Tuberculosis detection by giant african pouched rats

In recent years, operant discrimination training procedures have been used to teach giant African pouched rats to detect tuberculosis (TB) in human sputum samples. This article summarizes how the rats are trained and used operationally, as well as their performance in studies published to date. Available data suggest that pouched rats, which can evaluate many samples quickly, are sufficiently accurate in detecting TB to merit further investigation as a diagnostic tool.     

Active tuberculosis detection by pouched rats in 2014: More than 2,000 new patients found in two countries

Tuberculosis (TB) is a major problem in poor countries because sensitive diagnostic tools are unavailable. In 2014, our pouched rats evaluated sputum from 21,600 Tanzanians and 9,048 Mozambicans whose sputum had previously been evaluated by microscopy, the standard diagnostic for TB. Evaluation by the rats revealed 1,412 new patients with active TB in Tanzania and 645 new patients in Mozambique, increases of 39% and 53%, respectively, when compared to detections by microscopy alone. These results provide further support for the applied use of scent‐detecting rats.     

A meta-analysis of the relationship between anxiety and telomere length

Background and objectives: Telomeres are protective caps at the ends of chromosomes, and shorter telomeres are associated with poor physical health. The present study set out to consolidate the varying effect sizes found so far in studies of anxiety and telomere length.

Design and methods: A meta-analytic investigation of the relationship between anxiety and telomere length used information from 17 different samples comprising a total of 19,424 participants.

Results: The results showed a small but significant association, r?=??.06, between higher anxiety and shorter telomeres. Studies comparing individuals diagnosed with an anxiety disorder with other individuals had a significant effect size, and studies that did not use this comparison threshold did not have a significant effect size.

Conclusions: Anxiety is associated with an important biomarker related to health. Future experimental studies that examine the impact of interventions intended to reduce anxiety in conjunction with measurement of telomere length can further clarify the impact of anxiety on telomere length.     

Degeneracy of the local structure renormalizing infinite time and space

A model for a system consisting of elements which detect the measurement apparatus of other elements is proposed. By any apparatus one can observe locally, however it can refer to non‐local property because apparatus itself is indefinite. In taking this aspect into consideration, I formulate expressions for a local interaction referring to non‐local property. This formalization can satisfy the aspect of what is called, internal measurement. This system shows teleological global motion toward criticality which is relevant to the degeneracy of a specific element featuring D ? Hom(Z), E) by which infinite time and space are renormalized.     

Risk of bias in trial-based economic evaluations: Identification of sources and bias-reducing strategies

Objective: The objectives of this article are first to give an overview of the risks of bias in trial-based economic evaluations and, second, to identify how key sources for bias can be revealed and overcome (i.e. what bias-reducing strategies might be employed) in future trial-based economic evaluations in the field of health psychology.

Design: Narrative review discussing sources of bias in trial-based economic evaluations and bias-reducing strategies.

Results: We identified 11 biases and assigned them to a particular trial phase. A distinction is made between pre-trial biases, biases during the trial and biases that are relevant after the actual trial. All potential forms of bias are discussed in detail and strategies are shown to detect and overcome these biases.

Conclusion: In order to avoid bias in trial-based economic evaluations, one has to be aware of all the possible forms of bias. All stakeholders have to examine trial-based economic evaluations in a rigorous and stringent manner. This article can be helpful in this examination as it gives an overview of the possible biases which researchers should take into account.     

The experiences and understandings of obesity: Families’ decisions to attend a childhood obesity intervention

Objectives: This study investigated the families’ experiences of a childhood obesity intervention and sought to understand factors that influence attendance and lifestyle behaviours.

Design: Eleven semi-structured interviews were conducted and analysed using Interpretative Phenomenological Analysis.

Results: Four themes emerged highlighting the differences and similarities between attendees and non-attendees perceptions of childhood obesity, perceptions of the intervention, practical barriers and overcoming hurdles to attending and, availability and suitability of local facilities.

