Infant frontal EEG asymmetry moderates the association between maternal behavior and toddler negative affectivity

Relatively little work has examined potential interactions between child intrinsic factors and extrinsic environmental factors in the development of negative affect in early life. This work is important because high levels of early negative affectivity have been associated with difficulties in later childhood adjustment. We examined associations between infant frontal electroencephalogram (EEG), maternal parenting behaviors, and children’s negative affect across the first two years of life. Infant baseline frontal EEG asymmetry was measured at 5 months; maternal sensitivity and intrusiveness were observed during mother-child interaction at 5 and 24 months; and mothers provided reports of toddler negative affect at 24 months. Results indicated that maternal sensitive behaviors at 5 months were associated with less negative affect at 24 months, but only for infants with left frontal EEG asymmetry. Similarly, maternal sensitive behaviors at 24 months were associated with less toddler negative affect at 24 months, but only for infants with left frontal EEG asymmetry. In contrast, maternal intrusive behaviors at 5- and 24-months were associated with greater toddler negative affect, but only for infants with right frontal EEG asymmetry at 5-months. Findings suggest that levels of negative affect in toddlers may be at least partially a result of interactions between children’s own early neurophysiological functioning and maternal behavior during everyday interactions with children in the first two years of life.     

Maternal posttraumatic stress symptoms and infant emotional reactivity and emotion regulation

The current study examined associations between maternal posttraumatic stress disorder (PTSD) symptoms and infant emotional reactivity and emotion regulation during the first year of life in a primarily low-income, urban, ethnic/racial minority sample of 52 mother–infant dyads. Mothers completed questionnaires assessing their own trauma exposure history and current PTSD and depressive symptoms and their infants’ temperament when the infants were 6 months old. Dyads participated in the repeated Still-Face Paradigm (SFP-R) when the infants were 6 months old, and infant affective states were coded for each SFP-R episode. Mothers completed questionnaires assessing infant trauma exposure history and infant current emotional and behavioral symptoms when the infants were 13 months old. Maternal PTSD symptoms predicted infants’ emotion regulation at 6 months as assessed by (a) infant ability to recover from distress during the SFP-R and (b) maternal report of infant rate of recovery from distress/arousal in daily life. Maternal PTSD symptoms also predicted maternal report of infant externalizing, internalizing, and dysregulation symptoms at 13 months. Maternal PTSD was not associated with measures of infant emotional reactivity. Neither maternal depressive symptoms nor infant direct exposure to trauma accounted for the associations between maternal PTSD symptoms and infant outcomes. These findings suggest that maternal PTSD is associated with offspring emotion regulation difficulties as early as infancy. Such difficulties may contribute to increased risk of mental health problems among children of mothers with PTSD.     

Postnatal maternal symptoms of depression and child emotion dysregulation: The mediation role of infant EEG alpha asymmetry

In a community-based sample of 104 infants and their mothers, we hypothesized a pathway from postnatal maternal symptoms of depression to child emotion dysregulation, and tested at 6 months of age the mediation role of alpha asymmetry at frontal and parietal sites. We recorded infant resting-state EEG at 6 months of age. Child emotion dysregulation was measured at 24 months by the Child Behavior Checklist Dysregulation Profile derived from the CBCL 1½-5. Maternal depression symptoms were scored 6 months after the delivery by the Anxious/Depressed scale of the Adult Self-Report. We used structural equation modeling to test the mediation model from maternal depression symptoms to child emotion dysregulation mediated by frontal and parietal alpha asymmetry. The mediation model provided an excellent fit to the data [χ2(3) = 3.088, p = .378; RMSEA = .017, CFI = .1.00; SRMR = 0.040] and explained 23.3% of the variance in child emotion dysregulation. The indirect path via parietal alpha asymmetry was significant (β = .065; SE = .033; 95% CI = .001–.139; p = .048), i.e. greater levels of maternal depression symptoms predicted left parietal alpha asymmetry, which predicted higher levels of child emotion dysregulation. The direct effect, i.e. the pathway linking maternal depression symptoms and child emotion dysregulation above and beyond the indirect effects, was also significant. We found evidence for a partial mediation role of left parietal alpha asymmetry in a longitudinal pathway from postnatal maternal symptoms of depression to child emotion dysregulation, providing support for left parietal asymmetry as an index of biological vulnerability to emotion dysregulation in the first years of life.     

