Drugs as instruments: a new framework for non-addictive psychoactive drug use

Most people who are regular consumers of psychoactive drugs are not drug addicts, nor will they ever become addicts. In neurobiological theories, non-addictive drug consumption is acknowledged only as a "necessary" prerequisite for addiction, but not as a stable and widespread behavior in its own right. This target article proposes a new neurobiological framework theory for non-addictive psychoactive drug consumption, introducing the concept of "drug instrumentalization." Psychoactive drugs are consumed for their effects on mental states. Humans are able to learn that mental states can be changed on purpose by drugs, in order to facilitate other, non-drug-related behaviors. We discuss specific "instrumentalization goals" and outline neurobiological mechanisms of how major classes of psychoactive drugs change mental states and serve non-drug-related behaviors. We argue that drug instrumentalization behavior may provide a functional adaptation to modern environments based on a historical selection for learning mechanisms that allow the dynamic modification of consummatory behavior. It is assumed that in order to effectively instrumentalize psychoactive drugs, the establishment of and retrieval from a drug memory is required. Here, we propose a new classification of different drug memory subtypes and discuss how they interact during drug instrumentalization learning and retrieval. Understanding the everyday utility and the learning mechanisms of non-addictive psychotropic drug use may help to prevent abuse and the transition to drug addiction in the future.     

Non-addictive psychoactive drug use: Implications for behavioral addiction

The newly proposed framework for non-addictive psychoactive substances postulated by Müller & Schumann (M&S) provides an interesting and plausible explanation for non-addictive drug use. However, with specific reference to the relevant behavioral addiction literature, this commentary argues that the model may unexpectedly hold utility not only for non-addictive use of drugs, but also for non-addictive use of other potentially addictive behaviors.     

Dissemination of psychoactive substance information by innovative drug users.

Internet-based drug information may be relayed by innovative drug users, a group of individuals who use the web to learn about a new drug, experiment with that substance, and then disseminate their knowledge and experiences to others. We investigated the mechanisms adopted by innovative drug-using adolescents to distribute Internet drug information and experiences to peers, the size and geographic distribution of the receiving group, and the age at which innovative drug users began to disseminate drug information. Method: Cross-sectional survey of adolescents recruited by a respondent-driven sampling method. Of 18 innovative drug users, 17 reported using instant messaging (IM) to disseminate drug information and experiences to peers. The average age at which respondents adopted IM for this purpose was 16 years. Fifteen of 17 described using a distribution list with as many as 200 individuals who received only drug information. Ten respondents instant messaged drug information to online peers greater than 250 miles distant; nine respondents attached links to online drug resources (including www.erowid.org). This study has identified that IM plays an important role in the dissemination of Internet-based drug information by individual innovative drug users into larger social networks. Pediatricians should consider assessing IM use in drug abuse evaluations and recommending that parents of children with drug abuse problems should consider suspending IM services as a means of truncating the delivery of reinforcing drug information.     

Modification of the punishing effects of psychoactive drugs in rats by previous drug experience.

In Experiment 1, it was shown that chronic prior exposure to amphetamine attenuated the conditioned avoidance of saccharin that was produced by both amphetamine and morphine during gustatory conditioning trials; the relationship between morphine and amphetamine was somewhat anomalous because of their pharmacological dissimilarity. The relationship was also asymmetrical, since in Experiment 2, chronic prior exposure to morphine failed to mitigate avoidance conditioning by amphetamine but was effective in attenuating conditioning by morphine itself. In a third experiment, it was found that prior treatment with chlordiazepoxide attenuated saccharin avoidance conditioned by chlordiazepoxide but not by amphetamine or morphine. The findings were related to Parker, Failor, and Weidman's hypothesis, based on findings with morphine, concerning the development of conditioned preferences for substances associated with the repletion of artificially induced biological needs. It was suggested that the findings were best interpreted as a reflection of drug tolerance rather than conditioned preference.     

New psychoactive drugs

Many psychologists function in mental health clinics and mental institutions where psychoactive drugs are prescribed and administered or treat patients in therapy for whom psychoactive drugs have been prescribed. Six years ago, psychoactive drugs available to patients and physicians were reviewed for psychologists (Murray, 1978). The variety of psychoactive drugs is greater now, and this review summarizes their impact on the brain and the nervous system and describes their effects on patients' behavior.     

