脐血内皮祖细胞的研究与应用

近年来,脐带血内皮祖细胞以其取材方便,数量丰富等独特优势受到越来越多科学家的青睐,其不仅能在体外扩增并移植到缺血组织、损伤血管中,并能参与组织修复和血管新生过程.本文归纳总结了脐带血来源内皮祖细胞的最新研究与应用现状及其在缺血性疾病治疗、血管修复及组织工程学中的临床运用中的重要意义.     

血管内皮生长因子与结直肠癌的研究

血管内皮生长因子（vascular endothelial growth factor,VEGF）是一高度特异作用于内皮细胞的糖蛋白,是目前发现的最重要的肿瘤血管生长因子之一。结直肠癌的生长、侵袭和转移与血管内皮生长因子有密切的关系,VEGF在结直肠癌治疗中的作用日益突出。本文就VEGF的功能、在结直肠癌中的表达和治疗的作用作一综述。     

血管内皮生长因子与结直肠癌的研究

血管内皮生长因子(vascular endothelial growth factor,VEGF)是一高度特异作用于内皮细胞的糖蛋白,是目前发现的最重要的肿瘤血管生长因子之一.结直肠癌的生长、侵袭和转移与血管内皮生长因子有密切的关系,VEGF在结直肠癌治疗中的作用日益突出.本文就VEGF的功能、在结直肠癌中的表达和治疗的作用作一综述.     

脐带血储存的相关法律问题浅析

脐带血在医学临床实践方面拥有广阔的应用前景.目前利用的脐带血绝大多数来源于脐带血库,后者是储存捐献和自体脐带血的专门机构.我国关于脐带血储存中的法律问题理论研究较为匮乏,现有的法律规制和监管亦存在缺失.就此方面作一分析和探讨,以期对我国脐带血储存的立法和监管的完善等有所裨益.     

结肠癌组织中血管内皮生长因子-C表达与淋巴转移的关系

探讨结肠癌组织中血管内皮生长因子-C（VEGF-C）表达与淋巴管、血管生成及淋巴转移、临床病理参数之间的关系。结论为VEGF-C高表达而淋巴转移阴性的患者亦有很强的淋巴结转移倾向,甚至可能已发生淋巴结微转移。VEGF-C主要通过调控结肠癌组织中微淋巴管的生成而影响结肠癌的淋巴结转移。     

结肠癌组织中血管内皮生长因子-C表达与淋巴转移的关系

探讨结肠癌组织中血管内皮生长因子-C(VEGF-C)表达与淋巴管、血管生成及淋巴转移、临床病理参数之间的关系.结论为VEGF-C高表达而淋巴转移阴性的患者亦有很强的淋巴结转移倾向,甚至可能已发生淋巴结微转移.VEGF-C主要通过调控结肠癌组织中微淋巴管的生成而影响结肠癌的淋巴结转移.     

内皮祖细胞治疗对经皮冠脉支架植入术后再内皮化研究进展

药物洗脱支架的使用很大程度上防止了支架内再狭窄,但随着其在临床上的广泛应用,晚期支架内血栓形成引起了人们的重视,这一并发症在一定程度上与再内皮化延迟有关.近年来对内皮祖细胞生物学特性的深入研究,使支架植入后快速再内皮化成为可能,从而为有效防止晚期支架内血栓形成提供了一个很好的研究方向.本文就此方面的研究进展作一综述.     

