Mental Contamination in Obsessive-Compulsive Disorder: Associations With Contamination Symptoms and Treatment Response

The most common symptom of obsessive-compulsive disorder (OCD) is contamination fear. Feelings of contamination can be provoked through contact with a physical contaminant, referred to as contact contamination (CC), as well as in the absence of one, referred to as mental contamination (MC). Prior research indicates that CC and MC are distinct, and MC may interfere with treatment for CC. However, no study to date has examined how MC may be associated with responses to physical contaminants and treatment response for CC. This study examined the relationships between CC and MC in a sample of individuals with elevated contamination symptoms (N = 88), half of whom met diagnostic criteria for OCD. Participants engaged in three sessions of exposure and response prevention (ERP) for CC and completed self-report measures and behavioral tasks assessing CC and MC at pretreatment, posttreatment, and follow-up. As hypothesized, at pretreatment, MC was positively associated with reactivity to physical contaminants, even after participants washed their hands. ERP for CC was associated with unique changes in CC and MC across self-report and behavioral measures, and greater pretreatment MC predicted greater posttreatment CC, though this effect was evident in only one of two CC measures. Additionally, specificity analyses indicated changes in MC were independent of changes in disgust propensity, a related construct. Pretreatment disgust propensity also predicted treatment outcome, though the addition of pretreatment disgust propensity as a covariate reduced the relationship between pretreatment MC and posttreatment CC to nonsignificance. Results suggest MC plays an important role in the manifestation and treatment of CC symptoms and may represent a manifestation of disgust proneness. Theoretical and clinical implications are discussed.     

Target absent trials in configural contextual cuing

In contextual cuing (CC), reaction times for finding targets are faster in repeated displays than in displays that have never been seen before. This has been demonstrated using target-distractor configurations, global background colors, naturalistic scenes, and covariation of targets with distractors. The majority of CC studies have used displays in which the target is always present. This study investigated what happens when the target is sometimes absent. Experiment 1 showed that, although configural CC occurs in displays when the target is always present, there is no CC when the target is always absent. Experiment 2 showed that there is no CC when the same spatial layout can be both target present and target absent on different trials. The presence of distractors in locations that had contained targets on other trials appeared to interfere with CC, and even disrupted the expression of CC in previously learned contexts (Exps. 3-5). These results show that target-distractor associations are the important element in producing CC and that, consistent with a response selection account, changing the response type from an orientation task to a detection task removes the CC effect.     

Mothers' attachment status as determined by the Adult Attachment Interview predicts their 6-year-olds' reunion responses: a study conducted in Japan

Following a 1986 study reporting a predominance of ambivalent attachment among insecure Sapporo infants, the generalizability of attachment theory and methodologies to Japanese samples has been questioned. In this 2nd study of Sapporo mother-child dyads (N=43), the authors examined attachment distributions for both (a) child, based on M. Main and J. Cassidy's (1988) 6th-year reunion, and (b) adult, via the Adult Attachment Interview (AAI). In contrast to the previous Sapporo study, children's 3-way or "organized" distribution did not differ from the global distribution. However, when the disorganized-controlling (D) and cannot classify (CC) categories were applied to the analyses, a high proportion of D/CC children was found. Comparable analyses for Japanese mothers, including the unresolved/disorganized (U) and CC categories, were found to deviate slightly from the global norm. However, turning from global distributions to mothers' AAI classification as related to their child's reunion classification, all matches were surprisingly close to those established worldwide. When, as is customary, mothers' U and CC classifications were combined (U/CC) and compared with the child's D and CC classifications (also customarily combined as D/CC), mothers' U/CC status strongly predicted child D/CC status (r=.60, d=1.50). Additionally, mothers' AAI subclassifications predicted child subclassifications.     

