How to do basic medical research

The following editorial is a reprint of an article inLegacies in the Study of Behavior: The Wisdom and Experience of Many (edited by Joseph Warren Cullen and published by Charles C Thomas (1975) Springfield, Illinois) by Irvine H. Page, born 1901, a graduate of Cornell Medical College, and editor of “Modern Medicine.” The life of Dr. Page has been an enviable one and extremely colorful, reminiscent of the more comprehensive, less technically oriented careers of a bygone era. Beginning as Director of the Chemical Division of the Kaiser Wilhelm Institute in Munich from 1928 to 1931, later Director of the Research Division of the Cleveland Clinic Foundation (1945–1966), he pioneered in the mechanism of arteriosclerosis and hypertension, the isolation of serotonin, and in the research on angiotensin. Having been a successful experimental investigator as well as an eminent clinician, he speaks with a direction and brevity from a long experience. Because of the great value of his counsel, his article is reprinted here with his permission and that of the editor, J. W. Cullen, and the publisher Payne Thomas.

     

Observing ben wyckoff: from basic research to programmed instruction and social issues

L. Benjamin Wyckoff's seminal contributions to both psychological theory and application are the subject of this review. Wyckoff started his academic career as a graduate student at Indiana University, where he developed the observing-response procedure under the guidance of B. F. Skinner and C. J. Burke. At the University of Wisconsin-Madison, Wyckoff refined his mathematical theory of secondary reinforcement. This theory was the impetus for his creation of an electronic simulation of a rat running a T maze, one of the first "computer models" of learning. Wyckoff next went to Emory University, leaving there to help create two of the most successful companies dedicated to the advancement of programmed instruction and teaching machines: Teaching Machines, Inc. and the Human Development Institute. Wyckoff's involvement in these companies epitomizes the application of basic behavior-analytic principles in the development of technology to improve education and human relationships. The emergent picture of Wyckoff is that of a man who, through his research, professional work in educational applications of behavioral principles, and active involvement in the civil rights movement of the 1960s, was strongly committed to applying behavioral science to positively influence human behavior change.     

Smoking research: basic research, intervention, prevention, and new trends

Smoking is a behavior that is influenced by a variety of factors that cut across methodologies, disciplines, and content areas within health psychology. The present article is designed to show the diversity and richness of smoking research by examining smoking from four perspective: basic laboratory research, intervention, prevention and deterrence, and new directions in smoking research. Methodologies that were derived from such varied sources as psychopharmacology, behavioral pharmacology, behavior therapy, clinical psychology, public health and health promotion, and social and developmental psychology have been used to study the smoking problem. The subject populations in these investigations ranged from animal models, to the individual smoker attempting to quit, to communities involved in health promotion and public health approaches. Future research should seek to provide new and improved examples of interdisciplinary research within the field of health psychology to multidisciplinary approaches from the basic and applied sciences.     

Observational assessment systems use for basic and applied research

Three observational assessment systems, the Time-Sample Behavioral Checklist, the Staff-Resident Interaction Chronograph, and the Clinical Frequencies Recording System, are shown to have remarkable utility for a wide range of basic and applied research questions. The assessment systems have already been employed to measure independent and dependent variables in a number of treatment outcome and staff training studies and as measures in more basic studies of environmental history effects for chronic mental patients. Current and planned investigations employing the observational measures are outlined. These include psychometric studies of the instruments themselves, investigations of various parameters of ongoing treatment programs, and empirical validations of proposed nosological diagnostic schemas. Finally, several metamethodological issues germaine to observational assessment, in general, are noted, including the observation vs. interpretation debate and the role of precise observational measurement in applied research contexts.The research reported in this article was supported, in part, by Public Health Service Grants MH-15553 and MH-25464 from the National Institute of Mental Health, and by grants from The Joyce Foundation, Illinois Department of Mental Health and Developmental Disabilities, and the Purdue Research Foundation.Based on a paper presented at the 87th Annual Meeting of the American Psychological Association, New York City, September 1979, as part of a symposium New Assessment systems for residential treatment, management, research, and evaluation.     

