替罗非班以及不同给药途径对AMI患者PCI术后sICAM-1的影响

探讨替罗非班以及不同给药途径对急性心肌梗死（AMI）患者经皮冠状动脉介入术（PCI）后可溶性细胞间粘附因子-1（sICAM-1）的影响.选择AMI直接PCI患者90例随机分成A、B、C三组：A组不给予替罗非班;B组PCI术后静脉给予替罗非班,C组PCI术中对梗死相关冠状动脉（IRA）内注射替罗非班,两组均静脉滴注36h;分别检测三组术前及术后24h血浆sICAM-1的浓度水平.结果显示,A组PCI术后24h血浆sICAM-1的浓度水平较术前高,而B、C两组较术前均降低,差异有统计学意义（P＆lt;0.05）,但B、C两组PCI术后差异无统计学意义（P＞0.05）.因此,对于行PCI术的AMI患者应给予替罗非班,抑制术后炎症反应以及粘附反应,降低PCI术后再狭窄的发生率,但其作用效果与给药途径无关.     

急性冠脉综合征患者血液Rho激酶活性分析

探讨 Rho 激酶（ROCK）活性与急性冠脉综合征（ACS）患者冠状动脉狭窄程度及预后的关系。选取2012年6月至2013年3月住院的129例患者,其中急性心肌梗死（AMI）组68例、不稳定型心绞痛（UA）组30例、对照（CON ）组31例。Western Blot 检测血液白细胞中 ROCK 、ROCK1、ROCK2活性,同时根据冠状动脉的狭窄程度及是否发生心血管意外分组再次比较。 AMI 组和 UA 组 ROCK 、ROCK1、ROCK2活性均增高;且 AMI 组高于 UA 组;三支、双支、单支病变组活性依次减低,Gensini 评分≥20分组及发生心血管意外组均高于 Gensini 评分＜20分组及未发生心血管意外组,差异均有统计学意义（P＜0．05）。 ROCK 活性可能对 ACS 患者预后观察、评估有重要意义。     

急性心肌梗死患者直接经皮冠状动脉介入治疗前后窦性心律振荡的临床观察

探讨急性心肌梗死（AMI）患者直接经皮冠状动脉介入（PCI）前后窦性心律振荡（HRT）的变化及意义.选择伴室性早搏的AMI患者（观察组）和无器质性心脏病的室性早搏患者（对照组）各42例,PCI前伴室早的观察组患者,用节律Ⅱ导联记录室早的心电图,PCI后2周时观察组及对照组均记录24h动态心电图（AECG）,计算其震荡初始（TO）和震荡斜率（TS）,并行心脏彩色多普勒超声检查,测定左室射血分数（LVEF）.结果观察组PCI后2周时和对照组LVEF分别为：（59.1＆#177;7.5）%和（61.3＆#177;8.4）%.观察组PCI前TO显著升高,TS显著降低,差异有统计学意义（P＜0.05）;观察组PCI后2周TO较前降低,TS较前升高,但和对照组相比差异仍有统计学意义（P＜0.05）;观察组PCI后2周时和对照组左室射血分数（LVEF）相比无差异.提示AMI患者HRT减弱,PCI后2周HRT改善但和观察组相比仍有统计学意义,提示AMI患者PCI后早期仍存在心脏自主神经功能下降,HRT可作为评价AMI患者预后的一个指标.     

血清Cys C的检测对肾移植术后患者肾功能评价的临床意义

探讨分析血清胱抑素C（Cys C）水平在肾移植术后患者肾功能监测中的应用价值.对25例肾移植成功患者在术前、术后第1、3、5、7、10天的血清Cys C、Scr、β2-MG、BUN水平进行动态监测,同时随机抽取健康体检者中的20例作为对照组.发现移植组的Cys C、Scr、β2-MG、BUN水平在术前均明显高于健康对照组（P＜0.01）.这四项指标在手术后第一天都有所下降,且术后第1、3、5、7、10天的水平都比术前低（P＜0.01）.四项指标与GFR的关系均为显著性负相关（P＜0.01）,其中血清Cys C与GFR的相关性最好.Cys C、Scr、β2-MG、BUN检测后的ROC曲线下面积分别是：0.937、0.838、0.798、0.772,其差异都具有统计学意义（P＜0.05）.血清Cys C优于Scr、β2-MG、BUN,在肾移植患者术后的动态监测中具有重要的临床应用价值.     

