Serum testosterone determination in the antiandrogen therapy of sexual deviations with cyproterone acetate (preliminary report of experiences)

Total testosterone concentrations in the serum of patients treated with antiandrogens were measured by means of an industrially produced radioimmunological testosterone assay kit (VEB S?chsisches Serumwerk Dresden). Antiandrogen therapy using cyproterone acetate (Androcur) leads to a reduction in serum testosterone concentration which is significant at the p less than 0.01 level. The data suggest that testosterone concentrations vary inversely with increasing Androcur dosage; they are around 7 nmol/l at the doses conventionally administered. The testosterone concentrations obtained under depot-Androcur treatment suggest that intervals between injections should be less than 10 days.     

Risky economic choices and frontal EEG asymmetry in the context of Reinforcer-Sensitivity-Theory-5

This study investigated individual risky choice behavior in a gambling task and its relation with traits proposed by the Reinforcer-Sensitivity-Theory-5 (RST-5; Corr & McNaughton in Neuroscience and Biobehavioral Reviews, 36(10), 2339–2354, 2012) as well as with frontal EEG asymmetry. As assumed by the RST-5, the results showed independent influences of approach/avoidance and gain/loss sensitivities on participants’ behavior in risky choices. Individual approach/avoidance sensitivity was predicted by trait measures of the behavioral approach system (BAS) and the behavioral inhibition system (BIS), while no such correlation was present for gain/loss sensitivity. EEG recordings revealed relatively stronger left-frontal cortical activity for trials with approach motivation compared to conflict and avoidance motivation. On the individual level, relatively stronger left-frontal cortical activity was associated with trait BAS. In addition, activity changes in frontal EEG asymmetry were associated relatively higher behavioral approach sensitivity. We conclude that frontal EEG asymmetry is an especially useful neuronal marker of BAS sensitivity and that the traits proposed by the RST-5 (measured by frontal EEG asymmetry and self-report) can be used to explain individual differences in risky choice behavior.     

3~4岁幼儿创造性人格与气质的交叉滞后分析

以幼儿创造性人格倾向教师评定问卷、儿童气质教师评定问卷作为研究工具,对287名3岁和4岁组幼儿进行为期一年的追踪研究,考察幼儿气质与创造性人格的发展变化情况,以及幼儿气质与其创造性人格之间的关系。结果发现：随着时间的发展,幼儿气质对其创造性人格有显著影响。幼儿的情绪性、活动性、反应性及专注性均能够显著正向预测其创造性人格,而幼儿的社会抑制性则能够显著负向预测其创造性人格。     

Valproate dosage

Starting from Valproat dosage recommendations and serum levels and patient risk from acute hepatic failure, the results of our therapeutic service are set forth. The question comes up for discussion as to whether the proposal of Mattson et al. of a mean therapeutic blood level of between 40 and 45 micrograms per ml should be aimed at.     

Serum anticonvulsant levels in therapy-resistant epileptics

The continuous occurrence of particularly severe epileptic attacks represent a great stress for the patients. For this reason, we have conducted anticonvulsant blood-level studies particularly in these patients, this paper being based on 146 first determinations. Among the patients, most of whom are adults and are treated with combinations of drugs, only 24 per cent reached the assumed normal phenytoin range while 69 per cent remained below it. With the administration of phenobarbital, however, 50 per cent reached the therapeutic range and only 14 per cent reached the lower limiting value. It is only i the last-mentioned group that we assumed primarily an insufficient intake of the drugs while with DPH the problems of the determination of the plasma water range had to be discussed. In practice, blood level determinations have their special value for the detection of the intake of a wrong dosage of the drugs as well as bland anticonvulsant intoxications.     