Maternal sensitivity during distressing tasks: a unique predictor of attachment security

The extent to which maternal sensitivity during a non-arousing free play task and during distressing tasks at 6 months predicted infant-mother attachment security was examined. When considered simultaneously, only maternal sensitivity during distressing tasks predicted subsequent attachment security. Infant temperament was unrelated to attachment security.     

Negative affectivity and EEG asymmetry interact to predict emotional interference on attention in early school-aged children

Negative affectivity (NA) is a broad construct that has been associated with the development of psychopathologies, such as anxiety, and with exaggerated attention to threatening stimuli. EEG asymmetry reflects biological individual differences in emotional reactivity that may underlie the association between NA and attention to threat. The present study included a sample of 31 five-seven year olds (M age in months = 74.39, SD = 6.57) to test the hypothesis that greater NA, combined with greater right anterior and posterior asymmetries, predicts increased attention interference following threat stimuli. Children completed an executive attention task which presented task-irrelevant threat (angry) and non-threat (neutral) faces prior to each trial. EEG asymmetry was measured at baseline for anterior, anterior-temporal and posterior scalp regions and child NA was measured via maternal report. As predicted, children showing greater NA and greater right anterior-temporal asymmetry showed more attention interference following angry faces. Additionally, two trend-level effects emerged: children showing greater NA and greater left anterior-temporal asymmetry showed less attention interference following angry faces, and children showing greater NA and greater left posterior asymmetry showed less attention interference, but only following neutral faces. Discussion focuses on the utility of using EEG asymmetry in the study of temperament, attentional biases, and the biological processes by which temperament confers risk for psychopathology.     

Laboratory stressors in clinically anxious and non-anxious individuals: The moderating role of mindfulness

Objective

Mindfulness forms the basis for multiple clinical interventions and has been induced in laboratory settings. However, few studies have examined the effects of dispositional or trait mindfulness. The purpose of this study was to investigate the relationship of trait mindfulness to laboratory stressor responding across fear-based anxiety disorder and non-anxious samples. We hypothesized that trait mindfulness would be associated with diminished stressor responding above and beyond the contribution of anxiety and depression-related variables, and to a greater extent in high anxiety than low anxiety individuals.

Methods

90 participants, including 46 with anxiety disorders and 44 non-anxious controls, were assessed on hyperventilation and relaxation stressors. The relationship of trait mindfulness to stressor-related anxiety, negative affect, and duration was investigated in a hierarchical multiple regression model.

Results

Trait mindfulness predicted stressor responding in over 80% of measured outcomes, and predicted to a greater extent among high anxiety individuals in 50% of outcomes.

Conclusions

Trait mindfulness was associated with diminished responses to laboratory stressors in clinically anxious and non-anxious samples. Implications for emotion regulation and clinical interventions are discussed.     

Maternal sensitivity moderates the impact of prenatal anxiety disorder on infant responses to the still-face procedure

Animal studies have demonstrated the interactive effects of prenatal stress exposure and postnatal rearing style on offspring capacity to manage stress. However, little is known about how parenting quality impacts the association between maternal prenatal anxiety and stress reactivity in human infants. This prospective study examined the impact of prenatal anxiety disorder and maternal caregiving sensitivity on infants’ responses to a standardised interactive stressor (still-face procedure). Eighty-four women completed a clinical interview during pregnancy to assess anxiety symptoms meeting DSM-IV diagnostic criteria. At infant age 7 months, maternal sensitivity to infant distress and infant negative affect were observed and coded during the still-face procedure. Maternal postnatal (concurrent) anxiety and depression were also assessed at this time. Results indicated a negative association between maternal sensitivity to infant distress and infant negative affect responses to the still-face procedure. An unexpected finding was a positive association between parity and infant reactivity. The main effect for sensitivity was qualified by a significant interaction, p < .05, suggesting that the impact of sensitivity was particularly marked among infants of women who experienced an anxiety disorder during pregnancy. This finding is consistent with a cumulative risk model suggesting that maternal prenatal anxiety and quality of maternal care act in concert to shape infant outcomes.     

