Depotentiation of vdccLTP Requires NMDAR Activation

Long-term potentiation is an enduring increase in synaptic efficacy following repeated stimulation of afferent fibers that is thought to underlie memory. In area CA1 of the hippocampus at least two forms of synaptic potentiation coexist at the same synapses; nmdaLTP and vdccLTP. NmdaLTP is induced by Ca2+ entry through NMDARs and is dependent on serine/threonine kinase activation, while vdccLTP is induced through Ca2+ entry through VDCCs and is dependent on tyrosine kinase activation. Depotentiation is a mechanism known to reverse nmdaLTP through phosphatase activation. The depotentiation of vdccLTP has not been previously investigated. We used hippocampal slices (area CA1) from male Long-Evans rats to induce vdccLTP with a 200-Hz tetanus in the presence of 50 microM APV. The 200-Hz tetanus resulted in a slowly developing vdccLTP that remained stable for at least 30 min. Thirty minutes after vdccLTP was induced, a low-frequency tetanus (3, 10, 20, 30, or 40 Hz) was applied in the presence of APV in an attempt to depotentiate vdccLTP. The 3- and 10-Hz low-frequency tetani resulted in no depotentiation. The 20- and 30-Hz tetani partially depotentiated vdccLTP (by approximately 13%), whereas the 40-Hz tetanus resulted in further potentiation. When APV was washed out prior to the 3-Hz low-frequency tetanus, the vdccLTP was completely depotentiated--presumably by NMDAR mechanisms. Our results indicate that vdccLTP is resistant to depotentiation under low-frequency stimulation conditions that readily depotentiate nmdaLTP. As tetanus frequencies are increased a small depotentiation is observed, suggesting that vdccLTP can be depotentiated to a small extent. When NMDARs are unblocked, vdccLTP can be completely depotentiated by a 3-Hz low-frequency tetanus, suggesting that vdccLTP can be depotentiated via activation of NMDAR mechanisms.     

Qualia im Knotenpunkt zwischen Leib und Seele: „Argumentatives“ Dilemma in der gegenwärtigen Diskussion über die Subjektivität mentaler Zustände

Qualia in the node-point between mind and body: Dilemma of present discussion about the subjectivity of mental states. The present discussion about qualia shows a bewildering variety of different positions. We show implicit assumptions about brain, subject, and qualia of this complex discussion. By means of three assumptions we divide the discussion about qualia into three different positions (proposition, opposition, intermediate solutions). These positions and their exemplaric authors are briefly presented along the lines of the three assumptions. The next step shows how each position solves the dilemma which arises if one relates all three assumptions by eliminating at least one of the three assumptions. Finally, general problems in the discussion of qualia are shown by means of which the dilemma of the relation between brain, subject and qualia may be brought closer to a solution without eliminating one assumption.     

A narwhal is an animal: partial word knowledge biases adults' decisions

Adults' accuracy on a sentence verification task was measured to assess reliable biases in their responses as a function of their level of knowledge about the target words, as well as adults' ability to reject incorrect ontological category membership for their partially known words. Three levels of word knowledge (known, frontier, and unknown) were assessed in two experiments. Results indicated that participants were conservative decision-makers about sentences using the vocabulary words and that the conservative bias increased in strength as their level of knowledge about the target word increased. When biased guessing was discouraged, results indicated that participants were able to accurately identify both correct and incorrect sentences using targets at all three levels of knowledge, including their partially known words, but were least reliable at rejecting false sentences using unknown targets. Implications for the role of knowing not in adults' vocabulary acquisition are discussed.     

The application of the satir model of family therapy to the families in Hong Kong: A personal reflection

Practitioners in Hong Kong have shown an increasing interest in various family therapy approaches since the 1980s. This paper offers a critique of the major concepts and techniques of the Satir model applied to families in Hong Kong. Cultural considerations are examined in relation to the family structure and hierarchy, the Chinese self and self-esteem, communication patterns, and family rules. Implications for the application of the Satir model of family therapy in Hong Kong are discussed.     

Remarks on Gregory's “Actually” Operator

In this note we show that the classical modal technology of Sahlqvist formulas gives quick proofs of the completeness theorems in [8] (D. Gregory, Completeness and decidability results for some propositional modal logics containing actually operators, Journal of Philosophical Logic 30(1): 57–78, 2001) and vastly generalizes them. Moreover, as a corollary, interpolation theorems for the logics considered in [8] are obtained. We then compare Gregory's modal language enriched with an actually operator with the work of Arthur Prior now known under the name of hybrid logic. This analysis relates the actually axioms to standard hybrid axioms, yields the decidability results in [8], and provides a number of complexity results. Finally, we use a bisimulation argument to show that the hybrid language is strictly more expressive than Gregory's language.     

