Germline Manipulation and Our Future Worlds

Two genetic technologies capable of making heritable changes to the human genome have revived interest in, and in some quarters a very familiar panic concerning, so-called germline interventions. These technologies are: most recently the use of CRISPR/Cas9 to edit genes in non-viable IVF zygotes and Mitochondrial Replacement Therapy (MRT) the use of which was approved in principle in a landmark vote earlier this year by the United Kingdom Parliament. The possibility of using either of these techniques in humans has encountered the most violent hostility and suspicion. However it is important to be aware that much of this hostility dates back to the fears associated with In Vitro Fertilization (IVF) and other reproductive technologies and by cloning; fears which were baseless at the time concerning both IVF and cloning the use of both of which have proved to be highly beneficial to humanity and which have been effectively regulated and controlled. This paper argues that CRISPR should by pursued through researh until it is safe enough for use in humans but there is no reason to suppose at this stage that such use will be unsafe or unethical (Collins 2015).     

Ontologies and Worlds in Category Theory: Implications for Neural Systems

We propose category theory, the mathematical theory of structure, as a vehicle for defining ontologies in an unambiguous language with analytical and constructive features. Specifically, we apply categorical logic and model theory, based upon viewing an ontology as a sub-category of a category of theories expressed in a formal logic. In addition to providing mathematical rigor, this approach has several advantages. It allows the incremental analysis of ontologies by basing them in an interconnected hierarchy of theories, with an operation on the hierarchy that expresses the formation of complex theories from simple theories that express first principles. Another operation forms abstractions expressing the shared concepts in an array of theories. The use of categorical model theory makes possible the incremental analysis of possible worlds, or instances, for the theories, and the mapping of instances of a theory to instances of its more abstract parts. We describe the theoretical approach by applying it to the semantics of neural networks.     

Sensory Processing Differences in Children Diagnosed With Tourette's Disorder

The objectives of this research were to determine whether sensory processing differences existed in children between the ages of 5 and 10 years diagnosed with Tourette's disorder and to examine whether further differences existed if these children had an additional diagnosis of Attention Deficit Hyperactivity Disorder. The Short Sensory Profile was completed by caregivers for 75 children with Tourette's disorder, 47 who were also diagnosed with Attention Deficit Hyperactivity Disorder. Differences in sensory processing were identified in the total sample. More significant differences were found in the group of children with dual diagnoses, especially in the area of auditory processing.     

The Multiplicative AHP,SMART and ELECTRE in a Common Context

This paper presents a comparative study of three popular methods for multicriteria decision analysis based on a particular model of human preferential judgement. Since decisions are invariably made within a given context, we model relative preferences as ratios of increments or decrements in an interval on an axis of desirability. Next we sort the ratio magnitudes into a small number of categories, represented by numerical values on a geometric scale. We explain why the analytic hierarchy process (AHP) and the French collection of ELECTRE methods, typically based on pairwise comparison methods, are concerned with categories of ratio magnitudes, whereas the simple multiattribute rating technique (SMART) essentially uses orders of magnitude of these ratios. This phenomenon provides a common basis for the analysis of the methods in question and for a cross-validation of their results. We illustrate the approach via a well-known case study, the choice of a location for a nuclear power plant. We conclude by discussing the scope of the comparative study. © 1997 John Wiley & Sons, Ltd.     

Sex Differences in Clinical Pain: A Multisample Study

A recent meta-analysis of the experimental pain literature revealed effect sizes of .55 for pain threshold and .57 for pain tolerance, indicating a moderate difference in pain perception between men and women, with women reporting an increased sensitivity to pain. The current study investigated the relationship between sex and clinical pain ratings, in patients seeking care at a tertiary care facility. Five samples of chronic pain patients were recruited from several diverse clinics associated with the University of Florida. Analyses of clinical pain ratings revealed similar effect sizes for all samples, ranging from –.07 to –.25, indicating small differences, with women reporting higher levels of clinical pain. This is the first paper to report effect sizes for differences in report of pain in samples of chronic pain patients presenting for treatment at a tertiary care facility.     

