Rescuing human embryonic stem cell research: the Blastocyst Transfer Method

Despite the therapeutic potential of human embryonic stem (HES) cells, many people believe that HES cell research should be banned. The reason is that the present method of extracting HES cells involves the destruction of the embryo, which for many is the beginning of a person. This paper examines a number of compromise solutions such as parthenogenesis, the use of defective embryos, genetically creating a "pseudo embryo" that can never form a placenta, and determining embryo death, and argues that none of these proposals are likely to satisfy embryoists, that is, those who regard the embryo as a person. This paper then proposes a method of extracting HES cells, what might be called the Blastocyst Transfer Method, that meets the ethical requirements of embryoists, and it considers some possible concerns regarding this method. It concludes by encouraging future HES cell research to investigate this method.     

EMBRYONIC PERSONHOOD,HUMAN NATURE,AND RATIONAL ENSOULMENT

This essay briefly describes a few of the problems associated with using personhood language to defend the right to life of the pre‐implantation embryo. Arguing that an immaterial soul explains the personal identity of an embryo is problematic for many people because there is no apparent spiritual activity in the unborn. While some scholars argue that the embryo has the potential to act as an adult person and thus should be protected from harm, others contend that potentiality alone is insufficient reason to ascribe special moral worth to the embryo in utero. For Thomas Aquinas, the soul is not only the life‐principle that organizes the human body, but it is also that by which the human being thinks and wills. By making suitable corrections to Aristotle's hylomorphic depiction of the soul–body relation, I suggest that a rational soul must be present from the moment of conception and that it is at the service of the (embryonic) person. What is of critical importance here is to accept that a human being is present from the moment of conception, something the vast majority of embryologists maintain, notwithstanding the inveiglement of those who state that the pre‐implantation blastocyst is simply a disorganized clump of cells.     

Are human embryos Kantian persons?: Kantian considerations in favor of embryonic stem cell research

One argument used by detractors of human embryonic stem cell research (hESCR) invokes Kant's formula of humanity, which proscribes treating persons solely as a means to an end, rather than as ends in themselves. According to Fuat S. Oduncu, for example, adhering to this imperative entails that human embryos should not be disaggregated to obtain pluripotent stem cells for hESCR. Given that human embryos are Kantian persons from the time of their conception, killing them to obtain their cells for research fails to treat them as ends in themselves. This argument assumes two points that are rather contentious given a Kantian framework. First, the argument assumes that when Kant maintains that humanity must be treated as an end in itself, he means to argue that all members of the species Homo sapiens must be treated as ends in themselves; that is, that Kant regards personhood as co-extensive with belonging to the species Homo sapiens. Second, the argument assumes that the event of conception is causally responsible for the genesis of a Kantian person and that, therefore, an embryo is a Kantian person from the time of its conception. In this paper, I will present challenges against these two assumptions by engaging in an exegetical study of some of Kant's works. First, I will illustrate that Kant did not use the term "humanity" to denote a biological species, but rather the capacity to set ends according to reason. Second, I will illustrate that it is difficult given a Kantian framework to denote conception (indeed any biological event) as causally responsible for the creation of a person. Kant ascribed to a dualistic view of human agency, and personhood, according to him, was derived from the supersensible capacity for reason. To argue that a Kantian person is generated due to the event of conception ignores Kant's insistence in various aspects of his work that it is not possible to understand the generation of a person qua a physical operation. Finally, I will end the paper by drawing from Allen Wood's work in Kantian philosophy in order to generate an argument in favor of hESCR.     

Persons and Affordances

Abstract

Interdisciplinary interest in affordances is increasing. This paper is a philosophical contribution. The question is: Do persons offer affordances? Analysis of the concepts ‘person’ and ‘affordance’ supports an affirmative answer. On a widely accepted understanding of what persons are, persons exhibit many of the features typical of socionormative affordances. However, to understand persons as offering affordances requires, on the face of it, stretching traditional understandings of the concept of affordance: persons, in contrast to the organisms that partially constitute persons, do not seem to be available to perception. This and similar worries are responded to.     