Conclusions: The findings relate to identity and health communication. For some families attending an obesity intervention may challenge social and individual identities, which may have an impact on subsequent behavioural decisions. Those who attend the obesity intervention may experience a shift in identity, which may or may not initially be perceived as a positive outcome. Public Health and those involved in treatment interventions should aim to bridge the gap between people’s in-group identities and those associated with particular lifestyle behaviours. In order to be effective, services must meet the needs of their clients and address any preconceived negative perceptions by carefully considering how health information is presented, how it is understood and most importantly how identity may affect motivation to engage in, and sustain, new behaviours.     

2006年沈阳市胸科医院肺结核住院患者痰抗酸杆菌涂片结果分析

回顾性分析了2006年3月至2006年12月沈阳市胸科医院确诊为肺结核3644例住院患者的临床资料。评价我院痰涂阳性的住院患者的性别比率及临床意义。共有痰涂阳性住院病例207例,痰涂阳性病人男女性别比例为3．31：1。痰菌涂阳病例对性别的比值比为1．67（95％的可信限为1．20～2．33）,男性和女性痰菌阳性结果比较差异有统计学意义（Χ^2=9．48,P〈0．01）。提示我院痰涂阳性住院患者存在有明显的性别差异。     

Panning for the gold in health research: Incorporating studies’ methodological quality in meta-analysis

Background: Systematic reviews now routinely assess methodological quality to gauge the validity of the included studies and of the synthesis as a whole. Although trends from higher quality studies should be clearer, it is uncertain how often meta-analyses incorporate methodological quality in models of study results either as predictors, or, more interestingly, in interactions with theoretical moderators.

Objective and methods: We survey 200 meta-analyses in three health promotion domains to examine when and how meta-analyses incorporate methodological quality.

Results: Although methodological quality assessments commonly appear in contemporary meta-analyses (usually as scales), they are rarely incorporated in analyses, and still more rarely analysed in interaction with theoretical determinants of the success of health promotions. The few meta-analyses (2.5%) that did include such an interaction analysis showed that moderator results remained significant in higher quality studies or were present only among higher quality studies. We describe how to model quality interactively with theoretically derived moderators and discuss strengths and weaknesses of this approach and in relation to current meta-analytic practice.

Conclusions: In large literatures exhibiting heterogeneous effects, meta-analyses can incorporate methodological quality and generate conclusions that enable greater confidence not only about the substantive phenomenon but also about the role that methodological quality itself plays.     

A Comparative Study of Groups of High and Low Intelligence in Learning a Maze

In accordance with the determination of base-line heart rate and running in an activity wheel, 14 Long-Evans male rats were given ten 30 minute sessions of Immobile-Avoid conditioning followed by 30 minute sessions of Active-Avoid conditioning. Control Ss were yoked to the experimental Ss.

Experimental Ss made significantly fewer responses in the immobile-avoid period and significantly more responses in the active-avoid period than did the yoked control Ss. Heart rate was correlated with skeletal activity both for experimental and control Ss. For experimental Ss, low heart rate was concomitant with a low amount of activity in the immobile-avoid period and high heart rate was concomitant with greater skeletal activity in the active-avoid period.

These results support the position that heart rate is secondary to responses of the somatic-motor system and that heart rate during immobile-avoid or active avoid conditioning is more closely related to the level of somatic-motor activity than to the emotional stress which purportedly motivates instrumental avoidance behavior.     

Double trouble: restrained eaters do not eat less and feel worse

Objective: While high levels of dietary restraint do not appear to reflect actual caloric restraint, it has been found to be a risk factor for a wide array of maladaptive eating patterns. These findings raise the question what, if not caloric restriction, dietary restraint entails. We propose that the very finding that restrained eaters do not eat less than they intend to do can provide an answer. Based on this disparity between the intention to restrain oneself and actual behaviour, we therefore hypothesised that high levels of restraint are associated with eating-related guilt.

Method: Three studies (N?=?148) using unobtrusive measures of food intake; different restraint scales; and different measures of guilt tested whether restraint is related to eating-related guilt.

Results: Results indicated that restraint was not associated with food intake, but instead was associated with increased levels of guilt after eating. Guilt was explicitly related to food intake. Moreover, the observed guilt could not be attributed to a general increase in negative affect.