“A sweet smile”: the modulatory role of emotion in how extrinsic factors influence taste evaluation

It has recently been demonstrated that the reported tastes/flavours of food/beverages can be modulated by means of external visual and auditory stimuli such as typeface, shapes, and music. The present study was designed to assess the role of the emotional valence of the product-extrinsic stimuli in such crossmodal modulations of taste. Participants evaluated samples of mixed fruit juice whilst simultaneously being presented with auditory or visual stimuli having either positive or negative valence. The soundtracks had either been harmonised with consonant (positive valence) or dissonant (negative valence) musical intervals. The visual stimuli consisted of images of emotional faces from the International Affective Picture System (IAPS) with valence ratings matched to the soundtracks. Each juice sample was rated on two computer-based scales: One anchored with the words sour and sweet, while the other scale required hedonic ratings. Those participants who tasted the juice sample while presented with the positively-valenced stimuli rated the juice as tasting sweeter compared to negatively-valenced stimuli, regardless of whether the stimuli were visual or auditory. These results suggest that the emotional valence of food-extrinsic stimuli can play a role in shaping food flavour evaluation and liking.     

Individual Differences in Divergent Thinking as a Function of Variations in Sensory Status

Recent neuropsychological data have suggested that visual imagery and visual stimulus processing may share some common cortical processing areas. Because imagery involves the recreation of sensory images, it could be the case that the quality of the sensory inputs may determine the usefulness of imagery in problem solving. This study investigated whether a relation exists between sensory status and divergent thinking ability. A sample of 1,461 participants was tested for visual acuity, color discrimination ability, stereopsis, and pure tone hearing ability. Two measures of divergent thinking involving alternate uses of familiar objects also were taken. Individuals with moderate deficits in visual acuity and stereopsis (which are the abilities that will most profoundly affect relevant aspects of the images for these divergent thinking tasks) performed significantly worse. Performance of those with moderate color discrimination or auditory deficits (both irrelevant to manipulating the images) was indistinguishable from those without such deficits. Thus poor visual acuity and stereopsis may reduce success in divergent thinking tasks because the effectiveness of imagery in achieving novel solutions is reduced when stored images are lacking in details.     

Visual Technologies, Cosmographies, and Our Sense of Place in the Universe

The first part of this paper surveys the visual technologies that have transformed the modern visual environment and argues for the relevance of their study to an understanding of modernity in general and to the field of religion and science in particular. The term cosmography is adopted for the visual and spatial manifestation of a worldview, and the importance of analyzing and advancing modern cosmography is asserted. In the second part, the focus shifts to one particular challenge presented by modern cosmography: how to represent and find visual meaning in the new range of size scales that have been offered up by the modern scientific worldview. Six strategies for representing and finding meaning in this new expanded picture of the universe are explored.     

Individual Differences as Predictors of Illicit Drug Use Among Turkish College Students

ABSTRACT

Although the prevalence of drug use in the young adult population in Turkey is still far below the figures reported for most European Union countries and the United States, there seems to be a noteworthy increase in drug use, especially among high school and college students. The purpose of the present study was to examine the extent of drug use among college students in Turkey and to identify some of the individual-difference variables associated with drug use. Participants were 781 college students. A survey package including (a) measures of sensation seeking–risk taking, self-esteem, affectivity level, global mental health, overall life satisfaction, and the rate and nature of substance use and (b) demographic questions was administered to the participants during regularly held class meetings. A logistic regression analysis revealed that sensation seeking?risk taking, parental education level, smoking, and frequency of alcohol use predicted illicit drug experience. Implications of the findings and limitations of the study are discussed using the context of the study as a framework.     

Linear Analogue Self-Assessment and Procrustean Measurement: A Critical Review of Visual Analogue Scaling in Pain Assessment

Visual analogue scales (VASs) are one of the most widely used self-report measures of clinical pain. This article reviews the empirical literature on linear analogue self-assessment (LASA) and critically examines the features that appear to have made it such an attractive measurement option in pain assessment. It is concluded that analogue scaling does not withstand critical scrutiny as a primary measure of either pain intensity or pain affect and that, in most circumstances, the overall clinical utility of VASs is inferior to that of more structured pain indices.     

