Romantic Attachment,Empathy, and the Broader Autism Phenotype among College Students

Recent research suggests that mild autistic-like characteristics can be measured among relatives of individuals with autism and in the general population. These characteristics have been referred to as the broader autism phenotype (BAP), and include pragmatic language difficulties, aloofness, and rigidity. Evidence is growing to suggest that individuals with BAP encounter difficulties in their social interactions. Recent work demonstrates that college students scoring high on the BAP report more loneliness (Jobe & Williams White, 2007) and more interpersonal problems (Wainer, Ingersoll, & Hopwood, 2012). Because intimate relationships are important in development and are very salient in emerging adulthood, the authors examined the relation of the BAP to romantic attachment and empathy among young adults. Higher BAP scores were associated with lower empathy and higher attachment anxiety and avoidance. Specifically, pragmatic language difficulties were related to higher rates of avoidant attachment and this relationship was mediated by empathy. In contrast, pragmatic language deficits were directly related to anxious attachment.     

The Broader Autism Phenotype,Social Interaction Anxiety,and Loneliness: Implications for Social Functioning

Recent research has begun to focus on the subclinical presentation of autistic-like traits in individuals, a construct termed the broader autism phenotype (BAP). The presence of the BAP has been established in both first-degree relatives of individuals with autism as well as in the general population. The current study aimed to examine how self-reported BAP characteristics, social interaction anxiety, and fear of negative evaluation relate to social functioning (specifically, loneliness) in a sample of college students. Results showed that for all subjects, BAP, social interaction anxiety, and fear of negative evaluation did not predict loneliness in a regression model. However, for males these predictors accounted for approximately 48 % of the variance in loneliness scores. Among males, individuals rating themselves as having lower social skills, lower imagination, and higher social interaction anxiety were more likely to also report feeling lonely. These results indicate that the predictors used may function differently among males and females. Although BAP characteristics and social interaction anxiety may not be important correlates of social functioning for females in this sample, they appear to be very important for males’ subjective feelings of loneliness.     

Broader Autism Phenotype in Parents of Children with Autism: A Systematic Review of Percentage Estimates

The broader autism phenotype (BAP) is a collection of sub-diagnostic autistic traits more common in families of individuals with autism spectrum disorder (ASD) than in the general population. BAP is a latent construct that can be defined using different domains, measured using multiple instruments, and reported using different techniques. Therefore, estimates of BAP may vary greatly across studies. Our objective was to systematically review studies that reported occurrence of BAP in parents of children with ASD in order to quantify and describe heterogeneity in estimates. We systematically searched PubMed and Scopus using PRISMA guidelines for studies quantifying percentage of parents of children with ASD who had BAP. We identified 41 studies that measured BAP in parents of children with ASD. These studies used eight different instruments, four different forms of data collection, and had a wide range of sample sizes (N?=?4 to N?=?3299). Percentage with BAP ranged from 2.6% to 80%. BAP was more prevalent in fathers than mothers. Parental BAP may be an important tool for parsing heterogeneity in ASD etiology and for developing parent-mediated ASD interventions. However, the variety in measurement instruments and variability in study samples limits our ability to synthesize estimates. To improve measurement of BAP and increase consistency across studies, universal methods should be accepted and adopted across studies. A more consistent approach to BAP measurement may enable efficient etiologic research that can be meta-analyzed and may allow for a larger evidence base that can be used to account for BAP when developing parent-mediated interventions.     

Why We Should Study the Broader Autism Phenotype in Typically Developing Populations

The broader autism phenotype (BAP) is a term applied to individuals with personality and cognitive traits that are similar to but milder than those observed in autism spectrum disorder (ASD). Subtle autistic traits in the core diagnostic domains of social communication and rigid behavior were described in family members of people with an ASD even in the initial reports of ASD. In this article, we discuss the benefits and limitations of researching the BAP in typically developing individuals for understanding autism and development.     

