Midline theta dissociates agentic extraversion and anhedonic depression

The agency facet of extraversion is related to individual differences in reward anticipation and has been linked to the neurotransmitter dopamine. Dopamine has also been associated with components of anhedonia, which is one of the cardinal symptoms of depression and refers to lack of responsiveness to pleasurable stimuli. This raises the question whether low agency is associated with anhedonia symptoms in depression and if agency and anhedonia are characterized by similar neurobiological mechanisms. To address this hypothesis, we tested whether questionnaire measures of agency and anhedonia are correlated within depressed (n = 20) and non-depressed (n = 22) participants. Further, we investigated whether dopamine-related signatures in the EEG recorded during a gambling task (feedback-evoked theta activity, and frontal versus posterior theta activity) similarly relate to agency and anhedonia. Results indicated that anhedonia was significantly elevated in the depression group, and negatively correlated with agency. However, while theta activity evoked by negative vs. positive feedback was sensitive to anhedonia and depression status but unrelated to agency, frontal versus parietal theta activity predicted agency, but was unrelated to anhedonia and depression. Together, this double dissociation suggests that in spite of considerable phenotypical overlap, anhedonia and agency may be linked to partially distinct neurobiological markers.     

Covering all the BAS’s: A closer look at the links between BIS,BAS, and socio-emotional functioning in childhood

The purpose of this study was to investigate associations between the BIS, BAS, and socio-emotional functioning in childhood. Participants were 368 children (181 boys) ranging in age from 9 to 13 years (M_age = 10.16, SD = .95). Children provided self-report assessments of BIS/BAS sensitivity, indices of internalizing problems (e.g., depression, social anxiety, loneliness), and perceptions of their peer relations. Parents also rated child internalizing and externalizing problems. Results from confirmatory factor-analysis suggested that the three-factor solution for the BAS (typically reported in adult samples) provided a better fit of the data than a one-factor (typically employed in previous studies with children). Moreover, BAS subscales were associated differentially with different indices of socio-emotional functioning. Support for the joint subsystems hypothesis was also found, with specific BAS subscales serving as moderators of the relations between the BIS and socio-emotional functioning.     

Relationships Among Sleep Disturbance,Reward System Functioning,Anhedonia, and Depressive Symptoms

Recent models propose reward system dysfunction as a key mediator of the relationship between sleep and depression and anhedonia. This study explored interrelationships among sleep disturbance, depressive symptoms, anhedonia, and reward responsiveness. Two-hundred and sixty undergraduate students completed questionnaires and a daily diary paradigm assessing sleep, reward responsiveness, depression, anhedonia, and positive affect over 1 week. Baseline sleep disturbance was associated with depressive symptoms, anhedonia, and reward responsiveness. Daily diary sleep parameters showed differential associations with anticipatory versus consummatory reward responsiveness and positive affect. Poorer sleep quality, shorter sleep duration, and longer awakening after sleep onset predicted blunted anticipatory and consummatory reward responsiveness, while increased sleep onset latency and lower sleep efficiency predicted only decreased consummatory reward responsiveness. All sleep indices, except sleep onset latency, were associated with positive affect. Findings demonstrate unique associations between disparate sleep disturbance and reward responsiveness elements, highlighting new treatment mechanisms for anhedonia and depression.     

Disruption in Pavlovian-Instrumental Transfer as a Function of Depression and Anxiety