Individual differences in the development of sensation seeking and impulsivity during adolescence: further evidence for a dual systems model

Consistent with social neuroscience perspectives on adolescent development, previous cross-sectional research has found diverging mean age-related trends for sensation seeking and impulsivity during adolescence. The present study uses longitudinal data on 7,640 youth from the National Longitudinal Study of Youth Children and Young Adults, a nationally representative sample assessed biennially from 1994 to 2006. Latent growth curve models were used to investigate mean age-related changes in self-reports of impulsivity and sensation seeking from ages 12 to 24 years, as well individual differences in these changes. Three novel findings are reported. First, impulsivity and sensation seeking showed diverging patterns of longitudinal change at the population level. Second, there was substantial person-to-person variation in the magnitudes of developmental change in both impulsivity and sensation seeking, with some teenagers showing rapid changes as they matured and others maintaining relatively constant levels with age. Finally, the correlation between age-related changes in impulsivity and sensation seeking was modest and not significant. Together, these results constitute the first support for the dual systems model of adolescent development to derive from longitudinal behavioral data.     

Food-search behavior and its relation to the central excitatory state in the genetic analysis of the blow fly Phormia regina

Dethier (1957) described an aspect of food-search behavior in Phormia regina as the blow fly dance. A hungry fly walks in relatively straight lines with its proboscis retracted until it encounters food (sucrose). After ingesting even a small amount of sucrose, the fly begins making frequent, tight turns, flexes its front tarsi to bring more chemosensory hairs into contact with the substrate and repeatedly extends and retracts its proboscis. Like the central excitatory state (CES), which causes an increase in proboscis extensions to water when a fly is stimulated with sucrose, the dance lasts longer in hungrier flies or with higher sucrose concentrations. It was considered that dance behavior might be an ethologically relevant manifestation of CES. In order to test this hypothesis, dance duration in lines selected for high- and low-CES levels was measured. As predicted, flies from the high-CES line danced longer than those from the low-CES line, and the CES-dance correlation in individual flies was high. This phenotypic correlation disappeared in the F2 generation of a cross between the high- and low-CES lines, a result indicating that the observed variations in CES and dance duration were not caused by the same set of genes. Further characterization of the underlying genetic system showed that several linked autosomal genes with digenic epistatic interactions and a complex pattern of maternal inheritance were responsible for the difference in dance durations between the high- and low-CES lines.     

Developmental Experiments in Hypnosis

Two-hundred-forty children, including ten boys and girls at each year level from five through sixteen, were selected from the entire public school population of a small city for testing on the Children's Hypnotic Susceptibility Scale. For most of these children, testing was repeated yearly for the next two years. Reliability for the Children's Scale was quite satisfactory for individual prediction. There were absolutely no differences in the hypnotic susceptibility of boys and girls in this sample. Intelligence had only low positive correlations with susceptibility. The correlation of age with susceptibility, measured either cross-sectionally or longitudinally, is positive and significant, but small. Changes in individual performance over time are generally minimal, and hypnotic susceptibility may be considered a relatively stable component of personality structure.     

梅尔美术判断测验在中国应用的信、效度检验

目的:修订梅尔美术判断测验(Meier Art Judgment Test)并对其信度、效度进行检验。方法:通过对来自6所大学、中专共2270人施测梅尔美术判断测验,采用CTT区分度和IRT的模型拟合检验、区分度筛选项目,以霍兰德艺术分测验、学生艺术创作水平自评与艺术过往经历分量表为效标,以及采用效标组法(美术与非美术专业)检验效标关联效度。结果:保留的61题都拟合IRT的2参数logistic模型,量表得分与各效标得分相关显著,美术与非美术专业学生得分存在显著差异; 但测验信息量分析表明,对高能力被试的测量误差相对较大。结论:修订的量表能测量个体的美术判断能力; 今后改进方向应该是增加更难的试题。     

Case report of stuttering acquired in association with phenytoin use for post-head-injury seizures

Previous research indicates that stuttering and deficits in motor performance may be associated with the use of phenytoin (Dilantin). The present report concerns a case of stuttering acquired in association with phenytoin use for post-head-injury seizures. The extent and nature of dysfluencies and the motor performance of speech and nonspeech muscle systems were evaluated over an extended period during which changes in anticonvulsant medication were made. Reductions in dysfluency levels and improved motor performance were observed following a medication change from phenytoin to carbamazepine. Performance on tests assessing nonmotor functions, such as memory and attention, was equivalent before and after the medication change. The apparent association between dysfluency levels, motor performance deficits, and phenytoin suggest that in the present case stuttering resulted in part from a general impairment in motor control.     

