腹侧通路与背侧通路在词汇阅读中的作用

腹侧通路与背侧通路是视觉加工的两条通路。随着认知神经科学的发展,研究发现腹侧和背侧通路与词汇阅读有关。其中腹侧通路与词汇识别有关,背侧通路与阅读的关系比较复杂。本文简要回顾了两条通路在词汇阅读中的作用。     

威胁性信息检测的脑机制

快速而准确地检测威胁性信息是进化过程中形成的一种重要能力,是有效应对危险的前提条件,对有机体的生存具有重要价值.威胁性信息的检测由不同的神经通路合作完成.在视觉通道中,皮层通路的精确检测和皮层下通路的快速检测在杏仁核得到整合.杏仁核能接受多感觉通道的信息输入,并接受额叶的调节,是威胁性信息加工中连通自上而下加工和自下而上加工的枢纽.将来的研究需要进一步关注杏仁核的功能以及不同的神经通路如何合作完成威胁性信息的检测.     

丘脑枕核参与情绪信息加工的多条通路

丘脑枕核参与多条加工情绪信息的神经通路因而在情绪信息加工中具有重要作用。第一：丘脑枕核参与到上丘-丘脑枕核-杏仁核通路。该通路可以在没有初级视觉皮层参与情况下对情绪信息进行快速加工; 第二：丘脑枕核以皮层-丘脑枕核-皮层环路和上丘-丘脑枕核-皮层通路两种形式参与到丘脑枕核-皮层通路。该通路通过控制皮层间同步化水平促进信息传递的效率; 同时通过整合皮层和皮层下情绪信号扩大其在行为输出方面的影响力。     

视觉的知觉-动作双系统理论中的论争

视觉的知觉-动作双系统理论认为,视觉的腹侧和背侧通路是两个独立系统,功能分别为表征世界和指导动作,相对应的视觉加工是彼此分离的。有关两条通路之间关系的其他观点可归结为两类：一类否认这种分工,另一类强调两个系统能相互影响。首先评述各种理论的核心问题、实验证据和贡献,进而分析视觉加工发生在一个特定系统的条件,得出的结论是：两个系统之间的功能划分是相对的,并因此导致了视觉加工的多变性。     

任务类型对上下视野优势的影响

视觉信息加工的单侧视野优势效应一直是认知心理学领域的研究热点。本研究采用变化检测范式探讨文字和几何信息在上下视野中的优势效应。结果发现：当加工文字材料时,颜色和位置检测任务均出现上部视野优势效应;加工几何图形时,则出现下部视野优势效应。上述结果表明,任务信息所需要的加工类型影响上下视野的优势效应,支持Previc提出的视野优势效应的生态假说。     

Boys' Experimentation and Persistence in Developmental Pathways Toward Serious Delinquency

We expand on earlier work documenting developmental pathways in disruptive child behavior towards serious forms of delinquency in boys. Three pathways we hypothesized in our previous work: (a) An Authority Conflict Pathway prior to the age of 12, that starts with stubborn behavior, and has defiance as a second stage, and authority avoidance as a third stage; (b) A Covert Pathway that starts with minor convert acts, has property damage as a second stage, and moderate to serious delinquency as a third stage; and (c) An Overt Pathway that starts with minor aggression, has physical fighting as a second stage, and violence as a third stage. We now refine this work by distinguishing between boys who experiment and those who persist in disruptive behavior. Data are presented showing that the fit for the three pathways is better for persisters than for experimenters. Also, the proportion of persisters that enter each pathway at the first stage (rather than at later stages) is higher than that for experimenters. Penetration in each pathway was more common among boys who received a diagnosis of Attention-Deficit Hyperactive Disorder. Boys' rate of offending increased with penetration into pathways and with persistence on more than one pathway. Boys' persistence and advancement in the Overt or the Covert Pathway was almost invariably accompanied by their advancement in the Authority Conflict Pathway. The classification of boys according to persistence and pathways accounted for the majority of high rate offenders, according to both self-report and court adjudicated offenses.     

