Phagocytic reactivity of granulocytes in the peripheral blood of patients with multiple sclerosis and normal probands

For estimation of phagocytic activity the uptake by granulocytes of heat-inactivated, opsonised yeast particles (Saccharomyces cerevisiae) was measured. Peripheral granulocytes of multiple sclerosis patients revealed an enhanced ability for phagocytosis in comparison to normal healthy controls, if tested with normal serum as opsonic source. An activated state of cells in multiple sclerosis is supposed. The selective influence on granulocyte phagocytosis of treatment by ultraviolet-irradiated blood in multiple sclerosis patients supports the view of altered reactivity of these cells in comparison to normal controls.     

流式细胞术在骨髓增生异常综合征及再生障碍性贫血诊断中的应用

为探讨骨髓增生异常综合征患者与再生障碍性贫血患者骨髓髓系细胞的免疫表型变化,用流式细胞术检测骨髓增生异常综合征、再生障碍性贫血及正常对照髓系细胞的表面抗原。结果显示骨髓增生异常综合征组髓系细胞较正常对照组及再生障碍性贫血组表面抗原表达明显不同。因此,流式细胞术有助于二者的诊断及鉴别诊断。     

The effect of hypnosis therapy on the symptoms and disease activity in Rheumatoid Arthritis

Abstract

The present study aimed to assess the effectiveness of clinical hypnosis on the symptoms and disease activity of Rheumatoid Arthritis (RA). Sixty six RA patients participated in a controlled group design. Twenty six patients learnt the hypnosis intervention, 20 patients were in a relaxation control group and 20 patients were in a waiting-list control group. During hypnosis, patients developed individual visual imagery aimed at reducing the autoimmune activity underlying the RA and at reducing the symptoms of joint pain, swelling and stiffness. Subjective assessments of symptom severity and body and joint function, using standardised questionnaires and visual analogue scales, were obtained. Objective measures of disease activity via multiple blood samples during the therapy period and at the two follow-ups were also taken. These measurements were of erythrocyte sedimentation rate. C-reactive protein, haemoglobin and leukocyte total numbers. Results indicate that the hypnosis therapy produced more significant improvements in both the subjective and objective measurements. above relaxation and medication. Improvements were also found to be of clinical significance and became even more significant when patients practised the hypnosis regularly during the follow-up periods.     

The effect of hypnosis therapy on the symptoms and disease activity in Rheumatoid Arthritis

Abstract The present study aimed to assess the effectiveness of clinical hypnosis on the symptoms and disease activity of Rheumatoid Arthritis (RA). Sixty six RA patients participated in a controlled group design. Twenty six patients learnt the hypnosis intervention, 20 patients were in a relaxation control group and 20 patients were in a waiting-list control group. During hypnosis, patients developed individual visual imagery aimed at reducing the autoimmune activity underlying the RA and at reducing the symptoms of joint pain, swelling and stiffness. Subjective assessments of symptom severity and body and joint function, using standardised questionnaires and visual analogue scales, were obtained. Objective measures of disease activity via multiple blood samples during the therapy period and at the two follow-ups were also taken. These measurements were of erythrocyte sedimentation rate. C-reactive protein, haemoglobin and leukocyte total numbers. Results indicate that the hypnosis therapy produced more significant improvements in both the subjective and objective measurements. above relaxation and medication. Improvements were also found to be of clinical significance and became even more significant when patients practised the hypnosis regularly during the follow-up periods.     

Expert judgments of hypnosis from subjective state reports.

Suggestibility was assessed in 60 college students after a traditional hypnotic induction, an alert induction, progressive relaxation training, or instruction in goal-directed imagery. Responsiveness to suggestion did not differ between groups. Subjects also generated open-ended reports of their states of awareness and of their experience of 3 hypnotic suggestions. A sample of these reports from 24 moderately to highly suggestible subjects were evaluated by 18 experts in the field of hypnosis. Expert ratings of subjects' open-ended reports indicated that (a) traditional hypnotic inductions produce a state of consciousness that is indistinguishable from nonhypnotic relaxation training, (b) the subjective experience of hypnotic suggestions after imagination training is indistinguishable from that after hypnotic inductions, and (c) suggestibility is unrelated to state of consciousness as assessed by experts.     