Rigidity of thought and behavior: 100 years of research

Rigidity is one of the oldest psychological constructs, with systematic research dating back to the late 19th century. The authors review this research in an attempt to clarify the construct of rigidity and to investigate its correlates. Rigidity is described as a multidimensional construct encompassing the tendency to form and perseverate in the use of mental and behavioral sets. A series of meta-analyses was performed based on three measures of behavioral rigidity: the Einstellung Water-Jar Task, the Wisconsin Card Sorting Task, and the motor-cognitive dimension of the Test of Behavioral Rigidity. The results indicated that rigidity is curvilinearly related to age, positively related to authoritarianism (particularly under stressful situations), and negatively related to intelligence; that men are more rigid than women; that obsessive-compulsiveness is positively related to rigidity; and that schizophrenics are more rigid than nonschizophrenic siblings and normal controls. Unresolved issues and gaps in the research are discussed.     

Autistic Traits Below the Clinical Threshold: Re-examining the Broader Autism Phenotype in the 21st Century

Diagnosis, intervention and support for people with autism can be assisted by research into the aetiology of the condition. Twin and family studies indicate that autism spectrum conditions are highly heritable; genetic relatives of people with autism often show milder expression of traits characteristic for autism, referred to as the Broader Autism Phenotype (BAP). In the past decade, advances in the biological and behavioural sciences have facilitated a more thorough examination of the BAP from multiple levels of analysis. Here, the candidate phenotypic traits delineating the BAP are summarised, including key findings from neuroimaging studies examining the neural substrates of the BAP. We conclude by reviewing the value of further research into the BAP, with an emphasis on deriving heritable endophenotypes which will reliably index autism susceptibility and offer neurodevelopmental mechanisms that bridge the gap between genes and a clinical autism diagnosis.     

Diminished emotion recognition with reduced face gaze in complex situation in individuals with broad autism phenotype

Background/objectiveIndividuals with broad autism phenotype (BAP) showed a diminished ability to recognize emotion. This study aims to examine whether their decline in emotion recognition ability could be more clearly identified as task complexity increased and whether their decline could be influenced by their eye-gaze patterns.Method41 individuals with BAP and 40 healthy controls performed two types of emotion recognition tasks. After confirming conditions wherein the BAP group did not perform well compared to the control group, we compared gaze proportion on faces and context between groups when performing the conditions.ResultsThe more difficult the task, the clearer the significant relationships between the level of autistic traits and emotion recognition ability. The BAP group showed lower accuracy compared to the control group when a face with mild emotional intensity was presented with context. In terms of gaze proportion, the BAP group looked less at faces when recognizing emotions compared to the control group.ConclusionThese findings indicate that diminished emotion recognition ability in individuals with BAP may be influenced by face gaze.     

Using Behavioral Skills Training to Teach Interview Skills to Young Adults with Autism

With unemployment rates for adults with autism as high as 85%, it is important for young adults to learn necessary prevocational skills (e.g., interviewing) to help them succeed in their search for employment. There is little research showing that individuals with autism can be taught to respond appropriately during an interview to secure future employment opportunities. We replicated the results of Stocco et al. (J Appl Behav Anal 50:495–510, 2017. https://doi.org/10.1002/jaba.385) who evaluated the effects of behavioral skills training on the interview skills of college students. We used a multiple baseline design across three responses (i.e., asking questions, answering questions and appropriate body language) to extend these results to three young adults with autism. During baseline, responding was low across all three responses for all three participants. Behavioral skills training consisted of role-playing simulated interviews, providing feedback and performance rehearsals. For two of the participants, behavioral skills training alone was effective at increasing all three responses. For the third participant, we added textual cues and reinforcement during behavioral skills training to reach criterion performance. Results demonstrated that adults with autism can benefit from modified behavioral skills training to improve interview skills and employment opportunities. Social validity of responses was assessed by asking community members to rate video-taped segments of the interviews.