Trait Meta-Mood,gender and EEG response during emotion-regulation

Effective emotion-regulation is central to emotional intelligence. Relationships between the Trait Meta-Mood Scale (TMMS) and wellbeing may reflect individual differences in the strategies used for regulating negative emotions. The present study (N = 136) manipulated emotion-regulation strategy during viewing of a fear-inducing film clip. EEG response was assessed across five frequency bands in reappraisal, suppression and control conditions. The TMMS predicted higher power in theta and gamma bands, a pattern of response that may represent directed attention to emotional processing. Gender differences included elevated theta in females in the reappraisal condition, but effects of gender and Trait Meta-Mood appeared to be dissociable.     

Frontal brain electrical activity (EEG) and heart rate in response to affective infant-directed (ID) speech in 9-month-old infants

Many studies have shown that infants prefer infant-directed (ID) speech to adult-directed (AD) speech. ID speech functions to aid language learning, obtain and/or maintain an infant's attention, and create emotional communication between the infant and caregiver. We examined psychophysiological responses to ID speech that varied in affective content (i.e., love/comfort, surprise, fear) in a group of typically developing 9-month-old infants. Regional EEG and heart rate were collected continuously during stimulus presentation. We found the pattern of overall frontal EEG power was linearly related to affective intensity of the ID speech, such that EEG power was greatest in response to fear, than surprise than love/comfort; this linear pattern was specific to the frontal region. We also noted that heart rate decelerated to ID speech independent of affective content. As well, infants who were reported by their mothers as temperamentally distressed tended to exhibit greater relative right frontal EEG activity during baseline and in response to affective ID speech, consistent with previous work with visual stimuli and extending it to the auditory modality. Findings are discussed in terms of how increases in frontal EEG power in response to different affective intensity may reflect the cognitive aspects of emotional processing across sensory domains in infancy.     

Right frontal EEG asymmetry and behavioral inhibition in infants of depressed mothers

Recent studies have shown associations between maternal psychopathology and inhibited behaviors in infants. Moreover, physiological factors have been identified as affecting the continuity of behavioral inhibition across childhood. The purpose of the present study was to examine electroencephalogram (EEG) activity and inhibited behavior in 12-month-old infants of depressed versus non-depressed and mothers. Repeated measures MANOVAs indicated that the infants of mothers with stable psychopathology had greater relative right frontal EEG asymmetry, a pattern that typically accompanies greater negative affect and greater withdrawal behaviors. Infants of affectively ill mothers also showed more proximal behaviors toward a stranger and a novel toy than infants of well mothers, but fewer non-proximal behaviors toward their mothers. These results are discussed within a framework of behavioral inhibition for infants exposed to early psychopathologies in their mothers.     

The moderating role of emotional differentiation on satiation

People tend to like experiences less the more they repeat them, a process commonly referred to as satiation. Despite an increasing interest in satiation among consumer researchers, we still know very little about the role that emotions play in the process. Through a series of three experiments, we show paradoxically that when individuals differentiate between the positive and negative emotions that arise during repeated consumption, they satiate at a slower rate. We show that a cognitive re‐appraisal process drives this emotional differentiation effect, whereby, when individuals focus on negative emotions they exhibit increased enjoyment of repeated consumption sequences. We demonstrate these effects for both trait and state emotional differentiation and across both continued and repeated consumption contexts. Theoretical implications of these findings for satiation, emotional differentiation, and emotion regulation literatures are then discussed.     

Maternal anxiety and toddler depressive/anxiety behaviors: The direct and moderating role of children's focused attention

Attention mechanisms have a pertinent role in shaping developmental pathways to anxiety and depressive disorders. The current study examined the direct and interactive associations between maternal anxiety symptoms, children's focused attention, and children’s anxiety and depression behaviors in early toddlerhood. Participants were 150 mother-child dyads (50 % female) that were assessed at two time points. At 12 months of child age, mothers reported about their anxiety symptoms and children's focused attention. Children's focused attention was also observed and rated from an individual play task. At 18 months of age, mothers reported about children's anxiety and depression behaviors. Focused attention predicted child anxiety and depressive behaviors, with different patterns of associations between observed and reported measures of attention. There was also a significant interaction between maternal anxiety symptoms and observed children's focused attention. A positive association between maternal anxiety symptoms and child anxiety and depression symptoms was evident only for children with above-average levels of observed focused attention during play. Results suggest that different aspects of focused attention play a role in maternal reported anxiety and depression behaviors in early development and may modulate the intergenerational transmission of anxiety.     