The Potentiality of the Embryo and the Somatic Cell

Recent arguments on the ethics of stem cell research have taken a novel approach to the question of the moral status of the embryo. One influential argument focuses on a property that the embryo is said to possess—namely, the property of being an entity with a rational nature or, less controversially, an entity that has the potential to acquire a rational nature—and claims that this property is also possessed by a somatic cell. Since nobody seriously thinks that we have a duty to preserve the countless such cells we wash off our body every day in the shower, the argument is intended as a reductio ad absurdum of the claim that the embryo should be afforded the same moral status as a fully developed human being. This article argues that this argument is not successful and that it consequently plays into the hands of those who oppose embryonic stem cell research. It is therefore better to abandon this argument and focus instead on the different argument that potentiality, as such, is not a sufficient ground for the creation of moral obligations towards the embryo.     

到底路有多长--对干细胞移植治疗研究的一点思考

目前干细胞研究的争论主要集中于干细胞研究的过程和方式,诸如干细胞来源以及被提取干细胞的胚胎的权利与地位等伦理问题是争论的焦点所在,而对于研究的最终目的是治病而非克隆人则少有争议.然而在伦理问题等争论相对较小的干细胞应用研究领域,就应用于人的技术层面而言还有很多问题有待解决.安全性(safety)和有效性(efficacy)原则是目前公认的干细胞临床应用研究的基准.干细胞移植治疗最终应用于临床可能还有相当一段路程要走,无论是研究者还是伦理学家以及社会舆论和普通百姓在其中都应当并可以发挥积极的作用.     

On Persons and Immortality Symposium on Pedro Tabensky,Happiness: Personhood,Community, Purpose

Abstract

This paper considers Tabensky’s method of critical introspection, and in particular the conception of personhood that informs it. By interrogating the lives of pure hedonism, divinity and immortality from our already existing conception of personhood, Tabensky argues that such lives are incompatible with what it is to be a person, and desiring to live them is therefore irrational. Concentrating on the example of immortality, I argue that, while there are undoubtedly disadvantages associated with the immortal life, these are contingent rather than essential to the notion of being a person. In fact, we have very little idea of the boundaries of that concept. The paper concludes by looking at the consequences of Tabensky’s approach for issues surrounding moral vision and improvement, and new technologies of the person.     

The Getting and Losing Wisdom

SUMMARY

The role of aging and culture in the attainment of wisdom is examined m this chapter. The concept of wisdom m industrialised societies is briefly explored. It is argued that both biology and culture can be positive or negative factors m the capacity of a person to be “wise.” It is concluded that, for many, the negative impact of biological factors of aging are overwhelming, but, for a few, aging enriches their insight.     

The acceptability of prophylactic mastectomy among lay people and health professionals: A pilot study

IntroductionWomen with certain genetic mutations have a risk of up to 85% of developing breast cancer. Bilateral prophylactic mastectomy is the most effective way to reduce risk of cancer.ObjectiveThis pilot study focuses on the acceptability of prophylactic breast surgery and examines, in a series of concrete cases, the cognitive processes by which health professionals and lay people make their judgments. This research also aims to identify the factors involved in these judgments. An additional objective is to determine whether there are groups with different patterns of responses.MethodWe recruited two samples in France, one comprising 90 lay people and the other 30 health professionals (n = 120) and asked them how acceptable it would be for a woman at a high risk of breast cancer to undergo a prophylactic surgery (mastectomy), in each of the 64 scenarios presented to them. The scenarios were all combinations of two levels of age, of marital status, of parenting status, of body appearance investment, of reconstructive surgery and also two levels of the person suggesting oncogenetic diagnosis.ResultsWe found that lay people and health professionals structured the factors in the scenarios in nearly the same way. They assigned importance to three factors: the most important one was reconstructive surgery, and then the age of the woman. The least important factor was the person who requested the genetic test. Furthermore, the age of the participants, and knowing a person who had cancer impacted the degree of acceptability assigned by participants. Being a lay person or a health professional did not have a direct impact on acceptability but influenced the integration of factors. In addition, cluster analysis showed that only a small group was opposed to mastectomy.ConclusionThis pilot study demonstrated that three factors have to be considered when judging the acceptability of prophylactic mastectomy and showed a common cognitive foundation for future discussion, at the levels of both clinical care and health policy, of the conditions under which prophylactic surgery might be acceptable.     

