The Legacy of Adolf Meyer''s Comparative Approach: Worcester Rats and the Strange Birth of the Animal Model

The breeding of albino rats had an enormous impact on experimental psychology in the twentieth century. Rats were, and for many questions still remain, the "standard animal" for laboratory research in neurology, psychology, and physiology. Albert Meyer was one of the figures most responsible for developing the albino rat as an experimental model. Despite Meyer's pioneering work with albino rats, his rat research has received only sparse attention. Little is known about the way in which the animal served Meyer's more famous psychiatric program. In this article, the author discusses the role that albino rats played in Meyer's animal research. He then turn to the contrast between the way in which Meyer viewed the animal's role in research and the way rats were later used as a laboratory "standard" to assure scientific generality. This comparison highlights the changes that occurred in comparative psychology in the twentieth century, and it further clarifies some of the concerns associated with the use of animal models today.     

Probability, logic and the cognitive foundations of rational belief

Since Pascal introduced the idea of mathematical probability in the 17th century discussions of uncertainty and “rational” belief have been dogged by philosophical and technical disputes. Furthermore, the last quarter century has seen an explosion of new questions and ideas, stimulated by developments in the computer and cognitive sciences. Competing ideas about probability are often driven by different intuitions about the nature of belief that arise from the needs of different domains (e.g., economics, management theory, engineering, medicine, the life sciences etc). Taking medicine as our focus we develop three lines of argument (historical, practical and cognitive) that suggest that traditional views of probability cannot accommodate all the competing demands and diverse constraints that arise in complex real-world domains. A model of uncertain reasoning based on a form of logical argumentation appears to unify many diverse ideas. The model has precursors in informal discussions of argumentation due to Toulmin, and the notion of logical probability advocated by Keynes, but recent developments in artificial intelligence and cognitive science suggest ways of resolving epistemological and technical issues that they could not address.     

Commentary on "Quantifying the value of human life

...In his article, "Quantifying the value of human life for cost accounting of safeguards," L. Eugene Arnold proposes a cost-benefit analysis to address three allocation issues concerning the very expensive program of blood monitoring proposed by Sandoz at the time it placed Clozaril...on the American market....It is important to realize that the use of seemingly value-free procedures to arrive at answers to ethically complex questions does not eliminate the values that underlie the choice of variables to be analyzed. The analyses employed by the author to three ethical questions illustrate this point very well....     

HUSSERLIAN INTENTIONALITY AND THE CHINESE CONCEPT OF "MIND"

The phenomenology of Edmund Husserl is, in one sense, a theory of pure consciousness that aims to set forth an absolute, ultimate, rigorous ground for the sciences based on the field of pure consciousness. Husserl believed that, on the basis of this field of pure consciousness, he could secure eternal significance for the spiritual life of man. Intentionality is the key element in this theory of pure consciousness and it plays a crucial part in the realization of Husserl's philosophical goal. By contrast, traditional Chinese philosophy was not concerned to seek an absolute, ultimate ground for the sciences or to derive a set of moral norms and a theory of value for human life from logical and scientific truths. Rather, Chinese philosophy sought to adjust the relationships between man and nature and between man and man in their ordinary, secular existence. It placed no value in the ideas of pure logic, pure science, or pure consciousness. Traditional Chinese philosophers inquired into the experiential, intuitive 'mind' ( xin ^a). This approach to 'mind'was understood by the Chinese to require rigorous logical proof or scientific theory:— anyone can perceive one's 'mind'in daily life and, by analogy, anyone can 'perceive'other 'minds'. If Husserl's intentionality is the transcendental reason of Western philosophy, the 'mind'is the practical reason of Chinese philosophy. What, then, are the essential features of Husserl's 'intentionality'and the Chinese 'mind'? What are their respective theoretical features? Can they be brought together and compared in a philosophically significant fashion?     

The role of the anterodorsal thalami nuclei in the regulation of adrenal medullary function, beta-adrenergic cardiac receptors and anxiety responses in maternally deprived rats under stressful conditions