CyclinD1、VEGF、Flt-1在肝细胞癌中的表达及临床意义

探讨肝细胞癌( Hepatocellular carcinoma,HCC)、胆管癌、肝硬化及正常肝组织中周期素D1 (CyclinD1)、血管内皮生长因子(VEGF)及血管内皮生长因子受体(Flt-1)蛋白表达的意义及其与肝癌生物学行为关系.对52例符合要求的HCC组织、10例胆管癌组织、10例肝硬化组织及10例正常肝组织采用免疫组化S-P法检测CyclinD1、VEGF及Flt-1蛋白.CyclinD1、VEGF及Flt-1在HCC的强阳性表达率分别为55.8％、55.8％及67.3％,均显著高于胆管癌、肝硬化及正常肝组织(P＜0.001).CyclinD1及VEGF表达与肿瘤包膜完整、血管侵犯及肿瘤分化程度明显有关(P＜0.05);Flt -1与肿瘤分化程度明显有关(P＜0.05).CyclinD1与VEGF间、CyclinD1与Flt-1间及VEGF与Flt-1间的蛋白表达均呈正相关(R=0.445,P＜0.01、R=0.368,P＜0.01、R=0.332,P＜0.01).CyclinD1、VEGF及Flt-1蛋白的过表达可促使肝癌细胞增殖,使肝癌细胞具有更强的侵袭力,与肝癌的发生、发展密切相关.     

鼻咽癌组织VEGF、TNF—α及其受体VEGFR1、P55的表达及意义

观察鼻咽癌黏膜上皮中血管内皮生长因子（VEGF）、肿瘤坏死因子α（TNF—α）及受体血管生长因子1（VEGFR1）,肿瘤坏死生长因子受体蛋白55（P55）的表达情况,探讨其在鼻咽癌发病及进展中的意义。我们应用免疫组化SP法检测60例鼻咽癌和60例正常鼻黏膜上皮组织VEGF、TNF—α及VEGFR1、P55表达情况,分析其在鼻咽癌组织中的表达变化及意义。结果显示鼻咽癌黏膜上皮的VEGF、TNF—α、VEGFR1、P55表达高于正常鼻黏膜上皮。因此VEGF、TNF—α及其受体VEGFR1、P55在鼻咽癌黏膜上皮中过度表达,可能参与鼻咽癌的发病及疾病进展,对于鼻咽癌的预防及治疗具有重要意义。     

鼻咽癌组织VEGF、TNF-α及其受体VEGFR1、P55的表达及意义

观察鼻咽癌黏膜上皮中血管内皮生长因子(VEGF)、肿瘤坏死因子α(TNF-α)及受体血管生长因子1(VEGFR1),肿瘤坏死生长因子受体蛋白55(P55)的表达情况,探讨其在鼻咽癌发病及进展中的意义.我们应用免疫组化SP法检测60例鼻咽癌和60例正常鼻黏膜上皮组织VEGF、TNF-α及VEGFR1、P55表达情况,分析其在鼻咽癌组织中的表达变化及意义.结果显示鼻咽癌黏膜上皮的VEGF、TNF-α、VEGFR1、P55表达高于正常鼻黏膜上皮.因此VEGF、TNF-α及其受体VEGFR1、P55在鼻咽癌黏膜上皮中过度表达,可能参与鼻咽癌的发病及疾病进展,对于鼻咽癌的预防及治疗具有重要意义.     

Together – apart: in touch in a time of separation

This paper explores the experience of working as a Jungian analyst through the various phases of the global COVID-19 pandemic, examining the importance of the physical containing space alongside the analyst’s internal mind and how technology can both help and hinder understanding. A number of clinical vignettes illustrate the challenge of communicating over a distance, paying particular attention to the way countertransference phenomena can become re-attuned. Reference is made to mythology and symbols of hope, and consideration given to the meaning and purpose of the pandemic.     

The Possibility of Meaning in Human Evolution

Science undermines the certitude of non-naturalistic answers to the question of whether human life has meaning. I explore whether evolution can provide a naturalistic basis for existential meaning. Using the work of philosopher Daniel Dennett and scientist Ursula Goodenough, I argue that evolution is the locus of the possibility of meaning because it has produced intentionality, the matrix of consciousness. I conclude that the question of the meaning of human life is an existentialist one: existential meaning is a product of the individual and collective tasks human beings undertake.     

