Possible uses of Convulsofin liquid in the treatment of pediatric epilepsies

The effect of Convulsofin-liquidum on several epilepsies and types of seizure in childhood is described. Typical and atypical absences, tonic-clonic seizures of primary generalised epilepsies as well as atonic or myoclonic seizures are considered to be the main indications for the treatment with Convulsofin. To the special advantage of the application in drops especially with infants is referred.     

The epidemiology of the epilepsies in children

The epilepsies are a heterogeneous collection of neurological conditions and syndromes characterized by recurrent, unprovoked, paroxysmal seizure activity. There are several types of epileptic seizures and syndromes that are unique to children, including infantile spasms, Lennox-Gastaut syndrome and absence seizures. Febrile seizures and neonatal seizures, while not epilepsy, are relatively common types of seizures in infants and children and are likely markers of risk of later epilepsy. Thus, it is important to consider the epidemiological features of the epilepsies as they occur specifically in infants and children. The purpose of this review is to summarize what is currently known about the epidemiology of the childhood epilepsies and to identify promising areas for further population-based studies. The epilepsies are an important cause of neurological morbidity in children. The average annual rate of new cases (incidence) of epilepsy is approximately 5-7 cases per 10,000 children from birth to age 15 years, and in any given year, about 5 of every 1,000 children will have epilepsy. There is evidence that the incidence of the epilepsies in some populations of children may be decreasing over time, and this possibility merits further investigation. Factors that are known to increase risk of the epilepsies in children include congenital malformations of the central nervous system (CNS), moderate or severe head trauma, CNS infections, certain inherited metabolic conditions, and genetic factors. However, these account for only 25% to 45% of cases, and thus, the etiology of most cases of the epilepsies remains obscure. The paucity of well-controlled etiological studies is due largely to formidable methodological problems in conducting epidemiological studies of the epilepsies. The prognosis for seizure control is generally good, although children with remote symptomatic seizures and those with additional neurological disabilities do less well.     

The debt of neuropsychology to the epilepsies.

Both neuropsychology and psychology in general have been enhanced markedly by brain-behavior models derived from the study of the epilepsies. A significant body of neuropsychological concepts originated or were confirmed through epilepsy-based treatment and research. These concepts include the peri-Rolandic homunculus, the role of the hippocampal-temporal lobe complex in cognitive memory, hemisphere plasticity for speech in childhood, the intracarotid amytal procedure for determining hemisphere memory patency, and hemisphere-based models of cognition confirmed through human commissurotomy. Personality and social-emotional research in epilepsy are additional areas in which new conceptual models grounded in psychological science can both repay our debt to the epilepsies and provide much needed psychological research and treatment.     

Evaluation of psychological performance parameters in the use of Finlepsin and Convulsofin

The psychomotorial tempo was investigated in a particular case study of seven patients during the introduction of Convulsofin respectively Finlepsin. For this end the reaction rate was registered at the same moment as the EEG. The valuation of the psychological parameters referred to optimal courses of the introduction. Three months after the beginning of introduction the examined criterions (psychological, clinical, pharmacological, EEG) showed a equally positive tendency. An observation period for the prognosis valuation of at least three months is recommended. Negative deviations can be involved by drugs or by disturbances of the compliance.     

Serotonin in autism and pediatric epilepsies

Serotonergic abnormalities have been reported in both autism and epilepsy. This association may provide insights into underlying mechanisms of these disorders because serotonin plays an important neurotrophic role during brain development--and there is evidence for abnormal cortical development in both autism and some forms of epilepsy. This review explores the hypothesis that an early disturbance in the serotonin system affects cortical development and the development of thalamocortical innervation, and is a potential mechanism, common to autism and pediatric epilepsies associated with cortical dysplasia. An argument is made that cortical malformation leads to abnormalities of thalamocortical connectivity, and that serotonin plays a critical role in this process. Finally, a role for altered metabolism of the serotonin precursur, tryptophan, in both epilepsy and autism is discussed.     

Results of catamnestic studies on the social prognosis of childhood epilepsies

Owing to the progress in pharmakotherapy the individual prognosis of epilepsy is characterized above all by brainorganic or psychoreactive caused disorders of the adaptability. The results of the examination of 153 children are presented, which were stationary treated for epilepsy. The special problems in the family, the school and in the choice of a job are referred.     

