Response acquisition by zebrafish (Danio rerio) with delayed reinforcement

Zebrafish (Danio rerio) is a common vertebrate animal model in biomedical research and is a promising species for studying how genes interact with environmental factors in determining behavior. The present study investigated how reinforcement parameters affect zebrafish behavior by assessing response acquisition with delayed reinforcement, which has been studied with other species (e.g., rats, pigeons, humans, etc.) but not with zebrafish. Twenty‐four experimentally naïve subjects were exposed to a tandem fixed‐ratio 1 differential‐reinforcement‐of‐other‐behavior x‐s schedule of reinforcement, where x varied across subjects. There were six different delay‐to‐reinforcement durations and sets of four fish were assigned to each delay duration. All of the fish assigned to a 0‐, 0.5‐, or 1‐s delay acquired responding. Two fish acquired responding with a 3‐s delay and one fish appeared to have acquired it with a 6‐s delay although the latter result was less clear. None acquired responding with a 12‐s delay. These results suggest that zebrafish behavior is sensitive to delays to reinforcement and the time frame over which reinforcement is effective may be limited approximately to 6 s. This time frame is shorter than that found with other species. Practical and theoretical implications of the present finding are discussed.     

Effects of noncontingent reinforcement on problem behavior and stimulus engagement: the role of satiation, extinction, and alternative reinforcement

This study examined the effects of noncontingent reinforcement (NCR) with and without extinction on problem behavior and stimulus engagement (consumption of reinforcement) of 4 participants. Reductions in problem behavior using NCR have frequently been attributed to both satiation of the reinforcer and extinction. In the current study, aspects of the NCR treatment effects were difficult to explain based solely on either a satiation or an extinction account. Specifically, it was found that stimulus engagement remained high throughout the NCR treatment analysis, and that problem behavior was reduced to near-zero levels during NCR without extinction. The implications of these findings are discussed with respect to the satiation and extinction hypotheses frequently described in the applied literature. Findings from basic studies examining the effects of response-independent schedules are presented, and are used as the basis for a matching theory account of NCR-related effects. It is proposed that reductions in problem behavior observed during NCR interventions may be a function of the availability of alternative sources of reinforcement.     

The combined effects of noncontingent reinforcement and punishment on the reduction of rumination

The current study extends the literature on the assessment and treatment of rumination through the evaluation of a combined reinforcement‐ and punishment‐based intervention. The study included a single participant with a history of rumination maintained by automatic reinforcement, as identified via a functional analysis. Both noncontingent reinforcement (NCR) with preferred edible items and punishment, in the form of a facial screen, were implemented separately to evaluate their independent effects on the occurrence of rumination. The final treatment package included both NCR and punishment procedures. Implementation of the combined treatment resulted in a 96.5% reduction in rumination relative to baseline. Procedural modifications and integrity errors also were evaluated.     

Arousal modulates temporal preparation under increased time uncertainty: Evidence from higher-order sequential foreperiod effects

When the foreperiod (FP) is unpredictably varied in reaction-time tasks, responses are slow at short but fast at long FPs (variable-FP effect), and further vary asymmetrically as a function of FP sequence (sequential FP effect). A trace-conditioning model attributes these phenomena to time-related associative learning, while a dual-process model views them as resulting from combined effects of strategic preparation and trial-to-trial changes in arousal. Sometimes, responses are slower in long-long than in short-long FP sequences. This pattern is not predicted from the trace-conditioning account, since FP repetitions should speed up, rather than slow down, responses (due to reinforcement). The effect, however, might indicate the contribution of arousal, which according to the dual-process model, is heightened after a short FP(n-1) but decreased after a long FP(n-1). In five experiments, we examined higher-order sequential FP effects on performance, with a particular emphasis on analyzing performance in long-FP(n) trials as a function of FP length in the two preceding trials, varying temporal FP context (i.e. average FP length) and reaction mode (simple vs. choice reaction). Slower responses in long-long-long (compared with short-short-long) FP sequences were not found within a short-FP context (Exps. 1 & 2) but clearly emerged within a long-FP context (Exps. 3-5). This pattern supports the notion that transient arousal changes contribute to sequential performance effects in variable-FP tasks, in line with the dual-process account of temporal preparation.     

Generality of the practical functional assessment and skill‐based treatment among individuals with autism and mental health disorders

A practical functional assessment format was recently developed that informed a skill‐based treatment for the problem behavior of children diagnosed with autism spectrum disorder. Since its inception there have been multiple replications of the procedures; however, the comprehensive model has rarely been applied to populations with more complex comorbid disorders and severe problem behavior such as those diagnosed with anxiety or depression. We conducted the current study to systematically replicate the entire practical functional assessment and skill‐based treatment model with two participants diagnosed with multiple mental health disorders admitted to a severe behavior outpatient unit. The practical functional assessment identified reinforcers that were provided contingent on increasingly complex forms of communication. Problem behavior remained low for both participants after reinforcement was thinned by increasing a response requirement of completing difficult tasks. Furthermore, the results were socially validated by the parents and teachers and the treatment was extended to the home setting.     

