humans, who gaze alternate frequently from early in development, chimpanzees did not begin to gaze alternate frequently until adulthood. Bonobos produced very few gaze alternations, regardless of age. Thus, it may be the early emergence of gaze alternations, as opposed gaze alternations themselves, that is derived in the human lineage. The distinctively early emergence of gaze alternations in humans may be a critical underpinning for the development of complex human social‐cognitive abilities.     

The effects of co‐occurring ADHD symptoms on electrophysiological correlates of cognitive control in young people with Tourette syndrome

Efficient cognitive control is implicated in tic control in young people with Tourette syndrome (TS). Attention‐deficit/hyperactivity disorder (ADHD) frequently co‐occurs with TS and is associated with impaired cognitive control. Young people with TS and ADHD (TS+ADHD) show poorer cognitive control performance than those with TS, but how co‐occurring ADHD affects underlying neural activity is unknown. We investigated this issue by examining behavioural and event‐related potential (ERP) correlates of cognitive control in young people with these conditions. Participants aged 9–17 with TS (n = 17), TS+ADHD (n = 17), ADHD (n = 11), and unaffected controls (n = 20) performed a visual Go/Nogo task during electroencephalography (EEG) recording. Behavioural performance measures (D‐prime, RT, reaction time variability, post‐error slowing) and ERP measures (N2, P3, error‐related negativity (ERN), error positivity (Pe)) were analysed in a 2 (TS‐yes, TS‐no) × 2 (ADHD‐yes, ADHD‐no) factorial analysis to investigate the effects of TS, ADHD, and their interaction. The results of these analyses showed that ADHD was associated with poorer performance and reduced amplitude of all ERPs, reflecting widespread cognitive control impairments. Tourette syndrome was associated with slowed RTs, which might reflect a compensatory slowing of motor output to facilitate tic control. There was no interaction between the TS and ADHD factors for any behavioural or ERP measure, indicating the impairing effects of ADHD on behaviour and electrophysiological markers of cognitive control were present in TS+ADHD and that RT slowing associated with TS was unaffected by co‐occurring ADHD symptoms.     

The development of emotional face and eye gaze processing

Recent research has demonstrated that infants' attention towards novel objects is affected by an adult's emotional expression and eye gaze toward the object. The current event-related potential (ERP) study investigated how infants at 3, 6, and 9 months of age process fearful compared to neutral faces looking toward objects or averting gaze away from objects. Furthermore, we examined how the processing of novel objects is affected by gaze direction and emotional expression. We hypothesized that an adult's fearful expression should be particularly salient when it is directed toward a referent in the environment. Furthermore, responses to objects should be increased if the face previously expressed fear toward the object. Three-month-olds did not show differential neural responses to fearful vs. neutral faces regardless of gaze direction. Six-month-olds showed an enhanced negative central (Nc) component for fearful relative to neutral faces looking toward objects, but not when eye gaze was averted away from the objects. Furthermore, 6-month-olds showed an enhanced Nc for objects that had been gaze-cued by a fearful compared to a neutral face. Nine-month-olds showed an enhanced Nc for fearful relative to neutral faces in both eye gaze conditions and showed an enhanced Nc for objects that had been gaze-cued by a neutral face. The findings are discussed in the context of social cognitive and brain development.     

Neural correlates of facial emotion processing in infancy

In the present study we examined the neural correlates of facial emotion processing in the first year of life using ERP measures and cortical source analysis. EEG data were collected cross‐sectionally from 5‐ (N = 49), 7‐ (N = 50), and 12‐month‐old (N = 51) infants while they were viewing images of angry, fearful, and happy faces. The N290 component was found to be larger in amplitude in response to fearful and happy than angry faces in all posterior clusters and showed largest response to fear than the other two emotions only over the right occipital area. The P400 and Nc components were found to be larger in amplitude in response to angry than happy and fearful faces over central and frontal scalp. Cortical source analysis of the N290 component revealed greater cortical activation in the right fusiform face area in response to fearful faces. This effect started to emerge at 5 months and became well established at 7 months, but it disappeared at 12 months. The P400 and Nc components were primarily localized to the PCC/Precuneus where heightened responses to angry faces were observed. The current results suggest the detection of a fearful face in infants’ brain can happen shortly (~200–290 ms) after the stimulus onset, and this process may rely on the face network and develop substantially between 5 to 7 months of age. The current findings also suggest the differential processing of angry faces occurred later in the P400/Nc time window, which recruits the PCC/Precuneus and is associated with the allocation of infants’ attention.     