A predictive model for psychological reactions to crime in Italy: an analysis of fear of crime and concern about crime as a social problem

In this study a model for predicting fear of crime (FC) and concern about crime as a social problem (CC) in Italy has been built, using three sets of independent variables concerning: (a) the sociodemographic and criminal victimization domain; (b) the psychosocial domain; and (c) the mass media. A secondary analysis on data gathered by the Observatory of the North‐West (N = 3262, a mail panel that is representative of the Italian population over 18) has been performed. Results showed that FC and CC are related yet distinct constructs: FC is less widespread than CC, and has different predictors. FC predictors are sociodemographic, psychosocial and, above all, victimization variables; whereas mass media and psychosocial variables predict CC. Results were compared with the literature on the topic. Implications, limitations, and future directions are discussed. Copyright © 2004 John Wiley & Sons, Ltd.     

The corpus callosum: Some anatomical and functional considerations with special reference to language

Recent studies on the anatomy and development of the corpus callosum (CC) are reviewed, and discussed in relation to present theories of the function of the CC. The contributions of various pathological conditions of the CC, as well as that of the split-brain studies, to the understanding of the functions of the CC are considered. The recent theory that the language dominant hemisphere exerts inhibitory influences over the nondominant hemisphere via the CC did not receive much support, and an alternative theory implicating the CC in the establishment of lateralization of language is presented. Direct evidence for this view is as yet not available, but it receives some support from cases of agenesis of the CC.     

A configural dominant account of contextual cueing: Configural cues are stronger than colour cues

Previous work has shown that reaction times to find a target in displays that have been repeated are faster than those for displays that have never been seen before. This learning effect, termed “contextual cueing” (CC), has been shown using contexts such as the configuration of the distractors in the display and the background colour. However, it is not clear how these two contexts interact to facilitate search. We investigated this here by comparing the strengths of these two cues when they appeared together. In Experiment 1, participants searched for a target that was cued by both colour and distractor configural cues, compared with when the target was only predicted by configural information. The results showed that the addition of a colour cue did not increase contextual cueing. In Experiment 2, participants searched for a target that was cued by both colour and distractor configuration compared with when the target was only cued by colour. The results showed that adding a predictive configural cue led to a stronger CC benefit. Experiments 3 and 4 tested the disruptive effects of removing either a learned colour cue or a learned configural cue and whether there was cue competition when colour and configural cues were presented together. Removing the configural cue was more disruptive to CC than removing colour, and configural learning was shown to overshadow the learning of colour cues. The data support a configural dominant account of CC, where configural cues act as the stronger cue in comparison to colour when they are presented together.     

The MCMI-II depression scales: do they assist in the differential prediction of depressive disorders?

This study examined the diagnostic efficiency of the Millon Clinical Multiaxial Inventory-II (MCMI-II) Major Depression (CC) and Dysthymia (D) scales for the differential prediction of unipolar depressive disorders. The MCMI-II was administered to 109 inpatients at a large private psychiatric hospital in the Midwest. All patients had a primary Axis I diagnosis of a depressive disorder, given at discharge by the attending psychiatrists. When CC scores were compared to clinician diagnoses, results indicated that the sensitivity of the CC scale was improved over what had previously been reported for studies involving the MCMI-I CC scale. However, overall, the D scale functioned slightly better as a predictor of major depression than did the CC scale. One likely factor in explaining this finding is that the CC scale contains very few items assessing vegetative/somatic symptomatology, which are the critical factors in distinguishing major depression from other unipolar depressive disorders.     