急性情绪应激对大鼠行为和脑神经颗粒素磷酸化水平的影响

为探讨急性情绪应激对大鼠旷场行为的影响,以及脑神经颗粒素（Neuroganin,NG）变化与应激性行为效应之间的相互关系。以急性不确定性空瓶刺激,建立情绪应激动物模型。将40只雄性SD大鼠随机分为情绪应激组1（ES1,接受情绪应激和旷场测试）、情绪应激组2（ES2,只接受情绪应激）、正常对照组1（C1,无情绪应激,但接受旷场测试）和正常对照组（C2,无情绪应激,也无旷场测试）（n=10）。以旷场行为和高架十字迷宫任务来评定大鼠应激后的行为变化,Western印迹杂交法（Western blotting）测定海马和前脑皮层中的NG含量和磷酸化水平。结果表明：（1） 应激后ES1组的水平活动增加,与C1组比较,差异有显著性, p<0.01;（2）ES1组海马和前脑皮层的NG磷酸化水平高于C1和C2组,差异有显著性, 均为p<0.05; ES2组的前脑皮层NG的磷酸化水平高于C1组,差异有显著性,为p<0.05;（3） 海马的NG磷酸化水平与水平活动之间的相关达显著水平。提示急性情绪应激能导致动物明显的行为改变如焦虑,这种行为改变可能与脑内NG磷酸化水平的变化有关。水平活动可能是反映急性情绪应激的较敏感行为指标,海马NG磷酸化水平可能是预测急性情绪应激所致焦虑或抑郁行为的较敏感生物学指标     

心血管病患者择期介入手术前后焦虑抑郁及影响因素分析

探讨择期介入治疗心血管病患者术前术后焦虑抑郁水平及其影响因素。连续调查我院心内科行择期介入治疗的住院患者100例,分别于术前及术后记录患者静息血压和心率,填写贝克抑郁量表、状态焦虑量表、自制担心评定量表、SF-36生活质量调查问卷;SPSS 17．0软件对焦虑抑郁影响因素进行了统计分析。介入患者术后血压（141．2＆#177;10．6）mmHg /（75．1＆#177;11．9）mmHg 较术前（145．4＆#177;18．0）mmHg/（79．8＆#177;12．2）mmHg 显著下降,心率（72．1＆#177;11．6）次/分也较术前（78．2＆#177;12．9）次/分显著降低;术前患者普遍存在焦虑情绪（43．4＆#177;8．4）,焦虑水平与学历、血压及心率均呈正相关（P＜0．05）,与年龄、生活质量呈负相关（P＜0．05）;介入术后患者焦虑水平显著下降（41．2＆#177;7．6,P＜0．03）;抑郁水平在手术前后无明显变化。本结果提示择期介入治疗心血管病患者术前存在明显焦虑,焦虑水平与年龄、学历、血压、心率及生活质量密切相关。     

肥胖男性血浆脂联素水平及影响因素

检测正常男性血浆脂联素水平,探讨其与各检测指标之间的相关性。选取正常男性96例,按体重指数（BMI）将上述两组分为2个亚组：肥胖（BMI≥25kg／m^2）组40例及体重正常（BMI〈25kg／m^2）组56例,测定空腹血浆脂联素浓度。肥胖组的血浆脂联素水平[（7．48±3．4）μg／m1]明显低于体重正常组[（10．57±4．73）μg／m1],差异有显著的统计学意义（P〈0．01）。相关分析显示血浆脂联素与体重指数（BMI）、腰围（WC）、血压（BP）、总胆固醇（TC）、血清胰岛素（FINs）、胰岛素抵抗指数（HOMA-IR）之间存在负相关,与高密度脂蛋白胆固醇（HDL-C）正相关。BMI、WC、HOMA-IR为影响血浆脂联素水平的独立因素。男性肥胖者血浆脂联素水平较体重正常者明显降低,血浆脂联素水平可能与肥胖及其相关疾病相关。     

2004至2016年中国大学生身体自尊的变迁:一项横断历史研究

大学生身体自尊是如何随年代变化的呢？研究对2004年至2016年107篇使用身体自尊量表的研究进行了横断历史研究,涉及大学生30738名。结果显示：（1）我国大学生身体自我价值感、运动能力和身体素质与年代有着显著正相关关系;（2）男女大学生身体自尊水平都有了一定提升;（3）男生在身体自尊各个因子的得分高于女生0.2~0.3个标准差,显示出了大学生在身体自尊水平上的性别差异;（4）从大学生整个群体来看,经济因素、高等教育因素与大学生身体自尊具有显著相关,而从不同性别群体来看,经济因素与人口压力对于男大学生的身体自尊影响更为明显。     

急性心肌梗死患者PCI术后无复流的相关因素探讨

探讨急性心肌梗死(AMI)患者PCI术后发生无复流的的相关因素.入选急诊PCI术中血管造影显示无复流患者110例入选无复流组;纳入同期行急诊PCI术经冠脉造影示血流正常的患者110例为正常血流组,搜集相关数据并进行单因素与二分类Logistic回归分析,再通过ROC曲线探讨入院后EPO对无复流发生的预测价值.最后显示EPO、血糖、中性粒细胞计数是无复流的独立预测因素;ROC曲线下面积0.75.当截点值取14.21mIU/ml时,EPO对PCI术后发生无复流预测价值较高.     

