A signal detection theory analysis of gap detection in the rat

An innocuous sensory event (a prestimulus) briefly preceding a startle-eliciting stimulus (SES) reduces the amplitude of the elicited reflex. This study used signal detection theory (SDT) techniques to quantify the effects of gaps (pauses in otherwise continuous noise) on the rat’s acoustic startle reflex. Sixteen rats were given four identical test sessions consisting of the randomized presentation of 150 trials of the SES alone and 150 trials of a gap-and-SES combination. Gap duration (1, 2, 4, and 8 msec) varied between sessions. Data analyses based on amplitude, difference scores, percentage scores, and SDT techniques identified similar patterns. The three longest gaps, but not the shortest, were reliably detected, and differences among these three were identified with percentage and SDT analyses. Analyses of amplitude changes over test sessions yielded different patterns for each measure. The results demonstrate that an SDT analysis is a sensitive index of prestimulus effects.     

Modification of the rat's acoustic startle response by antecedent visual stimulation.

Male hooded and albino rats were exposed to a light flash followed at various temporal intervals by a startle-eliciting 117 db. (re 20 muN/m2) burst of white noise. The visual stimulus engendered startle response inhibition (maximally when the lead time was 64-250 msec) as well as startle response latency reduction (maximally when the lead time was 2-8 msec). The temporal functions for the effects of visual stimuli paralleled those previously reported for startle modification by acoustic events. Further study revealed that, given optimal lead times, inhibition is produced reliably by weaker visual stimuli (3 X 10-6 cd-sec/cm2) than latency reduction (3 X 10-4 cd-sec/cm2). This differential sensitivity to visual stimuli is also analogous to previously reported findings for events in the acoustic environment. It reveals that the neural mechanisms that mediate latency reduction and inhibition can be engaged by either acoustic or visual stimulation.     

Reaction time to the second of two shortly spaced auditory signals both varying in intensity

Six subjects participated in a reaction time (RT) task in which the stimulus events consisted of two sinusoidal waves presented in close succession. The leading stimulus (S₁) had a duration of 25 msec while the binary reaction stimulus (S₂) was 250 msec. Presentation of the interstimulus interval (ISI) was irregular. S₁ as well as S₂ varied in intensity and were assigned randomly the values of 45, 68, 85 and 105 db (SPL). RT to S₂ was examined as a function of the intensity of both stimuli. Generally RT varied inversely with the intensity of S₁ and the downward gradient of RT with ISI became steepened at least for ISIs shorter than 200–250 msec. Concerning S₂, RT grew shorter as the intensity increased up to 85 db. Probably due to startle, RT tended to lengthen at S₂ = 105 db. When both S₁ and S₂ were 105 db the startle effect upon RT seemed most evident. Then the elevation in RT took place at especially those ISIs for which he fastest RTs might have been expected (about 200 msec). For the remaining intensities no interaction between S₁ and S₂ upon RT was found even for the shortest ISIs, implying that the effects of S₁ and S₂ intensities upon RT were independent.     

Prepulse effects on magnitude estimation of startle-eliciting stimuli and startle responses

The present studies investigated the relationship between prepulse effects on the modification of the brainstem startle reflex and magnitude estimates of startle-eliciting stimuli. In Experiment 1, startle eyeblink responses were elicited in 24 students, half of whom were instructed to estimate the loudness of the startle stimulus (actual intensities of 80, 90, and 100 dB) and half of whom were instructed to estimate the magnitude of their eyeblink. When weak acoustic prepulses preceded the startle-eliciting stimulus, eyeblink amplitude was inhibited, and estimates of response magnitude decreased, but estimates of startle stimulus magnitude decreased only when 100-dB startle stimuli were presented. In Experiment 2, the same startle stimuli were preceded on some trials by a vibrotactile prepulse to the hand. In conditions in which startle amplitude was inhibited, startle stimulus magnitude estimates were not affected. This suggests that the effect of acoustic prepulses on 100-dB startle stimuli in Experiment 1 may have been due to loudness assimilation, an effect independent of the prepulse inhibition of startle responding.     