Phenotypic plasticity and archetype: a response to common objections to the biological theory of archetype and instinct

Since Jung’s death in 1961, scholars have attempted to integrate growing biological science data into Jungian concepts such as the collective unconscious, instincts and the archetypes. This enterprise has been challenging due to persistent false dichotomies of gene and environment occasionally arising. Recent works by Roesler (2022a, 2022b) for example, have raised objections to the biological theory of archetypes, but the objections are plagued by such dichotomies. The concept of phenotypic plasticity, however, helps to both avoid this problem as well as bridge the gap between competing theories into a more integrated model with solid biological foundations.     

When is it time to stop? When good enough becomes bad enough

This article draws on Winnicott’s concept of the good enough mother to discuss how to know whether a therapeutic situation is good enough to continue or bad enough to end. This dilemma is explored in terms of clinical syndromes, such as anorexia and pathological gambling, but focuses mainly on analyst-initiated endings, which are termed the ‘Casablanca dilemma’, based on an amplification of the ending of the film Casablanca. The author goes on to discuss such one-sided endings, drawing on interviews with 40 analysts and therapists about their clinical experience. A typology of bad enough endings is presented. The psychological differences between a good enough analysis as opposed to a bad enough one are explored through the ideas of Winnicott and Neumann.     

Kann Es Ein Argument Für Den Skeptizismus Geben? Das Epistemische Problem Der Irrtumsmöglichkeit

Summary  Is there any argument for scepticism? The epistemic problem of the possibility of error. Arguments for scepticism rest on the assumption that knowledge claims are fallible. For this reason the concept of knowledge appears to be questionable. Since it is necessary to distinguish doubts from possible doubts, the arguments for scepticism appear to be unconvincing. If we take it into account that we know something that is immune to doubt, we should draw the conclusion that, contrary to scepticism, knowledge claims have to be compatible with being fallible. Thus any knowledge claim is capable of being doubted.     

The transcendent function in Spitteler’s Prometheus and Epimetheus

In August 2020, John Beebe and Steve Myers met via Zoom to discuss their differing interpretations of psychological typology and the different sources within Jung’s writings that influenced their books: Integrity in Depth: Energies and Patterns in Psychological Type (Beebe), and Myers-Briggs Typology vs Jungian Individuation (Myers). The discussion centred on Spitteler’s epic poem Prometheus und Epimetheus, which forms the basis of chapter V of Psychological Types. This is both the largest chapter and one of two chapters that Jung highlighted in the Argentine foreword as containing the essence of the book. Jung’s book is primarily about the transformation of personality rather than the categorization of people. Although it contains a critical psychology that deconstructs the nature of consciousness, that is only one half of the book and a stepping-stone to the other half, which is the reconciliation of opposites with particular emphasis on the relation of consciousness and the unconscious. Jung assumed that readers were already familiar with Prometheus und Epimetheus, an understanding of which sheds light on the nature of the transformation that Jung described – the development of a new attitude towards attitude itself.     

Chapter 6: Biblical Foundations for a Practical Theology of Aging

SUMMARY

This article reviews Biblical sources pertaining to the elderly, particularly the frail elderly. Founded on these sources, implications for elderly with Alzheimer's Disease and other forms of dementia are addressed through a personal perspective informed by writings of Christian mystics.     

Seeing in the Dark: A View into Dissociation and Healing

In this paper, I will explore the role of art-making, the experience of trauma and dissociation, and the process of working with self-states from an analytic and creative frame. Relevant literature on dissociation, trauma, and the use of art will be discussed. A case involving my work with an adolescent girl who had experienced sexual abuse from a family member will be shared, with an emphasis on the meaningful role images played during the therapeutic process. Both Jungian and psychoanalytic models of conceptualizing and working with dissociation are included, following Donald Kalsched’s (2013) recommendation for a “binocular stance” to treatment, including both a focus on the inner, intrapsychic world and the interpersonal, relational realm, and how art images both illuminated and expressed these realms. Within the therapeutic process, art images allowed the therapist a view into the client’s unconscious process, and created a meeting ground for dissociative barriers to be gradually seen, felt and known, by both therapist and client. The experience of dissociation, in images and in session, provided a reference point for myself and my client, Taylor, to develop a shared understanding and a framework for growth.