Maternal separation can interfere with growth and development of the brain and represents a significant risk factor for adult psychopathology. In rodents, prolonged separation from the mother affects the behavioral and endocrine responses to stress for the lifetime of the animal. Limbic structures such as the anterodorsal thalamic nuclei (ADTN) play an important role in the control of neuroendocrine and sympathetic-adrenal function. In view of these findings we hypothesized that the function of the ADTN may be affected in an animal model of maternal deprivation. To test this hypothesis female rats were isolated 4.5 h daily, during the first 3 weeks of life and tested as adults. We evaluated plasma epinephrine (E) and norepinephrine (NE), cardiac adrenoreceptors and anxiety responses after maternal deprivation and variable chronic stress (VCS) in ADTN-lesioned rats. Thirty days after ADTN lesion, in non-maternally deprived rats basal plasma NE concentration was greater and cardiac beta-adrenoreceptor density was lower than that in the sham-lesioned group. Maternal deprivation induced a significant increase in basal plasma NE concentration, which was greater in lesioned rats, and cardiac beta-adrenoreceptor density was decreased in lesioned rats. After VCS plasma catecholamine concentration was much greater in non-maternally deprived rats than in maternally-deprived rats; cardiac beta-adrenoreceptor density was decreased by VCS in both maternally-deprived and non-deprived rats, but more so in non-deprived rats, and further decreased by the ADTN lesion. In the plus maze test, the number of open arm entries was greater in the maternally deprived and in the stressed rats. Thus, sympathetic-adrenal medullary activation produced by VCS was much greater in non-deprived rats, and was linked to a down regulation of myocardial beta-adrenoceptors. The ADTN are not responsible for the reduced catecholamine responses to stress in maternally-deprived rats. Maternal deprivation or chronic stress also induced a long term anxiolytic effect, which was also not affected by ADTN lesion.     

Fine-Tuning, Multiple Universes, and the "This Universe" Objection

Abstract: When it is suggested that the fine-tuning of the universe for life provides evidence for a cosmic designer, the multiple-universe hypothesis is often presented as an alternative. Some philosophers object that the multiple-universe hypothesis fails to explain why this universe is fine-tuned for life. We suggest the "This Universe" objection is no better than the "This Planet" objection. We also fault proponents of the "This Universe" objection for presupposing that we could not have existed in any other universe and that the values of the free parameters of the Universe could have been different. Lastly, we reflect on why fine-tuning for life needs explaining     

Publishing in the Psychological Sciences: Enhancing Journal Impact While Decreasing Author Fatigue

ABSTRACT— The publication process in the psychological sciences is unduly tedious and would benefit from the adoption of a publishing model typical of the neurosciences and basic sciences. The author argues that such a change would result in higher impact publications in the psychological sciences and would also conserve the time of busy scientists.     

Stressful life events, bipolar disorder, and the "kindling model"

A common misconception is that bipolar disorder is an endogenous process. However, previous research suggests a role for life events in the onset of and recovery from bipolar episodes. Yet, there remains some question as to whether the relationship between life events and onset changes over the course of the disorder as a result of the number of episodes an individual has experienced. Using a rigorous interview measure of stressful life events, the current study tested the kindling model (R. M. Post, 1992), which theorizes that major life events play a diminishing role over the course of illness in bipolar patients. Analyses revealed that the number of episodes experienced does not appear to have a significant effect on bipolar 1 patients' reactivity to external stressors. In addition, the results suggest that a more complex relationship exists among age, stress, and onset of new episodes than can be adequately explained by the kindling model.     

Possibilities, Intentions and Threats: Dual Use in the Life Sciences Reconsidered

Due to the terrorist attacks of 9/11 and the anthrax letters of a few weeks later, the concept of dual use has spread widely in the life sciences during the past decade. This article is aimed at a clarification of the dual use concept and its scope of application for the life sciences. Such a clarification would greatly facilitate the work of policymakers seeking to ensure security while avoiding undesirable interventions of government in the conduct of science. The article starts with an overview of the main developments in life sciences in relation to dual use. This is illustrated by discussions on synthetic biology and dual use. The findings lead to a reconsideration of the dual use concept. An area in need of further attention is to what extent threats and intentions should have impact on the definition of dual use. Possible threats are analyzed against the background of the phenomenon of securitization of health care and life sciences: considering these sectors of society in security terms. Some caveats that should be taken into account in a dual use policy are described. An acceptable, adequate and applicable definition of the dual use concept could help researchers, universities, companies and policy makers. Such a definition should build upon, but go beyond, the view developed in the influential Fink-report, which concentrates on the so-called ??experiments of concern??, e.g. experiments that enhance the virulence of pathogens (National Research Council of the National Academies 2004) It will be argued that??in addition to these more technical aspects??a definition of dual use should include the aspect of threats and intentions.     

Melioration and self-experimentation

Operant researchers rarely use the arena of applied psychology to motivate or to judge their research. Absence of tests by application weakens the field of basic operant research. Early in their development, the physical and biological sciences emphasized meliorative aspects of research. Improvement of human life was a major goal of these young sciences. This paper argues that if basic operant researchers analogously invoked a melioration criterion, the operant field might avoid its tendency toward ingrowth and instead generate a broadly influential science. Operant researchers could incorporate melioration by (a) creating animal models to study applied problems; (b) confronting questions raised by applied analysts and testing hypotheses in applied settings; or (c) performing self-experiments—that is, using experimental methods and behavioral techniques to study and change the experimenter's behavior.     