The Pavlovian-Instrumental Transfer (PIT) paradigm examines probabilistic and reinforcement learning. Disruptions in mechanisms that mediate PIT (i.e., cues not triggering adaptive behaviors) are thought to be contributors to psychopathology, making the study of probabilistic and reinforcement learning clinically relevant. The current study evaluated an appetitive PIT effect and its relationship with symptom dimensions spanning depression and anxiety, with a particular focus on anhedonia. Forty young adults ranging in scores across dimensions of depression and anxiety symptoms completed the PIT paradigm and self-report symptom measures. The PIT paradigm consisted of three phases. The instrumental phase consisted of a contingent association in which participants squeezed a handgrip for monetary reward. The Pavlovian phase established a purely predictive association between three visual stimuli (CS?+?, CS-, baseline) and presence or absence of monetary reward. In the transfer phase, participants’ responses allowed for examination of whether motivational characteristics of Pavlovian predictors influenced the vigor of their handgrip squeezes (instrumental action), which were formerly independent of Pavlovian associations. Analyses revealed a baseline-reward PIT effect, whereby a reward-associated Pavlovian cue enhanced instrumental responding in the transfer phase. However, there were no significant differences between CS?+?and CS- or CS- and baseline cues, suggesting a disrupted interaction of Pavlovian and instrumental learning. Further, the appetitive PIT effect captured in this paradigm was not associated with anhedonia, fears, or general distress. Future work should investigate the influence of mood states using more specific appetitive PIT paradigms to further understanding of the implications of disrupted reflexive and instrumental responding.

     

Baseline reaction time predicts 12-month smoking cessation outcome in formerly depressed smokers.

Burgeoning evidence points to a positive association between cigarette smoking and depression. Moreover, depressive symptomatology, whether historical, current, or subsyndromal, appears to negatively influence smoking cessation efforts. Whereas depression is typically assessed via clinical interview or self-report, rarely are the known neurocognitive deficits linked to depression (e.g., global slowing) assessed in the context of smoking cessation research. Hence, this study examined whether simple reaction time -- color naming of affectively neutral words -- is predictive of 12-month smoking cessation outcome among a sample of formerly depressed smokers (N = 28). Results revealed a significant, positive correlation between reaction time and depressive symptoms such that those who exhibited slower reaction times were at heightened risk to relapse. Baseline depressive symptoms, as assessed via self-report, neither correlated with nor predicted smoking cessation outcome. Results from logistic regression analyses further showed that reaction time added incremental variance to the prediction of smoking cessation outcome. Therefore, simple reaction time may capture aspects of depression not typically assessed in self-report questionnaires. These results are discussed in terms of their theoretical and clinical implications for smoking cessation research.     

Effects of tobacco smoking on electroencephalographic, auditory evoked and event related potentials

After overnight abstinence, tobacco smokers smoked an average nicotine yield cigarette and nonsmokers sham smoked an unlit placebo cigarette. EEG alpha(1), delta, and theta frequency amplitudes decreased, whereas alpha(2) and beta frequency amplitude increased. Short, middle (EP) and long latency ERP were also studied in nonsmokers and smokers just after smoking, and after overnight abstinence from tobacco. Short latency potentials were unaffected by tobacco smoking or abstinence. Middle and long-latency potentials were reduced during abstinence and enhanced immediately after tobacco smoking. These findings indicate that compared to nonsmokers smokers have a higher arousal level after smoking than when partially abstinent. Evidence for both normalization from tobacco abstinence as well as stimulation was obtained.     

Impulsivity and Behavior-Dependent Life Events Mediate the Relationship of Reward Sensitivity and Depression,but Not Hypomania,Among at-Risk Adolescents

Both reward sensitivity and impulsivity are related to the development and course of bipolar spectrum disorders (BSDs) and have been implicated in other disorders and negative functional outcomes such as substance abuse, obesity, suicidal behaviors, and risk-taking. Furthermore, according to the transactional component of the Behavioral Approach System (BAS)/reward hypersensitivity theory of BSDs, people with reward hypersensitivity should experience more BAS-relevant events, and thus, are more vulnerable to mood symptoms and episodes via stress generation. Impulsivity may exacerbate stress generation in individuals at risk for BSDs based on exhibiting reward hypersensitivity. The current study examined whether impulsivity explained the generation of stress and subsequent mood symptoms beyond what is explained by reward sensitivity alone. Participants were 131 Moderate BAS and 216 High BAS sensitivity adolescents (M = 18.43 years, SD = 1.40), who completed baseline measures of reward sensitivity and impulsivity, as well as follow-up measures of life events and mood symptoms. Results from linear regression analyses indicated that higher baseline impulsivity predicted behavior-dependent, but not behavior-independent, life events. Furthermore, path analyses suggested that the effect of BAS group on depression symptoms at next follow-up was partly explained via the indirect effect of impulsivity and negative behavior-dependent life events. We did not find these effects for behavior-independent or positive-dependent events or for prediction of hypomanic symptoms. The findings suggest that impulsivity may account for stress generation of negative events that precede depression.     

