Serum levels of brain-derived neurotrophic factor (BDNF), BDNF gene Val66Met polymorphism, or plasma catecholamine metabolites, and response to mirtazapine in Japanese patients with major depressive disorder (MDD)

Object We investigated an association between the polymorphism of brain-derived neurotrophic factor (BDNF) gene Val66Met and the response to mirtazapine in Japanese patients with major depressive disorder (MDD). We also examined mirtazapine's effects on the serum BDNF and plasma levels of catecholamine metabolites in these patients. METHODS: Eighty-four patients who met the DSM-IV-TR criteria for MDD were treated with only mirtazapine for 4 weeks. The BDNF Val66Met polymorphism was detected by direct sequencing in the region, and serum BDNF levels and plasma levels of catecholamine metabolites were measured by ELISA and HPLC-ECD, respectively. RESULTS: Mirtazapine treatment for 4 weeks significantly increased serum BDNF levels in the responders, whereas nonresponders showed significant decreases. No association was found between either of the two genotypes (Val/Val vs. Met-carriers) and the response to mirtazapine at T4 or the serum BDNF levels at T0. Mirtazapine did not alter the plasma levels of homovanillic acid (HVA) or 3-methoxy-4-hydroxyphenylglycol (MHPG). Discussion The dynamics of serum BDNF levels, but not plasma levels of HVA and MHPG, reflect the response to mirtazapine treatment; the BDNF Val66Met polymorphism in patients with depression is, however, associated with neither a particular response to mirtazapine treatment nor baseline serum BDNF levels. Conclusion Serum BDNF levels, but not plasma levels of HVA or MHPG, and BDNF Val66Met polymorphism are related to the mirtazapine response in MDD.     

Sex differences in physical aggression to partners: a reply to Frieze (2000), O'Leary (2000), and White, Smith, Koss, and Figueredo (2000)

The following points are made in reply to critical comments on the author's meta-analysis of partner physical aggression (J. Archer, 2000): (a) The theoretical dichotomy used in the review is one clearly identifiable in published articles, and the distinction between acts (aggression) and consequences (violence) is clearer than alternative definitions involving victims' perceptions; (b) despite the database containing many samples of U.S. students, there were sufficient other samples to draw meaningful conclusions; (c) the Conflict Tactics Scale may be limited, but in contrast to suggested alternatives, it involves clearly defined categories; (d) sexual aggression, although forming an important part of partner violence, cannot legitimately be aggregated with nonsexual physical aggression; and (e) there is a marked contrast between sex differences in physical aggression toward partners and toward same-sex opponents.     

CER suppression, passive-avoidance learning, and stress-induced suppression of drinking in the Syracuse high- and low-avoidance strains of rats (Rattus norvegicus)

The Syracuse strains of Long-Evans rats were selectively bred for good (SHA) or poor (SLA) avoidance learning in a two-way shuttle box, which resulted in a phenotypic difference that is correlated with behavior patterns indicative of emotional reactivity, SLA animals showing evidence of greater emotional reactivity than SHA animals. The first three experiments examined conditioned suppression of bar pressing and compared paired and unpaired conditioned- and unconditioned-stimulus presentations to evaluate the influence of conditioning versus primary aversive stimulation on baseline responding. SLA animals acquired conditioned suppression faster than SHA animals and also showed greater suppression of baseline responding than SHA animals. In Experiment 4, SLA animals learned a passive-avoidance task faster than SHA animals. In Experiment 5, SLA animals showed greater stress-induced suppression of drinking a weak quinine solution than SHA animals. These data are consistent with the hypothesis that SLA animals are more emotionally reactive than SHA animals.     

Temporal overlap in the linguistic processing of successive words in reading: reply to Pollatsek, Reichle, and Rayner (2006a)

A. Pollatsek, E. D. Reichle, and K. Rayner argue that the critical findings in A. W. Inhoff, B. M. Eiter, and R. Radach are in general agreement with core assumptions of sequential attention shift models if additional assumptions and facts are considered. The current authors critically discuss the hypothesized time line of processing and indicate that the success of Pollatsek et al.'s simulation is predicated on a gross underestimation of the pretarget word's viewing duration in Inhoff et al. and that the actual data are difficult to reconcile with the strictly serial attention shift assumption. The authors also discuss attention shifting and saccade programming assumptions in the E-Z Reader model and conclude that these are not in harmony with research in related domains of study.     

