Menstrual cycle as focus of study and self-reports of moods and behaviors

Retrospective questionnaires show cyclical variations in moods and behaviors across the menstrual cycle. However, results obtained from daily mood questionnaires are inconsistent. In the present study, which ran for 11 weeks, self-report measures of menstrual symptomatology, using the 8-factor Moos (1968, 1969 a,c) Menstrual Distress Questionnaire (MDQ), were investigated. The MDQ was administered under conditions that made the menstrual cycle a salient (retrospective questionnaire) or not a salient (daily questionnaire) part of the study. The study included women who were taking and not taking oral contraceptives. A 2×3 analysis of variance (with the two groups of women and three menstrual cycle phases as independent variables) yielded broad cyclical variations only in the menstrual cycle salient condition. When the menstrual cycle was not a salient part of the study, only the pain factor reached significant cyclical variation (p<.01).A 2×3 analysis of variance (with the two types of questionnaires and three menstrual cycle phases as independent variables) indicated that for women not taking oral contraceptives the two questionnaires differed on pain (p<.01), concentration (p<.01), autonomic reaction (p<.05), and water retention (p<.01). Phase effects were significant on all factors, with largest cyclical variations in the menstrual cycle salient condition. A similar analysis for women taking oral contraceptives yielded fewer significant differences. These results suggest that questionnaires that make the menstrual cycle a salient part of the study may exaggerate possible cyclical variations in moods and behaviors.The authors are grateful to Dawn Christie Burns and Ross Hodges for their help in data reduction.     

MOOD FLUCTUATIONS

Mood fluctuations in women and men were studied both prospectively and retrospectively to determine whether cyclic changes occur over phases of the menstrual cycle, lunar cycle, and/or days of the week. The participants (15 women using oral contraceptives, 12 normally cycling women, and 15 men), who did not know the purpose of the study, recorded the pleasantness, arousal, and stability of their moods daily for 70 days (concurrent data). Later they recalled (retrospective data) their average mood for each day of the week and phase of the menstrual cycle (women only). The only evidence of mood fluctuation over the menstrual cycle in the concurrent reports was that normally cycling women reported more pleasant moods in the follicular and menstrual phase than did men and women on oral contraceptives. Women's moods fluctuated less over the menstrual cycle than over days of the week. Recollections of menstrual mood changes differed from actual changes: Women recalled more pleasant moods in the follicular phase and more unpleasant moods in the premenstrual and menstrual phases than they had reported concurrently. Bias also was evident in recollections of weekday mood fluctuations: Weekend highs were exaggerated and Monday blues were reported even though they were not reported concurrently. There was no evidence of mood fluctuations over the lunar cycle and the groups did not differ in mood stability. The retrospective reporting bias for both the mensural cycle and days of week suggests the influence of stereotypes about moods. Implications for research and practice are discussed.     

Auditory sensitivity and tone-sequence reproduction in oral contraceptive users and nonusers

In two stages spanning a single academic year, 10 women using oral contraceptives and 11 not using oral contraceptives were tested on their auditory threshold sensitivity to six frequencies (250, 750, 1500, 3000, 6000, and 8000 Hz) as a function of phases of the menstrual cycle. 11 women (5 users and 6 nonusers) were also tested on their ability to reproduce successively longer tone sequences. Results showed that there was little variation due to phase of the menstrual cycle, with the exception that oral contraceptive users showed lower relative thresholds at low frequencies during the postmenstrual phase. Over-all, oral contraceptive users had higher absolute and relative thresholds than nonusers, except at 3000 Hz. Although not statistically significant, results on the tone-reproduction test showed an enhanced ability to reproduce tones during the premenstrual phase for women using oral contraceptives. Results are discussed in relation to previous findings.     

Premenstrual syndrom

Premenstrual syndrome is a condition with cyclical mood changes occurring in 30 % of the female population of fertile ages. The symptom development is very closely related to the luteal phase indicating the existence of one or more factors during the luteal phase that provoke mental symptoms in sensitive patients. This is further supported by the fact that hysterectomized women with no menstrual bleedings but with the ovarian hormone cycle continue to show cyclical mood changes without having the cycle phase. The nature of the symptom provocating factor is still unknown but the ovarian hormones progesterone and/or estradiol are suspected. This as certain women taking oral contraceptives and sequential postmenopausal estrogen-progestagen treatment achieve mood changes. Psychological and personality factors are probably also involved, at least in the degree of the mood change and the type of mood experienced.     