     

Loneliness, social relationships, and a broader autism phenotype in college students

Impaired social functioning is a hallmark of autism spectrum conditions. The purpose of this study was to investigate possible relationship between social functioning and a broader autism phenotype. With a sample of non-clinical undergraduate students from a large, urban university (N = 97; mean age = 19.4 ± 2 years), characteristics associated with autism were measured as well as self-reported dating and friendship history, feelings of loneliness, and social motivation. Results indicate that those individuals with a stronger autism phenotype (e.g., rigidity, preference for sameness, high attention to detail) report significantly more loneliness (r = .52, p < 0.01) and fewer and shorter duration friendships. Also, for participants in romantic relationships, a stronger phenotype was moderately and positively correlated with length of relationship (r = .34, p < 0.05). Findings support the view that individuals with characteristics of autism and related conditions do not necessarily prefer aloneness, as once assumed, but rather experience increased levels of loneliness related to lack of social skill and understanding. Significance and limitations of these findings are discussed and future directions for research and possibilities for social skills training in this population are explored.     

Developmental regression in autism spectrum disorders

The occurrence of developmental regression in autism is one of the more puzzling features of this disorder. Although several studies have documented the validity of parental reports of regression using home videos, accumulating data suggest that most children who demonstrate regression also demonstrated previous, subtle, developmental differences. Counter to clinical intuition, the earlier development of social, language, and attachment behaviors followed by regression does not seem to support later recovery of skills or better developmental outcomes compared to children who never had speech or typical social responsivity. In fact, this regressive group may have somewhat greater developmental impairment than the nonregressive group, though the two groups do not appear to present different behavioral phenotypes. Although autism is not the only condition in which regression occurs, it appears to be the most frequent condition. Other disorders that demonstrate an early regression with no known etiology include total blindness from birth and childhood disintegrative disorder, both of which demonstrate behavioral relations to autism. In addition, two biological conditions with known etiologies also involve regression with some behaviors resembling autism behavioral phenotype: Rett syndrome (a genetic disorder; see Glaze, this issue) and Landau-Kleffner syndrome (see McVicar and Shinnar, this issue), which involves a seizure disorder.     

Designing mouse behavioral tasks relevant to autistic-like behaviors

The importance of genetic factors in autism has prompted the development of mutant mouse models to advance our understanding of biological mechanisms underlying autistic behaviors. Mouse models of human neuropsychiatric diseases are designed to optimize (1) face validity, i.e., resemblance to the human symptoms; (2) construct validity, i.e., similarity to the underlying causes of the disease; and (3) predictive validity, i.e., expected responses to treatments that are effective in the human disease. There is a growing need for mouse behavioral tasks with all three types of validity for modeling the symptoms of autism. We are in the process of designing a set of tasks with face validity for the defining features of autism: deficits in appropriate reciprocal social interactions, deficits in verbal social communication, and high levels of ritualistic repetitive behaviors. Social approach is tested in an automated three-chambered apparatus that offers the subject a choice between a familiar environment, a novel environment, and a novel environment containing a stranger mouse. Preference for social novelty is tested in the same apparatus, with a choice between the start chamber, the chamber containing a familiar mouse, and the chamber containing a stranger mouse. Social communication is evaluated by measuring the ultrasonic distress vocalizations emitted by infant mouse pups and the parental response of retrieving the pup to the nest. Resistance to change in ritualistic repetitive behaviors is modeled by forcing a change in habit, including reversal of the spatial location of a reinforcer in a T-maze task and in the Morris water maze. Mouse behavioral tasks that may model additional features of autism are discussed, including tasks relevant to anxiety, seizures, sleep disturbances, and sensory hypersensitivity. Applications of these tests include (1) behavioral phenotyping of transgenic and knockout mice with mutations in genes relevant to autism, (2) characterization of mutant mice derived from random chemical mutagenesis, (3) DNA microarray analyses of genes in inbred strains of mice that differ in social interaction, social communication and resistance to change in habit, and (4) evaluation of proposed therapeutics for the treatment of autism.     

Epileptic encephalopathies and their relationship to developmental disorders: do spikes cause autism?