Autism: from research to practice

Autism is the most commonly studied of a spectrum of developmental disorders that are believed to be neurobiologically based but which, at this point, for lack of good biomarkers, are defined purely by behavior. In the last 20 years, the definition of autism has shifted in emphasis from extreme aloofness and positive signs of abnormality in repetitive and sensorimotor behaviors to a greater awareness of the importance of more subtle reciprocal social communication deficits as core features. Standard diagnostic instruments were developed for research purposes to acquire information both through caregiver interviews and direct clinical observation. Use of these instruments in clinical practice resulted in major improvements, which in turn affected research results. These results yielded further improvements that led to changes in clinical practice over time. The synergism between research and clinical practice in the understanding of autism is discussed.     

The right to withdraw from research

The right to withdraw from participation in research is recognized in virtually all national and international guidelines for research on human subjects. It is therefore surprising that there has been little justification for that right in the literature. We argue that the right to withdraw should protect research participants from information imbalance, inability to hedge, inherent uncertainty, and untoward bodily invasion, and it serves to bolster public trust in the research enterprise. Although this argument is not radical, it provides a useful way to determine how the right should be applied in various cases.     

To a young basic scientist, about to embark on a program of translational research

From recent commentaries about the role of basic behavior scientists in translational research, I distill some advice to young investigators who seek to apply their basic science training to translational studies. Among the challenges are (a) devising use-inspired research programs that complement, and are not redundant with, existing efforts in basic and applied behavior analysis; and (b) making tactical decisions, such as the selection of methods and collaborators, based on the research topic rather than, necessarily, the existing traditions in behavioral research. Finally, it must be recognized that although use-inspired basic research has the potential to attract support to basic laboratories and contribute to "saving the world," neither of these outcomes is guaranteed. I discuss the relative risks for basic scientists who proceed with use-inspired basic research rather than ignore such translational questions.     

A year of unprecedented progress in Down syndrome basic research

The years 2006 and 2007 saw the publication of three new and different approaches to prevention or amelioration of Down syndrome effects on the brain and cognition. We describe the animal model systems that were critical to this progress, review these independent breakthrough studies, and discuss the implications for therapeutic approaches suggested by each.     

Modifying law enforcement training simulators for use in basic research

Several approaches to using simulation as a method for teaching good judgment in the use of firearms by law enforcement officers and military personnel were investigated for their potential applications to research: the GAMMA Live Fire Video Training System, the FireArms Training Systems Simulator (FATS), and the Judgment Under Stress Training (JUST) simulator. Each instrument uses real-time, computer-controlled, life-sized projected video images of scenarios that may or may not present a threat, and handguns that fire real or simulated ammunition. The subjects respond to a sequence of “shoot/no-shoot” judgment scenarios resulting in data on judgment, reaction time, and accuracy. The JUST simulator was found to be more easily modifiable in capturing data on performance at microanalytic levels. Although true interactive simulations are not feasible with this system, this was not seen as a hindrance to its usefulness for research.     

Immersive virtual environment technology as a basic research tool in psychology

Immersive virtual environment (IVE) technology has great promise as a tool for basic experimental research in psychology. IVE technology gives participants the experience of being surrounded by the computer-synthesized environment. We begin with a discussion of the various devices needed to implement immersive virtual environments, including object manipulation and social interaction. We review the benefits and drawbacks associated with virtual environment technology, in comparison with more conventional ways of doing basic experimental research. We then consider a variety of examples of research using IVE technology in the areas of perception, spatial cognition, and social interaction.     

从宗教学基本理论谈基督教绘画

任何宗教为使其教理、教义能更广泛地传播与发展,一方面尽可能通俗化,另一方面尽可能艺术化.因此宗教绘画艺术的表现题材涉及到宗教生活、世俗生活异常广泛的各个领域和不同层面.超自然物是人的本质的对象化,又是人的本质的异化或圣化,同时又是宗教信仰的核心,自然也是基督教绘画表现的核心.     

Temporal discounting: basic research and the analysis of socially important behavior

Recent basic research on human temporal discounting is reviewed to illustrate procedures, summarize key findings, and draw parallels with both nonhuman animal research and conceptual writings on self-control. Lessons derived from this research are then applied to the challenge of analyzing socially important behaviors such as drug abuse, eating and exercise, and impulsiveness associated with attention deficit hyperactivity disorder. Attending to the broader temporal context in which behavior occurs may aid in the analysis of socially important behavior. Applying this perspective to the study of behavior in natural environments also highlights the importance of combining methodological flexibility with conceptual rigor to promote the extension of applied behavior analysis to a broader array of socially important behaviors.