Conclusion: The results of these studies suggest that restraint is not an indicator of actual restricted food intake, but rather a reflection concerns about food and eating manifested in eating-related guilt.     

Goal-setting in diabetes self-management: A systematic review and meta-analysis examining content and effectiveness of goal-setting interventions

Background: Goal-setting is recommended and widely used within diabetes self-management programmes. However, empirical evidence around its effectiveness lacks clarity. This review aims to evaluate the effectiveness of goal-setting interventions on diabetes outcomes and to determine which behaviour change techniques (BCTs) are frequently used within these interventions.

Methods: A systematic search identified 14 studies, describing 12 interventions targeting diabetic-control which incorporated goal-setting as the main intervention strategy. Study characteristics, outcome measures and effect sizes of the included studies were extracted and checked by two authors. The BCT taxonomy v1 was used to identify intervention content. Meta-analyses were conducted to assess intervention effects on the primary outcome of average blood glucose levels (HbA1c) and on body-weight. Psycho-social and behavioural outcomes were summarised in narrative syntheses.

Results: Significant post-intervention improvements in HbA1C were found (?.22, 95% CI, ?.40, ?.04) across studies. No other main effects were identified. The BCT ‘goal-setting (behaviour)’ was most frequently implemented and was identified in 84% of the interventions.

Conclusions: Goal-setting interventions appear to be associated with reduced HbA1C levels. However, the low numbers of studies identified and the risk biases across studies suggest more research is needed to further explore goal-setting BCTs in diabetes self-management.     

Self-regulation and protective health behaviour: How regulatory focus and anticipated regret are related to vaccination decisions

Objective: We examined how individual motivational orientations and anticipated regret are related to the protective health decision of vaccination behaviour.

Design: The proposed relations were examined in a large-scale sample (N = 3168) and three medium-sized samples (N = 151, N = 194, N = 208). Questionnaires were applied to assess regulatory focus, anticipated regret and vaccination behaviour.

Results: Increased prevention-focused self-regulation – which is represented by concerns about security-related goals, responsibilities and obligations – was related to a greater likelihood of vaccination. Prevention-focused individuals’ higher likelihood of getting vaccinated seems at least in part to be a consequence of anticipated regret for not vaccinating. Study 3 suggests that regulatory focus is less related to vaccination decisions when regret is increased by the decision-making context; that is, when information highlighting vaccination effectiveness and a low likelihood of adverse responses is provided.

Conclusion: Prevention-focused self-regulation is related to a greater likelihood of engaging in health-protective behaviour. This can be explained by prevention-focused individuals’ greater tendency to anticipate regret about getting ill as a consequence of not adopting protective measures. If people perceive a protective measure such as a vaccination as highly effective, anticipated regret for not adopting it is generally increased, and individual differences in regulatory focus no longer predict the decision.     

Experimental Power for Indirect Effects in Group-randomized Studies with Group-level Mediators

Mediation analyses have provided a critical platform to assess the validity of theories of action across a wide range of disciplines. Despite widespread interest and development in these analyses, literature guiding the design of mediation studies has been largely unavailable. Like studies focused on the detection of a total or main effect, an important design consideration is the statistical power to detect indirect effects if they exist. Understanding the sensitivity to detect indirect effects is exceptionally important because it directly influences the scale of data collection and ultimately governs the types of evidence group-randomized studies can bring to bear on theories of action. However, unlike studies concerned with the detection of total effects, literature has not established power formulas for detecting multilevel indirect effects in group-randomized designs. In this study, we develop closed-form expressions to estimate the variance of and the power to detect indirect effects in group-randomized studies with a group-level mediator using two-level linear models (i.e., 2-2-1 mediation). The results suggest that when carefully planned, group-randomized designs may frequently be well positioned to detect mediation effects with typical sample sizes. The resulting power formulas are implemented in the R package PowerUpR and the PowerUp!-Mediator software (causalevaluation.org).     

Postnatal exposure to methyl mercury and neuropsychological development in 7-year-old urban inner-city children exposed to lead in the United States

Background: The most common route for general population exposure to methyl mercury (MeHg) is fish consumption. Recommendations to pregnant women about consuming fish contaminated with MeHg are also applied to children, but there are few studies available about the effects of low-level postnatal MeHg exposure in them.