Female sexual orientation and menstrual influences on person perception

Heterosexual women have previously been shown to display enhanced sensitivity to information that is both reproductively- and sexually-relevant (e.g., sexually mature male faces) during phases of high fertility. In the present study, homosexual women who maintained a regular menstrual cycle and did not use hormonal contraceptives completed a sex-categorization task at periods of high and low fertility within their menstrual cycle. For homosexual women there is a separation between reproductively-relevant (i.e., sexually mature males) and sexually-relevant (i.e., sexually mature females) targets. Our participants showed enhanced sensitivity to sexually-relevant information (i.e., female faces) at high fertility but showed no fluctuation in sensitivity to reproductively-relevant information (i.e., male faces) across testing sessions. These findings are considered in terms of adaptive person perception and the impact of sexual desire on mate preferences.     

Problem-Solving Appraisal,Oral Contraceptive Use,and Menstrual Pain1

The effects of self-appraisal problem-solving ability and oral contraceptive use on ratings of menstrual pain were studied among 130 undergraduate women. Participants completed the Problem-Solving Inventory (Heppner, 1988) and the Menstrual Distress Questionnaire (Moos, 1984). Regression analyses indicated that oral contraceptives–which are often prescribed to relieve menstrual pain among college women–were not predictive of lower pain ratings. Problem-solving appraisal, however, was significantly predictive of pain. Ratings of effective personal control during problem solving were associated with lower ratings of premenstrual and menstrual pain. Results are discussed as they pertain to the study of psychological factors in menstruation, and to the study of problem solving and behavioral health.     

Visual cerebral lateralization over phases of the menstrual cycle: a preliminary investigation

This study investigated whether visual cerebral asymmetries would change in phase with hormonal variations during the menstrual cycle. Lexical decision and line orientation tasks were administered during follicular, luteal, and menstrual phases of each woman's cycle. These tasks were also administered to a reference group of male subjects. Signal detection analyses indicated an unvarying RVF advantage in word/nonword discriminability (d') throughout the menstrual cycle, but a phase-dependent shift in left hemisphere response criterion (log beta). Gender differences were present for discriminability of line orientation, and female performance on this task varied over the cycle. The results imply that the neural systems subserving some cognitive functions are sensitive to fluctuations in gonadal steroids and suggest a hormonal basis for gender differences in some visual-spatial functions.     

Alteration of shock aversion thresholds during the menstrual cycle

Aversion thresholds for electrical shock were obtained from 5 males, 6 females who were taking oral contraceptives, and 12 females who were not. All subjects were volunteers from introductorylevel psychology courses. Measures were repeated 3 times per week for 5 weeks. Males and females taking oral contraceptives showed no cyclic fluctuations in threshold. The other female group had significant (p < .025) fluctuations in threshold, from a maximum at ovulation to a minimum 1 week after the onset of the menses.     

The Cutest Little Baby Face: A Hormonal Link to Sensitivity to Cuteness in Infant Faces

ABSTRACT— We used computer image manipulation to develop a test of perception of subtle gradations in cuteness between infant faces. We found that young women (19–26 years old) were more sensitive to differences in infant cuteness than were men (19–26 and 53–60 years old). Women aged 45 to 51 years performed at the level of the young women, whereas cuteness sensitivity in women aged 53 to 60 years was not different from that of men (19–26 and 53–60 years old). Because average age at menopause is 51 years in Britain, these findings suggest the possible involvement of reproductive hormones in cuteness sensitivity. Therefore, we compared cuteness discrimination in pre- and postmenopausal women matched for age and in women taking and not taking oral contraceptives (progestogen and estrogen). Premenopausal women and young women taking oral contraceptives (which raise hormone levels artificially) were more sensitive to variations of cuteness than their respective comparison groups. We suggest that cuteness sensitivity is modulated by female reproductive hormones.     

Hormones and dichotic listening: evidence from the study of menstrual cycle effects

This report presents evidence for changes in dichotic listening asymmetries across the menstrual cycle, which replicate studies from our laboratory and others. Increases in the right ear advantage (REA) were present in women at phases of the menstrual cycle associated with higher levels of ovarian hormones. The data also revealed correlations between hormone levels and behavioural measures of asymmetry. For example, the pre-ovulatory surge in luteinising hormone (LH) was related to a decrease in left ear scores, which comprised a key part of the cycle related shift in asymmetry. Further analysis revealed a subgroup of women who had not reached postovulatory status by days 18-25 of the cycle, as verified by low progesterone levels. These women showed laterality profiles at days 18-25 that looked more like the other women when measured at the periovulatory phase (i.e., days 8-11). Data were combined with those from a previous study to highlight the stability of effects. Results showed a distinct menstrual cycle related increase in asymmetry in the combined sample. This final comparison confirmed the nature of sex differences in dichotic listening as being dependent on hormone status in women.     