Slow potential changes and choice reaction time as a function of interstimulus interval

Slow potential changes were recorded over the vertex (C_z) during a choice reaction task. The constant interstimulus interval (ISI) between the visual warning (S₁) and the visual imperative signal (S₂) was either 200, 400, 1000 or 2000 msec. The contingent negative variation (CNV) was not only measured between S₁ and S₂ (CNV₂), but also before S₁ (CNV₁).The main results were: (1) The CNV₂ amplitude showed significant variation as a function of ISI. It reached its maximum with an ISI of 1000 msec. (2) CNV₁ developed only before the short ISIs (200 and 400 msec). (3) When CNV₁ and CNV₂ were summed the differences in CNV amplitudes and durations between different ISIs became smaller. (4) The peak-to-peak amplitude P₁-N₁ of the potential evoked by S₁ was enhanced with short ISIs. (5) The correlations between mean CNV and median reaction time (RT) were low but significant for ISIs of 400, 1000 and 2000 msec. When, however, the effect of subjects was partialized out these correlations were drastically reduced, whereas the partialization of session and block effects had no noticeable influence on these correlations. (6) The correlations between single RT and single CNV (measured for the ISI of 1000 msec, individually for two subjects) were weak or even completely lacking.The main conclusion was that CNV coincides with preparedness to react to a stimulus in a choice RT-task, but its amplitude at the moment of onset of the imperative stimulus does not reflect, or reflects weakly, the degree of preparedness (as indicated by RTs) at that moment.     

Strategic and automatic threat processing in chronic musculoskeletal pain: a startle probe investigation

Attentional bias research with chronic pain samples has yielded conflicting results. In the present investigation the startle paradigm was used to test the postulate that fear-based mechanisms play an important role in attentional biases for pain-related threat in chronic pain. Participants, including 31 individuals with chronic musculoskeletal pain and 20 healthy controls, completed a startle task designed to measure attention to different types of words (neutral vs sensory pain vs affective pain vs health catastrophe) presented at different levels of cognitive processing (strategic vs automatic). Measures of fear-based individual difference variables, including anxiety sensitivity and fear of pain, were also completed. Startle amplitudes and latencies to acoustic startle probes that followed word presentations were recorded. Data were analyzed with repeated measures ANOVAs and correlational analysis. Significant between-group differences were found indicating that, relative to chronic pain participants, healthy controls had higher startle amplitude index scores for health catastrophe words. There was also a trend among patients with chronic pain for greater startle amplitude index scores for strategic presentations of sensory pain words. In the automatic condition, all participants demonstrated a lower startle latency index for sensory words relative to both affect and health catastrophe words, suggesting participants had more difficulty disengaging from affect and health catastrophe words or were more avoidant of sensory words. Correlational analyses indicated that startle response indices for words related to health catastrophe became more pronounced for chronic pain patients as anxiety sensitivity and fear of pain increased. Implications and directions for future research are discussed.     

Set and temporal integration

An experiment was conducted to explore the temporal structure of set formation in a complex reaction time (RT) task. On each trial an instruction [I-event] was given telling Ss whether identity of color or form on a separately presented alternative display (A-event) was the dimension relevant on that trial. The A-event consisted of a pattern of four colored forms. The two forms on one side were matched for color and on the other side for form. S’s task was to depress one of two keys. The correct key was homolateral to the matched relevant dimension. The basic independent variable was the time interval separating the I- and A-events (ISI). At short ISIs, RT wasa linear function oflSI with slope equal to -0.5. RT was independent of the order in which the events occurred at short ISIs, although at longer ISIs (3 sec) RT was longer when the A-event followed the I-event. Also, RT was shorter at short ISIs when color was the relevant dimension rather than form. although this difference disappearedat longer ISIs. The results were discussed in relation to information processing models and previous research dealing with partialadvance information.     

Strategic and Automatic Threat Processing in Chronic Musculoskeletal Pain: A Startle Probe Investigation

Attentional bias research with chronic pain samples has yielded conflicting results. In the present investigation the startle paradigm was used to test the postulate that fear‐based mechanisms play an important role in attentional biases for pain‐related threat in chronic pain. Participants, including 31 individuals with chronic musculoskeletal pain and 20 healthy controls, completed a startle task designed to measure attention to different types of words (neutral vs sensory pain vs affective pain vs health catastrophe) presented at different levels of cognitive processing (strategic vs automatic). Measures of fear‐based individual difference variables, including anxiety sensitivity and fear of pain, were also completed. Startle amplitudes and latencies to acoustic startle probes that followed word presentations were recorded. Data were analyzed with repeated measures ANOVAs and correlational analysis. Significant between‐group differences were found indicating that, relative to chronic pain participants, healthy controls had higher startle amplitude index scores for health catastrophe words. There was also a trend among patients with chronic pain for greater startle amplitude index scores for strategic presentations of sensory pain words. In the automatic condition, all participants demonstrated a lower startle latency index for sensory words relative to both affect and health catastrophe words, suggesting participants had more difficulty disengaging from affect and health catastrophe words or were more avoidant of sensory words. Correlational analyses indicated that startle response indices for words related to health catastrophe became more pronounced for chronic pain patients as anxiety sensitivity and fear of pain increased. Implications and directions for future research are discussed.     