Personality Trait Change Across Late Childhood to Young Adulthood: Evidence for Nonlinearity and Sex Differences in Change

We explored patterns of self‐reported personality trait change across late childhood through young adulthood in a sample assessed up to four times on the lower order facets of Positive Emotionality, Negative Emotionality (NEM), and Constraint (CON). Multilevel modelling analyses were used to describe both group‐ and individual‐level change trajectories across this time span. There was evidence for nonlinear age‐related change in most traits, and substantial individual differences in change for all traits. Gender differences were detected in the change trajectories for several facets of NEM and CON. Findings add to the literature on personality development by demonstrating robust nonlinear change in several traits across late childhood to young adulthood, as well as deviations from normative patterns of maturation at the earliest ages. Copyright © 2015 European Association of Personality Psychology     

创造能力不同学生的分类加工过程差异的眼动特点

在分类理论观的基础上, 本研究在目标匹配范式下, 使用可以表示一定概念的现实物体或场景的图片材料, 通过眼动记录法对分类加工过程的分离, 考察了40名创造能力不同的中学生分类加工过程的差异。结果表明, 在首次加工阶段, 创造能力高和低的被试均先对目标类别概念进行加工, 然后再对选项区的待分类概念进行加工。创造能力高的被试更多地使用概括性的加工策略完成任务并表现出加工的有效性, 创造能力低的被试更多地使用比较性的加工策略表现出加工的无效性。在再加工阶段, 高和低创造能力的被试将加工的重点放在待分类概念上。创造能力低的被试通过概括和比较的策略完成任务。     

Individual Differences in Risky Decision Making: A Meta‐analysis of Sensation Seeking and Impulsivity with the Balloon Analogue Risk Task

To represent the state‐of‐the‐art in an effort to understand the relation between personality and risk taking, we selected a popular decision task with characteristics that parallel risk taking in the real world and two personality traits commonly believed to influence risk taking. A meta‐analysis is presented based on 22 studies of the Balloon Analogue Risk Task from which correlations with sensation seeking and impulsivity assessments could be obtained. Results calculated on a total of 2120 participants showed that effect size for the relation of sensation seeking with risk taking was in the small–moderate range ( = .14), whereas the effect size for impulsivity was just around the small effect size threshold ( = .10). Although we considered participants' demographics as moderators, we found only significantly larger effect sizes for the older adolescents and young adults compared with other ages. The findings of the present review supported the view that inconsistencies in personality–risk research were mostly due to random fluctuations of specific effect sizes, rather than to lack of theoretical ties or to measurement unreliability. It is also concluded that studies aimed at relating individual differences in personality to performance in experimental decision tasks need an appropriate sample size to achieve the power to produce significant results. Copyright © 2013 John Wiley & Sons, Ltd.     

Sex Differences in Perception: Exploring the Integration of Sensory Information with Respect to Vision and Proprioception

Inter- and intra-modal matching by right hand preferred Norwegian adults were tested using a matching task. The task required them to locate target pins visually, proprioceptively or in combination, while matching was always carried out without vision. When combined scores for both hands were analysed, the females showed superior performance in the intra-modal matching condition. For both groups, when the scores for the two hands were treated separately, superior performance was obtained in using the right hand to match under the visual condition. The only significant sex difference relative to hand preference was that the females matched the target more accurately with the right hand in the intra-modal matching condition. These findings are discussed relative to inter-hemispheric processing     

Critiquing Statistics in Student and Professional Worlds

This article compares students' critiques within a class discussion about an invented statistic to STEM professionals' critiques from interviews to better understand how the situated meanings of a statistic are similar and different across student and professional worlds. We discuss similarities and differences in how participants constructed meaning for the statistic, and argue that disciplinary practices in schooling will always have an approximate, and somewhat indeterminate, relation to the figured worlds of professional practice.     