Objectives: To investigate the association between postnatal methyl mercury exposure and neuropsychological development in a study of children also exposed to lead, both measured at 7 years.

Methods: We measured MeHg concentrations in blood samples from the Treatment of Lead-Exposed Children (TLC) trial in which 780 children with elevated concentrations of lead in blood were followed with neuropsychological tests from ages 12–33 months through 7 years. Here we examine blood MeHg concentration and neuropsychological test scores, both measured at age 7 years. We used a maximum likelihood method to estimate geometric mean MeHg concentration and generalized linear regression models to analyze MeHg and neuropsychological test scores.

Results: Geometric mean MeHg concentration was 0.56 (95% confidence interval: 0.52, 0.59) μg/L. A 1 μg/L increase in MeHg was associated with a 2.1 (95% confidence interval: 0.4, 3.8) point increase in Full-Scale IQ and 0.2 (95% confidence interval: 0.02, 0.4) point increase in Learning Slopeindex T-score on a test of verbal memory.

Conclusions: Our results suggest that the relatively low MeHg exposure in US school-aged children from this population has no detectable adverse effect on neuropsychological development. The positive associations observed between MeHg and neurodevelopment may indirectly reflect consumption of beneficial polyunsaturated fatty acids from seafood.     

Psychological intervention with couples coping with breast cancer: A systematic review

Objective: Information about psychological intervention with couples coping with breast cancer is not well-disseminated. This can be explained, at least in part, by the absence of knowledge about the efficacy of this kind of intervention. The aim of the present systematic review is to identify and describe psychological interventions for couples coping with breast cancer and evaluate their efficacy.

Design: Studies identified by a searching multiple literature databases related to health and psychology between 1975 and 2013. Rigorous inclusion and exclusion criteria were utilised.

Results: Of 129 abstracts, 13 were extracted for further analysis and a final ten studies were deemed eligible for inclusion. Data were extracted from each study regarding study sample characteristics, design, results and methodological limitations. The results obtained were mixed in regard to efficacy, although the overwhelming majority of studies (eight studies) found benefits for both women and their partners in some dimensions, such as quality of life, psychological distress, relationship functioning and physical symptoms associated with cancer.

Conclusion: Psychological interventions for couples coping with breast cancer appear to be effective for both women and their partners. However, further studies are needed to evaluate the efficacy of couple-based interventions and, to identify for whom and how they are more effective.     

Neural Synchrony and the Causal Efficacy of Consciousness

The purpose of this paper is to address a well-known dilemma for physicalism. If mental properties are type identical to physical properties, then their causal efficacy is secure, but at the cost of ruling out mentality in creatures very different to ourselves. On the other hand, if mental properties are multiply realizable, then all kinds of creatures can instantiate them, but then they seem to be causally redundant. The causal exclusion problem depends on the widely held principle that realized properties inherit their causal powers from their realizers. While this principle holds for functional realization, it fails on a broader notion of realization that permits the realization of complex qualitative properties such as spatial and temporal patterns. Such properties are best seen as dependent powerful qualities, which have their causal roles in virtue of being the qualities they are, and do not inherit powers from their realizers. Recent studies have identified one such property—neural synchrony—as a correlate of consciousness. If synchrony is also partially constitutive of consciousness, then phenomenal properties are both multiply realizable and causally novel. I outline a version of representationalism about consciousness on which this constitution claim holds.

     

Initial responses to the first dose of nicotine in novel smokers: The role of exposure to environmental smoking and genetic predisposition

Background: Sensitivity to initial smoking constitutes an early predictor of the risk of dependence. We investigated the role of exposure to smoking (by parents, siblings, and peers) and reward-related candidate gene polymorphisms (OPRM1 A118G, DRD2 TaqlA and DRD4?bp VNTR) in adolescents’ responses to initial smoking.

Methods: We used cross-sectional survey data and saliva samples from 171 Dutch students who had never inhaled on a cigarette (mean age: 13.9?years). The outcome measure was adolescents’ self-reported responses to initial smoking.