Oxidative stress in university students during examinations

Mental stress in psychiatric disease and in daily life contributes to oxidative stress in the body. In this study we investigated a connection between possible psychological stress caused by university undergraduate examinations and oxidative stress experienced by our test subjects. Some parameters of oxidative stress (single strand breaks of DNA in lymphocytes, sensitivity to lipid oxidation and antioxidant status) were studied in medical students on the day of the examination (stress condition) and compared with the same parameters obtained from the same students during the term between two examination periods (non-stress condition). The results show that in the stress condition oxidative damage to DNA and sensitivity to lipid oxidation were significantly increased (p<0.05) when compared with the same parameters in "non-stress" conditions. A significant decrease in plasma antioxidant activity (p<0.05) in students that were under stress was observed. These results suggest that during university examinations students are under increased oxidative stress.     

Stress relaxation in cobalt between 15 and 300 K

Abstract

The slope of the logarithmic stress–relaxation curve for a well-annealed cobalt polycrystal of 99·999% purity has been measured as a function of the initial stress level from which relaxation at constant strain was allowed to start at a given temperature between 15 and 300 K. A pronounced undulation was observed in the plot of the relation between the inverse of the stress sensitivity of the relaxation rate and temperature, with a maximum and a minimum at about 75 and 50 K, respectively. The ‘classically unexpected’ behaviour below about 80 K seems to arise from the progressive inhibition of dynamic recovery process as T→0 K, which necessitates the use of stresses higher than that applied in the basic equations describing the mode of deformation.     

A Randomized Open Trial Assessing the Feasibility of Behavioral Activation for Pathological Grief Responding

This study investigated the feasibility of using behavioral activation to treat enduring postbereavement mental health difficulties using a two-arm, multiple baseline design comparing an immediate start group to a delayed start group at baseline, 12-, 24-, and 36-weeks postrandomization. Participants received 12–14 sessions of behavioral activation within a 12-week intervention period starting immediately after the first assessment or after 12 weeks for the delayed start group. Prolonged grief, posttraumatic stress, and depression symptoms were assessed as outcomes. Compared with no treatment, behavioral activation was associated with large reductions in prolonged, complicated, or traumatic grief; posttraumatic stress disorder; and depression symptoms in the intent-to-treat analyses. Seventy percent of the completer sample at posttreatment and 75 percent at follow-up responded to treatment with 45 percent at posttreatment and 40 percent at follow-up being classified as evidencing high-end state functioning at 12-week follow-up.     

Cardiovascular responses to occupational stress in male medical students: a paradigm for ambulatory monitoring studies.

Hemodynamic responses to systematic variations in occupational stress were examined using ambulatory blood pressure monitors (ABPMs). The goals of this study were (a) to illustrate the effectiveness of employing naturally occurring, controlled variations in psychological stress levels in studies incorporating ABPMs and (b) to document the patterns of cardiovascular responses to acute examination stress in medical students. Heart rate, systolic blood pressure, diastolic blood pressure, rate-pressure product, and mood states were measured before, during, and after low-stress (lecture) and high-stress (examination) work in 44 healthy male medical students. The lecture day was characterized by stable patterns of cardiovascular activity across all three periods. Hemodynamic activity and reports of activation and distress were greater on the examination day than on the lecture day. Cardiovascular activity during the preexamination period was as high as that seen during the examination period itself, indicating an anticipatory stress effect. Pressor activity decreased after the examination, although some residual chronotropic activity was seen. Systematic changes in physiological responses to controlled variations in the level of this naturalistic stressor support the use of this paradigm for other ABPM studies. The elevations in preexamination responses seen here suggest the need to consider prestressor experiences in such studies.     

催眠定义探新：以恍惚为特色的深度沟通

综述催眠发展史上主要催眠观点,归纳其激活、意境、灵活、具身及整合等基本特征,继而提出催眠是一种以恍惚为特色的深度沟通的新定义,认为催眠本质上是一种沟通,恍惚是其特色,深度与恍惚相结合有助于界定催眠。未来应加强与认知神经科学、精神分析以及中国传统文化等的融合研究。     

Effect of chronic intermittent immobilization stress on Fos-like immunoreactivity in rat brain and adrenal medulla