Epileptic encephalopathies are progressive clinical and electroencephalographic syndromes where deterioration is thought to be caused by frequent seizures and abundant EEG epileptiform activity. Seizures occur in approximately 10-15% of children with pervasive developmental disorders (PDD) and 8-10% have epileptiform EEG abnormalities without seizures. Thirty percent of children with PDD have regression of social behavior and language at 2-3 years of age. Some authors speculate that the regression is caused by epileptiform activity even in the absence of overt clinical seizures ("autism with epileptic regression") and suggest that elimination of the epileptiform activity, either medically or surgically, should lead to improvement in behavior. This review examines the data showing that interictal epileptiform discharges are associated with transient clinical dysfunction and discusses the implications of these observations for autistic behavioral abnormalities. The results of resective surgery, vagal nerve stimulation, and multiple subpial transaction on children with autism and epileptiform EEG abnormalities are also discussed. I conclude that there is no evidence that interictal discharges per se cause (or contribute to) the complex behavioral phenotype of autism. There is no justification to support the use of anticonvulsant medication or surgery in children with PDD without seizures; that is, there is no evidence that treatment to eliminate EEG spikes will have a therapeutic effect on the behavioral abnormalities of PDD and autism.     

Mechanisms of developmental regression in autism and the broader phenotype: a neural network modeling approach

Loss of previously established behaviors in early childhood constitutes a markedly atypical developmental trajectory. It is found almost uniquely in autism and its cause is currently unknown (Baird et al., 2008). We present an artificial neural network model of developmental regression, exploring the hypothesis that regression is caused by overaggressive synaptic pruning and identifying the mechanisms involved. We used a novel population-modeling technique to investigate developmental deficits, in which both neurocomputational parameters and the learning environment were varied across a large number of simulated individuals. Regression was generated by the atypical setting of a single pruning-related parameter. We observed a probabilistic relationship between the atypical pruning parameter and the presence of regression, as well as variability in the onset, severity, behavioral specificity, and recovery from regression. Other neurocomputational parameters that varied across the population modulated the risk that an individual would show regression. We considered a further hypothesis that behavioral regression may index an underlying anomaly characterizing the broader autism phenotype. If this is the case, we show how the model also accounts for several additional findings: shared gene variants between autism and language impairment (Vernes et al., 2008); larger brain size in autism but only in early development (Redcay & Courchesne, 2005); and the possibility of quasi-autism, caused by extreme environmental deprivation (Rutter et al., 1999). We make a novel prediction that the earliest developmental symptoms in the emergence of autism should be sensory and motor rather than social and review empirical data offering preliminary support for this prediction.     

Self‐management of varied responding in three students with autism

One of the aspects of autism that is often held up as a hallmark of the disorder is a desire for sameness. Students with autism often show a marked lack of variability in language and play skills. The same behavioral patterns are repeated perseveratively, rather than attempting new patterns. In the current study, students diagnosed with autism were taught to self‐manage varied responding. Using a multiple baseline design, three children with autism were taught to self‐monitor and then to self‐manage in order to increase variability in play and social language. All three students demonstrated marked increases in variability during self‐management phases. These gains were maintained at one month follow‐up. Copyright © 2000 John Wiley & Sons, Ltd.     

The Abbreviated Dysregulation Inventory: Dimensionality and Psychometric Properties in Portuguese Adolescents

Psychological dysregulation is a complex and multidimensional construct encompassing cognitive, emotional, and behavioral dimensions. Research on psychological dysregulation emphasizes its importance in relation to several psychological disorders. However, assessing psychological dysregulation is often problematic because many of the existing instruments address a specific dysregulation dimension at a time, predominantly emotional dysregulation. The Abbreviated Dysregulation Inventory (ADI) was developed to assess three dimensions of psychological dysregulation: emotional, cognitive and behavioral. This study’s goal was to analyze the factor structure, internal consistency, and validity in relation to external variables of the Portuguese version of the ADI in a sample of 511 adolescents aged between 12 and 19 years old. The 3-factor solution was confirmed, and high internal consistency was found for the three subscales. Peculiar findings on the cognitive dysregulation subscale raised issues addressed in the discussion section. Results indicated that dysregulation associates positively with aggressive behavior and negatively with quality of life. Age and gender presented small influence on the cognitive and behavioral subscales scores, respectively. Findings suggested that ADI can be a valuable self-report measure to assess cognitive, behavioral or emotional dysregulation in youths, within research and psychological intervention settings.     