Treating the “Wise Baby”

In a previous examination of Ferenczis concept of the Wise Baby (1996), I had noted both its applications and its limitations in the analytic treatment of an unusually intelligent adult. Ferenczis concepts of the origin of intellect in trauma and of the wise baby have often left the indistinct impression of being interrelated phenomena. In this paper, I regard as arguable the notion that very high intelligence is pathological when it is precocious. This return visit to the territory of the wise baby extends Ferenczis ideas about the origin and use of the intellect to include a consideration of what may constitute effective treatment for those who suffer from giftedness.Judith E. Vida, M.D. edits On the Arts for this journal. She is a Founding Member and Faculty of the Institute of Contemporary Psychoanalysis in Los Angeles, CA, a member of both American and International Psychoanalytic Associations, and of the Sándor Ferenczi Society of Budapest. Her private practice is in Pasadena, CA.Address correspondence to Judith E. Vida, 301 S. Fair Oaks Ave., Suite 406A, Pasadena, CA 91105, USA; e-mail: jvida@spence.net     

The Impact of ‘the Dream’ on Women's Experience of the Midlife Transition

Daniel Levinson's claim for the universality of age-linked periods is considered highly controversial considering that his theory evolved from a study consisting of males only. Theories relating to women's development, particularly at midlife, are somewhat scarce and restricted. Using Levinson's theory of adult development as a framework, the present study retrospectively examined the Dream and its impact on women's psychological health and adjustment to the Midlife Transition. Three hundred midlife women completed a questionnaire examining Dream Status, Dream Content, Dream Success, and the psychological health variables, depression, anxiety, self-esteem, and life satisfaction. Dream Success was significantly related to psychological health on dimensions of well-being and composure, and interesting changes were observed in Dream Content across the early and current Dream. Our findings revealed that, despite the overall greater complexity of women's Dreams, Levinson's theory is largely applicable to women's development.     

Having a voice and getting a hearing: An educational perspective on free speech in a plural society

This paper examines Ronald Dworkin's claim that the right to free speech does not include a right to circumstances that encourage citizens to speak nor a right to competent and sympathetic understanding on the part of listeners. Drawing on familiar arguments for the existence of other human rights, the paper challenges Dworkin's claim. Even if, however, the challenge fails and it is not possible to show that there is such a right, that is not the end of the story. It is argued that democratic societies should try to foster conditions in which citizens are encouraged to speak and are listened to sympathetically in the interests of the well-being and flourishing of the polity. The important role education has to play in this is explored.     

Completeness and Decidability Results for Some Propositional Modal Logics Containing “Actually” Operators

The addition of actually operators to modal languages allows us to capture important inferential behaviours which cannot be adequately captured in logics formulated in simpler languages. Previous work on modal logics containing actually operators has concentrated entirely upon extensions of KT5 and has employed a particular model-theoretic treatment of them. This paper proves completeness and decidability results for a range of normal and nonnormal but quasi-normal propositional modal logics containing actually operators, the weakest of which are conservative extensions of K, using a novel generalisation of the standard semantics.     

Open live supervision in family therapy

This article reviews changes in models of supervision, resulting from technological developments and reflecting a variety of theoretical approaches. The focus is on open live supervision, conducted in the presence of the family. The supervisor and a therapeutic team join the therapist and the family, creating a complex supra-system that opens up several options for therapeutic intervention. Sessions are videotaped, and therapists use recordings for additional supervision and independent study. Therapists may also show recordings to the family as part of the therapeutic process. The advantages and disadvantages of the model are considered, and examples of some of the therapeutic options are described.This model was developed in the course of the author's work teaching and supervising students at the Counseling Department of the School of Education at the Hebrew University of Jerusalem, and supervising a multi-disciplinary team including physicians, psychologists, and social workers engaged in family therapy at the Municipal Psychological Services for Schools in Jerusalem. A shorter version of this article appeared in Hebrew inSihot 5 1991. Appreciation is expressed to Batya Stein for translating the final version of this article from Hebrew. Reprint requests should be addressed to Katrit Ron, Neve Granot 3-B, Jerusalem 93706, Israel.     