OPIOID ABSTINENCE REINFORCEMENT DELAYS HEROIN LAPSE DURING BUPRENORPHINE DOSE TAPERING

A positive reinforcement contingency increased opioid abstinence during outpatient dose tapering (4, 2, then 0 mg/day during Weeks 1 through 3) in non‐treatment‐seeking heroin‐dependent volunteers who had been maintained on buprenorphine (8 mg/day) during an inpatient research protocol. The control group (n = 12) received $4.00 for completing assessments at each thrice‐weekly visit during dose tapering; 10 of 12 lapsed to heroin use 1 day after discharge. The abstinence reinforcement group (n = 10) received $30.00 for each consecutive opioid‐free urine sample; this significantly delayed heroin lapse (median, 15 days).     

A translational comparison of contingency‐based progressive delay procedures and their effects on contextually appropriate behavior

Schedule thinning is an essential step in treating problem behavior, yet little research has been conducted to determine the method associated with sustained treatment effects. A frequently used method for thinning reinforcement is contingency‐based progressive delay, which requires the individual to meet some criteria before the reinforcers are returned. The response requirement could be dependent on (a) contextually appropriate behavior (differential reinforcement of alternative behavior‐based thinning) or (b) absence of problem behavior (differential reinforcement of other behavior‐based thinning). A translational arrangement with college students was implemented to determine the effects of these 2 response requirements. Tolerance was observed regardless of thinning method and was indicated by low rates of responding to the analogue problem behavior; however, more contextually appropriate behavior occurred during differential reinforcement of alternative behavior‐based thinning. These results support the use of response requirements for behaviors that are expected of the individual when reinforcement is not immediately forthcoming.     

The psychometric properties of the Quality of Life Inventory in an Australian community sample

The Quality of Life Inventory (QOLI, Frisch) is an importance‐weighted measure of life satisfaction that has been found to possess adequate psychometric properties in US and clinically‐based samples. The current study aimed to investigate the normative distribution, factor structure and key psychometric properties of the QOLI in an Australian general community sample. Results indicated that the Australian sample (n = 259) reported slightly better quality of life than the US‐based standardisation sample. Confirmatory factor analyses showed that a three‐factor model provided the best fit for the data. Psychometric properties were all generally found to be adequate and close to Frisch's reported levels. In conclusion, this study indicated that the QOLI may be used in the Australian context with confidence. Future research could examine the clinical utility of the three‐factor model.     

A translational evaluation of renewal of inappropriate mealtime behavior

The term renewal describes the recurrence of previously extinguished behavior that occurs when the intervention context changes. Renewal has important clinical relevance as a paradigm for studying treatment relapse because context changes are necessary for generalization and maintenance of most intervention outcomes. The effects of context changes are particularly important during intervention for pediatric feeding disorders because children eat in a variety of contexts, and extinction is an empirically supported and often necessary intervention. Therefore, we used an ABA arrangement to test for renewal during intervention with 3 children diagnosed with a feeding disorder. The A phase was functional reinforcement of inappropriate mealtime behavior in a simulated home setting with the child's caregiver as feeder, B was function‐based extinction in a standard clinic setting with a therapist as feeder, and the return to the A phase was function‐based extinction in a simulated home setting with caregiver as feeder. Returning to Context A resulted in renewal of inappropriate mealtime behavior across children, despite the caregivers' continued implementation of function‐based extinction with high levels of integrity.     

An evaluation of the single‐session interview‐informed synthesized contingency analysis

Functional analysis can often be a lengthy process requiring time and resources not readily available to practitioners working with children who exhibit severe problem behavior. The interview‐informed synthesized contingency analysis (IISCA) was recently developed as an alternative functional analysis format that improved analytic efficiency by requiring only 25 min to conduct. Furthermore, a within‐session analysis of the first test session of the entire IISCA could reduce the process to as little as a single 5‐min session. We extended this previous research by conducting what was termed the single‐session IISCA with three boys who exhibited severe problem behavior. A function‐based treatment package, including reinforcement thinning, informed by the results of the single‐session IISCA nearly eliminated problem behavior for all three participants. We suggest that the single‐session IISCA could be a viable alternative to other functional analysis formats when time is limited.     