儿童外部问题行为稳定性的研究

儿童早期外部问题行为对后期的学业、行为和同伴关系以及成人期的生活都有消极的影响。探讨外部问题行为的起源、影响因素和发展机制,对考察童年期外部问题行为是否可预测将来的问题、评估干预和预防措施的必要性和有效性,都是必不可少的。文章阐述了儿童外部问题行为稳定性的有关概念,介绍了外部问题行为的发展趋势、“童年期开始的”和“青春期开始的”外部问题行为的发展路径、行为遗传学研究成果以及影响外部问题行为稳定性的因素,并指出了这类研究对治疗和干预的意义     

正强化和负强化:概念、争议与神经机制

1975年,Michael首次正式提出应放弃"正强化"和"负强化"术语的使用,引起对"正强化和负强化是否本质上具有区别"这一问题的关注和争议。正负强化究竟本质上是否有区分、如何区分、以及区分它们的意义等问题,得到了众多行为心理学家的深入探讨。多数学者再度阐明正强化和负强化具有不同的心理机制,加以区分具有重要应用意义,主张沿用对它们的区分。最近,对正负强化神经机制的研究取得突破性进展,进一步揭示它们具有截然不同的神经相关过程。我们建议,分析强化作用进行时,机体是否在环境条件作用下已经偏离了基础、正常的心理稳态,有助于规范理解强化物启动的是正还是负强化的神经过程。     

空间频率影响恐惧面孔表情加工的神经通路

恐惧情绪由于其具有威胁性而优先得到有效的加工。其中空间频率作为处理面孔信息的基础成分, 通过不同的神经通路影响恐惧面孔表情的加工。双通路观点认为在皮层下通路上, 低空间频率的恐惧面孔表情存在优先传递性, 高空间频率则主要通过皮层通路对恐惧面孔表情进行精细化加工; 而多通路则能够更加灵活地处理空间频率对情绪加工的影响。未来研究应明确脑区及其子区域在多条通路上的作用, 从而进一步验证视觉信息是如何影响情绪加工的。     

The role of the magnocellular visual pathway in the attentional blink

Visual attention has temporal limitations. In the attentional blink (AB) a stream of stimuli such as letters or digits are presented to a participant on a computer monitor at a rapid rate. Embedded in the stream are two targets that the participant must try to identify. Identification of the second target is severely impaired if it is presented within approximately 500ms of the first target. This is the 'blink' in visual attention. In this study we examined the role of the magnocellular visual pathway in the AB. This fast conducting pathway has high temporal resolution and contrast sensitivity. It is also insensitive to the direction of chromatic contrast, and this attribute was exploited in order to isolate its contributions to temporal attention. Colour defined, luminance noise masked AB streams were compared to AB streams of varying achromatic contrast. The four observers, (2F and 2M) aged between 21 and 35years, had normal visual acuity and colour vision. The colour stimuli produced a similar blink to the moderate contrast achromatic stimuli. This indicates that the magnocellular pathway does not have a privileged role in the attentional blink. We provide an explanation of previous apparently contradictory findings in terms of the role of different types of visual masking in the attentional blink.     

SAFE通路参与缺血后处理心肌保护作用机制的探讨

缺血后处理(ischemic postconditioning,IPost)是在心肌缺血后持续再灌注前给予多次短暂的再灌注/缺血处理的处理方法,对心肌缺血/再灌注损伤有着重要的保护作用。其心肌保护的具体机制十分复杂,尚未完全阐明。生存活化因子增强(survivor activating factor enhancement,SAFE)途径是IPost中新近发现的保护通路,阐明其在IPost心肌保护中的作用,将为寻找新的药物治疗靶点提供新思路。     

扩展临床路径内涵 推进双向转诊开展

文章概括我国现阶段双向转诊状况及其存在的问题和问题产生原因,并在临床路径启示下,对寻找做好双向转诊工作的途径进行思考,探索全面长期深入开展双向转诊工作具体做法,论述了扩展临床路径内涵对推进双向转诊工作开展的意义,规范双向转诊,旨在形成推进双向转诊长效机制。     

临床路径管理模式的应用及效果评价

为了评价临床路径的效果,探索符合我国医院实际的临床路径实施办法,对某三级甲等综合医院对两种外科疾病应用临床路径的结果进行统计分析。结果显示:两种外科疾病的平均住院日缩短、住院费用降低、病人满意度提高。由此得出结论,临床路径管理模式能使病人得到高品质、低费用的医疗服务,有利于医疗规范化管理。但其广泛实施受到诸多因素的影响,尚需要结合医院的实际情况,加强各专业科室的协调,加强医院信息管理系统的建设,改革医疗费用支付方式等。     