Gender Differences in Cardiovascular Reactivity and Game Performance Related to Sensory Modality in Violent Video Game Play1

This study examined the gender‐specific cardiovascular and performance responses to playing the violent video game “DOOM” with and without the soundtrack. Men and women equally rated the game as more violent with the soundtrack. Men performed the game about twice as well with the soundtrack. Women's performance did not change at all. Only men's heart rates were significantly greater with the soundtrack, indicative of arousal. Only women's systolic and diastolic blood pressures were significantly greater with the soundtrack, indicative of stress. The game seemed to appeal more to men than to women. Moreover, women may possibly avoid violent video games, in part because they represent an undesirable stressor.     

Worlds in Motion: Temporality and Historicality

ABSTRACT

Worlds are always in motion; what kind of movement is at stake? In this essay, I will argue that Heidegger moves beyond Hegel by making the concept of world central to phenomenology. But how do worlds move? As history, Heidegger says; yet his initial attempt to interpret history, in the final sections of Being and Time, is at certain moments hampered by his attempt to ground the historicality of shared world in the temporality of individual Dasein. Derrida then moves beyond Heidegger by addressing paradoxes in our understanding of time and history. This allows Derrida to introduce the ethical dimension of world from the start as we are called to acknowledge that the Other brings their own world and awaits our response. Worlds are both singular and shared; and in any case, they move (and move us).     

Differences in psychosocial responses to pain between sufficiently and insufficiently active adults with arthritis

Objective: Adults with arthritis struggle to meet the physical activity recommendation for disease self-management. Identifying psychosocial factors that differentiate adults who meet (sufficiently active) or do not meet (insufficiently active) the recommendation is needed. This study sought to examine differences in psychosocial responses to arthritis pain among adults who were sufficiently or insufficiently active.

Design: This prospective study included adults with medically diagnosed arthritis (N = 136, M_age = 49.75 ± 13.88 years) who completed two online surveys: (1) baseline: pain and psychosocial responses to pain and (2) two weeks later: physical activity.

Main outcome measures: Psychosocial responses examined in this study were psychological flexibility in response to pain, pain anxiety and maladaptive responses to pain anxiety.

Results: A between-groups MANCOVA comparing sufficiently active (n = 87) to insufficiently active (n = 49) participants on psychosocial responses, after controlling for pain intensity, was significant (p = .005). Follow-up ANOVA’s revealed that sufficiently active participants reported significantly higher psychological flexibility and used maladaptive responses less often compared to insufficiently active participants (p’s < .05).

Conclusions: These findings provide preliminary insight into the psychosocial profile of adults at risk for nonadherence due to their responses to arthritis pain.     

类别学习多重系统理论的研究与展望

介绍了国外学者为验证类别学习的多重系统理论所做的行为实验研究及主要结果,包括反馈训练、延迟反馈、反应位置、间断的类别刺激分布等因素对信息整合的类别学习的影响,和数字Stroop任务、序列记忆扫描任务、类别数量等因素对基于规则的类别学习的影响;同时,作者指出了实验中没有很好地解决两种类别结构之间的难度差异等问题,并提出了今后需要进一步研究的课题     

Unraveling the Aging Skein: Disentangling Sensory and Cognitive Predictors of Age‐related Differences in Decision Making

Age‐related differences in sensory functioning, processing speed, and working memory have been identified as three significant predictors of the age‐related performance decline observed in complex cognitive tasks. Yet, the assessment of their relative predictive capacity and interrelations is still an open issue in decision making and cognitive aging research. Indeed, no previous investigation has examined the relationships of all these three predictors with decision making. In an individual‐differences study, we therefore disentangled the relative contribution of sensory functioning, processing speed, and working memory to the prediction of the age‐related decline in cognitively demanding judgment and decision‐making tasks. Structural equation modeling showed that the age‐related decline in working memory plays an important predictive role, even when controlling for sensory functioning, processing speed, and education. Implications for research on decision making and cognitive aging are discussed. Copyright © 2015 John Wiley & Sons, Ltd.