EFFECT OF REINFORCEMENT PROBABILITY AND PRIZE SIZE ON COCAINE AND HEROIN ABSTINENCE IN PRIZE‐BASED CONTINGENCY MANAGEMENT

Although treatment outcome in prize‐based contingency management has been shown to depend on reinforcement schedule, the optimal schedule is still unknown. Therefore, we conducted a retrospective analysis of data from a randomized clinical trial (Ghitza et al., 2007) to determine the effects of the probability of winning a prize (low vs. high) and the size of the prize won (small, large, or jumbo) on likelihood of abstinence until the next urine‐collection day for heroin and cocaine users (N = 116) in methadone maintenance. Higher probability of winning, but not the size of individual prizes, was associated with a greater percentage of cocaine‐negative, but not opiate‐negative, urines.     

Achieving socially significant reductions in problem behavior following the interview‐informed synthesized contingency analysis: A summary of 25 outpatient applications

Jessel, Hanley, and Ghaemmaghami (2016) reported the results of 30 interview‐informed, synthesized contingency analyses (IISCAs) and found the IISCAs to be an effective tool for identifying the functions of problem behavior across a variety of topographies, participants, and settings. Jessel et al. did not, however, include data on the effectiveness of the corresponding treatments. In the current study, we collected and summarized 25 additional applications, from analysis to treatment, in which the IISCA was applied in an outpatient clinic. The IISCA identified various social functions of problem behavior, which informed personalized treatments of functional communication training with contingency‐based reinforcement thinning. A 90% or greater reduction in problem behavior was obtained for every participant by the end of the treatment evaluation. The assessment and treatment process was socially validated by caregivers who rated the procedures highly acceptable and helpful, and the improvement in their child's behavior highly satisfactory.     

AN EVALUATION OF RESURGENCE DURING TREATMENT WITH FUNCTIONAL COMMUNICATION TRAINING

Extinction‐induced resurgence is the recurrence of previously reinforced behavior when another behavior is placed on extinction (Lieving, Hagopian, Long, & O'Connor, 2004). This phenomenon may account for some instances of treatment relapse when problem behavior recovers during extinction‐based treatments. The current study sought to determine whether resurgence of problem behavior would reliably occur with 5 participants who received treatment with FCT. Results showed that problem behavior reemerged for all but 1 participant when the communicative response was exposed to extinction or thin schedules of reinforcement. These findings suggest that resurgence may account for some instances of response recovery during treatment, and that the described procedure may be useful for the further study of resurgence and eventual prevention of this phenomenon.     

Parental desire and fertility preservation in assigned male at birth transgender people living in Belgium

Abstract

Introduction: Transgender people who chose to proceed with gender affirming hormonal and/or surgical therapy, may face reduced options for fulfilling their parental desire in the future. The ideas and concerns of adult transgender people regarding fertility preservation and parental desire have never been reported in a large, non-clinical sample of assigned male at birth (AMAB) transgender people.

Methods: A web-based survey on fertility and parenthood in (binary and non-binary) transgender people was conducted in Belgium. AMAB people were selected for this analysis.

Results: We included 254 AMAB persons, of which 196 (77.2%) self-identified as transgender women (TW), 14 (5.5%) as cross-dressers and 44 (17.3%) as gender non-binary (GNB) people. Fifty-five (21.6%) respondents had a current/future parental desire, parental desire was already fulfilled in 81 (31.9%) and not present in 57 people (22.4%) (other: 19.2%). TW were more likely to express a parental desire, compared to GNB people and cross-dressers (P?=?0.004). In total, 196 AMAB people previously sought medical assistance, of which 30 (15.3%) considered the loss of fertility due to the transitioning process undesirable. The majority (68.2%) did not want fertility preservation (FP). Fourteen people (9.8%) had proceeded with FP. The main reasons not to proceed with FP included not feeling the need (70; 68.0%), not desiring a genetic link with (future) child(ren) (20; 19.4%) and having to postpone hormone treatment (15; 14.6%). TW were more likely to have a parental desire and to have cryopreserved or to consider cryopreserving gametes, compared to GNB people.

Conclusion: Parental desire and FP use were lower in the current non-clinical sample than in previous research on clinical samples. This can possibly be explained by the barriers transgender people face when considering fertility options, including postponing hormone therapy. Also, GNB persons have different needs for gender affirming treatment and FP.     

Further analysis of subtypes of automatically reinforced SIB: A replication and quantitative analysis of published datasets

Hagopian, Rooker, and Zarcone (2015) evaluated a model for subtyping automatically reinforced self‐injurious behavior (SIB) based on its sensitivity to changes in functional analysis conditions and the presence of self‐restraint. The current study tested the generality of the model by applying it to all datasets of automatically reinforced SIB published from 1982 to 2015. We identified 49 datasets that included sufficient data to permit subtyping. Similar to the original study, Subtype‐1 SIB was generally amenable to treatment using reinforcement alone, whereas Subtype‐2 SIB was not. Conclusions could not be drawn about Subtype‐3 SIB due to the small number of datasets. Nevertheless, the findings support the generality of the model and suggest that sensitivity of SIB to disruption by alternative reinforcement is an important dimension of automatically reinforced SIB. Findings also suggest that automatically reinforced SIB should no longer be considered a single category and that additional research is needed to better understand and treat Subtype‐2 SIB.     