BNP和CRP在ACS患者的预后评估中的相关性分析研究

为了探讨血浆脑钠肽（BNP）和C反应蛋白（CRP）在急性冠状动脉综合征（ACS）患者的预后评估中两者的水平与临床预后的关系,连续性入选120例ACS患者。测定症状发作平均（34.2±16.3）h的血浆BNP和CRP水平,随访患者住院期间,30d,3个月病死率及主要心脏不良事件（MACE）（心原性死亡,再次心肌梗死,再发心绞痛,继发心衰和再入院的复合终点）发生率。结果显示,当将CRP、BNP和年龄等其他冠心病危险因素放入同一模型预测ACS的预后时,血浆CRP水平失去了预测效能,而血浆BNP水平升高独立于各因素预测30d和3个月病死率及MACE发生率。因此,BNP和CRP能够很好地对ACS患者进行危险分层,预测近期病死率和MACE发生率。BNP可能是较CRP更好的预测ACS患者近期临床预后的指标。     

伴家族史的2型糖尿病危险因素的病例对照研究

为探讨2型糖尿病代谢特征及发病的危险因素,选取大连地区91例有家族史的T2DM患者为病例组,以44例患者的配偶（糖耐量正常）为对照组,进行流行病学问卷调查和体格检查,同时测定空腹血糖、空腹胰岛素、总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白等指标,采用稳态模型法计算两组的胰岛素抵抗指数和β细胞功能指数,并进行多因素非条件Logistic回归分析。结果显示：TG、腰臀比和Ln（HOMAIR）病例组高于对照组,而Ln（HOMAβ）则病例组低于对照组,均具有统计学意义（P〈0．05）。多因素非条件Logistic回归分析结果提示,影响T2DM发病的因素有心血管疾病史、Ln（HOMAIR）及Ln（HOMAβ）。由此可见T2DM患者存在血脂代谢异常;心血管疾病史和Ln（HOMAIR）为发病的危险因素,Ln（HOMAβ）为保护因素。     

重症急性胰腺炎并发急性呼吸窘迫综合征危险因素的分析

为了探讨重症急性胰腺炎（SAP）并发急性呼吸窘迫综合征（ARDs）的危险因素,回顾性分析了我院76例SAP患者入ICU时的年龄、血糖、APACHEⅡ评分等17项指标,根据是否合并ARDS对各项指标进行单因素及多因素Logistic回归分析。单因素分析显示两组在年龄、呼吸频率、血糖、感染、APACHEⅡ评分、Ranson评分、CT评分、ICU住院日方面差异有显著性（P〈0．05）,多因素Logistic回归分析显示年龄、血糖、感染、APACHEⅡ、Ranson、CT评分与SAP并发ARDS有关。故得出结论,年龄、血糖、感染、APACHEⅡ、Ranson与CT评分是SAP并发ARDS的独立危险因素。     

Zur rückfallprognostischen Bedeutung des Tatverhaltens bei Sexualdelinquenz

The study examined the possibility of predicting sexual recidivism within a period of 5 years in a sample of 612 male sex offenders by means of behavioural crime scene variables. A total of 20 variables were selected based on a significant bivariate correlation with sexual recidivism. Multivariate analysis was conducted to determine combined predictive accuracy. Step-wise reverse logistic regression extracted 12 variables explaining 22% of total variance in sexual recidivism. The unweighted sum score of these variables showed considerable predictive power (AUC?=?0.76; r?=?0.34). Findings were robust not only for different subgroups of sexual offenders, but also when cross-validated on an independent sample. In addition, the unweighted sum score showed significant incremental validity above and beyond common risk measures [Static99, Sexual Violence Risk- (SVR-)20], both in the original and the cross-validation sample. Thus, the potential of crime scene analysis in predicting sexual recidivism has been clearly demonstrated. Future research should provide a more accurate access to psychologically meaningful interpretations of the risk immanent in crime scene actions by adapting risk scales to certain subgroups of perpetrators.     

