Cooling core body temperature may slow down neurodegeneration

Reduction of core body temperature has been proposed to contribute to the increased lifespan and the anti-aging effects conferred by caloric restriction in mice and higher primates. Cooler biologically compatible core body temperatures have also been hypothesized to combat neurodegenerative disorders. Yet, validation of these hypotheses has been difficult until recently, when it demonstrated that transgenic mice engineered to have chronic low core body temperature have longer lifespan independent of alteration in diet or caloric restriction. This article reviews the literature and highlights the potential influence of core body temperature's governing role on aging and in the pathophysiology of neurodegenerative disorders in humans. What makes recent findings more significant for humans is the existence of several methods to lower and maintain low core body temperatures in human subjects. The therapeutic potential of "cooler people" may also raise the possibility that this could reverse the adverse-health consequences of elevations in core body temperature.     

Cooling blocks ITM and LTM formation and preserves memory

In Lymnaea aerial respiratory behaviour can be operantly conditioned; snails learn not to perform this behaviour. Depending on the training procedure used, snails are competent to form either intermediate-term (ITM; lasting 1-3 h) or long-term (LTM; >4 h) memory. We found that cooling the snails for 1 h immediately after training was sufficient to block either ITM or LTM. Cooling snails for a similar period 10 or 15 min after cessation of training, failed to block ITM and LTM formation, respectively. Finally, we employed the cooling technique to extend both ITM and LTM. That is, cooling could prevent forgetting. Cooling extended LTM that normally persisted for 2 days to at least 8 days. These data are consistent with the hypothesis that forgetting is due to the learning and remembering of interfering events, and thus is an active process.     

Religion,reason and non-directive teaching: a reply to Trevor Cooling

In other work I have argued that decisions about what to teach directively and what non-directively should be governed by an epistemic criterion. Trevor Cooling has recently advanced some objections to my defence and application of the epistemic criterion and proposed an alternative to it. Here I reply to his objections and comment on his proposed alternative.     

Cooling the heat of temptation: Mental self‐control and the automatic evaluation of tempting stimuli

The present research investigated whether mental self‐control strategies can reduce the automatic positivity elicited by tempting stimuli. In two studies employing chocolate as the temptation of interest, we found that participants instructed to imagine a chocolate product in a nonconsummatory manner exhibited significantly less automatic positivity with regard to the product as compared to participants instructed to imagine the hedonic, consummatory aspects of the product and control participants engaged in a neutral task. These findings were replicated in a second study. Additionally, in Study 2 we found that automatic evaluations of chocolate were lowest for participants instructed to form implementation intentions to refrain from consumption. Taken together, these findings demonstrate that mental self‐control strategies such as nonconsummatory transformation and implementation intentions extend to the level of automatic processing by reducing the positivity of automatically activated affective responses. Copyright © 2009 John Wiley & Sons, Ltd.