Nicotine trained as a negative feature passes the retardation-of-acquisition and summation tests of a conditioned inhibitor

Nicotine functions as a negative feature in a Pavlovian discriminated goal-tracking task. Whether withholding of responding to the conditional stimulus (CS) reflects nicotine functioning as a conditioned inhibitor is unknown. Accordingly, the present research sought to determine whether nicotine trained as a negative feature passed the retardation-of-acquisition and summation tests, thus characterizing it as a pharmacological (interoceptive) conditioned inhibitor. In the retardation test, rats received either nicotine (0.4 mg/kg) or chlordiazepoxide (5 mg/kg) negative feature training in which the drug state signaled when a 15-sec light CS would not be paired with sucrose; light was paired with sucrose on intermixed saline sessions. Following acquisition of the discrimination, both groups received nicotine CS training in which sucrose was intermittently available on nicotine but not intermixed saline sessions. Acquisition of conditioned responding to the nicotine CS was slower in the nicotine negative feature group than in the chlordiazepoxide negative feature group. In the summation test, rats were assigned to either the nicotine negative feature group or a pseudoconditioning control. In this control, the light CS was paired with sucrose on half the nicotine and half the saline sessions. Both groups also received excitatory training in which a white noise CS was paired with sucrose. The summation test consisted of presenting the white noise in conjunction with nicotine. Conditioned responding evoked by the white noise was decreased in the negative feature but not the pseudoconditioning group. Combined, the results provide the first evidence that an interoceptive stimulus (nicotine) can become a conditioned inhibitor.     

To use or not to use: Expanding the view on non-addictive psychoactive drug consumption and its implications

Proposing a change to the view on psychoactive drug use in non-addicts touches a sensitive issue because of its potential implications to addiction prevention, therapeutic practice, and drug policy. Commentators raised nine questions that ranged from clarifications, suggested extensions of the model to supporting data previously not regarded, to assumptions on the implications of the model. Here, we take up the suggestions of the commentators to expand the model to behavioral addictions, discuss additional instrumentalization goals, and review the evidence from laboratory animal studies on drug instrumentalization. We consider further the role of sociocultural factors and individual development in the establishment in drug instrumentalization and addiction. Finally, we clarify which implications we think this model may have. We conclude that drug instrumentalization theory can be further applied to other behaviors but will require a sensitive debate when used for drug and addiction policy that directly affects prevention and treatment.     

Creation as transformation: Parenting as a turning point in drug users’ lives

This paper is drawn from a narrative inquiry into how ex‐drug users understand the connection between childhood trauma and their subsequent drug misuse. The research was commissioned by a community drugs project. Eight participants were selected from respondents to an advertisement in a counselling journal, five of whom are qualified psychological therapists. The particular focus of this paper is on the interconnection of childhood trauma/abuse, drug misuse and parenting, by showing participants’ own experience of being parented and how the experience of becoming a parent helped them to transform their relationship with drugs. The paper draws attention to the therapeutic value of recognising the complex contextual factors that influence the parenting abilities of problematic drug users, and of building upon the positive attitudes, hopes, values and capabilities that underscore the ‘good parenting’ found in their stories. The work suggests that drug rehabilitation, treatment or counselling might usefully focus on parent–child relationships, which can become a turning point for identity transformation.     

Money as tool, money as drug: the biological psychology of a strong incentive

Why are people interested in money? Specifically, what could be the biological basis for the extraordinary incentive and reinforcing power of money, which seems to be unique to the human species? We identify two ways in which a commodity which is of no biological significance in itself can become a strong motivator. The first is if it is used as a tool, and by a metaphorical extension this is often applied to money: it is used instrumentally, in order to obtain biologically relevant incentives. Second, substances can be strong motivators because they imitate the action of natural incentives but do not produce the fitness gains for which those incentives are instinctively sought. The classic examples of this process are psychoactive drugs, but we argue that the drug concept can also be extended metaphorically to provide an account of money motivation. From a review of theoretical and empirical literature about money, we conclude that (i) there are a number of phenomena that cannot be accounted for by a pure Tool Theory of money motivation; (ii) supplementing Tool Theory with a Drug Theory enables the anomalous phenomena to be explained; and (iii) the human instincts that, according to a Drug Theory, money parasitizes include trading (derived from reciprocal altruism) and object play.     