THERAPIST‐ AND SELF‐MONITORED DRO CONTINGENCIES AS A TREATMENT FOR THE SELF‐INJURIOUS SKIN PICKING OF A YOUNG MAN WITH ASPERGER SYNDROME

The use of differential reinforcement of other behavior (DRO) has decreased, at least partially due to the development of less effortful alternative behavioral interventions (e.g., noncontingent reinforcement; Vollmer, Iwata, Zarcone, Smith, & Mazaleski, 1993). The effort associated with DRO contingencies may be lessened by incorporating self‐monitoring components in which clients are responsible for the delivery of reinforcers for their own behavior. The current study evaluates the effectiveness of DRO in the treatment of self‐injury when implemented first by the therapist and subsequently by the client.     

Utilizing a home‐based parent training approach in the treatment of food selectivity

Evaluating effects of utilizing parents as therapists for treating behavior problems has become increasingly important in the dissemination and practice of applied behavior analysis. However, home‐based parent training approaches have been underused in treating feeding problems. In this study, mothers were trained to implement differential reinforcement of alternative behavior (DRA) combined with non‐removal of the spoon and demand fading for the treatment of their childrens' food selectivity. The procedures were highly effective and generalization to untargeted foods was observed. Parent procedural integrity and parent collected interobserver agreement (IOA) data remain high throughout the study. This study also demonstrated an effective method for systematically decreasing reinforcement magnitude and schedules in an effort to mimic traditional reinforcer delivery such as intermittently providing a dessert at the end of the meal. Finally, this study successfully increased a demand fading ratio of 50–150% without noticeable side effects. Copyright © 2010 John Wiley & Sons, Ltd.     

Predictors of treatment attendance among adolescent substance abusing runaways: a comparison of family and individual therapy modalities

This study explored and compared predictors of session attendance among substance abusing runaway adolescents and their parents using three manual‐driven interventions: ecologically‐based family therapy (EBFT), motivational enhancement therapy (MET), and the community reinforcement approach (CRA). Individual and family‐level variables, as well as time between intake and first session were used as predictors of session attendance. Adolescents (N=179) between the ages of 12–17 years old were recruited from the only runaway shelter in Columbus, Ohio. The findings showed that adolescents assigned to EBFT were more likely to attend at least one therapy session than those assigned to either CRA or MET. Fewer days between intake and the first therapy session were associated with higher family therapy attendance. Overall, individual and family factors predicted therapy attendance but these factors differed depending upon the treatment modality.     

Contingencies promote delay tolerance

The effectiveness of functional communication training as treatment for problem behavior depends on the extent to which treatment can be extended to typical environments that include unavoidable and unpredictable reinforcement delays. Time‐based progressive delay (TBPD) often results in the loss of acquired communication responses and the resurgence of problem behavior, whereas contingency‐based progressive delay (CBPD) appears to be effective for increasing tolerance for delayed reinforcement. No direct comparison of TBPD and CBPD has, however, been conducted. We used single‐subject designs to compare the relative efficacy of TBPD and CBPD. Four individuals who engaged in problem behavior (e.g., aggression, vocal and motor disruptions, self‐injury) participated. Results were consistent across all participants, and showed lower rates of problem behavior and collateral responses during CBPD than during TBPD. The generality of CBPD treatment effects, including optimal rates of communication and compliance with demands, was demonstrated across a small but heterogeneous group of participants, reinforcement contingencies, and contexts.     

Stimulus Fading and Response Elaboration in Differential Reinforcement for Alternative Behavior

A hallmark of applied behavior analysis is the development of function‐based interventions for problem behavior. A widely recommended function‐based intervention is differential reinforcement of alternative behavior (DRA), in which reinforcement is contingent upon socially acceptable alternatives to problem behavior (e.g., teaching communication skills). Typically, DRA is introduced under rich schedules of reinforcement. Although effective for initiating behavior change, rich schedules are often impractical in the natural setting. In this study, we evaluated the extent to which a stimulus fading program could be employed to elaborate alternative behavior (mands) in two individuals diagnosed with an autism spectrum disorder. For both participants, problem behavior was reduced substantially upon implementation of the DRA procedure. Further, problem behavior rates remained low and mand rates decreased to more practical levels as the DRA behavioral requirements increased during the fading program. The fading approach demonstrated in this paper may be a useful component of intervention packages for clinicians. Copyright © 2015 John Wiley & Sons, Ltd.