Menstrual Distress and Sex-Role Attributes

The relationship between severity of menstrual distress, measured by the Moos Menstrual Distress Questionnaire, and sex-role attributes, measured by the Bern Sex-Role Inventory, was examined for a group of 103 undergraduate women. Data were compared for women using and not using oral contraceptives and for women from different religious groups. Because trait anxiety, as measured by a 28-item short form adapted from the Taylor Manifest Anxiety Scale, was significantly correlated with menstrual distress, first-order correlations between distress and sex-role attributes partialled out anxiety scores. Although none of the sex-role attributes was significantly related to distress for the entire group or for the group of women using the pill, a significant positive relationship between masculinity and menstrual distress was noted for the group of women not using the pill. The pattern of results suggested that although sex role attributes and anxiety are related to reports of menstrual distress for Catholic women, only anxiety is associated with distress for Jewish women, and neither sex-role attributes nor anxiety is correlated with distress for Protestant women.     

Progesterone at encoding predicts subsequent emotional memory

Significant sex differences in the well-documented relationship between stress hormones and memory have emerged in recent studies. The potentiating effects of glucocorticoids on memory vary across the menstrual cycle, suggesting a potential interaction between these stress hormones and endogenously cycling sex hormones. Here, we show that memory for emotional materials changes significantly in accordance with hormonal changes across the menstrual cycle, suggesting that ovarian sex hormones influence the modulation of emotional memories. Sixty healthy, naturally cycling women rated 120 images on arousal and valence. One week later they completed free recall and recognition memory tests. Their menstrual cycle phases were estimated by self-report and confirmed by salivary assay of 17β-estradiol and progesterone. Memory for emotional items only was significantly better in the high hormone (luteal) phase compared with the low hormone (follicular) phase on the free recall test; on both tests memory correlated positively with progesterone collected at the time of encoding. These findings suggest that emotional memory performance changes across the menstrual cycle, and that this change is in part mediated by endogenous progesterone cycling.     

Changes in women’s interpersonal styles across the menstrual cycle

Past research suggests that women alter their behaviors during periods of high fertility to attract mates. Consistent with this notion, the current research examined the interpersonal style, as defined by the interpersonal circumplex, men tend to find most attractive in potential mates and the change in women’s interpersonal styles across the menstrual cycle. In Study 1, a sample of 101 single men reported the interpersonal style they found most attractive in a potential mate. In Study 2, a sample of 86 women reported their interpersonal styles during each day of their menstrual cycle. Results indicated that men tended to prefer mates who were interpersonally warm and that women tended to become more interpersonally warm during periods of high fertility.     

Differential effects of the menstrual cycle on reactive and proactive aggression in borderline personality disorder

Borderline personality disorder (BPD) is characterized by rapidly shifting symptoms, including intense anger and aggressive behavior. Understanding how fluctuations in ovarian hormones across the menstrual cycle may contribute to symptom instability is key for accurate assessment of BPD symptoms and effective interventions. Reactive and proactive aggression, as well as anger-in and anger-out, were assessed daily in 15 physically healthy, unmedicated naturally cycling female individuals meeting criteria for BPD across 35 days. Urine luteinizing hormone surge and salivary progesterone were used to confirm ovulation and verify the cycle phase. Multilevel models evaluated cyclical differences of symptoms between cycle phases. Both forms of aggressive behavior demonstrated marked cycle effects, with reactive aggression highest during the midluteal cycle phase, co-occurring with initial increases in anger and irritability and followed by perimenstrual peaks in anger and anger-in. In contrast, highest levels of proactive aggression were observed during the follicular and ovulatory phases, when emotional symptoms and anger were otherwise at lowest levels. These findings highlight the importance of identifying the function of aggression when considering potential psychological and biological influences. Naturally cycling individuals with BPD may be at elevated risk for luteal worsening of a range of interpersonally reactive symptoms, including reactive aggression, whereas proactive aggression may occur more in phases characterized by less emotional and cognitive vulnerability and greater reward sensitivity. Research on aggression in this population should consider cycle effects. Cycling individuals with BPD attempting to reduce aggressive behavior may benefit from cycle-tracking to increase awareness of these effects and to develop appropriate strategies.     