Head and eye movements affect object processing in 4‐month‐old infants more than an artificial orientation cue

This study investigates the effects of attention‐guiding stimuli on 4‐month‐old infants' object processing. In the human head condition, infants saw a person turning her head and eye gaze towards or away from objects. When presented with the objects again, infants showed increased attention in terms of longer looking time measured by eye tracking and an increased Nc amplitude measured by event‐related potentials (ERP) for the previously uncued objects versus the cued objects. This suggests that the uncued objects were previously processed less effectively and appeared more novel to the infants. In a second condition, a car instead of a human head turned towards or away from objects. Eye‐tracking results did not reveal any significant difference in infants' looking time. ERPs indicated only a marginally significant effect in late slow‐wave activity associated with memory encoding for the uncued objects. We conclude that human head orientation and gaze direction affect infants' object‐directed attention, whereas movement and orientation of a car have only limited influence on infants' object processing.     

Unfamiliar face recognition in children with autistic spectrum disorders

We investigated unfamiliar face recognition in low‐functioning children with autistic spectrum disorders (ASD) using a ‘part‐of‐face’ method. This method has not previously been used for unfamiliar faces with this population. The ‘part‐of‐face’ procedure provides measures of both face recognition accuracy and of processing style. We compared the performance of the children with ASD with three control groups: children with developmental delay (DD), typically developing (TD) children matched for verbal cognitive ability and TD children matched for chronological age (CA). Compared to the DD group, the ASD group showed similar processing in recognition accuracy and processing style. Compared to the TD children, the ASD group did not show the same level of accuracy as controls of the same CA, instead showing similar performance to younger TD children. However, as both children with ASD and DD showed the same performance, no ASD‐specific deficit was found. Copyright © 2009 John Wiley & Sons, Ltd.     

Early processing of emotional faces in children with autism: An event-related potential study

Social deficits are one of the most striking manifestations of autism spectrum disorders (ASDs). Among these social deficits, the recognition and understanding of emotional facial expressions has been widely reported to be affected in ASDs. We investigated emotional face processing in children with and without autism using event-related potentials (ERPs). High-functioning children with autism (n = 15, mean age = 10.5 ± 3.3 years) completed an implicit emotional task while visual ERPs were recorded. Two groups of typically developing children (chronological age-matched and verbal equivalent age-matched [both ns = 15, mean age = 7.7 ± 3.8 years]) also participated in this study. The early ERP responses to faces (P1 and N170) were delayed, and the P1 was smaller in children with autism than in typically developing children of the same chronological age, revealing that the first stages of emotional face processing are affected in autism. However, when matched by verbal equivalent age, only P1 amplitude remained affected in autism. Our results suggest that the emotional and facial processing difficulties in autism could start from atypicalities in visual perceptual processes involving rapid feedback to primary visual areas and subsequent holistic processing.     

The role of eye‐gaze in understanding other minds

From an early age, infants are sensitive to eye‐gaze direction. This study examined Baron‐Cohen's (1994, 1995) claim that the ability to use eye‐gaze plays a crucial role in the child's developing understanding of other minds. Children aged 3 and 4 years participated in a face‐reading task, which assessed their capacity to infer mental states from a character's direction of eye‐gaze, and in a false‐belief task. As predicted, no child passed the false‐belief task without prior success on the face‐reading task. However, contrary to a central claim within Baron‐Cohen's model of mind‐reading, presentation of an eye‐gaze cue in the false‐belief task did not enhance children's performance. Furthermore, children did not solely rely on eye‐gaze as a cue, but used another directional cue (an arrow) in inferring a character's desire and intention. These results question the special role of eye‐gaze in the child's developing ability to mind‐read.     