The importance of shared environmental influences in explaining the overlap between mother's parenting and sibling relationships: reply to Neale (1999)

This article addresses concerns raised by M. C. Neale (1999) in his commentary on the D. A. Bussell et al. (1999) Nonshared Environment in Adolescent Development (NEAD) study. These concerns fall into two categories: (a) model assumptions and sample design and (b) testing of alternative models. The validity of the assumptions of quantitative genetic models is a concern for all researchers in this area. Discussion of those assumptions in this reply is brief and focuses on those most relevant to the NEAD sample. The two alternative models proposed by Neale were designed to provide alternatives to the large shared environmental effect found in the original report of Bussell et al. Because these alternative models did not provide a better fit, the appropriateness of Bussell et al.'s basic model and the importance of shared environmental influences for explaining the association among family subsystems are supported.     

Concomitant short-term changes in the auditory evoked response, the EEG, and reaction-time performance in relation to the temporal parameters of stimulation

Abstract.— Two experiments are described in which short-term "habituation" of the auditory evoked response (AER) was examined using discrete trains of click stimuli and averaging across trains. In the first study, the stimuli consisted of randomly interspersed trains of regular clicks, at 3 or 10 sec interstimulus interval (ISI). In the second study, the ISIs were also short or long but were irregular varying between 2.4 and 3.6 sec in the former case and 6 to 12 sec in the latter. The N₁-P₂ component of the AER diminished within the 3 sec trains especially for the regular stimulation; no such development occurred with the longer ISI. The total voltage in the background EEG and the reaction-times to the stimuli showed essentially similar changes. The possible mechanisms governing the response decrement are discussed and it is concluded that the data may be interpreted in terms of the Groves and Thompson dual-process theory of habituation.     

Mood and emotion in sport: a response to Jones, Mace, and Williams (2000)

Examination of the mood and performance relationship in sport has been an important line of investigation in sport psychology for over 20 years. Recent research has challenged the notion that the Profile of Mood States is the instrument of choice. It has also moved away from the notion that successful performance is associated with an 'iceberg' profile (Morgan, 1980), arguing that researchers should consider mood and emotion as distinguishable constructs (Jones, Mace, & Williams, 2000; Lane & Terry, 2000. In the present paper, I expand the discussion on mood research in sport by re-examining some of the findings of Jones, et al. in the light of recent work.     

To think or not to think,that is the question: Individual differences in suppression and rebound effects in autobiographical memory

Two studies explored the effects of forget instructions on autobiographical memory at immediate test and following delays of either 12–13 months, or 3–4 months. Using the Autobiographical Think/No-Think procedure (cf., Noreen & MacLeod, 2013), 24 never-depressed participants (Study 1) first generated 12 positive and 12 negative autobiographical memories and associated cues. Participants were then asked to recall the memory associated with some of the cues (i.e., ‘think’ condition), or to avoid saying or thinking about the memory associated with other cues (i.e., ‘no-think’ condition). Participants were then asked to recall the memories associated with all the cues at immediate test and following a delay of 12–13 months. Participants were found to be successful at forgetting both positive and negative autobiographical memories following ‘no-think’ instructions at immediate test but this forgetting effect did not persist following a 12–13 month delay. This pattern of remembering and forgetting was replicated in a second study (using 27 never-depressed participants) following a 3–4 month delay. Participants who had been less successful at forgetting ‘no-think’ memories at immediate test, were more likely to show rebound effects for those memories following a delay compared to memories which received neither ‘think’ nor ‘no-think’ instructions. Individual differences in inhibitory control and the efficacy of potential therapeutic interventions of ‘no-think’ instructions are considered.     

Age and sex differences in paranormal beliefs: a response to Vitulli, Tipton, and Rowe (1999)

Vitulli, Tipton, and Rowe (1999) report evidence of age and sex differences in the strength of paranormal beliefs. An alternative interpretation of their data is offered in terms of differential item functioning. It is suggested that respondents' interpretation of paranormal belief test items may vary with age and sex, and that such differences in the strength with which such beliefs are endorsed has not been conclusively established by Vitulli, et al.     

Politics, operant conditioning, Galileo, and the American Psychological Association's response to Rind et al. (1998)

The controversy surrounding B. Rind, P. Tromovitch, and R. Bauserman (1998) provides valuable lessons into scientific independence, politics, and organizational decision making. In an unprecedented action, the U.S. Congress officially condemned findings of Rind et al. Meanwhile, the American Psychological Association took similarly unprecedented measures in an effort to assuage its Congressional critics. This article, written from the perspective of a psychologist serving in Congress, discusses the various political and organizational dynamics that developed during the controversy. Understanding and learning from this incident can help psychologists and their professional associations better prepare for and respond to potential controversies arising from research or other publications.     