Cyclic changes in pain perception: An ROC analysis

The rating scale responses of three groups of men and women to thermal and painful radiant heat stimuli were studied over a 4-week period. Receiver operating characteristic curve parameters were computed for each of the phases of the menstrual cycle. Women with normal menstrual periods experienced a heightened sensitivity to pain during ovulation. This effect was absent in women using oral contraceptive pills and in men. The findings demonstrate that past reports of pain threshold changes in association with menstrual phase were basically sensory effects and not just a result of shifts in the observer’s criteria for reporting pain. In addition, sex differences in pain perception were found only when men were compared with women who were ovulating.     

The McCollough effect across the menstrual cycle

The McCollough effect (ME) has been shown to be sensitive to cholinergic agents, being strengthened by hyoscine (antagonist) and weakened by physostigmine (agonist), and possibly to more generalized changes in CNS arousal. We therefore expected the ME to be sensitive to hormonal changes during the menstrual cycle, being strongest in the postovulatory phases when arousal is low. In two experiments we found a highly significant effect of menstrual phase for the normally cycling women, but not for oral contraceptive users: ME strength gradually increased across the cycle, reaching a premenstrual peak. These findings may be explained in terms of hormonally mediated changes in arousal across the menstrual cycle.     

Stress responsivity among dysmenorrheic women at different phases of their menstrual cycle: more ado about nothing

Dysmenorrheic and nondysmenorrheic women in the follicular, luteal and menstrual phase of their menstrual cycle participated in a stressful laboratory procedure. Pulse rate, pulse volume and skin conductance were measured continuously during baseline, during confrontation of three stressful tasks (i.e. stress-reactivity periods) and following each confrontation (i.e. stress-recovery periods). The hypothesis that dysmenorrheic Ss in the menstrual phase of their cycle would show greater stress responsitivity was generally not confirmed, and the broader contention that women differ in their stress responsivity as a function of their menstrual cycle phase was shown to be of questionable validity.     

Sex differences of salivary cortisol secretion in patients with major depression

Depression is associated with increased cortisol secretion and occurs more often in women than in men. Thus, it has been hypothesized that differences in cortisol secretion might, in part, be responsible for the greater risk of developing depression in women. However, only few studies have examined sex differences in baseline cortisol secretion in depressed patients and healthy controls. We examined sex effects on cortisol secretion in 52 medication-free patients with major depression (37 women, 15 men, mean ± SD age 35 ± 11 years, Hamilton Depression Scale mean score 27 ± 5) and 50 healthy age- and sex-matched control subjects. Salivary cortisol concentrations were measured at 8:00, 12:00, 16:00, and 22:00 h. Repeated measures analysis of covariance revealed a group × sex interaction (p = 0.05). Post hoc tests revealed higher cortisol concentrations in depressed compared to healthy men [F(1;29) = 7.5, p = 0.01]. No differences were found between depressed and non-depressed women. Our results do not support the hypothesis that differences in cortisol secretion between depressed and non-depressed subjects are more pronounced in women than in men. Study characteristics and methods as well as sex-specific confounding variables such as menstrual cycle, menopause and the use of oral contraceptives may account for inconclusive results across studies.     

The potential hedonic role of olfaction in sexual selection and its dominance in visual cross-modal interactions

Perfumes are commonly used to cover body odour, or to provide a positive, attracting, and interesting impact, or a smell that belongs to a social group. A role in sexual communication of such non-pheromonal olfactory cues has been suggested in the literature. However, there remain the questions whether these stimuli are involved in human chemosexual communication and, if so, at what level, and whether they interact with other sensorial modalities, in particular vision. To answer these, we investigated the influence of male and female perfumes as nonconscious stimulation during visual assessments of a range of facial qualities across and within the sexes. The female subjects were in their ovulatory phase, to avoid changes in perception across the menstrual cycle. Our data indicate that non-pheromonal olfactory cues are potentially involved in mate choice and may elicit strong hedonic responses that can dominate visual signs, with a cross-modal interaction.     

神经质程度和月经周期对女性主观情绪和生理反应的影响

分别选取两组神经质程度高、低女性16名和25名, 考察两组被试在月经周期不同阶段(经期、卵泡晚期、黄体中晚期)的激素(雌二醇、孕酮)波动以及观看情绪视频(中性、搞笑、悲伤、愤怒)的主观情绪感受和生理反应的差异。结果显示高神经质女性在月经周期中对负性情绪视频的主观情绪和生理反应变化明显, 黄体中晚期对愤怒视频主观情绪体验更低, 对悲伤视频生理反应更小, 而低神经质女性的情绪反应不受月经周期影响。研究表明高神经质女性的情绪反应更易受月经周期影响, 这可能与其对孕酮水平波动的敏感性高有关。