Results: Exposure to peer smoking was associated with increased liking (OR?=?1.74, CI?=?1.13–2.70) and more pleasant sensations (β?=?.21, p?=?.01). Exposure to maternal smoking was associated with less unpleasant sensations (β?=??.20, p?=?.01). Adolescents carrying the G-variant of the OPRM1 A118G polymorphism were more likely to report liking (OR?=?2.50, CI?=?1.09–5.73) and adolescents homozygous for the C-variant of the DRD2 TaqlA polymorphism reported less unpleasant sensations (β?=?.18, p?=?.04).

Conclusion: Although preliminary, these findings suggest that exposure to environmental smoking and polymorphisms in the OPRM1 and DRD2 gene may affect initial sensitivity to nicotine, an early phenotype of the risk of dependence. In the future, collaborative efforts to combine data from multiple studies in meta-analyses are needed to improve accuracy of estimated effects in genetic studies.     

Ideological analytics: A study of evolving world values

This study analyses ideologies in a comparative perspective. It does so by treating ideologies as normative mental systems interacting with environmental physical realities and following their evolution in the contemporary world. As a result, it exemplifies a systematic method of undertaking a diagnosis, anagnosis, and prognosis of the global ideological situation.

The study introduces a relevance tree reflecting the conceptual framework of ideological analytics. On this basis, it presents three levels of generality which contain the outline of a substantive analysis. The examples given therein illustrate the model and could serve as prototypes for more detailed studies.

Finally, the study draws the main conclusions from the above generalizations by identifying the dialectical process of ideological dynamics. This process together with the non‐linear development of social systems produce the macrohistorical cycles of world evolution. Thus, the proposed hypothesis of dialectichaos can contribute to a better understanding oïideosocial change.     

Religion and Prejudice Toward Immigrants and Refugees: A Meta-Analytic Review

ABSTRACT

Religion is often a driving force in negative attitudes; however, in the specific case of migrant-based attitudes, research has produced conflicting findings. That is, religion can paradoxically facilitate either tolerance or intolerance toward this group. In light of these inconsistent findings, we conducted a meta-analytic review to estimate the effect size of this relationship with two major aims—first, to explore differences as a function of how religion was operationalised, and second, to explore differences in the target migrant-type (e.g., differences in religion-based attitudes toward immigrants and refugees/asylum seekers). Our search strategy was applied to PsycINFO, EBSCO Psychology and Behavioural Sciences Collection, Web of Science, PsycEXTRA, and ProQuest Central for peer-reviewed English language studies and made calls for unpublished data through relevant professional bodies. This search strategy yielded 37 records (including 43 studies; N = 472,688). Religion was quantified in two ways: either as categorical religious affiliations (k = 60) or as individual differences in self-reported religiosity (k = 30). The meta-analyses revealed that religion quantified as affiliation, but not religiosity, was related to negative migrant attitudes. Specifically, religiously affiliated samples report more negative attitudes than nonreligious affiliated samples, and this effect was often stronger when the target groups were refugees rather than immigrants. In addition, analyses revealed that Muslims have more negative attitudes toward migrants than Christians. Religiosity was unrelated to negative attitudes. These findings are discussed in light of rising antimigrant attitudes.     

Comparing score tests and other local dependence diagnostics for the graded response model

Score tests for identifying locally dependent item pairs have been proposed for binary item response models. In this article, both the bifactor and the threshold shift score tests are generalized to the graded response model. For the bifactor test, the generalization is straightforward; it adds one secondary dimension associated only with one pair of items. For the threshold shift test, however, multiple generalizations are possible: in particular, conditional, uniform, and linear shift tests are discussed in this article. Simulation studies show that all of the score tests have accurate Type I error rates given large enough samples, although their small‐sample behaviour is not as good as that of Pearson's Χ² and M₂ as proposed in other studies for the purpose of local dependence (LD) detection. All score tests have the highest power to detect the LD which is consistent with their parametric form, and in this case they are uniformly more powerful than Χ² and M₂; even wrongly specified score tests are more powerful than Χ² and M₂ in most conditions. An example using empirical data is provided for illustration.