The present study examined the influence of short- and long-term chronic intermittent immobilization stress throughout the brain and on the adrenal medulla of intact rats using Fos-like immunoreactivity (Fos-LI) as a marker of cellular activation. The effect of adreno-medullectomy on the central nervous system (CNS) response to chronic immobilization stress was also examined. It was found that control unoperated, unstressed rats had no Fos-LI cells in the brain or in the adrenal medulla. In intact rats, neither short term (1 week) nor long term (4 weeks) chronic intermittent immobilization stress produced significant increases in Fos-LI in the CNS compared with control animals. However, marked increase in the number of Fos-LI cells was observed in the adrenal medulla of animals stressed for 4 weeks compared with control, unstressed animals or those stressed for 1 or 2 weeks. In adreno-medullectomised rats, 4 weeks, but not 1 week, chronic immobilization stress produced significant increases in numbers of Fos-LI neurons in the paraventricular hypothalamic and supraoptic nuclei and the medial amygdala compared with intact animals stressed for a similar period of time. It is concluded that long term stress produces chronic Fos-LI in the adrenal medulla and that adreno-medullectomy increases the Fos response of the PVN, supraoptic nucleus and medial amygdala to long term stress.     

Examination stress, personality and self-reported physical symptoms

Thirty-nine undergraduate students were investigated to determine the effects of examination stress on self-reported physical symptoms and sensations. Testing was undertaken six weeks prior to a final examination (phase I), immediately after the written part of the examination was over (phase II), and 12–14 days afterwards, but before an oral examination (phase III). The results showed that examination stress was associated with an increase in state anxiety and self-reported physical symptoms with the exception of heart-complaints which showed a gradual decline over the three experimental phases. In phase III, all symptom measures showed a reduction below baseline levels and below the control group's levels. Correlation analyses revealed that symptom scores were associated with variables reflecting psychological vulnerability (e.g. Recent stress and Neuroticism) and dysphoric affect, especially anxiety. The results are discussed in light of theories of attribution, attentional focusing and phychophysiological activation.     

Examination stress as an ecological inducer of cortisol and psychological responses to stress in undergraduate students

The purpose of the present study was to investigate basic methodological issues related to the usage of an examination stress protocol in studies of psychoneuroendocrinology. In the present study, 57 undergraduate students served as participants. All subjects provided salivary samples and completed psychological inventories during a low examination stress period and again during a high examination stress period. Salivary samples were analyzed for cortisol. Three major findings were observed. First, the examination stress protocol proved to be an effective trigger of elevations in both psychological measures of stress and in cortisol levels. Second, sex differences were observed in cortisol levels, such that males showed an elevation in cortisol during the high examination stress session whereas females did not. Finally, no significant correlations were observed between elevations in psychological measures of stress and elevations in cortisol levels. These findings suggest that the examination stress protocol used in the present study effectively elevated both psychological stress and cortisol levels. Furthermore, these findings suggest that there are biological differences in how males and females respond to stress. Finally, no evidence was found to suggest a relationship between psychological and hormonal levels of stress. Together, these findings suggest the need to better define and consider the implications of both the specific measures of stress being used and individual differences in the subject samples in psychoendocrine studies.     

Delsartean hypnosis for girls' bodies and minds: Annie Payson Call and the Lasell Seminary nerve training controversy

In the summer of 1890, news that two students at Lasell Seminary for Young Women in Auburndale, MA had suffered a complete nervous collapse as a result of being hypnotized by an instructor in a nerve training class caused a brief but sharp national sensation regarding hypnotism and nerve training in girls' education. The instructor, Annie Payson Call, denied practicing hypnotism, and the seminary's principal defended both Call and the "mind concentration" course she taught at Lasell. Call's approach to nerve training blended Delsartean relaxation exercises, New Thought psychology, and self-hypnotic techniques into a therapeutic regimen which can be termed "Delsartean hypnosis." Developed further in her 1891 popular self-help handbook, Power Through Repose, Call's variety of Delsartean hypnosis was incorporated into the procedures of proponents of suggestive therapeutics, and it served as a model for subsequent relaxation training programs in the early- and mid-20th century.     