Parental alcohol consumption and postneonatal mortality

The purpose of this study was to evaluate the role of maternal and paternal alcohol consumption as independent risk factors in postneonatal mortality. Questions on the frequency and quantity of alcoholic drinks consumed were included in a questionnaire used as part of a case-control study. Over a period of 11 months the families of 157 cases and 468 controls, matched for age and locality, were interviewed. Odds ratios and 95% confidence intervals were obtained by matched univariate analysis and by multiple conditional logistic regression. Maternal consumption during pregnancy, maternal consumption during breastfeeding and maternal consumption in the past year were not risk factors for postneonatal mortality. A multiple matched analysis did not alter these results. Matched univariate analysis of paternal alcohol consumption gave several positive results, including variables pertaining to the father's consumption in a multiple logistic regression model with traditional risk factors, which revealed that the frequency of paternal consumption in the last year, as estimated by the mother, was found to have a significant effect on postneonatal mortality.     

Job strain and risk indicators for cardiovascular disease in young female nurses.

This study examined the possible effects of job demands, decision latitude, and job-related social support on risk indicators for cardiovascular disease (CVD) in 165 female nurses. Job strain was measured with the Job Content Questionnaire; CVD risk was measured with insulin, total cholesterol, triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), fibrinogen, tissue-type plasminogen activator (tPA) antigen, tPA activity, plasminogen activator inhibitor-1 antigen, and blood pressure. Multivariate analysis of covariance and regression analyses revealed no effects of either job strain or social support on these risk indicators. All risk indicators deteriorated with age and body mass index. Oral contraceptive use improved fibrinolytic potential and increased HDL-C but had adverse effects on TG levels. Results suggest that in healthy young women job strain is not associated with an unfavorable metabolic or fibrinolytic risk profile.     

Social support in the short- and middle-term prediction of welfare volunteers' permanence

This work explores the significance of different types and sources of social support in the short- and middle-term prediction of volunteer permanence. Volunteers ( N = 1362) belonging to 109 different Spanish organizations were surveyed to gather social support data and other information related to factors traditionally associated with sustained volunteerism prediction. In spite of the fact that a relationship between social support and permanence was found, logistic regression analysis showed that social support variables did not appear to be relevant to make this kind of prediction at short term, because the only factors associated with volunteers' permanence in the multivariate model obtained were the volunteers' previous time in the organization, their intention of remaining in service, and their sex and religious attitudes. In contrast, at middle term, social support and, in particular, informational social support from other volunteers was significant, integrating the multivariate model with the other aforementioned factors, except for sex.     

Risk profiles of adolescent girls who were victims of dating violence

The prevalence of dating violence, as well as its relationship to potential risk factors, was examined among a nationally representative sample of 9th-through 12th-grade U.S. females (N = 7,824) who completed the 1999 Youth Risk Behavior Survey. The dependent variable was physical dating violence; the independent variables were violence, suicide, substance use, and sexual risk behavior. Unadjusted odds ratios (OR) and 95% confidence intervals were examined, and multivariate logistic regression analysis was conducted to identify the most significant risk factors. It was found that nearly one in ten of the adolescent girls reported dating violence. Twelfth-grade girls had the highest prevalence of dating violence. Girls who were victims of dating violence were more likely to be involved in other violent behaviors, to report extreme sadness and suicidal actions, to use illicit substances, and to engage in risky sexual behavior. Multivariate analysis revealed that dating violence was associated with sad/hopeless feelings (OR = 2.13), binge drinking (OR = 1.96), cocaine or inhalant use (OR = 2.90), multiple sex partners (OR = 2.38), nonuse of condoms (OR = 1.53), and ethnicity, specifically being Black (OR = 2.32) or Hispanic (OR = 1.82). These findings provide further evidence that there is a clustering of risk factors among certain adolescents, specifically girls who experience dating violence.     

Improving forensic tribunal decisions: the role of the clinician

Three empirical investigations of forensic decision-making were conducted: a study of 104 hearings by a forensic tribunal; an evaluation of which aspects of forensic patients' clinical presentation were empirical predictors of violence; and a survey of forensic clinicians to determine which factors they said they used to assess risk of violent recidivism and which they actually used. Results showed a significant correlation between actuarial risk and clinical advice to the tribunal, and a nonsignificant trend for patients higher in actuarial risk to receive more restrictive dispositions. Psychotic diagnoses and symptoms were not indicators of increased risk of violent recidivism. Clinicians endorsed some empirically valid indicators of risk, but also relied on some invalid indicators. There was also inconsistency between factors clinicians said they used and factors actually related to their hypothetical decision-making. An automated system is presented as an illustration of how the consistency and validity of forensic decisions could be enhanced.     

德州地区进展性缺血性脑卒中相关危险因素的研究

探讨进展性缺血性脑卒中（SIP）的相关危险因素。选择德州市人民医院1999年～2009年163例SIP患者,首先对18个变量行单因素分析,然后对阳性变量行多因素Logistic逐步回归分析,筛选SIP发生的相关危险因素。高血压史、感染、加拿大卒中量表（CNS）评分、高血糖、TG、纤维蛋白原、脑水肿、颈动脉粥样硬化性狭窄...