Electrophysiological correlates of face distortion after-effects

When observers are exposed to a distorted face the perceived configuration of a subsequently presented face is altered, a phenomenon called face distortion after-effect (FDAE). We compared the face-related components of the event-related potential (ERP) after adaptation to noise images—veridical and distorted faces. We found large bilateral adaptation effects on the P100 and N170 components that are related to face detection. Moreover, we found smaller adaptation effects on the N170, recorded over the right hemisphere, which can be related to the behavioural distortion after-effect and to face configurations. Our results suggest that the observed ERP adaptation effects are general for various steps of face processing and that the FDAEs similarly to gender after-effects are related to the early face-specific ERP components.     

眼睛注视的知觉及其线索效应

对眼睛注视知觉、眼睛注视线索效应及其影响因素等相关研究进行了总结和分析。结果发现:(1)婴儿从一出生就对眼睛注视线索表现出强烈的敏感性,眼睛注视知觉对语言和社会等能力的发展有很大影响;(2)颞上沟是加工眼睛注视线索的特异神经结构,它与实时监控情绪和情感的杏仁核存在神经联结,成为社会认知神经系统的重要组成部分;(3)对眼睛注视线索的早期加工显示出特异的脑电活动模式;(4)眼睛注视线索效应与外周线索的反射式效应相类似,但持续时间较长;(5)眼睛注视线索效应不仅受面部结构信息的影响,也受自上而下加工等高水平认知因素的调节,并显示出明显的个体差异。对眼睛注视线索效应的进一步研究应涉及人格判断、喜好评价和心理理论等高级社会认知活动。     

Characterizing visual behaviour in a lineup task

Eye tracking was used to monitor participants' visual behaviour while viewing lineups in order to determine whether gaze behaviour predicted decision accuracy. Participants viewed taped crimes followed by simultaneous lineups. Participants (N = 34) viewed 4 target‐present and 4 target‐absent lineups. Decision time, number of fixations and duration of fixations differed for selections vs. non‐selections. Correct and incorrect selections differed only in terms of comparison‐type behaviour involving the selected face. Correct and incorrect non‐selections could be distinguished by decision time, number of fixations and duration of fixations on the target or most‐attended face and comparisons. Implications of visual behaviour for judgment strategy (relative vs. absolute) are discussed. Copyright © 2009 John Wiley & Sons, Ltd.     

Are the literacy difficulties that characterize developmental dyslexia associated with a failure to integrate letters and speech sounds?

The ‘automatic letter‐sound integration hypothesis’ (Blomert, 2011 ) proposes that dyslexia results from a failure to fully integrate letters and speech sounds into automated audio‐visual objects. We tested this hypothesis in a sample of English‐speaking children with dyslexic difficulties (N = 13) and samples of chronological‐age‐matched (CA; N = 17) and reading‐age‐matched controls (RA; N = 17) aged 7–13 years. Each child took part in two priming experiments in which speech sounds were preceded by congruent visual letters (congruent condition) or Greek letters (baseline). In a behavioural experiment, responses to speech sounds in the two conditions were compared using reaction times. These data revealed faster reaction times in the congruent condition in all three groups. In a second electrophysiological experiment, responses to speech sounds in the two conditions were compared using event‐related potentials (ERPs). These data revealed a significant effect of congruency on (1) the P1 ERP over left frontal electrodes in the CA group and over fronto‐central electrodes in the dyslexic group and (2) the P2 ERP in the dyslexic and RA control groups. These findings suggest that our sample of English‐speaking children with dyslexic difficulties demonstrate a degree of letter‐sound integration that is appropriate for their reading level, which challenges the letter‐sound integration hypothesis.     

Changes in Attachment‐Related Behavioural Problems of Internationally Adopted Toddlers in Finland: Results from the FinAdo Study

This study investigated attachment‐related behavioural problems and their change over time among internationally adopted toddlers (N = 171, boys 40%) in Finland. The parents filled in questionnaires posted in 2007 and again in 2009. At the baseline (on average, 1.9 years from adoption), the mean age of the adoptees was 2.8 years. The comparison group (N = 244, boys 46%) was collected through well‐baby clinics. Results from the paired t‐test and mixed models showed that the adoptees' attachment‐related behavioural problems decreased during the 2‐year follow‐up and that they did not manifest more problems than their age‐mates any more 4 years after adoption. The decrease in behavioural problems was associated with the child's female gender, country of origin and adoptive parents' positive experience about adoption. A child's stereotypic or self‐injurious behaviour was not associated with the change in attachment‐related behaviour over time, although both were associated with behavioural problems. Copyright © 2014 John Wiley & Sons, Ltd.     