元音范畴知觉中特征分析和整合的时间进程

采用启动范式,在三个实验中通过操纵启动音和目标音的频谱相似度和时间间隔,考察了汉语听者元音范畴知觉中特征分析和整合的时间进程。结果发现随着启动音（从纯音、复合音到目标元音本身）和目标元音频谱相似度的增加,启动效应延续的时间越来越长。实验结果支持语音范畴知觉存在早期的声学特征分析和整合到后期的范畴知觉阶段,并为这些加工阶段的时间进程提供了初步的证据。     

如何建立聊天机器人与用户间的数字治疗联盟：关系线索的作用

近年来,研究者们将“治疗联盟”(Therapeutic Alliance,TA)的概念与在线自助干预(Internet-based Self-help Interventions,ISIs)相结合,以解决ISIs中用户参与度较低的问题。这种在数字环境中形成的TA,被称之为“数字治疗联盟”(Digital Therapeutic Alliance, DTA)。随着人工智能的迅速发展,聊天机器人可模拟人类指导,相对于传统ISIs程序更易于与用户建立关系,可通过友好、尊重、倾听、鼓励、真诚、理解、信任这几个关系线索来促进DTA的发展,为解决用户低参与度的问题提供了一种新思路。未来的研究可从影响因素、ISIs技术迭代、测量规范、实验操纵等方面对DTA作进一步的探索。     

Inhibition of return to color: A replication and nonextension of Law, Pratt, and Abrams (1995)

We presented subjects with an unpredictive cue that was followed after a 150- to 900-msec interstimulus interval (ISI) by a detection target. Cue and target were blue or red squares that appeared at fixation and in an otherwise uniform black field. In a filler condition, a task-irrelevant filler stimulus (magenta square) was presented during the ISI; in a no-filler condition, no stimulus appeared during the ISI. Using only a 900-msec ISI, Law, Pratt, and Abrams (1995) reported slower reaction times (RTs) when cue and target were the same color, but only when the task-irrelevant filler was presented during the ISI. They argued that attention is first drawn to the cue color and that inhibition of return (IOR; see Posner & Cohen, 1984) is established when attention is drawn away from that cue color representation by the task-irrelevant filler. Critical to their view is the assumption that IOR occurs only after attention is drawn away from the cue color by the filler. Assuming a time course for the withdrawal of attention from the cue color representation, Law et al. ’s view predicts growth of the inhibitory effect as a function of ISI in the filler condition as well as facilitation at early ISIs in the no-filler condition (because there is no filler to withdraw attention from the cue color). Contrary to these predictions, we found that the inhibitory effect observed by Law et al. at the 900-msec ISI was present at—and did not vary in magnitude across—the range of ISIs tested. And there was never facilitation in the no-filler condition. These results challenge Law et al. ’s inference that IOR for foveally presented colors was operating in their paradigm.     

Acoustic startle in maltreated children

We investigated the eyeblink component of acoustic startle reactions in maltreated children. Previous research indicates that acoustic startle is enhanced in adult males with posttraumatic stress disorders (PTSD) whereas findings on women with PTSD have been inconsistent. In accord with the only previous report for children with PTSD, we found that maltreated boys, particularly those who had been physically abused, responded to increases in startle probe loudness with smaller increments in amplitude of startle eyeblink and smaller reductions in blink latency than did comparison boys. Results for girls were inconsistent: younger maltreated girls had smaller startle amplitude and slower onset latency than controls, whereas older maltreated girls exhibited the opposite pattern.     

Effects of stimulus variability on perception and representation of spoken words in memory

A series of experiments was conducted to investigate the effects of stimulus variability on the memory representations for spoken words. A serial recall task was used to study the effects of changes in speaking rate, talker variability, and overall amplitude on the initial encoding, rehearsal, and recall of lists of spoken words. Interstimulus interval (ISI) was manipulated to determine the time course and nature of processing. The results indicated that at short ISIs, variations in both talker and speaking rate imposed a processing cost that was reflected in poorer serial recall for the primacy portion of word lists. At longer ISIs, however, variation in talker characteristics resulted in improved recall in initial list positions, whereas variation in speaking rate had no effect on recall performance. Amplitude variability had no effect on serial recall across all ISIs. Taken together, these results suggest that encoding of stimulus dimensions such as talker characteristics, speaking rate, and overall amplitude may be the result of distinct perceptual operations. The effects of these sources of stimulus variability in speech are discussed with regard to perceptual saliency, processing demands, and memory representation for spoken words.     