Frontal and parietal EEG asymmetries interact to predict attentional bias to threat

Frontal and parietal electroencephalographic (EEG) asymmetries mark vulnerability to depression and anxiety. Drawing on cognitive theories of vulnerability, we hypothesise that cortical asymmetries predict attention to threat. Participants completed a dot-probe task in which bilateral face displays were followed by lateralised targets at either short (300 ms) or long (1050 ms) SOA. We also measured N2pc to face onset as an index of early attentional capture. At long SOA only, frontal and parietal asymmetry interacted to predict attentional bias to angry faces. Those with leftward frontal asymmetry showed no attentional bias. Among those with rightward frontal asymmetry those with low right parietal activity showed vigilance for threat, and those with high right parietal activity showed avoidance. Asymmetry was not related to the N2pc or to attentional bias at the short SOA. Findings suggest that trait asymmetries reflect function in a fronto-parietal network that controls attention to threat.     

The role of TPH2 variant rs4570625 in shaping infant attention to social signals

TPH2, the rate-limiting enzyme in the synthesis of serotonin, has been connected to several psychiatric outcomes. Its allelic variant, rs4570625, has been found to relate to individual differences in cognitive and emotion regulation during infancy with T-carriers of rs4570625 showing a relatively heightened attention bias for fearful faces. A significant gene-environment interaction was also reported with the T-carriers of mothers with depressive symptoms showing the highest fear bias.We investigated these associations in a sample of 8-month old infants (N = 330), whose mothers were prescreened for low/high levels of prenatal depressive and/or anxiety symptoms. Attention disengagement from emotional faces (neutral, happy, fearful, and phase-scrambled control faces) to distractors was assessed with eye tracking and an overlap paradigm. Maternal depressive symptoms were assessed at several time points during pregnancy and postpartum. The mean levels of symptoms at six months postpartum and the trajectories of symptoms from early pregnancy until six months postpartum were used in the analyses (N = 274).No main effect of the rs4570625 genotype on attention disengagement was found. The difference in fear bias between the genotypes was significant but in an opposite direction compared to a previous study. The results regarding the interaction of the genotype and maternal depression were not in accordance with the previous studies.These results show inconsistencies in the effects of the rs4570625 genotype on attention biases in separate samples of infants from the same population with only slight differences in age.     

The impact of breastfeeding on mothers' attentional sensitivity towards infant distress

Background

Maternal response towards infant distress has an important impact on infant development. In animals it is established that lactation and pup suckling plays an important role in maintaining maternal responses. Previous research suggests that breastfeeding is associated with sensitive maternal responses in human mothers. However, this may be because women who are more sensitive to their infant choose to breastfeed. The current study investigated the attentional sensitivity towards infant distress in women who went on to breast or formula feed during pregnancy as well as after birth. We hypothesised that differences in breast and formula feeding mothers would only emerge after birth once feeding had commenced.

Method

Women were recruited during pregnancy through community midwives as part of a longitudinal study. 51 women were seen during late pregnancy and between 3 and 6 months after birth (27 were breast and 24 were formula feeding). Sensitivity to infant distress was measured as the extent of women's attentional bias towards infant distress stimuli.

Results

After birth, we found that our index of attentional bias towards infant distress was 37 ms (0.5 S.D.s) (CI; 6-69, p = 0.021) higher in breastfeeding compared to formula feeding mothers. However, mothers who went on to breastfeed did not show greater attentional bias towards infant distress already during late pregnancy.

Conclusions

Our results suggest that the act of breastfeeding may influence mothers’ attentional sensitivity towards infant distress. Previous research suggests breastfeeding is indicative of sensitive parenting. The current findings may suggest a mechanism by which breastfeeding and/or associated infant interaction could contribute to this sensitivity.     

Maternal prenatal stress and infant regulatory capacity in Mexican Americans

The early postpartum period lays important groundwork for later self-regulation as infants’ dispositional traits interact with caregivers’ co-regulatory behaviors to produce the earliest forms of self-regulation. Although emerging literature suggests that fetal exposure to maternal stress may be integral in determining child self-regulatory capacity, the complex pathways that characterize these early developmental processes remain unclear. The current study considers these complex, transactional processes in a low income, Mexican American sample. Data were collected from 295 Mexican American infants and their mothers during prenatal, 6- and 12-week postpartum home interviews. Mother reports of stress were obtained prenatally, and mother reports of infant temperament were obtained at 6 weeks. Observer ratings of maternal sensitivity and infant regulatory behaviors were obtained at the 6- and 12-week time points. Study results indicate that prenatal stress predicts higher levels of infant negativity and surgency, both of which directly or interactively predict later engagement in regulatory behaviors. Unexpectedly, prenatal stress also predicted more engagement in orienting, but not self-comforting behaviors. Advancing understandings about the nature of these developmental pathways may have significant implications for targets of early intervention in this high risk population.     