Women in the midluteal phase of the menstrual cycle have difficulty suppressing the processing of negative emotional stimuli: An event-related potential study

Emotion regulation deficits have been implicated in anxiety and depressive disorders, and these internalising disorders are more prevalent in women than men. Few electrophysiological studies have investigated sex differences in emotional reactivity and emotion regulation controlling for menstrual phase. Event-related potentials (ERPs) were recorded from 28 early follicular women, 29 midluteal women, and 27 men who completed an emotion regulation task. A novel finding of increased N2 amplitude during suppression was found for midluteal women compared with men. These findings suggest midluteal women may be significantly less able to suppress cortical processing of negative stimuli compared to men. This ERP finding was complemented by behavioral ratings data which revealed that while both early follicular and midluteal women reported more distress than men, midluteal women also reported greater effort when suppressing their responses than men. P1 and N1 components were increased in midluteal women compared to men regardless of instructional set, suggesting greater early attentional processing. No sex or menstrual phase differences were apparent in P3 or LPP. This study underscores the importance of considering menstrual phase when examining sex differences in the cortical processing of emotion regulation and demonstrates that midluteal women may have deficits in down-regulating their neural and behavioural responses.     

Infants’ intentionally communicative vocalizations elicit responses from caregivers and are the best predictors of the transition to language: A longitudinal investigation of infants’ vocalizations,gestures and word production

What aspects of infants’ prelinguistic communication are most valuable for learning to speak, and why? We test whether early vocalizations and gestures drive the transition to word use because, in addition to indicating motoric readiness, they (a) are early instances of intentional communication and (b) elicit verbal responses from caregivers. In study 1, 11 month olds (N = 134) were observed to coordinate vocalizations and gestures with gaze to their caregiver's face at above chance rates, indicating that they are plausibly intentionally communicative. Study 2 tested whether those infant communicative acts that were gaze‐coordinated best predicted later expressive vocabulary. We report a novel procedure for predicting vocabulary via multi‐model inference over a comprehensive set of infant behaviours produced at 11 and 12 months (n = 58). This makes it possible to establish the relative predictive value of different behaviours that are hierarchically organized by level of granularity. Gaze‐coordinated vocalizations were the most valuable predictors of expressive vocabulary size up to 24 months. Study 3 established that caregivers were more likely to respond to gaze‐coordinated behaviours. Moreover, the dyadic combination of infant gaze‐coordinated vocalization and caregiver response was by far the best predictor of later vocabulary size. We conclude that practice with prelinguistic intentional communication facilitates the leap to symbol use. Learning is optimized when caregivers respond to intentional vocalizations with appropriate language.     

Gaze and arrow cueing of attention reveals individual differences along the autism spectrum as a function of target context

Observing averted gaze results in a reflexive shift of attention to the gazed‐at location. In two experiments, participants scoring high and low on the Autism‐Spectrum Quotient questionnaire (AQ; Baron‐Cohen, Wheelwright, Skinner, Martin, & Clubley, 2001 ) observed arrow and gaze cues to investigate cueing effect magnitude as a function of the context in which peripheral targets could appear. While identical cueing effects were found with gaze and arrow cues, the more striking results concerned target stimuli. In Experiment 1, targets could appear on a peripheral face, or on scrambled face parts. Overall, greater cueing effects were found when the target appeared on a face. However, this face bias was only observed in participants with low AQ scores, whereas high AQ scorers oriented more to scrambled features. Experiment 2 found equal cueing to targets appearing on tools, as compared with tool parts. However, individual differences were again observed, where low AQ scorers showed larger cueing towards tools, while high scorers oriented more to scrambled parts, as in Experiment 1. These results support the idea that low AQ individuals orient strongly to objects attended by others. However, since the same results were found for arrow cues, this effect may generalize to all central cues to attention. High AQ scorers possessing many more autistic‐like traits tended to orient more to scrambled shapes, perhaps reflecting a bias for orienting to local details.