Consistency of individual exponents in cross-modal matching

An important question about individual differences in the exponent of the psychophysical power law is how they should be interpreted. The differences may reflect permanent characteristics of individuals, and it has been argued that, if this is so, the range of these differences is so great as to identify the class of data as exceptional among the physical and biological sciences. Cited as evidence of such permanence has been the correlation between individual exponents obtained on two separate occasions. In a previous paper, we showed that increasing the time interval between occasions reduced the correlation to a nonsignificant level; we argued, therefore, that obtained individual differences in exponents, even though large, depended upon the operation of factors only incidentally associated with the particular observer. In a series of new studies of session-to-session correlation between individual exponents, we provide evidence that: (1) our original finding for magnitude estimates of visual size is repeatable, with the correlation dropping to nearly zero after 1 week; (2) when judged line length is matched to brightness, a delay of I week is sufficient to produce a nonsignificant correlation; (3) in contrast, magnitude estimates of loudness yield significant correlations after a week’s delay; (4) but, when moduli are arbitrarily changed between sessions by the experimenter, these correlations for magnitude estimates of loudness drop to a nonsignificant level, even for a zero-delay condition. We conclude that, whereas in some scaling tasks the passage of time alone between sessions is sufficient to disrupt what appears to be the mnemonic basis for session-to-session correlation, in other (less familiar) tasks, more positive interference (in the form of a modulus change) is needed to achieve the same end. The evidence is consistent with the belief that enduring characteristics of the observer contribute only a small portion of the variability in individual power law exponents.     

The role of sociocultural context for culture competence and depressive symptoms among ethnic minority youths in junior high school

The aim of the study was to examine whether school sociocultural context affects culture competence and its relationship to depressive symptoms. As part of the Youth, Culture and Competence study conducted in the Norwegian Institute of Public Health, questionnaire data was collected from 373 immigrant students in two junior high schools within Oslo. The school contexts were represented in terms of proportion of ethnic minority students, 90% versus 60% referred to as the concentrated and balanced context, respectively. Results showed a relatively low level of depressive symptoms and high level of ethnic and host culture competence regardless of context. Ethnic culture competence showed an inverse relationship to depression in both contexts. Host culture competence was also negatively correlated with depression, but only in the balanced context. In the concentrated context this correlation was unsubstantial. Thus, the sociocultural context was found to moderate this correlation.     

化学性免疫调节剂在溃疡性结肠炎中的应用

近年来,免疫调节剂（如硫唑嘌呤、6-巯基嘌呤、甲氨喋呤、环孢素等）已广泛应用于临床中,主要用于治疗激素依赖型或激素无效的溃疡性结肠炎患者,显示有良好的疗效。然而,这些药物的剂量、副作用和长期维持治疗,应根据个人的具体情况适当选择适应证,以达到最佳疗效。     

Stress induces glucocorticoid-mediated apoptosis of rat Leydig cells in vivo

Stress can disrupt endocrine signalling in the male reproductive axis through high concentrations of glucocorticoids, the hallmark of stress. Our previous work revealed that a stress level of exogenous glucocorticoids could induce apoptosis of rat Leydig cells, which are the primary source of testosterone. The aim of this study was to investigate whether stress can induce apoptosis in rat Leydig cells in vivo and, if so, whether the process is the result of a direct effect of glucocorticoids. In a chronically stressed rat model, serum corticosterone concentration was increased significantly whereas serum testosterone was decreased. The frequency of apoptotic Leydig cells in stressed rats was also increased. Adrenalectomised rats subjected to chronic stress showed an elevated serum testosterone, while the apoptotic frequency of Leydig cells was not increased. It was established that glucocorticoid-induced Leydig cell apoptosis is mediated by glucocorticoid receptors (GRs), which translocate from cytoplasm to nucleus. Adenovirus microRNA-induced downregulation of GR expression in vitro alleviated the corticosterone-induced increase in apoptosis of Leydig cells. These results indicate that the stress-induced increase in corticosterone secretion resulted in apoptosis in rat Leydig cells in vivo, and thereby decreased testosterone synthesis.     