The psychological refractory period and vertex evoked potentials

The averaged sensory evoked potential (EP) was recorded from the scalp (vertex to mastoid) in a psychological refractory period experiment in which 12 young adults participated. Reaction times (RTs) were measured to either both or only the second of pairs of stimuli, in different trial blocks, with inter-stimulus intervals (ISIs) of 100, 200, 300 and 400 msec occurring in random sequence. EPs were recorded at each ISI. No latency changes could be found in the prominent non-specific components (P1-N1-P2) of the EP to stimulus 2 even at ISIs where the RT was substantially delayed. Thus the notions that the RT2 delay is due to occupation of a single channel central processor by S1 and that non-specific EP components reflect the time course of information processing in underlying neural tissue, do not lend each other mutual support. Furthermore, as profound amplitude refractoriness in components P1-N1 and N1-P2 persisted at ISIs where RT was as fast or faster than simple RT, there appears to be a dissociation between “psychological refractoriness” and “physiological refractoriness”. The implications of these results are discussed.     

Spare the rod and spoil the icon

Short-term visual storage was investigated with a successive field paradigm, so that correct performance depended upon combining visual information from two targets that were never on simultaneously. In the first two experiments, the stimuli consisted of two slides, each containing a 10' red dot on a gray surround, and separated by an interstimulus interval (ISI) from 20 to 400 msec. Subjects had to determine if the dots were vertically or horizontally aligned. In Experiment 1, the stimuli had either no contrast for the rods or no luminance contrast for the cones or high contrast. At short ISIs the cone contrast determined performance, whereas at long ISIs the rod contrast determined performance. In fact, when the dots were invisible to the rods, the task was impossible for long ISIs. In Experiment 2, performance was compared for zero log rod contrast and for small departures from zero. Even a small departure from zero log rod contrast resulted in above-chance performance. In Experiment 3, the stimuli were luminous rectangles and the task was to decide whether or not a 4' spatial gap was present between the two successively presented rectangles. Wavelength, luminance, and ISI were varied under both photopic and scotopic adapting conditions. The result was that the rods performed the task for ISIs of 150 msec or longer under scotopic conditions and under the photopic conditions that we were able to test. The results of the experiments taken together are consistent with the hypothesis that the cone icon is short, whereas the rod icon is robust and long lasting.     

Task-load manipulation in the Symbol Digit Modalities Test: An alternative measure of information processing speed

ObjectiveTo evaluate the utility of an oral fMRI-adapted version of the Symbol Digit Modalities Test (SDMT) to assess information processing speed (IPS) using three different interstimulus intervals (ISI).MethodsNineteen right-handed healthy controls performed the adapted version of the SDMT, consisting of a block design that had a total of 6 control/activation block pairs with 3 different ISIs (1.5, 2 and 2.5 s) presented in two different runs: in ascending and descending orders. The brain activation patterns during different ISIs were assessed by effective functional connectivity analysis based on independent component analysis.ResultsAs expected, all conditions yielded activations in the fronto-parietal networks (FPNs) related to attention processes. Shorter ISIs (1.5 and 2 s) not only yielded greater patterns of connectivity within fronto-parietal and occipital regions such as the FPN and fronto-occipital network (FON), but also recruited more functional networks overall. Task performance at the shortest ISI was negatively correlated with connectivity at the FPN and activity of the pre-supplementary motor area extending to the cingulate gyrus.ConclusionIncreasing IPS demands due to shorter ISIs resulted in an increased level and number of functional networks required, increased connectivity within the FPN and FON, and enhancement of the prefrontal cortex. IPS does not arise from activity of a single b area but from affective information transfer among distant cortical regions of the frontal and parietal cortices. This adapted version of the SDMT may be useful for studying alterations of IPS in clinical and nonclinical populations.     