Developing a measure of interpretation bias for depressed mood: An ambiguous scenarios test

The tendency to interpret ambiguous everyday situations in a relatively negative manner (negative interpretation bias) is central to cognitive models of depression. Limited tools are available to measure this bias, either experimentally or in the clinic. This study aimed to develop a pragmatic interpretation bias measure using an ambiguous scenarios test relevant to depressed mood (the AST-D).¹ In Study 1, after a pilot phase (N = 53), the AST-D was presented via a web-based survey (N = 208). Participants imagined and rated each AST-D ambiguous scenario. As predicted, higher dysphoric mood was associated with lower pleasantness ratings (more negative bias), independent of mental imagery measures. In Study 2, self-report ratings were compared with objective ratings of participants’ imagined outcomes of the ambiguous scenarios (N = 41). Data were collected in the experimental context of a functional Magnetic Resonance Imaging scanner. Consistent with subjective bias scores, independent judges rated more sentences as negatively valenced for the high versus low dysphoric group. Overall, results suggest the potential utility of the AST-D in assessing interpretation bias associated with depressed mood.     

The Aura of Tobacco Smoke: Cigars and Cigarettes as Image Makers

Male and female college undergraduates evaluated the character traits of men and women who were seen smoking cigars, smoking cigarettes, or not smoking. The evaluated adults were about 10 years older than the students. Irrespective of the evaluated persons' gender, ratings of appeal were specific to the gender of the evaluator. Men and women agreed in their perception of cigarette smokers as being less appealing than nonsmokers. However, whereas men ascribed markedly less appeal to cigar smokers than to cigarette smokers, women perceived cigar smokers as being as appealing as nonsmokers. This pattern was observed for all positive aspects of appeal; the inverse pattern was apparent for all negative aspects of appeal. In contrast, men and women concurred in judging cigar smokers as being more confident and secure than either nonsmokers or cigarette smokers.     

Obsessive-compulsive symptoms and cigarette smoking: an initial cross-sectional test of mechanisms of co-occurrence

ABSTRACT

Tobacco addiction and obsessive-compulsive symptoms (OCS; intrusive thoughts or impulses that cause distress and rituals) are both mediated by compulsivity and negative reinforcement. Little evidence exists to guide theory, research, treatment, and population-based prevention of this co-occurrence. We propose a conceptual model of OCS-smoking co-occurrence in which smokers with elevated OCS capitalize on smoking to assuage OCS. This secondary analysis examined associations between OCS levels and self-reported smoking motives that are model-concordant: i) negative reinforcement—smoking for relief; ii) sensorimotor—benefits of behaviors and sensations of the tobacco self-administration ritual; and iii) habitual—smoking without conscious control. A community sample of cigarette smokers enrolled in a cessation trial (N = 458; 47.2% female; M _age = 36.9; SD = 13.6) completed pre-quit self-report measures of OCS levels and smoking motives. Regression models adjusted for sociodemographic covariates and non-OCS psychopathologies indicated that OCS level was positively associated with each model-concordant motive. OCS level was also correlated with tobacco dependence severity and greater withdrawal symptom severity experienced during previous quit attempts. Those with higher OCS report greater motivation to smoke for negative reinforcement, sensorimotor behavioral-ritualistic, habit/automaticity, and stimulation reasons. Further examination of the proposed model of OCS-smoking co-occurrence is warranted to guide theory and intervention for this population.     