Discrete and contextual cue alterations eliminate the instrumental appetitive-to-aversive transfer impairment in phenytoin-treated rats

We have shown previously that the antiepileptic phenytoin impairs transfer in an instrumental learning task (Banks et al., 1999). The present study examined the effects of contextual alterations on appetitive-to-aversive transfer performance of rats treated with either phenytoin or tang. Adult rats were tested in tone-signaled appetitive and aversive instrumental tasks, where the animal bar-pressed to obtain a food reward (sugar pellet) or to avoid shock. Rats were trained on the appetitive task for 31 days. Beginning on the twenty-first day, rats were gavaged with either phenytoin or tang twice daily. Animals were then transferred to aversive training, with the phenytoin or tang treatment continuing throughout the 25 testing days. For some animals, contextual changes were introduced as they shifted from appetitive to aversive training, while for other animals these changes were not made. Phenytoin-treated rats that were presented with changes in context as they transferred from the appetitive to the aversive task learned the avoidance response to levels substantially higher than drug-treated rats not presented with the contextual changes. These results indicate that phenytoin impairs avoidance learning following transfer from the appetitive task, and that this impairment can be eliminated by introducing changes in context at the point of transfer. In the tang-treated control subjects, on the other hand, there was no improvement in transfer learning performance associated with the changes in contextual cues. This pattern of results suggests that contextual encoding processes in rats being trained in an instrumental appetitive-to-aversive paradigm are dramatically affected by phenytoin.     

Differences between diurnal patterns of salivary cortisol and dehydroepiandrosterone in healthy female adolescents

The adrenal hormones cortisol and dehydroepiandrosterone (DHEA) share a common secretagogue: adrenocorticotropic hormone; however, secretion of these hormones can be dissociated suggesting subtle individual regulation at the level of the adrenal gland. We examined differences in the diurnal patterns of cortisol and DHEA secretion in healthy adolescent girls, with the aim of informing the possibility of exploiting these differences to aid interpretation of data from clinical populations in which these patterns can become dysregulated. Fifty-six healthy females aged 10-18 years provided saliva samples at 0 and 30 min (morning samples) and 12 h post-awakening on 2 consecutive weekdays. For morning salivary cortisol in relation to morning DHEA concentrations, correlational analysis revealed only a trend (p = 0.054). Similarly, the association between evening cortisol and DHEA was characterised as a trend (p = 0.084). Mean morning DHEA concentrations showed more day-to-day consistency than equivalent cortisol samples (r = 0.829 for DHEA and 0.468 for cortisol; z = 3.487, p < 0.0005). Unlike the cortisol pattern, characterised by a marked awakening response (cortisol awakening response, CAR), a significant rise in DHEA concentration post-awakening was not evident. Finally, there was a strong association between morning and evening concentrations of DHEA, not found for cortisol. The study shows differences in cortisol and DHEA secretion in the post-awakening period and informs work that seeks to examine correlates of dysregulated hypothalamic-pituitary-adrenal axis function. Parallel examination of both hormones enables enhanced interpretation of aberrant patterns of the CAR, i.e. an exploration of whether dysregulation affects both hormones (reflecting overall steroidogenic capacity) or cortisol alone (CAR-specific mechanisms).     