The Mystery of Edwin Drood: a case study in creativity theories / El Misterio de Edwin Drood: estudio de un caso en las teorías de la creatividad

Abstract

This article analyses the Broadway musical The Mystery of Edwin Drood, by Rupert Holmes, as a case study through which to discuss and highlight modern creativity theories. The musical is viewed through the lens of the Five As, Four Cs, and many other person and product approaches.     

Rethinking covert stuttering

PurposeThe experience of passing as fluent, also called covert stuttering, has been uncritically framed as an inherently negative pursuit. Historically passing has been understood as a repression of one’s true, authentic self in response to either psychological distress or social discrimination. The authors of this paper seek a more nuanced understanding of passing. We ask, how must a person relate to herself in order to pass as fluent?MethodologyThis is a qualitative research study in which the authors utilized the ethical theories of philosopher Michel Foucault to contextualize data obtained from semi-structured interviews with nine participants who pass as fluent.ResultsRather than a repression of an authentic self our data suggests passing is more usefully understood as a form of resistance by people who stutter to a hostile society. Participants learned from experiences of delegitimization that their stuttering had ethical ramifications. Consequently, they used a variety of self-forming practices to pass and thereby achieve the privileges that come with perceived able-bodiedness.ConclusionPassing as fluent is not an inauthentic form of stuttering but a form of stuttering that is produced through the use of specific technologies of communication. These technologies of communication are constituted by the unique ethical relationship of the person who stutters with herself. Passing can be understood as an active form of resistance rather than a passive form of repression. By theorizing passing as fluent as an ethical relationship, we open up the possibility of changing the relationship and performing it differently.     

The relationship between personality traits and psychotic like experiences in a large non-clinical adolescent sample

ObjectiveThe relationship between personality and psychosis is well established. It has been suggested that this relationship may be partly accounted for by higher levels of depression in individuals with certain personality traits. We explored whether the link between personality and psychotic symptoms is already apparent in adolescence, and if this association would still hold when depression was controlled for.Method654 secondary school students were surveyed via self-report questionnaires measuring the Five-Factor model of personality (NEO-FFI), depression (CES-D) and psychotic-like experiences (CAPE).ResultsPositive associations were found between Neuroticism and all CAPE-subscales except Magical Thinking, which was in turn associated with all other personality traits when at high levels. Agreeableness was negatively associated with all CAPE-subscales, while Openness to Experience was only positively associated with Persecutory Ideas and Magical Thinking. After controlling for depression, many of the significant associations remained.ConclusionOur findings suggest that the chance of having psychotic like experiences is more likely for adolescents with certain personality traits. These associations are not fully explained by depression, especially when psychotic experiences are at higher levels. Future research is needed to investigate if these personality traits might put a person at risk for the development of full-blown psychosis.     

Information search activity: An overview

IntroductionThis article exposes a brief history of information search models, from general and behavioural models to cognitive ones and presents recent theoretical advances in this research field.Literature findingsSince the beginning of 1990s, many theoretical models have tried to describe and predict the human behaviours involved in the information search tasks, and specifically when this activity is performed in computer systems. Some of these models elaborated by psychologists have attempted to infer the cognitive processes involved.DiscussionInformation search can be considered as a complex cognitive activity that involves various individual (cognitive, affective), contextual and social factors.ConclusionWe also suggest research issues to be developed in order to increase our knowledge in this area and we plead for further research on specific concepts depending on future and/or recent areas of interest.     

Someplace in Mind

This paper is a meditation on the interpenetration of mental and physical, particularly architectural, place. Its premise is that the relationship between person and place is transitional, ever in flux, person continually defining place into a continuous reality, and reality perpetually placing person. Further, this interchange occurs against the backdrop of an inconceivable void whereby the very terms of the interchange can be nullified. Such a void is unconscious and outside in the sense that it is outside what can be known. The matter of opening the inside to the outside becomes an endeavor shared by psychoanalysis and by architecture, notably sacred architecture. The exchange between inside and outside is considered using as examples the body, Freud's office, Disneyland, and the cathedral. Implications are extrapolated as to the provisional nature of the self.     