Residual effects of cigarette smoking on cognitive performance in normal aging

The present study examined the residual effects of smoking status on cognitive function in 76 nondemented older adults. Current smokers, ex-smokers, and nonsmokers who were screened for health and intellectual impairments were administered a battery of standardized neuropsychological tests to measure problem solving, psychomotor speed, memory, attention span, perception, and language production. Performance decrements were found for smokers on measures of psychomotor speed. No between-group differences were noted on any of the nonspeeded tests. There were no differences between nonsmokers and ex-smokers on any measures. The results suggest that the residual effects of current cigarette smoking negatively influence speeded cognitive capabilities in older adults.     

A Clinical Trial of In-Home CBT for Depressed Mothers in Home Visitation

Despite negative outcomes for depressed mothers and their children, no treatment specifically designed to address maternal depression in the context of home visitation has emerged. In-Home Cognitive Behavioral Therapy (IH-CBT) is an adapted treatment that is delivered in the home, focuses on the needs of new mothers, and leverages ongoing home visiting to optimize engagement and outcomes. This study examined the efficacy of IH-CBT using a randomized clinical trial. Subjects were 93 new mothers in a home visiting program. Mothers with major depressive disorder identified at 3 months postpartum were randomized into IH-CBT and ongoing home visitation (n = 47) or standard home visitation (SHV; n = 46) in which they received home visitation alone and could obtain treatment in the community. Depression was measured at pre- and posttreatment, and 3-month follow-up using interviews, clinician ratings, and self-report. Mothers receiving IH-CBT showed improvements in all indicators of depression relative to the SHV condition and these gains were maintained at follow-up. For example, 70.7% of mothers receiving IH-CBT were no longer depressed at posttreatment in terms of meeting criteria for major depressive disorder compared to 30.2% in the SHV group. These findings suggest that IH-CBT is an efficacious treatment for depressed mothers in home visitation programs.     

Smoking,personality, and imagery preference in Relation to spontaneous bilateral electrodermal activity

Effects of smoking on spontaneous bilateral skin conductance were studied as a consequence of interactions with set and setting. Bilateral skin conductance was recorded in six men and six women who smoked and an equal number of nonsmokers on two different days. On the first day, spontaneous electrodermal activity was recorded before and after a 10-minute rest period during which half the smokers smoked a cigarette. On the second day, one week later, spontaneous activity was again recorded before and after a 10-minute rest period during which the remaining smokers smoked a cigarette. Nonsmokers did not smoke at any time. Following smoking there was a significant negative correlation between a preference for visual over nonvisual imagery and spontaneous skin conductance responsivity in the left as compared to the right hand. Correlations were significantly different in smokers and nonsmokers. Smokers showed significantly greater preferences for either visual or nonvisual imagery than nonsmokers. Nonresponding nonsmokers were higher on the psychoticism (P) scale of the Eysenck Personality Questionnaire (EPQ) than responding nonsmokers. Smokers scored higher on P than nonsmokers. Interactions between personality, cognitive style, and the experimental situation, set, and setting were discussed in relation to the arousing effects of nicotine.     

Mapping the protective pathway of emotional intelligence in youth: From social cognition to smoking intentions

The purpose of this study was to test perceptions of the social consequences of smoking as a mediator of the relationship between emotional intelligence (EI) and intentions to smoke cigarettes among youth. Upper elementary school students (N = 255, M_age = 10.9 years, 49% male) completed measures of EI, verbal intelligence, smoking-related intentions, past behavior, and perceived social consequences. Mediation was tested using the Sobel test. Perceived social consequences was a marginally significant mediator of the impact of total EI on intentions to smoke (Z = 1.91, p = .057). Follow-up analyses showed that perceived social consequences significantly mediated the effect of 2 EI abilities on smoking intentions: using emotions (Z = 2.02, p = .043) and managing emotions (Z = 2.28, p = .023). The results indicate that the role of higher EI in deterring smoking among youth may be related to social processing ability (i.e., greater perceptions of the negative social consequences of smoking). These findings contribute to a growing body of research demonstrating that EI may reduce cigarette smoking among youth by influencing their social perceptions.     