感知环境不确定性与环境扫描对认知变化的影响——认知闭合需要与认知需要的调节作用

对426名大学生进行问卷调查,考察了感知环境不确定性对认知变化的影响,环境扫描行为的中介作用以及认知闭合需要与认知需要对两阶段中介模型的调节作用。结果发现：（1）感知环境不确定性能够正向预测认知变化水平,并且环境扫描行为的两个维度都起到中介作用;（2）认知闭合需要能够负向调节中介模型的前后两个阶段;（3）认知需要对环境扫描有直接正向作用,并且对关注程度的促进更大,但是负向调节扫描频率和认知变化之间的关系。     

Contextual conditioning in rats as an animal model for generalized anxiety disorder

Animal models of psychiatric disorders are important translational tools for exploring new treatment options and gaining more insight into the disease. Thus far, there is no systematically validated animal model for generalized anxiety disorder (GAD), a severely impairing and difficult-to-treat disease. In this review, we propose contextual conditioning (CC) as an animal model for GAD. We argue that this model has sufficient face validity (there are several symptom similarities), predictive validity (it responds to clinically effective treatments), and construct validity (the underlying mechanisms are comparable). Although the refinement and validation of an animal model is a never-ending process, we want to give a concise overview of the currently available evidence. We suggest that the CC model might be a valuable preclinical tool to enhance the development of new treatment strategies and our understanding of GAD.     

Critical Consciousness: An Alternative Pathway for Positive Personal and Social Development

This paper presents a conceptual model of the integrative psychological construct of critical consciousness (CC), defined as a moral awareness which propels individuals to disembed from their cultural, social, and political environment, and engage in a responsible critical moral dialogue with it, making active efforts to construct their own place in social reality and to develop internal consistency in their ways of being. The ontogeny of CC is analyzed in terms of the synergistic interaction between its two main components, structural developmental and moral motivation. The paper describes the cross-cultural interview research which allowed the elaboration of the CC developmental pathway. It posits the dimension of moral motivation as distinguishing the CC pathway, and illustrates the continuum between predominantly moral and expediency motivation through brief case vignettes. The paper differentiates three developmental macrolevels of CC, and illustrates through case vignettes two alternatives of social consciousness at the level of conventional morality—CC and non-CC. Some possible sources of moral motivation in personal history and biography are discussed.     

Developmental Characteristics of Disparate Bimanual Movement Skills in Typically Developing Children

Mastery of many tasks in daily life requires role differentiated bimanual hand use with high spatiotemporal cooperation and minimal interference. The authors investigated developmental changes in the performance of a disparate bimanual movement task requiring sequenced movements. Age groups were attributed to changes in CNS structures critical for bimanual control such as the corpus callosum (CC) and the prefrontal cortex; young children (5–6 years old), older children (7–9 years old), and adolescents (10–16 years old). Results show qualitative changes in spatiotemporal sequencing between the young and older children which typically marks a phase of distinct reduction of growth and myelination of the CC. Results show qualitative changes in spatiotemporal sequencing between the young and older children, which coincides with distinct changes in the growth rate and myelination of the CC. The results further support the hypothesis that CC maturation plays an important role in the development of bimanual skills.     

Effects of shock source and method of contact upon runway escape behavior

Rats performed better in a shock-escape apparatus with L-shaped metal strips as a runway when a constant-current (CC) shock source was used as compared to a matched impedance source. CC source superiority disappeared when the shock surface was wet (saline solution). Several additional demonstrations strongly suggest that the superiority of the CC source was not related to aversiveness per se but to responses peculiar to particular shock sources.     

TEACHING CHILDREN TO SPELL: DECREASING CONSONANT CLUSTER ERRORS BY ELIMINATING SELECTIVE STIMULUS CONTROL

Six elementary-aged children were taught to spell words containing initial consonant clusters (CCs). They were trained to select printed words in response to the corresponding spoken words using computerized matching-to-sample procedures. After each training session, they were tested for spelling with a constructed-response transfer test. Based on previous selective stimulus control research, we hypothesized that only the first letter of an initial CC might control spelling when CC spelling errors are made. Thus, a critical-difference matching-to-sample training condition that required the children to respond to both letters of the CC to be correct was compared to a multiple-difference training condition that required the children to respond to only one letter of the pair. Results showed that children made fewer errors during the multiple-difference training condition than during the critical-difference training condition. On the constructed-response transfer tests, however, more overall errors and CC errors were made in the multiple-difference condition than in the critical-difference condition, and the words trained in the multiple-difference condition required more training sessions to reach criterion. All children improved their spelling of novel CC words by the completion of training. If normal classroom or home reading was to be supplemented by computer tasks of the kind used here, some spelling problems could be circumvented without costly intervention by a teacher or a special trainer.     