The treatment of sleep-maintenance insomnia with stimulus-control techniques

Sleep-maintenance insomniacs received either a stimulus-control (n = 7) or a credible placebo treatment (n = 8), administered in small groups for 4 weeks. Self-reports of time awake after sleep onset, total number of arousals and number of arousals exceeding 10 min were collected at baseline, at termination of treatment (post-treatment), and at a 3-month follow-up. Results showed a statistically- and clinically-significant reduction on all three dependent measures from baseline to post-treatment for both groups; these gains were maintained through the follow-up period. However, the results achieved with stimulus-control procedures were not significantly different from reductions found with a credible placebo condition. These findings compare favorably with other reports of behavioral treatments of both onset and maintenance insomnia.     

The treatment of addiction by aversion conditioning with apomorphine

An account is given of the techniques employed in using apomorphine for the treatment of chronic alcoholism, addiction to other drugs and addiction to cigarette smoking. No evaluation is made here but each technique is illustrated by the report of a case in which the result is considered, after a reasonable follow-up period, to be highly satisfactory.     

The out-patient treatment of patients with an obsessional-compulsive disorder

The results in the treatment of patients with obsessional-compulsive disorders were poor, until Meyer, Rachman, Foa and Emmelkamp developed a strategy which combined exposure and response prevention. Their method is generally applied in a clinical setting, with considerable direct supervision of the patient. A programme that employs the same strategy, but which can be performed in the patient's natural environment, without the need of supervision, is described. A self-control procedure is utilized to assist the patient in carrying out the exposure and response-prevention regime. The results of this outpatient programme do not differ essentially from the results obtained by means of the clinical approach. Advantages of out-patient over clinical treatment are discussed.     

The treatment of muscle tics with dissimilar competing response practice

Prior research has shown that muscle tics can be suppressed by the performance of a competing response contingent on the occurrence of the muscle tics. In an effort to determine whether the topography of the competing response was important to the muscle tic suppressing effects of contingent competing response practice, we evaluated the effects of a competing response that was topographically dissimilar to the muscle tic. Three subjects engaged in dissimilar competing responses contingent on the occurrence of a muscle tic; 2 of these subjects subsequently engaged in similar competing response practice. The results showed a decrease in objective measures of muscle tic frequency with the introduction of dissimilar competing response practice for each subject; subsequent exposure to similar competing response practice for 2 subjects resulted in no additional decrement in the level of muscle tics. These results suggest that the topography of the competing response may not be crucial for the suppression of muscle tics. Discrepancies between the objective measures of muscle tics and self-recorded measures are noted and discussed.     

The treatment of borderline personalities with rational emotive behavior therapy

The rational emotive behavior therapy (REBT) theory holds that individuals with severe personality disorders in general, and borderline personalities in particular usually are biologically different from “normal” neurotics and are born with a predisposition to be highly vulnerable to stressful environmental conditions. They tend to have cognitive, emotional, and behavioral deficits or disabilities that handicap them socially, vocationally, and in other important aspects of their lives. But they also have distinct, and sometimes exceptionally strong, neurotic tendencies to demand that they absolutely must perform well, that other people have to treat them kindly and fairly, and that frustrating conditions ought not exist. Their neurosis exacerbates their cognitive-emotive-behavioral handicaps, produces even greater life difficulties, and often interferes with their working hard at therapy. A summary is presented of how borderline personalities can be treated with rational emotive behavior therapy (REBT).     

The behavioural treatment of obsessional-compulsive disorders, with and without clomipramine

The effects of behavioural treatment alone, and in combination with clomipramine, were assessed on 40 patients with chronic obsessional-compulsive disorders, using a 2 × 2 factorial design. These effects were assessed by behavioural measures and mood measures.The behavioural treatment was followed by significant improvements on most behavioural measures. Clomipramine administration was followed by significant improvements on mood scales and some behavioural measures. There were no significant interactions between these two experimental conditions.     

The effects of varying levels of treatment integrity on child compliance during treatment with a three-step prompting procedure

The effects of three levels of treatment integrity (100%, 50%, and 0%) on child compliance were evaluated in the context of the implementation of a three-step prompting procedure. Two typically developing preschool children participated in the study. After baseline data on compliance to one of three common demands were collected, a therapist implemented the three-step prompting procedure at three different integrity levels. One integrity level was associated with each demand. The effects of the integrity levels were examined using multielement designs. The results indicate that compliance varied according to the level of treatment integrity that was in place.