Prevalence of cigarette smoking in Iran.

The current research assessed the prevalence of cigarette smoking in Shiraz, Iran by randomly selecting 1,335 subjects (782 men and 553 women) from the city for a face-to-face interview and completion of a questionnaire. Of the participants, 205 (26%) of the men and 20 (3.6%) of the women reported being current smokers. The mean ages of smokers and nonsmokers were 41.8 and 37.0 yr., respectively (range between 16 and 90 years for smokers and nonsmokers). The mean age of starting to smoke cigarettes was 21.3 yr. (range of 10 to 60). The most common reasons for current cigarette smoking were Need to avoid withdrawal symptoms, Release of tension, and Pleasurable purposes. Foreign filter-tipped cigarettes were the most common type consumed. The mean number of cigarettes per day was 13.4 (SD = 10.3). Reports for onset of cigarette smoking included Modeling, Release of tension, and Pleasurable purposes. Cigarette smoking was reported by more males than females. The most common reason for onset of cigarette smoking was different from that for current smoking. Frequencies of smokers within age groups were varied.     

Association between the HTR2B gene and the personality trait of fun seeking

Previous research reported that a rare serotonin receptor 2B gene (HTR2B) stop codon mutation predisposes subjects to severe impulsivity and novelty seeking. In this study, we expanded this previous work by testing six single nucleotide polymorphisms (SNPs) within the HTR2B gene for potential associations with the behavioral inhibition system (BIS) and the three components of the behavioral approach systems (BAS: fun seeking, drive, and reward responsiveness) in a Han Chinese sample (N = 478). Association analysis for individual SNPs indicated that four of the six SNPs (i.e., rs6437000, rs10194776, rs16827801, and rs1549339) were significantly associated with BAS fun seeking (p = .0003–.0022). Haplotype-based association analysis revealed that fun seeking was positively associated with haplotype A–A–G–A for SNPs rs6437000–rs10194776–rs16827801–rs1549339 (p = .0002), which survived Bonferroni correction. Except for the association between BAS reward responsiveness and rs16827801 (p = .005), no other association was found for BAS drive, BAS reward responsiveness, or BIS. This study provides the first evidence for the involvement of the HTR2B gene in BAS fun seeking. A better understanding of the genetic basis of the BIS and BAS would allow us to develop more effective diagnosis, treatment, and prevention of impulsive behavioral problems.     

Effects of impulsivity, reinforcement sensitivity, and cognitive style on Pathological Gambling symptoms among frequent slot machine players

Pathological Gambling (PG) is the inability to resist recurrent urges to gamble excessively despite harmful consequences to the gambler or others. A cognitive-behavioral Pathways Model of PG (Blaszczynski & Nower, 2002) suggests individual differences in rash impulsivity and reward sensitivity, together with a cognitive style that promotes poor decision making, as risk factors. These individual differences were examined in a community sample of experienced slot machine players (N = 100), who were classified into Low, Moderate, and Problem gambling groups according to the Problem Gambling Severity Index (Ferris & Wynne, 2001). There were significant group differences on rash impulsivity as measured by the Eysenck Impulsivity scale, and on reward sensitivity as measured by the BIS/BAS Drive scale. For cognitive style, there were differences on Actively Openminded Thinking (AOT), but not the Rational Experiential Inventory. Hierarchical regression analyses found that impulsivity and AOT predicted severity of PG, but that AOT mediated the effect of BAS Drive. A thinking style that promotes erroneous cognition may correlate with PG, but individual differences in rash impulsivity and reward-seeking play a more critical role in the etiology of PG. The individual characteristics of Pathological Gamblers are similar to those of people with Substance Use Disorders.     