A review of the impact of hypnosis,relaxation, guided imagery and individual differences on aspects of immunity and health

This review considers psychological interventions involving relaxation and guided imagery targeting immune functions. The review provides evidence of immune control accompanied by reports of enhanced mood and well-being. Three recent investigations of the author and his colleagues with self-hypnosis training incorporating imagery of the immune system are outlined. In two studies, hypnosis buffered the effects of stress on immune functions in medical students at exam time, and the comparison of self-hypnosis with and without immune imagery confirmed advantages to targeted imagery for both immune function and mood, and importantly, fewer winter viral infections. The implications for health were investigated in a third study in patients with virulent and chronic herpes simplex virus-2 HSV-2). Six weeks of training almost halved recurrence, improved mood and reduced levels of clinical depression and anxiety. Immune functions were up-regulated, notably functional natural killer cell activity to HSV-1. Individual differences in hypnotic susceptibility and absorption have typically been found to predict efficacy. New replicable evidence is reviewed of the importance of cognitive activation, a personality difference whose neurophysiological underpinning is consistent with left hemispheric preferential influences over the immune system. Now that the validation of psychological interventions includes advantages for health, this field of enquiry, which has been characterised by modest, small scale, largely preliminary studies, warrants a greater investment in research.     

Hormonal and psychological effects of examination stress

Twelve undergraduate students were tested to determine the effects of examination stress on psychological and endocrine variables. Testing was undertaken six weeks prior to a final written examination (phase I), at the time of the examination (phase II), and 12–14 days after the examination (phase III). A control group consisted of students not taking an examination. The results demonstrated an increase in state anxiety, global stress level, systolic blood pressure and serum prolactin during stress (i.e. in phase II). In phase III, the psychological responses were normalized, but both systolic and diastolic blood pressure as well as serum prolactin, were still elevated.     

Hypnosis versus relaxation: accuracy and confidence in dating international news events

This study compared participants who were administered either a hypnosis (n=50) or a relaxation (n=44) recall priming procedure in terms of the ability to estimate the dates of 20 relatively memorable (‘easy’) vs. less memorable (‘difficult’) international news events. The hypnosis and relaxation groups performed comparably in terms of the accuracy of estimates of when the events occurred, self‐reported confidence in estimates, and the memorability and emotionality of the events that were reported during hypnosis and relaxation. After these initial ratings, participants were informed that ‘at least one’ of their estimates was incorrect, and they were given the opportunity to change their estimates of the date of when one or more of the events occurred. Participants who generated their initial estimates during hypnosis were less likely to change their previous estimates of both easy and difficult events, than were participants in the relaxation condition. The measure of self‐reported confidence and a behavioural measure of willingness to change initial reports were largely dissociated from one another. Copyright © 2005 John Wiley & Sons, Ltd.     

Are coping resources related to humoral reaction induced by academic stress? An analysis of specific salivary antibodies to Epstein-Barr virus and cytomegalovirus

The aim of the present study was to investigate whether coping resources mediated the changes in Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) specific salivary antibodies caused by academic stress. Fifty-four first-year female students of nursing and physiotherapy completed pencil and paper written questionnaires and concurrently donated saliva samples. The instrument included the short version of the Sense of Coherence (SOC) scale, measures of social support, current health, health practices, the scale of psychological distress, and state anxiety questionnaire. Data and saliva samples were collected one month after the beginning of the first semester, during term examinations period and a month into the second semester. Statistically significant changes in the level of specific salivary EBV and HCMV antibodies were observed between the four study points. State anxiety and psychological distress were significantly associated with HCMV-specific salivary antibody level increase during examinations and its decrease after the stress was over. Coping resources, however, were not associated with changes in any of the antibodies studied.     

Suggested visual hallucinations in and out of hypnosis

We administered suggestions to see a gray-scale pattern as colored and a colored pattern in shades of gray to 30 high suggestible and eight low suggestible students. The suggestions were administered twice, once following the induction of hypnosis and once without an induction. Besides rating the degree of color they saw in the stimuli differently, participants also rated their states of consciousness as normal, relaxed, hypnotized, or deeply hypnotized. Reports of being hypnotized were limited to highly suggestible participants and only after the hypnotic induction had been administered. Reports of altered color perception were also limited to high suggestibles, but were roughly comparable regardless of whether hypnosis had been induced. These data indicate that suggestible individuals do not slip into a hypnotic state when given imaginative suggestions without the induction of hypnosis, but nevertheless report experiencing difficult suggestions for profound perceptual alterations that are pheonomenologically similar to what they report in hypnosis.