Putting some feeling into it--the conceptual and empirical relationships between the classic and emotional Stroop tasks: comment on Algom, Chajut, and Lev (2004)

D. Algom, E. Chajut, and S. Lev presented a series of definitional, conceptual, and empirical arguments in support of their conclusion that the classic and emotional Stroop effects are, in their words, "unrelated phenomena" (p. 336), such that the term emotional Stroop effect is a misnomer in reference to the relatively greater interference in ink color naming of emotional versus neutral words. These are strong claims. In this comment, the author critically examines each component of Algom et al.'s case and argues that, in fact, none of these components represents compelling evidence in support of their eventual conclusions.     

Rejoinder to Irwin's (2000) "age and sex differences in paranormal beliefs: a response to Vitulli, Tipton, and Rowe (1999)"

Issues in making an independent test of Irwin's alternative interpretation of Vitulli, Tipton, and Rowe's data are presented.     

A Multitrait Multimethod Measurement Approach to the Traits (or States) of Anxiety,Depression and Hostility

This study tested the convergent and discriminant validities of various psychological techniques used for the measurement of the affects of anxiety, depression and hostility. The subjects were 29 psychiatric patients and 25 normal controls, all males. Subjects were interviewed and rated for the three affects and given an extensive battery of tests. Anxiety and depression measures from ratings, checklists, and questionnaires demonstrated good convergent validity but poor discriminant validity. The projective methods did not demonstrate much convergent validity. Hostility was separable from anxiety and depression but the tests showed poor convergent validity for hostility. In the normals, fantasy hostility (TAT) and admitted hostility (Multiple Affect Adjective Check List) showed some convergence, but in the patients there was no congruence between these two levels.     

Social support as a mediator in the relation between sensation seeking (need for stimulation) and psychological adjustment in older adults

This article investigates the potential role of social support as a mediator between sensation seeking (in the sense of a basal need for stimulation) and psychological adjustment in older adults. A sample of 325 individuals aged between 65 and 95 years were tested using questionnaires, which assess social support, sensation seeking, global self-worth, sense of coherence, and satisfaction with life. Path analyses provided support for a mediator model in which the relationship between sensation seeking and psychological adjustment was fully mediated by social support (the path coefficient between sensation seeking and psychosocial adjustment declines from β = .27 to β = .02, when adding an indirect path mediated by social support). Findings further suggest that this mediation effect was independent of sex and age. The study demonstrates the relevance of measuring sensation seeking as a personality trait in older adults.     

Caution in interpreting confirmatory factor analysis of the group environment questionnaire: a response to Sullivan, Short, and Cramer (2002)

Reasons for cautious interpretation of the confirmatory factor analysis of the Group Environment Questionnaire by Sullivan, Short, and Cramer (2002) are specified.     

For God (or) country: the hydraulic relation between government instability and belief in religious sources of control

It has been recently proposed that people can flexibly rely on sources of control that are both internal and external to the self to satisfy the need to believe that their world is under control (i.e., that events do not unfold randomly or haphazardly). Consistent with this, past research demonstrates that, when personal control is threatened, people defend external systems of control, such as God and government. This theoretical perspective also suggests that belief in God and support for governmental systems, although seemingly disparate, will exhibit a hydraulic relationship with one another. Using both experimental and longitudinal designs in Eastern and Western cultures, the authors demonstrate that experimental manipulations or naturally occurring events (e.g., electoral instability) that lower faith in one of these external systems (e.g., the government) lead to subsequent increases in faith in the other (e.g., God). In addition, mediation and moderation analyses suggest that specific concerns with order and structure underlie these hydraulic effects. Implications for the psychological, sociocultural, and sociopolitical underpinnings of religious faith, as well as system justification theory, are discussed.     

Rats (Rattus norvegicus) selectively bred to differ in avoidance behavior also differ in response to novelty stress, in glycemic conditioning, and in reward contrast

The behavior of the Syracuse high avoidance (SHA) and Syracuse low avoidance (SLA) rats, selectively bred by Brush (F. R. Brush, J. C. Froehlich, & P. Sakellaris, 1979, Behavior Genetics, 9, 309-316) to differ in avoidance behavior, was examined in several different tasks. The SLA rats showed a greater elevation in plasma glucose when exposed to a novel environment; after 7 days of exposure to this environment there was evidence of habituation in the SHA rats but not in the SLA rats; the SHA rats showed a hyperglycemic conditioned response in a glycemic conditioning procedure, the SLA rats showed no evidence of conditioning but had higher overall levels of plasma glucose; both strains showed reliable successive negative contrast effects in consummatory behavior when shifted from 32 to 4% sucrose, but the contrast was larger in the SLA rats; the administration of chlordiazepoxide eliminated negative contrast in the SLA rats but had no effect on contrast in the SHA rats; and the SLA rats were reliably heavier than the SHA rats. The behavioral differences were considered in the context of differences in emotional reactivity between the two strains.