Nonselective read-out from iconic memory in normal, borderline and retarded adolescents

The hypothesis that retarded individuals read-out information from iconic memory at a slower rate, relative to their CA matched peers, was tested. Three IQ groups (normal, borderline and retarded) were selected with 10 subjects in each group. A tachistoscope presented a stimulus array and a post-stimulus cue for 100 msec. each, separated by a variable interstimulus interval (ISI). This stimulus array consisted of 10 letters arranged on two horizontal rows. The post-stimulus cue was a circle which surrounded the position of the correct letter. Nine ISIs were used and ranged from −100 (cue before array) to 500 msec. A 3 × 9 repeated-measures analysis of variance revealed non-significant effects for IQ and the IQ × ISI interaction. A significant effect was found for ISIs (p < .01) which reflected reduced performance at the intermediate ISIs for all intelligence groups. The hypothesis of a read-out deficit in the retarded was not supported. The present findings were discussed in relation to previous research which supported a read-out deficit in the retarded.     

Inhibition of acoustic startle using different mechanoreceptive channels

In this experiment, we investigated the impact of vibrotactile prepulse frequency and intensity on the acoustically elicited startle response in humans. Mechanoreceptive channels differing in their sensitivity to transient stimulation have been identified in the skin. The Pacinian channel is optimally sensitive to vibrations at approximately 300 Hz and is specialized for the detection of stimulus transients, whereas the non-Pacinian I and III channels are optimally sensitive to vibrations at approximately 30 Hz. Vibrotactile prepulses with frequencies of 30 and 300 Hz and intensities of 95 and 130 mV were presented for 50 msec to the dominant hand of college students (N = 31), followed on some trials by a 95-dB broadband acoustic startle stimulus. The 300-Hz prepulses resulted in significantly more pronounced inhibition of startle magnitude, amplitude, and probability, whereas only the 30-Hz prepulses significantly facilitated blink latency. These results support the idea that the inhibition of acoustic startle is determined more by transient than by sustained aspects of vibrotactile prepulse stimuli. This study also demonstrates that different aspects of the startle response differentially reflect stimulus characteristics of the prepulse.     

Cardiac modulation of startle: Effects on eye blink and higher cognitive processing

Cardiac cycle time has been shown to affect pre-attentive brainstem startle processes, such as the magnitude of acoustically evoked reflexive startle eye blinks. These effects were attributed to baro-afferent feedback mechanisms. However, it remains unclear whether cardiac cycle time plays a role in higher startle-related cognitive processes, as well. Twenty-five volunteers responded first by ’fast as possible’ button pushes (reaction time, RT), and second, rated perceived intensity of 60 acoustic startle stimuli (85, 95, or 105 dB; 50 ms duration; binaural; instantaneous rise time), which were presented either 230 or 530 ms after the R-wave, and eye blink responses were measured by EMG. RT was divided into evaluation and motor response time according to previous research. Increasing stimulus intensity enhanced startle eye blink, intensity ratings, and RT components. Eye blinks and intensity judgments were lower when startle was elicited at a latency of R + 230 ms, but RT components were differentially affected: the evaluative component was attenuated, and the motor component was accelerated when stimuli were presented 230 ms after the R-wave. We conclude that the cardiac cycle affects the attentive processing of acoustic startle stimuli.     

Effects of time-order, interstimulus interval, and feedback in duration discrimination of noise bursts in the 50- and 1000-ms ranges

Participants compared durations of paired white-noise bursts, with interstimulus interval (ISI) 100, 300, 900, or 2700 ms, presented in the order standard (St)-comparison (Co) or Co-St. St was 50 or 1000 ms, and 75% difference thresholds for "longer" and "shorter" judgments were estimated. In Experiment 1 feedback was given; in Experiment 2, with ISIs 900 and 2700 ms, there was no feedback. For St=1000 ms, the just noticeable difference (JND) in noise duration was generally smaller with the order St-Co than with Co-St; for St=50 ms, the JND relation was the opposite. JNDs increased with shorter ISIs. Time-order errors were positive for St=50 ms and negative for St=1000 ms, and approached zero for longer ISIs. Using Hellstr?m's sensation-weighting (SW) model, the ratio of the stimulus weights for the first and second burst was estimated; this ratio was generally >1 for St=50 ms and <1 for St=1000 ms. JNDs were smaller with feedback than without; the greatest reduction was found for St=1000 ms and an ISI of 2700 ms with the order Co-St, possibly because feedback increased participants' attention to the first stimulus. These results demonstrate the sensitivity of discrimination measures for long as well as brief durations to the factors of ISI, presentation order, and feedback. They also suggest different modes of stimulus processing for short and long durations.