From gaze cueing to perspective taking: Revisiting the claim that we automatically compute where or what other people are looking at

ABSTRACT

Two paradigms have shown that people automatically compute what or where another person is looking at. In the visual perspective-taking paradigm, participants judge how many objects they see; whereas, in the gaze cueing paradigm, participants identify a target. Unlike in the former task, in the latter task, the influence of what or where the other person is looking at is only observed when the other person is presented alone before the task-relevant objects. We show that this discrepancy across the two paradigms is not due to differences in visual settings (Experiment 1) or available time to extract the directional information (Experiment 2), but that it is caused by how attention is deployed in response to task instructions (Experiment 3). Thus, the mere presence of another person in the field of view is not sufficient to compute where/what that person is looking at, which qualifies the claimed automaticity of such computations.     

Walking through doorways causes forgetting: active and passive interaction

ABSTRACT

The current study explored the location updating effect when people passively interacted with an environment. This was assessed experimentally by having one person actively navigate through a virtual environment while picking up and putting objects down. A second person passively viewed the movement. Both participants responded to memory probes for objects they encountered. Probes appeared when the active participant moved halfway across a room or immediately after moving into a new room. Consistent with previous research, a location updating effect was found. That is, memory was worse following a shift to a new room. This effect was found for both active and passive participants but was smaller for the passive group. Thus, the shift from one event to another causes information to be harder to remember, reinforcing the importance of event cognition in memory. However, the more involved a person is in the interactive event, the more pronounced the effects.     

Depression and Spirituality in Australian Aged Care Homes

SUMMARY

A national survey of Australian aged care homes has found that between 40% and 60% of high care residents and 25% to 51 % of low care residents are depressed, depending on the method used to assess depression. While this survey did not specifically include items on spirituality, an analysis based the Geriatric Depression Scale question “Do you feel that your life is empty?” provides some insights into the type of person who may benefit from spiritual help.

The view is expressed that those committed to the provision of spiritual care must be more assertive in making the positive contribution to the reduction in depression that empirical research carried out over the last thirty years suggests is possible. The basic step of identifying those who are ready to talk about spiritual matters and who are depressed is offered as a starting point and some ways of doing this are described.     

Within lab familiarity through ambient images alone

ABSTRACT

This study examines the limits of image variability, commonly referred to as Ambient Images, in face learning. To measure face learning, the authors used the face sorting paradigm from Jenkins et al. [(2011). Variability in photos of the same face. Cognition, 121(3), 313–323]. Before completing the face sorting task, participants viewed either 5, 15, or 45 ambient images of an unfamiliar person’s face. The authors aimed to observe whether there is an incremental benefit of ambient images and whether studying many ambient images could predict perfect performance. The results revealed that performance greatly improved from a low to medium exposure group; however, performance plateaued after viewing 15 ambient images. In addition, participants who viewed 45 images did not always achieve perfect performance. Results of this study also found that time data can serve as a quantitative measure of familiarity. The authors concluded that future research must extend past ambient images to fully understand the process of familiarity.     

Stem cell research: an ethical evaluation of policy options

In February 2004, South Korean researchers became the first in the world to successfully harvest stem cells and establish a stem cell line from a cloned human embryo. This is just one of eight possible policy options concerning human embryonic stem cell research. In practice, every kind of stem cell research can be done in one country or another. This paper evaluates the eight policy options concerning human embryonic stem cell research in light of the arguments and decisions behind them.     

Control of the Mind Edited by Seymour M. Farber and Roger H. L. Wilson

Abstract

This article describes an innovative model of couples therapy designed to mitigate marital instability. The authors suggest that combining ongoing couples therapy with a separate relationship-focused group for each partner favorably impacts each person’s neuropsychophysiological regulation and their ability to participate in a stable intimate marriage.

The neurobiology of attachment theory is seen as providing understanding of the affect regulation issues operational in many couple relationships. The safe and secure attachments worked out in the relationship-focused group therapy are seen as improving neuropsychophysiological integration and regulation.