How rats perform spatial working memory tasks: Limitations in the use of egocentric and idiothetic working memory

Rats of the Dark Agouti strain were trained on delayed alternation under conditions that should encourage egocentric working memory. In two experiments a T-maze was set within a cross-maze so that different arms could be used for the sample and test runs. The maze had high opaque side-walls, and testing was conducted in low light levels so that distal visual cues might be eliminated. By rotating the maze 90° between the sample and choice run and by using two identical mazes set side by side it was possible to nullify other spatial strategies. Experiments 1 and 2 showed that rats preferentially used place information, intramaze cues, and direction cues, even though only egocentric or idiothetic (nonmatch-to-turn) working memory could successfully solve every trial. Rats were able to maintain an accurate sense of location within the maze even though distal cues were not visible and the animal was moved between the sample and choice runs. Experiment 2 confirmed that another rat strain (Long-Evans) shows the same learning profiles. Both experiments indicate that rats are very poor at using either egocentric or idiothetic information to alternate, and that retention delays as short as 10 s can eliminate the use of these forms of memory.     

How rats perform spatial working memory tasks: limitations in the use of egocentric and idiothetic working memory

Rats of the Dark Agouti strain were trained on delayed alternation under conditions that should encourage egocentric working memory. In two experiments a T-maze was set within a cross-maze so that different arms could be used for the sample and test runs. The maze had high opaque side-walls, and testing was conducted in low light levels so that distal visual cues might be eliminated. By rotating the maze 90° between the sample and choice run and by using two identical mazes set side by side it was possible to nullify other spatial strategies. Experiments 1 and 2 showed that rats preferentially used place information, intramaze cues, and direction cues, even though only egocentric or idiothetic (nonmatch-to-turn) working memory could successfully solve every trial. Rats were able to maintain an accurate sense of location within the maze even though distal cues were not visible and the animal was moved between the sample and choice runs. Experiment 2 confirmed that another rat strain (Long-Evans) shows the same learning profiles. Both experiments indicate that rats are very poor at using either egocentric or idiothetic information to alternate, and that retention delays as short as 10 s can eliminate the use of these forms of memory.     

The wisdom of nature in integrating science, ethics and the arts

This paper deals with an approach to the integration of science (with technology and economics), ethics (with religion and mysticism), the arts (aesthetics) and Nature, in order to establish a world-view based on holistic, evolutionary ethics that could help with problem solving. The author suggests that this integration is possible with the aid of “Nature’s wisdom” which is mirrored in the macroscopic pattern of the ecosphere. The corresponding eco-principles represent the basis for unifying soft and hard sciences resulting in “deep sciences”. Deduction and induction will remain the methodology for deep sciences and will include conventional experiments and aesthetic and sentient experiences. Perception becomes the decisive factor with the senses as operators for the building of consciousness through the subconscious. In this paper, an attempt at integrating the concepts of the “true”, the “right” and the “beautiful” with the aid of Nature’s wisdom is explained in more detail along with consequences. The author is a bioprocess engineer with a research interest in environmental issues.     

Making decisions with a continuous mind

Neuroeconomics is a rapidly expanding field at the interfaces of the human sciences. The interdisciplinary nature of this field results in several challenges when attempts are made to solve puzzling questions in human decision making, such as why and how people discount future gains. We argue that an empirical approach based on dynamic systems theory (DST) could inspire and advance the neuroeconomic investigation of decisionmaking processes in three ways: by enriching the mental model, by extending the empirical tool set, and by facilitating interdisciplinary exchange. The present article addresses the challenges neuroeconomics faces by focusing on intertemporal choice. After a brief introduction of DST and related research, a DST-based conceptual model of decision making is developed and linked to underlying neural principles. On this basis, we outline the application of DST-informed empirical strategies to intertemporal choice. Finally, we discuss the general consequences of and possible objections to the proposed approach to research in intertemporal choice and the field of neuroeconomics.     

The role of the dorsal and ventral hippocampus in olfactory working memory

Olfactory working memory and pattern separation for odor information was assessed in male rats using a matching-to-sample for odors paradigm. The odor set consisted of a five aliphatic acids with unbranched carbon chains that varied from two- to six-carbons in length. Each trial consisted of a sample phase followed by a choice phase. During the sample phase, rats would receive one of five different odors. Fifteen seconds later during the choice phase one of the previous odors was presented simultaneously side by side with a different odor that was based on the number of aliphatic acids that varied in the carbon chains from two- to six-carbons in length and rats were allowed to choose between the two odors. The rule to be learned in order to receive a food reward was to always choose the odor that occurred during the study phase. Odor separations of 1, 2, 3 or 4 were selected for each choice phase and represented the carbon chain difference between the study phase odor and the test phase odor. Once an animal reached a criterion of 80–90% correct across all temporal separations based on 40 trials, rats received a control, dorsal hippocampal, or ventral hippocampal lesion and were retested on the task. On postoperative trials, only the ventral hippocampal lesion group was impaired relative to both control and dorsal hippocampal groups groups. There were no effects on odor pattern separation. All groups of rats could discriminate between the odors. The data suggest that the ventral hippocampus, but not dorsal hippocampus, supports working memory for odor information.     