Work function dependence on the thickness and substrate of carbon contamination layers by Kelvin probe force microscopy

The contact potential difference (CPD) between carbon contamination (CC) layers and the several substrates on which they were deposited has been measured as a function of the film thickness by means of Kelvin probe force microscopy (KPFM). The observed CPD trends may be divided into three categories:

2. an increase, or decrease, in CPD with thickness up to a saturation value with sign inversion with respect to the substrates (Al and Si);

3. an oscillation with no sign inversion (substrates, gold and platinum);

4. an oscillation through sign inversion (palladium substrate).

Effects (ii) and (iii) seem to be typical of CC, since they have not been observed for other materials, including evaporated carbon. Several possible causes of the above two effects are examined, but a satisfactory interpretation has not been found yet. The sensitivity of KPFM is such that CC layers 10 nm thick are easily visible, whereas they are hardly detectable by topography.     

Accounting for occurrences: An explanation for some novel tendencies in causal judgment from contingency information

Contingency information is information about empirical associations between possible causes and outcomes. In the present research, it is shown that, under some circumstances, there is a tendency for negative contingencies to lead to positive causal judgments and for positive contingencies to lead to negative causal judgments. If there is a high proportion of instances in which a candidate cause (CC) being judged is present, these tendencies are predicted by weighted averaging models of causal judgment. If the proportion of such instances is low, the predictions of weighted averaging models break down. It is argued that one of the main aims of causal judgment is to account for occurrences of the outcome. Thus, a CC is not given a high causal judgment if there are few or no occurrences of it, regardless of the objective contingency. This argument predicts that, if there is a low proportion of instances in which a CC is present, causal judgments are determined mainly by the number of Cell A instances (i.e., CC present, outcome occurs), and that this explains why weighted averaging models fail to predict judgmental tendencies under these circumstances. Experimental results support this argument.     

The predictive strength of personal constructs versus conventional constructs: self-image disparity and neuroticism

Idiographic personal construct (PC) measures of self-image disparity were hypothesized to be stronger than nonidiographic conventional construct (CC) measures in predicting neuroticism. Ninety-six college students completed PC and CC measures of real self, ideal self, social self, and ideal social self; the NEO Five-Factor Inventory; and the Marlowe-Crowne Social Desirability Scale. Content analysis showed that individuals' PC measures were unique. The disparity between real self and ideal self and the disparity between social self and ideal social self were computed for PC and CC; test-retest reliabilities were .76 to .81. Results of simultaneous multiple regression analyses supported the hypothesis. Also, the two-variable PC self-image disparity scores were stronger than one-variable PC esteem scores in predicting neuroticism. Implications were discussed for research method, self-concept theory, personal construct theory, neuroticism, and psychotherapy.     

Critical consciousness: current status and future directions

In this chapter, the authors consider Paulo Freire's construct of critical consciousness (CC) and why it deserves more attention in research and discourse on youth political and civic development. His approach to education and similar ideas by other scholars of liberation aims to foster a critical analysis of society--and one's status within it--using egalitarian, empowering, and interactive methods. The aim is social change as well as learning, which makes these ideas especially relevant to the structural injustice faced by marginalized youth. From their review of these ideas, the authors derive three core CC components: critical reflection, political efficacy, and critical action. They highlight promising research related to these constructs and innovative applied work including youth action-research methodology. Their conclusion offers ideas for closing some of the critical gaps in CC theory and research.     