Psychological distress and resilience as risk and protective factors of psychoactive substance use among Chinese nonengaged youth

Nonengaged youth (NEY) are those who have neither been working nor studying for a prolonged period of time. They are at risk of psychoactive substance use, but relevant studies are scarce. Based on a population‐based telephone survey and referrals, we anonymously interviewed 479 Hong Kong Chinese NEY aged 15–24 years. Of them, 14.8–23.7% reported moderate to severe depression, anxiety, and stress. Moreover, one fourth of the participants (24.8%; n = 119) had used psychoactive substances. Adjusted analyses showed that these three psychological distress variables were positively associated with, while resilience was negatively associated with, both ever‐use of psychoactive substances and intention to use such substances in the next 12 months. Loneliness was associated only with intention to use psychoactive substances. The mediating role of psychological distress was shown: Anxiety significantly mediated the association between resilience and ever‐use of psychoactive substances, whereas depression mediated that between resilience and behavioural intention. Resilience was not a significant moderator on the relationship between psychological distress and ever‐use of psychoactive substance use or behavioural intention to use those substances. The findings suggest that anti‐drug interventions should outreach NEY and should include mental health support as well as building up resilience, as NEY are prone to psychological distress that increases risk of substance use.     

尼古丁作用的辩证思考

尼古丁是一种液态生物碱 ,无色易挥发 ,溶于水 ,并易形成可溶性盐。它作为烟草中的主要毒性物质 ,在吸烟引起的许多疾病中起到了重要作用 ,在医学领域 ,这方面的研究已相当广泛和深入。但近几年来随着对尼古丁药用价值的探讨发现 ,其对许多疾病有缓解和潜在的治疗作用。本文就尼古丁致病和治病效应的两个方面作一综述。1　尼古丁的致病作用1.1　慢性阻塞性疾病 ,动脉粥样硬化等慢性炎症疾病尼古丁促进中性粒细胞 (PMNs)浸润、活化 ,释放炎性介质溶酶体酶、花生四烯酸及活性氧 ,作用于弹性蛋白、胶原蛋白 ,引起损伤。收集大鼠腹腔内PMNs ,…     

尼古丁依赖的神经生物学机制

尼古丁依赖是香烟成瘾的主要原因,其特征为无法克制的尼古丁觅求冲动,以及强迫性地、连续地使用尼古丁,以体验其带来的欣快感和愉悦感,并避免可能产生的戒断症状。该文主要从动物模型和人类脑功能成像两个方面来综述已有关于尼古丁依赖的神经生物学机制的研究成果,发现中脑边缘多巴胺系统是尼古丁依赖中的重要神经生物学基础。然而,目前对于尼古丁依赖的研究主要从静态的角度出发,较少研究其动态过程;并且尼古丁依赖与其他药物依赖之间的差异也缺乏直接的证据,因此这些都将成为将来可能的研究方向。     

Nicotine and familial vulnerability to schizophrenia: a discordant twin study

Tobacco use is significantly associated with schizophrenia. However, it is not clear if smoking is associated with the illness itself, treatment, or underlying vulnerability to the disease. Smoking was studied in a sample of schizophrenic probands (n = 24), their unaffected co-twins (n = 24), and controls (n = 3,347). Unaffected co-twins had higher rates of daily smoking than controls. Probands and co-twins were more frequently unsuccessful in attempts to quit than controls. Probands reported shaky hands and depression following smoking cessation more often than controls, whereas unaffected co-twins reported difficulty concentrating, drowsiness, nervousness, and headache following smoking cessation more often than controls. Results are consistent with the hypothesis that nicotine use is influenced by familial vulnerability to schizophrenia, not just clinical schizophrenia per se.     

Navigation in the Morris swim task as a baseline for drug discrimination: a demonstration with morphine

A morphine versus saline discrimination was demonstrated using the Morris swim task as the behavioral baseline. The apparatus was a large circular pool filled with water made opaque by floating polypropylene pellets. Rats were placed in the tank in randomly selected locations (12 trials per session) and could escape by swimming to a platform submerged 2 cm below the surface. Morphine (5.6 mg/kg) or saline was injected prior to training sessions. The position of the platform in a given session depended on the drug condition, thus forming the basis for discriminative responding. Three of the 4 rats acquired the discrimination, as evidenced by direct swims to the condition-appropriate platform. Generalization probe sessions were conducted following acquisition. Probe sessions were preceded by injections of morphine (0, 1.0, 3.0, 5.6, or 10.0 mg/kg) and involved placing the rat in the pool for 1 min without a platform. Swim patterns revealed a gradient, with probe swimming more concentrated in the area of the morphine platform position after higher morphine doses. In addition, dose-dependent increases in the likelihood of swimming first to the morphine-associated platform location were obtained. These results illustrate the generality of drug discrimination across different behavioral procedures, and of particular interest with respect to spatial learning, demonstrate interoceptive stimulus control of navigation.