Effects of maternal depressive symptoms on sensitivity to infant distress and non-distress: Role of SES and race

The goals of the present study were to examine the extent to which (a) maternal depressive symptoms (prenatal vs. postnatal depressive symptoms) undermine maternal sensitivity toward both infant distress and non-distress; (b) such effects are stronger in the context of socioeconomic risk. SES risk and depressive symptoms interacted such that depressive symptoms, both pre and postnatal, only predicted lower sensitivity among mothers at heightened SES risk. The effects were comparable for sensitivity to distress and non-distress and did not vary by maternal race.     

The expression and regulation of anger in toddlers: relations to maternal behavior and mental representations

Anger is an intense and adaptive approach emotion that undergoes significant development during the toddler years. We assessed the expression of anger and the strategies toddlers use to regulate it in relation to maternal behavior and mental representations. Seventy-four toddlers were observed in three anger-eliciting paradigms: toy removal (TR), still-face (SF), and delayed gratification (DG). Anger expression and three clusters of regulatory behaviors were micro-coded: putative regulatory behaviors, attention manipulation, and play behaviors. Maternal relational style was coded for sensitivity and intrusiveness, and mental representations of the mother-child relationship were assessed for joy and anger. Children expressed the most anger during the TR, less during the SF, and minimally during the DG. Use of putative regulatory behaviors was highest during the SF, whereas during the TR children employed newly acquired skills, such as focused attention and substitutive play, in the service of anger regulation. Anger expression and regulation were differentially related to the negative and positive components in the mother's behavior and representations, and maternal intrusiveness moderated the relations between angry representations and the degree of child anger during the SF. Results are consistent with dynamic models of emotions and accord with perspectives that emphasize the role of sensitive parenting in facilitating emotion regulation.     

The influence of parenting on infant emotionality: A multi-level psychobiological perspective

Infant temperament is theorized to have a strong genetic basis. Yet, studies of the stability of temperament and molecular genetics research on temperament have revealed inconsistent findings. One reason may be because research has not taken into account the influence of early social experiences. We review research on aspects of infant emotionality presumed to be temperamental in origin, emotion reactivity and emotion regulation, and integrate research addressing parenting influences on physiology and genetics of infant emotionality with traditional research on behavioral expression of emotionality. Empirical research supports the theory that sensitive and appropriately responsive parenting in infancy is related to more optimal patterns of behavioral and physiological reactivity and regulation. Molecular genetics research with both animal and human populations has produced consistent results when environmental experiences are taken into account. Findings suggest that the short allele of the serotonin transporter gene and the long allele of the DRD4 dopamine receptor gene may be related to distinct patterns of infant emotionality and to later problems with depression, impulse control problems, and externalizing/antisocial behaviors, primarily when paired with insensitive parenting, abuse or neglect, or other adverse family environments. Future directions and limitations in the field are discussed.     

Emotion regulation choice in an evaluative context: the moderating role of self-esteem

Evaluative contexts can be stressful, but relatively little is known about how different individuals who vary in responses to self-evaluation make emotion regulatory choices to cope in these situations. To address this gap, participants who vary in self-esteem gave an impromptu speech, rated how they perceived they had performed on multiple evaluative dimensions, and subsequently chose between disengaging attention from emotional processing (distraction) and engaging with emotional processing via changing its meaning (reappraisal), while waiting to receive feedback regarding these evaluative dimensions. According to our framework, distraction can offer stronger short-term relief than reappraisal, but, distraction is costly in the long run relative to reappraisal because it does not allow learning from evaluative feedback. We predicted and found that participants with lower (but not higher) self-esteem react defensively to threat of failure by seeking short-term relief via distraction over the long-term benefit of reappraisal, as perceived failure increases. Implications for the understanding of emotion regulation and self-esteem are discussed.