Corpus callosum size is linked to dichotic deafness and hemisphericity, not sex or handedness

Individuals differ in the number of corpus callosum (CC) nerve fibers interconnecting their cerebral hemispheres by about threefold. Early reports suggested that males had smaller CCs than females. This was often interpreted to support the concept that the male brain is more "lateralized" or "specialized," thus accounting for presumed male predominance in mathematics, as well as for aggressive behavior. Ultimately, meta-analyses of these many reports found no significant overall sex differences in inter-cerebral information carrying capacity. Here, using quantitative MRI, we found the midline CC area of 113 subjects was significantly correlated, not with handedness or sex, but with dichotic deafness, and even more so with redefined hemisphericity, the latter accounting for over 19% of CC variability. That is, both dichotic hearing and right brain-oriented individuals of either sex had significantly larger CCs than dichotically deaf or left brain-oriented persons. Thus, current traditions of brain laterality and gender may benefit from revisions that include redefined hemisphericity.     

Microstructural organization of corpus callosum projections to prefrontal cortex predicts bimanual motor learning

The corpus callosum (CC) is the largest white matter tract in the brain. It enables interhemispheric communication, particularly with respect to bimanual coordination. Here, we use diffusion tensor imaging (DTI) in healthy humans to determine the extent to which structural organization of subregions within the CC would predict how well subjects learn a novel bimanual task. A single DTI scan was taken prior to training. Participants then practiced a bimanual visuomotor task over the course of 2 wk, consisting of multiple coordination patterns. Findings revealed that the predictive power of fractional anisotropy (FA) was a function of CC subregion and practice. That is, FA of the anterior CC, which projects to the prefrontal cortex, predicted bimanual learning rather than the middle CC regions, which connect primary motor cortex. This correlation was specific in that FA correlated significantly with performance of the most difficult frequency ratios tested and not the innately preferred, isochronous frequency ratio. Moreover, the effect was only evident after training and not at initiation of practice. This is the first DTI study in healthy adults which demonstrates that white matter organization of the interhemispheric connections between the prefrontal structures is strongly correlated with motor learning capability.     

NMDA receptor blockade in the basolateral amygdala disrupts consolidation of stimulus-reward memory and extinction learning during reinstatement of cocaine-seeking in an animal model of relapse

Previous research from our laboratory has implicated the basolateral amygdala (BLA) complex in the acquisition and consolidation of cue-cocaine associations, as well as extinction learning, which may regulate the long-lasting control of conditioned stimuli (CS) over drug-seeking behavior. Given the well established role of NMDA glutamate receptor activation in other forms of amygdalar-based learning, we predicted that BLA-mediated drug-cue associative learning would be NMDA receptor dependent. To test this hypothesis, male Sprague-Dawley rats self-administered i.v. cocaine (0.6 mg/kg/infusion) in the absence of explicit CS pairings (2-h sessions, 5 days), followed by a single 1-h classical conditioning (CC) session, during which they received passive infusions of cocaine discretely paired with a light+tone stimulus complex. Following additional cocaine self-administration sessions in the absence of the CS (2-h sessions, 5 days) and extinction training sessions (no cocaine or CS presentation, 2-h sessions, 7 days), the ability of the CS to reinstate cocaine-seeking on three test days was assessed. Rats received bilateral intra-BLA infusions (0.5 microl/hemisphere) of vehicle or the selective NMDA receptor antagonist, 2-amino-5-phosphonovalerate (AP-5), immediately prior to the CC session (acquisition), immediately following the CC session (consolidation), or immediately following reinstatement testing (consolidation of conditioned-cued extinction learning). AP-5 administered before or after CC attenuated subsequent CS-induced reinstatement, whereas AP-5 administered immediately following the first two reinstatement tests impaired the extinction of cocaine-seeking behavior. These results suggest that NMDA receptor-mediated mechanisms within the BLA play a crucial role in the consolidation of drug-CS associations into long-term memories that, in turn, drive cocaine-seeking during relapse.