临床路径在医疗质量管理中的应用与思考

就临床路径的发展和概念进行了描述,阐明了临床路径的实施步骤,讨论了临床路径在医院医疗质量管理中的作用,同时对其未得到普及的原因和在我国的发展前景进行了分析。     

Health Focused Psychotherapy In Treating a Dual Diagnosed Patient

Health-focused psychotherapy offers a contemporary model used in assessment, treatment planning and evaluation in addressing patients with both medical and psychiatric diagnoses. Clinicians in the health and mental health disciplines must know and understand the importance of standards of care and models of intervention and evaluation in clinical practice for this type of patient. Examined is the use of a specific model providing a tailored orientation to patient education, along with the development and use of a clinical algorithm and care pathway for clinical practice. Provided is a case study for applying the development and use of a clinical algorithm and care pathway for a dual diagnosed patient receiving health-focused psychotherapy.     

视觉意识及其神经机制

视觉意识的神经机制是当前认知神经科学研究的热点问题之一。过去普遍认为视觉信息加工主要有两条通路:腹侧通路和背侧通路;而新近的研究表明还存在不经过初级视觉皮层(V1区)的第三条通路。高级视觉皮层、V1区和皮层下结构都对意识觉知的产生起到了相应的作用。已有的实验证据表明,意识的产生过程异常复杂,仍有很多问题值得继续深入讨论和研究。     

Pathways to flourishing among pharmacy students: The role of study demands and lecturer support

This study investigated possible pathways to flourishing among pharmacy students attending a South African university (N = 799; females = 81.6%; Afrikaans-speakers = 84.7%, mean age = 20.42 years, SD = 2.25 years). The students completed the Mental Health Continuum – Short Form (MHC-SF) and an Overload and Lecturer Support Survey. Of the 779 pharmacy students, 40.3% self-reported as flourishing, with high mean scores on workload and lecturer support. The level of emotional well-being of year group 2 was the highest. Following structural equation modelling, overload and lecturer support explained between 18% and 31% of the variance in the flourishing of the different year groups. From the second to the third year, the predictive value of overload and lecturer support for flourishing decreased by 8.8%. Lecturer support and low overload appear to play a positive role in the flourishing of higher education students.     

临床路径制定过程中应用循证医学探讨

临床路径作为一种新的质量效益型管理模式将病种医疗服务标准化。本文通过概述循证医学在临床路径服务项目和内容以及住院时间制定过程中的应用方法以及循证实践步骤,为进一步制定科学合理的临床路径提供了循证来源,从而促进我国医院循证管理得到更好的实践。     

A mixed methods exploration of the parent perspective of talent development environments across a national multi-sport landscape

Parents are known to be important influencers in the talent development process but are often overlooked. Understanding the parent perspective may help National Governing Bodies and coaches improve their support for young talented athletes. This study aims to understand the parent perspective of the talent development experience across a national multi-sport landscape using mixed methods. Four hundred and eighty-five parents of pathway athletes completed the talent development environment questionnaire for parents (TDEQ-P), which included the opportunity for parents to respond in an open fashion. The results revealed several key relative strengths and weaknesses of the talent development environment. Areas identified for improvement included 1) Communication related to pathway understanding, planning, guidance, and feedback, 2) Individualised training, goal setting, and feedback, 3) Facilities, 4) Access to a specialist support network, in particular psychology support, 5) Engagement between coaches and, 6) Dual career management and engagement with educational institutions. The results also revealed evidence of context specific needs between performance level, sport type, and age group. The TDEQ-P may be an efficient and effective way coaches can access important feedback, improve communication, and build relationships with parents in sport.     

情绪自动化加工的证据与争议

情绪信息对人类的生存非常重要, 研究者一直在探讨情绪产生的本质问题：情绪的产生是“自动”的吗？已有的大量实验证据表明, 情绪可以被快速识别, 甚至在非注意条件下或者无意识条件下, 情绪信息也可以被大脑(尤其是杏仁核)识别。大量实验结果分析了情绪自动化加工的表现, 并探讨了情绪自动化加工的大脑机制：皮层下通路。视觉信息在视网膜接受后, 经上丘脑与枕核传递至杏仁核, 这条通路被称为皮层下通路, 负责情绪信息的快速化加工。但是新的研究对已有的实验范式与技术手段进行了质疑, 反驳情绪的自动化加工, 并质疑皮层下通路存在的可能性。为了进一步理清情绪加工的本质与大脑机制, 今后的研究应当采用更为严格地控制意识、注意资源的实验范式, 以及采用更精确、更高时间与空间分辨率的技术手段。