Parent Prediction of Autism Spectrum Disorder in Infants at Risk: A Follow-up Study

Later-born siblings of children with autism spectrum disorder are considered at biological risk for autism spectrum disorder and the broader phenotype. Early screening may detect first signs of autism spectrum disorder and expedite diagnosis and early intervention. In this follow-up study, we re-examine a validated second-degree autism spectrum disorder screener for children at biological risk of autism spectrum disorder, the parent observation of early markers scale. Using available follow-up information up to age 13 years, 110 children (the original 108 infants plus 2 infants recruited after the completion of the original study) were divided into three groups: diagnosed group (n?=?13), lost diagnosis group (n?=?5), and undiagnosed group (n?=?92). The parent observation of early markers scale continued to show acceptable predictive validity. The parent observation of early markers scale total scores and mean number of elevated items were significantly higher in the diagnosed group than the undiagnosed group. The lost-diagnosis group did not differ from the undiagnosed group on parent observation of early markers scale total scores and elevated items at any age, but the lost-diagnosis group had significantly lower total scores, and number of elevated items than the diagnosed group starting at 18 months. Both autism spectrum disorder core and subsidiary behaviors differentiated the diagnosed and undiagnosed groups from 9 to 36 months of age. We hereby provide further evidence that the parent observation of early markers scale may serve as a low-cost early screener for autism spectrum disorder in at-risk children and pinpoint specific developmental ,and behavioral problems that may be amenable to very early intervention.     

A genetic factor explains most of the variation in the psychopathic personality

The psychopathic personality can be conceptualized as three interrelated dimensions, (a) an interpersonal style of glibness, grandiosity, and manipulation; (b) an affective disposition of callousness, lack of empathy, and unemotionality; and (c) a behavioral/lifestyle dimension of impulsivity, need for stimulation, and irresponsibility, underpinning a higher order construct, psychopathic personality. The authors used a self-report questionnaire (The Youth Psychopathic Traits Inventory) to study the importance of genetic and environmental influences on psychopathic personality traits in a sample of 1,090 monozygotic and dizygotic twin pairs, aged 16-17 years. Results showed a strong genetic influence behind the higher order "psychopathic personality" factor, underpinned by the three psychopathic personality dimensions. Over and above the effects to the higher order factor, significant unique genetic influences were also found in the callous/unemotional and in the impulsive/irresponsible dimension, but not in the grandiose/manipulative dimension. The authors propose that this latent psychopathic personality factor is a meaningful target for future etiological research.     

Examining the Efficacy of Parent–Child Interaction Therapy with Children on the Autism Spectrum

Externalizing behaviors are a common component of the clinical presentation of autism spectrum disorders. Although traditionally used with typically-developing children, parent–child interaction therapy (PCIT) is one behaviorally-based parent training program that has demonstrated success in increasing child compliance, reducing problem behavior, and improving parent–child communication. The study examined the efficacy of PCIT as a treatment for children with autism spectrum disorders by employing a single subject, non-concurrent multiple baseline design across three subjects. Primary findings revealed increases in child compliance, reductions in child disruptive behavior, and improved parenting skills across participants. In addition, each caregiver reported high levels of satisfaction with the intervention. Results suggested that PCIT may be a treatment option for children on the autism spectrum with co-occurring behavioral difficulties. Although the non-concurrent nature of the multiple baseline design is a limitation, this study replicates and extends previous research investigating the efficacy of PCIT with children with autism and their parents.     

Behavioral Telehealth Consultation with Families of Children with Autism Spectrum Disorder

In this study, desktop video teleconferencing was used to facilitate behavioral consultation at a distance with three parents of school‐age children with autism spectrum disorders. Parents were supported via desktop video teleconferencing as they conducted functional analyses and learned to implement an antecedent manipulation strategy, functional communication training, and a consequence‐based strategy. Parents then conducted a brief multi‐element treatment comparison to evaluate the preliminary effectiveness of each intervention strategy on their child's challenging behavior. The results of this study provide additional support to previous research suggesting that a telehealth model of behavioral consultation may be an effective way to assist parents of children with autism spectrum disorders address challenging behavior that disrupts family routines. Suggestions for future research are discussed. Copyright © 2016 John Wiley & Sons, Ltd.