Legal and ethical issues in neuroimaging research: human subjects protection,medical privacy,and the public communication of research results

Humans subjects research entails significant legal and ethical obligations. Neuroimaging researchers must be familiar with the requirements of human subjects protection, including evolving standards for the protection of privacy and the disclosure of risk in "non-therapeutic" research. Techniques for creating veridical surface renderings from volumetric anatomical imaging data raise new privacy concerns, particularly under the federal medical privacy regulation. Additionally, neuroimaging researchers must consider their obligation to communicate research results responsibly. The emerging field of neuroethics should strive to raise awareness of these issues and to involve neuroimaging researchers in the legal, ethical, and policy debates that currently surround human subjects research.     

Ethical issues related to the artificial heart

This paper is a general survey of ethical issues related to the artificial heart. It begins by looking at the history of funding of the artificial heart program through the National Institute of Health in 1965. Attention is paid to the problem of the lack of planning related to social, ethical, economic, and legal implications. The paper then deals with three areas of ethical concerns. They are those issues relating to the experimental versus therapeutic benefits, the cost, and public involvement with a private interest.     

The limitations of "vulnerability" as a protection for human research participants

Vulnerability is one of the least examined concepts in research ethics. Vulnerability was linked in the Belmont Report to questions of justice in the selection of subjects. Regulations and policy documents regarding the ethical conduct of research have focused on vulnerability in terms of limitations of the capacity to provide informed consent. Other interpretations of vulnerability have emphasized unequal power relationships between politically and economically disadvantaged groups and investigators or sponsors. So many groups are now considered to be vulnerable in the context of research, particularly international research, that the concept has lost force. In addition, classifying groups as vulnerable not only stereotypes them, but also may not reliably protect many individuals from harm. Certain individuals require ongoing protections of the kind already established in law and regulation, but attention must also be focused on characteristics of the research protocol and environment that present ethical challenges.     

The perils of protection: vulnerability and women in clinical research

Subpart B of 45 Code of Federal Regulations Part 46 (CFR) identifies the criteria according to which research involving pregnant women, human fetuses, and neonates can be conducted ethically in the United States. As such, pregnant women and fetuses fall into a category requiring “additional protections,” often referred to as “vulnerable populations.” The CFR does not define vulnerability, but merely gives examples of vulnerable groups by pointing to different categories of potential research subjects needing additional protections. In this paper, I assess critically the role of this categorization of pregnant women involved in research as “vulnerable,” both as separate entities and in combination with the fetuses they carry. In particular, I do three things: (1) demonstrate that pregnant women qua pregnancy are either not “vulnerable” according to any meaningful definition of that term or that such vulnerability is irrelevant to her status as a research participant; (2) argue that while a fetus may be vulnerable in terms of dependency, this categorization does not equate to the vulnerability of the pregnant woman; and (3) suggest that any vulnerability that appends to women is precisely the result of federal regulations and dubious public perceptions about pregnant women. I conclude by demonstrating how this erroneous characterization of pregnant women as “vulnerable” and its associated protections have not only impeded vital research for pregnant women and their fetuses, but have also negatively affected the inclusion of all women in clinical research.     

On the impact of human operant research: Asymmetrical patterns of cross-citation between human and nonhuman research

Reactions to published accounts of research with human subjects, as well as research with nonhuman subjects, were assessed by examining citations in several samples of empirical articles in the Journal of the Experimental Analysis of Behavior. A stable, asymmetrical pattern emerged: Nonhuman research was cited in both human and nonhuman articles, but human research was cited primarily in human articles. Thus, human operant research appears to have had little influence on the nonhuman research which constitutes the bulk of the experimental analysis of behavior. Interpretation of this lack of impact depends on the functions one envisions for human research, several of which are discussed.     

Yogicchakra symbols: Mirrors of the human mind/heart

This paper describes the classical understanding of the system ofchakras, or centers of spiritual energy, in tantric yoga. Eachchakra is presented in terms of its traditional understanding. Each is also discussed in the light of contemporary psychological stage theories of development, showing that thechakras can be seen as a model of spiritual development. The preoccupations, concerns, and attitudes associated with eachchakra are portrayed as a mirror of the human mind/heart when spiritual energy is concentrated at that location.She is also founder and chair of the board of Resources for Ecumenical Spirituality.     

Performing the imago Dei: human enhancement,artificial intelligence and optative image-bearing

If the imago Dei is not a taxonomic definition but rather something that is performed in context, what are the implications for questions of human enhancement and the development of artificial intelligence (AI)? The author considers Alistair McFadyen’s performative vision of the imago Dei, one that actively seeks humanity in concrete situations, in the context of human enhancement and AI, asking the questions, ‘Does becoming cyborg through human enhancement make us less bearers of the divine image?’ And, ‘Can AI ever be considered to be in the image of God?’ Briefly tracing the shift in perspectives on the imago Dei, before considering what a performance of the image might look like, the author proposes three performances that have significant implications for questions about what it means to be human. To be an image-bearer is not dependent upon human DNA or species membership, but on an optative performance of the imago Dei.     

Animal models in the research of human aggression

At present, one of the major fields of interest in psychobiological research is the study of human aggression. Besides its contribution to our basic scientific knowledge and its potential value in the development of different applied sciences, research on human aggression will also, hopefully, aid in control of violence and social conflicts, and thereby improve the living condition of man, an ideal that we all should embrace. In addition, further knowledge in this area will permit a more adequate treatment of some mental diseases. The purpose of the present review is to offer a schematic approach designed to illustrate how animal models have a heuristic, hypothesis-generating function, providing important parallels with human aggression and suggesting new directions for future research.