Implicit alcohol and smoking associations among young adult heavy drinkers: Associations with smoking status and alcohol-cigarette co-use

Implicit memory associations may play a role in motivation to use alcohol and cigarettes, but the relationship between implicit associations and co-use of alcohol and cigarettes is currently unknown. This study provided an initial examination of alcohol and smoking implicit associations among young adult drinkers who were either nonsmokers or relatively light smokers (i.e., 10 or fewer cigarettes per day) as a function of smoking frequency and daily-level alcohol-cigarette co-use. Drinkers (n?=?129) completed alcohol-arousal and smoking-valence variants of the implicit association test as well as a daily-level assessment of past 90-day alcohol and cigarette use. Smokers were grouped according to whether they reported daily or nondaily smoking frequency. Results showed that although implicit alcohol-arousal associations did not differ between smokers and nonsmokers, stronger implicit alcohol-arousal associations were observed for nondaily smokers relative to daily smokers after controlling for drinking frequency. Further, implicit positive-smoking associations were stronger for smokers relative to nonsmokers. Within the subgroup of nondaily smokers, more frequent co-use of alcohol and cigarettes was associated with stronger implicit positive-smoking associations when controlling for total drinking and smoking frequency. The findings suggest that implicit alcohol and smoking associations may be linked with smoking patterns (daily vs. nondaily) and co-use of alcohol and cigarettes among young adult drinkers who are not heavy smokers, highlighting the need for more research on the role of implicit associations in the co-use of cigarettes and alcohol.     

Smoking and psychological health in relation to country of origin

In English-speaking, Western-Anglo countries, where smoking has become stigmatized in recent decades as a result of widespread anti-smoking campaigns, smokers commonly report poorer psychological health on average than nonsmokers do. This may be indirectly related to the strong pressures to quit in such countries, as poorer psychological health is associated with a reduced likelihood of quitting, thus leading to a selection bias for smokers with relatively poorer psychological health. In the present study, 147 smoker and nonsmoker participants either came from Western-Anglo countries where smoking has become stigmatized (Australia, Canada, USA) or countries in regions where smoking remains relatively more accepted (Asia, Latin America, Europe). Smokers and nonsmokers were assessed on a widely used self-report measure of anxiety, depression, and stress. Multivariate analysis revealed a significant interaction between smoker status (smoker, nonsmoker) and country of origin (Western-Anglo, other) on psychological health ratings, with univariate analysis showing a significant interaction on anxiety scores. Among those from Western-Anglo countries, smokers reported significantly higher levels of anxiety than nonsmokers did, whereas there was no difference in anxiety between smokers and nonsmokers from other countries. There was no difference in the number of cigarettes smoked per day between the samples of smokers, indicating very similar levels of nicotine intake in the two groups. The findings support the notion that a selection bias for smokers with relatively poorer psychological health is occurring in Western-Anglo countries.     

Coping mediates relationships between reinforcement sensitivity and symptoms of psychopathology

Limited research has evaluated whether coping strategies mediate the relationships between reinforcement sensitivity theory (RST) and symptoms of psychopathology. Undergraduates (n = 293) completed questionnaires assessing RST, coping, and symptoms of psychopathology. Consistent with our hypotheses, bootstrapping analyses indicated that emotion- and avoidance-focused coping mediated the relationship between high Behavioral Inhibition System (BIS) and depression, anxiety, and worry. Less problem-focused coping mediated the relationship between low Behavioral Approach System (BAS) and depression. Avoidance-focused coping mediated the effects of high BIS on drug and alcohol use whereas high BAS directly predicted alcohol and drug use. Unexpectedly, emotion-focused coping mediated the relationship between BAS and anxiety and worry. These results provide support for the hypothesis that personality variables are associated with psychopathology partially through coping.