The threshold model of scientific change and the continuity of scientific knowledge

The continuity thesis of the Pozna school threshold model of the growth of scientific knowledge is considered in the light of the example of Van der Waals' and Boyle-Mariotte's laws. It is argued — using both traditional logical means and the structuralist reconstruction of the example — that the continuity thesis does not hold.A distinction between a historical and a systematic point of view is introduced and it is argued that the continuity thesis of the threshold model presupposes the systematic point of view. However, looking at matters from the systematic point of view need not yield the original theory, looked at from the historical point of view. Applied to the case of Van der Waals/Boyle-Mariotte laws, it turns out that the latter law is not a true idealizing special case of the former, contrary to the continuity thesis.     

Lordship, Bondage, and the Formation of Homo Religiosus

After a brief exploration of Hegel's writing on the formation of self-consciousness, including the place of religiosity in this formation, the article examines Kojeve's response to a Hegelian homo religiosus, followed by a counter-response to Kojeve's atheism through a peculiar, Jaspersian reading of Erich Fromm's discussion of the x experience. Finally, it will be argued that the desire for mutual recognition, and humanity's yearning for transcendence, are essential experiences in the formation of self-consciousness.     

Bringing “The Dead” to Life: Reading James Joyce

The author offers a personal reading of James Joyce's The Dead. She focuses on how the sounds of the language are used to portray the main character's deadness and his beginning to come to life once the barriers to inner self and self-knowledge are broken.     

Corporal Punishment

This paper examines the reasons why corporal punishment in the judicial sphere has fallen into moral disfavour in recent decades. Standard objections to the practice, both practical and ethical, are considered and found to be inconclusive. It is argued that corporal punishment is not inevitably more cruel or demeaning than conventionally preferred punitive methods and that consideration should be given to its limited experimental reintroduction.     

AFRICANA PHILOSOPHY

“Africana Philosophy” is a gathering notion used to cover collectively particular articulations, and traditions of particular articulations, of persons African and African-descended that are to be regarded as instances of philosophizing. (The notion is meant to cover, as well, the philosophizing efforts of persons not African or African-descended, efforts that are, nonetheless, contributions to the philosophizing endeavors that constitute Africana philosophy.) A central concern of the essay is the question whether there are characteristics of the philosophizing practices of persons identified as members of social groups thought to comprise a geographically and historically dispersed and ethnically diverse race that do, or should, distinguish the practices by virtue of being those of persons African and/or African-descended. Is there, can there be, should there be a properly determined field of philosophy that is constituted, first and foremost, by the efforts of persons of a particular race and its ethnic groups?     

The Shaping of Family Therapy Education: An Update

The preparation and credentialing of marital and family therapists in the United States and Canada continues to be significantly affected by the role of accreditation in MFT graduate education. This report on a study of Commission on Accreditation for Marriage and Family Therapy Education accredited degree programs and non-accredited programs shows some significant differences between the two paths to preparation and credentialing. Accredited programs tend to have more faculty, lower faculty-student ratios, more Approved Supervisors, more financial aid, more programs requiring practica and internships, and more emphasis on professional identification with marital and family therapy. Nonaccredited programs provide more emphasis on psychopathology, psychodiagnostic testing, and cognitive behavioral therapy.     

Choice and Logic

There is a little known paradox the solution to which is a guide to a much more thoroughgoing solution to a whole range of classic paradoxes. This is shown in this paper with respect to Berrys Paradox, Heterologicality, Russells Paradox, and the Paradox of Predication, also the Liar and the Strengthened Liar, using primarily the epsilon calculus. The solutions, however, show not only that the first-order predicate calculus derived from Frege is inadequate as a basis for a clear science, and should be replaced with Hilbert and Bernays conservative extension. Standard second-order logic, and quantified propositional logic also must be substantially modified, to incorporate, in the first place, nominalizations of predicates, and whole sentences. And further modifications must be made, so as to insist that predicates are parts of sentences rather than forms of them, and that truth is a property of propositions rather than their sentential expressions. In all, a thorough reworking of what has been called logic in recent years must be undertaken, to make it more fit for use.Portions of this paper have previously been published in Logical Studies, vol. 9, http://www.logic.ru/LogStud/09/No9-06.html, and the Australasian Journal of Logic, vol. 2, http://www.philosophy.unimelb.edu.au/ajl/2004/2004_4.pdf.     

Der “dritte Weg” der “neo-eurasischen” Zeitschrift “Elementy” -- zurück ins Dritte Reich?

Studies in East European Thought - Articulated in the twenties, the doctrines of the exiled Russian ‘Evrazijstvo’ movement are undergoing a renaissance in Russia today. As the...