Discrete and Contextual Cue Alterations Eliminate the Instrumental Appetitive-to-Aversive Transfer Impairment in Phenytoin-Treated Rats

We have shown previously that the antiepileptic phenytoin impairs transfer in an instrumental learning task (Banks et al., 1999). The present study examined the effects of contextual alterations on appetitive-to-aversive transfer performance of rats treated with either phenytoin or tang. Adult rats were tested in tone-signaled appetitive and aversive instrumental tasks, where the animal bar-pressed to obtain a food reward (sugar pellet) or to avoid shock. Rats were trained on the appetitive task for 31 days. Beginning on the twenty-first day, rats were gavaged with either phenytoin or tang twice daily. Animals were then transferred to aversive training, with the phenytoin or tang treatment continuing throughout the 25 testing days. For some animals, contextual changes were introduced as they shifted from appetitive to aversive training, while for other animals these changes were not made. Phenytoin-treated rats that were presented with changes in context as they transferred from the appetitive to the aversive task learned the avoidance response to levels substantially higher than drug-treated rats not presented with the contextual changes. These results indicate that phenytoin impairs avoidance learning following transfer from the appetitive task, and that this impairment can be eliminated by introducing changes in context at the point of transfer. In the tang-treated control subjects, on the other hand, there was no improvement in transfer learning performance associated with the changes in contextual cues. This pattern of results suggests that contextual encoding processes in rats being trained in an instrumental appetitive-to-aversive paradigm are dramatically affected by phenytoin.     

Reactive aggression tracks within‐participant changes in women's salivary testosterone

The relation between testosterone and aggression has been relatively well documented in men, but it is less well understood in women. Here we assessed the relationship between salivary testosterone and reactive aggression (i.e., rejection rate for unfair offers) in the Ultimatum Game. Forty naturally cycling women were tested twice, once in the late follicular phase (around ovulation) and once during the luteal phase. Ovulation was determined using urine test strips measuring luteinizing hormone levels. Salivary samples were assayed for testosterone, estradiol, progesterone, and cortisol at both test sessions. There was no association with the cycle, but multilevel modeling revealed a significant within‐participant association between testosterone and rejection rate for extremely unfair offers (i.e., high reactive aggression), indicating that women showed greater reactive aggression when their testosterone levels were higher. Additionally, we found that women with relatively high individual concentrations of testosterone were more likely to reject extremely unfair offers than women with relatively low concentrations of testosterone. This study is the first to demonstrate that women react more aggressively in response to provocation when their testosterone level is high than when their testosterone is low, suggesting that testosterone plays an important role in the regulation of women's aggressive behavior following social provocation.

     

任职者任务绩效水平对其工作分析结果的影响

在控制了个体人口统计学变量和排除组织水平变量的影响下,探讨了电厂设计和编辑两个职位任职者的任务绩效水平对于他们Occupational Information Network (以下缩写为O*NET)工作分析问卷评价结果的影响。层次回归结果发现,控制了相关因素后,发电厂设计人员的任务绩效水平能显著影响其对技术性技能的水平评价,编辑的任务绩效水平能显著影响信息处理的重要性评价和水平评价,在一定程度上证实了“工作分析结果差异来源于真实差异”的理论     

Individual temporal differences in precompetition anxiety and hormonal concentration

This investigation explored individual differences in hormonal concentration and directional perception of anxiety 24hrs, 2hrs and 1 hr before an important competition. Those who perceived their anxiety level as positive to performance (i.e. facilitators) showed an increase in testosterone concentration as time-to-event approached that contrasted markedly with those who perceived their anxiety intensity as negative to performance (i.e. debilitators). The facilitatory group also exhibited a lower cortisol response 2 hrs and 1 hr, relative to 24 hrs before the event, whilst the response of the debilitatory group was elevated as time-to-event approached. Finally, the facilitatory group evidenced a trend towards rapid elevations in all of the catecholamines, whilst the concentration amongst the debilitatory group remained stable as the event approached. The findings add further substance to the veracity of the directional construct in acting as the important distinguishing variable which accounts for significant individual differences. Additionally it addresses the mechanism by which the relationship between anxiety direction and performance may be brought about. Such underpinning biochemical mechanisms offer one possible yet long awaited explanation to aid our understanding of the pre-event anxiety direction response of competitive individuals.