Rats (Rattus norvegicus) do not prefer salted solid food

Many studies have demonstrated that when sodium-replete rats are given a choice between water and isotonic saline, they consume more of the isotonic saline. Their ingestive responses to a choice between salted and unsalted food, however, have not been studied in the same detail. Because humans consume salt in or on food rather than in pure water, this lack of information calls into question the use of the rat as the animal model for human excess salt consumption. In Experiment 1, 16 Sprague-Dawley rats were given 1-hr access to salted and unsalted foods (potato chips, peanuts, soup) commonly consumed by humans in the salted form. In each choice situation, rats consumed more of the unsalted variety of solid food. In Experiment 2, the concentration of salt in a wider variety of foods was varied. Fifteen rats were allowed a choice of a given salt concentration or the unsalted food. In no case was the salted solid food eaten in excess of the unsalted solid food, and in general, more of the unsalted solid food was eaten. In a third experiment, two groups of 8 rats were given exposure from weaning to either salted or unsalted potato chips. Three-months of exposure to salted chips or unsalted chips did not alter the rats' relative intake of salted chips. When given a choice, more unsalted chips were consumed by both groups. These experiments indicate that sodium-replete Sprague-Dawley rats generally prefer unsalted solid foods to salted ones.     

Preference reversals with food and water reinforcers in rats

Rats were given a choice between a smaller, immediately available reward and a larger reward available after a delay. In one phase, the reward was food and in another phase, the reward was water. Constant delays were added between the choice presentation and the delivery of the reward alternatives. As the time between choice and reward delivery increased from 0 to 25 s, all rats (except one in the water phase) reversed their preference from the smaller, sooner alternative to the larger, later alternative. These findings extend the generality of the preference-reversal animal model to qualitatively different reinforcers. Furthermore, the presence of both impulsive and self-control choices within the same animal is consistent with the view that self-control may be understood as choice behavior, and that species differences in self-control may be differences in degree, not kind.     

Choice in the time-left procedure and in concurrent chains with a time-left terminal link.

In two experiments, rats chose between a standard fixed-duration food-associated stimulus and a stimulus whose duration was the time remaining to reinforcement in an elapsing comparison interval. In Experiment 1, 4 rats responded in a time-left procedure wherein a single initial-link variable-interval schedule set up two potential terminal links simultaneously. As time elapsed in the initial-link schedule, the choice was between a standard fixed-interval 30-s terminal link and a time-left terminal link whose programmed interval requirement equaled 90 s minus the elapsed time in the initial link. Rats generally responded more on the lever with the shortest programmed terminal-link duration, but the temporal parameters of the procedure were found to vary with response distributions. Contrary to previous reports, therefore, time-left data were well predicted by choice models that make no assumptions about animal timing. In Experiment 2, 8 rats responded on a concurrent-chains schedule with independent variable-interval initial links and a time-left terminal link in one of the choice schedules. On the time-left lever, the programmed terminal-link delay equaled 90 s minus the elapsed time in the time-left initial link. On the standard lever, terminal-link responses were reinforced according to a variable-interval schedule whose average value varied over four conditions. Relative time-left initial-link responses increased in the elapsing time-left initial-link schedule as the time-left terminal link became shorter relative to the standard terminal link. Scalar expectancy theory failed to predict the resultant data, but a modified version of the delay-reduction model made good predictions. An analysis of the elaboration of scalar expectancy theory for variable delays demonstrated that the model is poorly formulated for arithmetically distributed delays.     

Rats' knowledge of incorrect responses in a matching-to-sample task

The idea that rats possess some knowledge about having been incorrect when having previously made an incorrect response is proposed. A matching-to-sample task with a second choice was used to assess the hypothesis. Only if the correct lever was chosen on the second choice was the animal rewarded. Further, the second choice was offered whether the animal was initially correct or incorrect in its first choice, preventing it from "knowing" if it had been correct in its initial decision. If rats possessed some knowledge whether they had been correct or not, then the number of correct second choice responses after an incorrect first one should have been greater than chance. The current experiment provided some evidence that the rats did "know" when its choices were incorrect.